| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | Method of making a microbead array with attached biomolecules | US11760814 | 2007-06-11 | US20070259449A1 | 2007-11-08 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 62 | System and method of sorting materials using holographic laser steering | US10630904 | 2003-07-31 | US07241988B2 | 2007-07-10 | Lewis Gruber; Kenneth Bradley; Ward Lopes; Robert W. Lancelot; Joseph S. Plewa; David G. Grier |
| The present invention employs a beam steering apparatus to isolate valuable cells from other cells, tissues, and contaminants. In one embodiment, the system balances optical trapping against biasing flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation. | ||||||
| 63 | Assays Employing Randomly Distributed Microbeads with Attached Biomolecules | US11673687 | 2007-02-12 | US20070154934A1 | 2007-07-05 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 64 | Use of multiple optical vortices for pumping, mixing and sorting | US11266989 | 2005-11-04 | US07176445B2 | 2007-02-13 | Jennifer E. Curtis; Brian A. Koss; David G. Grier |
| A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations. The method also involves employing the rotation induced in trapped particles by optical vortices to assemble clusters of particles into functional micromachines, to drive previously assembled micromachines, to pump fluids through microfluidics channels, to control flows of fluids through microfluidics channels, to mix fluids within microfluidics channels, to transport particles, to sort particles and to perform other related manipulations and transformations on matter over length scales. | ||||||
| 65 | Encoded random arrays and matrices | US10365993 | 2003-02-13 | US07156315B2 | 2007-01-02 | Michael Seul; Chiu Wo Chau |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. The invention is also for a system and method for programmable illumination pattern generation, including a novel method and apparatus to generate patterns of illumination and project them onto planar surfaces or onto planar interfaces such as the interface formed by an electrolyte-insulator-semiconductor (EIS), e.g., as described herein. This enables the creation of patterns or sequences of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest. The use of the LCD technology provides flexibility and control over spatial layout, temporal sequences and intensities (“gray scales”) of illumination patterns. The latter capability permits the creation of patterns with abruptly changing light intensities or patterns with gradually changing intensity profiles. | ||||||
| 66 | Light-controlled electrokinetic assembly of particles near surfaces | US11436718 | 2006-05-17 | US20060228741A1 | 2006-10-12 | Seul Michael |
| A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 67 | Method and apparatus for a solid-state atomic frequency standard | US10929100 | 2004-08-26 | US07030704B2 | 2006-04-18 | Christopher White |
| The present invention relates generally to frequency standards. More specifically, the present invention relates to a method and apparatus for solid-state atomic frequency standard based on the hyperfine spectrum of paramagnetic dopants in solids. | ||||||
| 68 | Light-controlled electrokinetic assembly of particles near surfaces | US10910466 | 2004-08-03 | US20060040411A1 | 2006-02-23 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolytc solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The preset invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 69 | Multiple optical vortices for manipulating particles | US11059876 | 2005-02-17 | US06995351B2 | 2006-02-07 | Jennifer E. Curtis; Brian A. Koss; David G. Grier |
| A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations. The method also involves employing the rotation induced in trapped particles by optical vortices to assemble clusters of particles into functional micromachines, to drive previously assembled micromachines, to pump fluids through microfluidics channels, to control flows of fluids through microfluidics channels, to mix fluids within microfluidics channels, to transport particles, to sort particles and to perform other related manipulations and transformations on matter over length scales. | ||||||
| 70 | Method for separating micro-particles | US09843902 | 2001-04-27 | US06936811B2 | 2005-08-30 | Osman Kibar |
| A system and method for separating particles is disclosed in which the particles are exposed to a moving light intensity pattern which causes the particles to move a different velocities based on the physical properties of the particles. This system and method allows particles of similar size and shape to be separated based on differences in the particles dielectric properties. | ||||||
| 71 | Microfluidic sorting device | US10848972 | 2004-05-18 | US20050164158A1 | 2005-07-28 | Mark Wang; Erhan Ata; Sadik Esener |
| Small particles, for example 5 μm diameter microspheres or cells, within, and moving with, a fluid, normally water, that is flowing within microfluidic channels within a radiation-transparent substrate, typically molded PDMS clear plastic, are selectively manipulated, normally by being pushed with optical pressure forces, with laser light, preferably as arises from VCSELs operating in Laguerre-Gaussian mode, at branching junctions in the microfluidic channels so as to enter into selected downstream branches, thereby realizing particle switching and sorting, including in parallel. Transport of the small particles thus transpires by microfluidics while manipulation in the manner of optical tweezers arises either from pushing due to optical scattering force, or from pulling due to an attractive optical gradient force. Whether pushed or pulled, the particles within the flowing fluid may be optically sensed, and highly-parallel. low-cost, cell- and particle-analysis devices efficiently realized, including as integrated on bio-chips. | ||||||
| 72 | Optical peristaltic pumping with optical traps | US11041640 | 2005-01-24 | US20050145785A1 | 2005-07-07 | David Grier; Sven Behrens |
| A method of use for holographic optical traps or gradients in which repetitive cycling of a small number of appropriately designed arrays of traps are used for general and very complex manipulations of particles and volumes of matter. Material transport results from a process resembling peristaltic pumping, with the sequence of holographically-defined trapping or holding manifolds resembling the states of a physical peristaltic pump. | ||||||
| 73 | SYSTEM AND METHOD FOR SEPARATING MICRO-PARTICLES | US09843902 | 2001-04-27 | US20050094232A1 | 2005-05-05 | Osman Kibar |
| A system and method for separating particles is disclosed in which the particles are exposed to a moving light intensity pattern which causes the particles to move a different velocities based on the physical properties of the particles. This system and method allows particles of similar size and shape to be separated based on differences in the particles dielectric properties. | ||||||
| 74 | Optical peristaltic pumping with optical traps | US10651370 | 2003-08-29 | US06847032B2 | 2005-01-25 | David G. Grier; Sven Holger Behrens |
| A method of use for holographic optical traps or gradients in which repetitive cycling of a small number of appropriately designed arrays of traps are used for general and very complex manipulations of particles and volumes of matter. Material transport results from a process resembling peristaltic pumping, with the sequence of holographically-defined trapping or holding manifolds resembling the states of a physical peristaltic pump. | ||||||
| 75 | Method for sorting particles | US09993376 | 2001-11-14 | US06833542B2 | 2004-12-21 | Mark M. Wang; Eugene Tu; James P. O'Connell; Kristie L. Lykstad; William F. Butler |
| A method for sorting a particle of interest from a plurality of particles includes the steps of determining an absorption maxima of the particle of interest, providing a light source for generating a beam of coherent light at a wavelength correlating to the absorption maxima, providing a plurality of particles on a support surface, and imparting relative motion between the beam of coherent light and the plurality of particles so as to cause differential movement between the particle of interest and the plurality of particles. The particle of interest is then collected. | ||||||
| 76 | Method for separation of particles | US09993318 | 2001-11-14 | US06815664B2 | 2004-11-09 | Mark M. Wang; Eugene Tu; James P. O'Connell; Kristie L. Lykstad; William F. Butler |
| Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a method is provided for separating particles by flowing the particles within a first constrained path, the first constrained path having an input and an output, and a sorting region, the sorting region coupling to a second constrained path, the second constrained path including an output, illuminating the sorting region with a moving optical gradient, characterized in that certain of the particles flow in a laminar manner between the first inlet and the output of the first constrained path, and selected particles are diverted from the first constrained path to the second constrained path under the force of the moving optical gradient. | ||||||
| 77 | Method of separating particles using an optical gradient | US09993377 | 2001-11-14 | US06784420B2 | 2004-08-31 | Mark M. Wang; Eugene Tu; James P. O'Connell; Kristie L. Lykstad; William F. Butler |
| Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a method is provided for interacting an optical gradient field in three dimensions with a particle by interfering two beams to generate a plurality of planar fronts, providing a plurality of particles in a medium, and moving the planar fronts relative to the particles, whereby the particles are separated at least in part based upon the dielectric constant of the particles. | ||||||
| 78 | Methods of separating particles using an optical gradient | US09993326 | 2001-11-14 | US06744038B2 | 2004-06-01 | Mark M. Wang; Eugene Tu; James P. O'Connell; Kristie L. Lykstad; William F. Butler |
| Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. The invention includes methods for separating particles in a medium where the particles having differing dielectric constants by providing a medium having a dielectric constant between the dielectric constants of the particles, subjecting the particles in the media to an optical gradient field, and separating the particles. | ||||||
| 79 | Microsystem for the dielectric and optical manipulation of particles | US10432793 | 2003-09-05 | US20040063196A1 | 2004-04-01 | Torsten Muller; Thomas Schnelle; Gunter Fuhr |
| Described is a fluidic microsystem (100) with at least one compartment (10) for the receiving and/or the through-flow of a liquid and having an electrode arrangement (20) with a multiplicity of electrodes (21-28), between which a coaction zone (11) is established, whereby the compartment (10) possesses at least one wall (12-14), through which electromagnetic radiation can be linked into the said coaction zone (11) in accord with a predetermined incident direction (B), and on at least one electrode (21-28) a cooling apparatus is provided, and on which at least one respective electrode (21-28) at least one reflector layer (21b, 22b, 25b, 26b, 26c, 21c) is provided, and wherein the respective electrode (21-28) is at least partially shielded in reference to the incident beam direction (B), and having at least one heat conducting layer (50) by means of which the respective electrode (21-28) stands in thermal communication with a wall of the compartment (10), and/or includes an active cooling element (21c), which is placed in thermal contact with the respective electrode (21-18). | ||||||
| 80 | Arrays formed of encoded beads having ligands attached | US10645426 | 2003-08-21 | US20040037744A1 | 2004-02-26 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
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