| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 141 | MULTIPLE LAMINAR FLOW-BASED PARTICLE AND CELLULAR SEPARATION WITH LASER STEERING | US13412969 | 2012-03-06 | US20120183947A1 | 2012-07-19 | Daniel MUETH; Joseph PLEWA; Jessica SHIREMAN; Amy ANDERSON; Lewis GRUBER; Neil Harris ROSENBAUM |
| The invention provides a method, apparatus and system for separating cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One exemplary method includes providing a first flow having a plurality of components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first cellular component of the plurality of components into the second flow while concurrently maintaining a second cellular component of the plurality of components in the first flow. The second flow having the first cellular component is then differentially removed from the first flow having the second cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage. | ||||||
| 142 | Zeeman-slower, coil for a Zeeman-slower device and a method for cooling an atom beam | US12305098 | 2007-05-24 | US08049162B2 | 2011-11-01 | Tzenka Miteva; Gabriele Nelles; Akio Yasuda; Stanislav Balouchev |
| A Zeeman-slower device, a coil for such a Zeeman-slower device, and a method for cooling an atom beam. The Zeeman-slower includes a cooling section including an inner passage extending along a longitudinal axis, the inner passage having a cross-section perpendicular to the longitudinal axis, wherein the area of the cross-section of the inner passage increases monotonously along the longitudinal axis at least in a part of the cooling section. | ||||||
| 143 | Assays employing randomly distributed microbeads with attached biomolecules | US11673687 | 2007-02-12 | US08039271B2 | 2011-10-18 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 144 | Single-shot spatially-resolved imaging magnetometry using ultracold atoms | US12434005 | 2009-05-01 | US07915577B2 | 2011-03-29 | Fredrik K. Fatemi; Mark Bashkansky; Matthew L. Terraciano |
| A method and system for remotely imaging a magnetic field within an atom cloud is provided. An atom sample held in a magneto-optical trap is released, and the released atom cloud is illuminated by a Raman beam. Resonant atoms having certain velocities will absorb photon momenta from the Raman beam. The velocities of those resonant atoms will change in response to the absorbed momenta, causing a change in the travel distance of those atoms as compared with non-resonant atoms. The atom cloud is imaged by an imaging device such as a CCD camera and the presence of the resonant atoms is shown in the images as bright lines in the atom cloud. The distance traveled by the resonant atoms and therefore the separation of the lines in the image is a function of the magnetic fields in the atom cloud. The system and method of the present invention can image the magnetic fields within an atom cloud with a high spatial resolution over the entire atom cloud in a single imaging cycle, and analysis of the image provides information regarding the magnetic fields. | ||||||
| 145 | ATOM CHIP DEVICE | US12675790 | 2008-08-11 | US20100320995A1 | 2010-12-23 | Tal David; Jonathan Japha; Valery Dikovsky; Ron Folman |
| Ultra-cold (nano-Kelvin) neutral atoms can be trapped, manipulated, and measured, using integrated current carrying micro-structures on a nearby surface (Atom Chips). This can be utilized for the realization of ultra-sensitive sensors and quantum computation devices based on the quantum mechanical properties of the trapped atoms. However, harmful processes arise from the interactions between the atoms and the nearby surface. According to the present invention these harmful processes can be highly suppressed by using electrically anisotropic materials. It is shown that time-independent trapping potential corrugation leading to fragmentation of the trapped atom cloud can be suppressed, and that time dependent noise processes arising from the coupling of atoms to the nearby surface, and leading to loss of atoms from the trap, heating and loss of coherence can be significantly reduced. | ||||||
| 146 | Method and apparatus for producing a discrete droplet for subsequent analysis or manipulation | US10399823 | 2001-10-23 | US07785897B2 | 2010-08-31 | George Agnes; Xiao Feng; Michael Bogan |
| A method and apparatus for producing a discrete particle for subsequent analysis (such as mass spectrometry) or manipulation is disclosed. A discrete particle is generated by a particle generator. A net charge is induced onto the particle by an induction electrode. The particle is delivered to a levitation device where it is then electrodynamically levitated. If the particle is a droplet, desolvation will occur, leading to Coloumbic fissioning of the droplet into smaller droplets. The movement of the levitated droplet(s) can be manipulated by an electrode assembly. The droplet(s), and the charge thereon, can be delivered to a mass spectrometer in one aspect of the invention, providing an ion source for mass spectrometry without the detrimental space charge effects of electrospray ionization techniques. In another aspect of the invention, the levitated particle(s) may be controllably and precisely deposited onto a plate for subsequent analysis by matrix assisted laser desorption and ionization mass spectrometry. | ||||||
| 147 | METHODS AND APPARATUS FOR USE OF OPTICAL FORCES FOR IDENTIFICATION, CHARACTERIZATION AND/OR SORTING OF PARTICLES | US12545624 | 2009-08-21 | US20100108577A1 | 2010-05-06 | Mark M. Wang; Eugene Tu; Luis M. Pestana; Andrew E. Senyei; James P. O'Connell; Tina S. Nova; Kristie L. Lykstad; Jeffrey M. Hall; William F. Butler |
| Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a particle may be characterized by determining its optophoretic constant or signature. For example, a diseased cell has a different optophoretic constant from a healthy cell, thereby providing information, or the basis for sorting. In the event of physical sorting, various forces may be used for separation, including fluidic forces, such as through the use of laminar flow, or optical forces, or mechanical forces, such as through adhesion. Various techniques for measuring the dielectric constant of particles are provided. | ||||||
| 148 | Light-controlled electrokinetic assembly of particles near surfaces | US10910466 | 2004-08-03 | US07427512B2 | 2008-09-23 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The preset invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 149 | Microsystem for the dielectric and optical manipulation of particles | US10432793 | 2001-11-28 | US07276207B2 | 2007-10-02 | Torsten Muller; Thomas Schnelle; Gunter Fuhr |
| Described is a fluidic microsystem with at least one compartment for the receiving and/or the through-flow of a liquid and having an electrode arrangement with a multiplicity of electrodes, between which a coaction zone is established, whereby the compartment possesses at least one wall, through which electromagnetic radiation can be linked into the said coaction zone in accord with a predetermined incident direction, and on at least one electrode a cooling apparatus is provided, and on which at least one respective electrode at least one reflector layer is provided, and wherein the respective electrode is at least partially shielded in reference to the incident beam direction, and having at least one heat conducting layer by means of which the respective electrode stands in thermal communication with a wall of the compartment, and/or includes an active cooling element, which is placed in thermal contact with the respective electrode. | ||||||
| 150 | Optical fractionation methods and apparatus | US10845758 | 2004-05-14 | US07233423B2 | 2007-06-19 | David G. Grier |
| Static arrays of optical traps can be used to sort microscopic objects with exponential sensitivity to size. Such optical fractionation relies on competition between an externally applied force and the moving objects' differing affinities for optical gradient traps. In a reverse fractionation method, objects that are more strongly influenced by the traps tend to become kinetically locked in to the array and are systematically deflected back into an input flow. In a thermal ratcheting method, patterns are spaced to allow particle diffusion, thus providing the opportunity for forward or reverse movement through the patterns. Unlike other sorting techniques, optical fractionation can operate continuously and can be continuously optimized. The exponential sensitivity arises quite generally from the particle size dependence of the potential wells' apparent widths. | ||||||
| 151 | System and method for programmable illumination pattern generation | US09768413 | 2001-01-24 | US07144119B2 | 2006-12-05 | Michael Seul; Chiu Wo Chau |
| An apparatus providing programmable illumination pattern generation for the manipulation of colloidal particulates and biomolecules in suspension between electrodes, is disclosed. The apparatus implements LEAPS (Light-controlled electrokinetic assembly of particles near surfaces), which relies on: AC electric field-induced assembly of particles the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The apparatus generates patterns of illumination and projects then onto planar surfaces, i.e., a LEAPS electrode. This enables the creation of patterns using graphical design or drawing software on a personal computer and the projection or said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest, to provide for arrangements and assembly of particles in such patterns. | ||||||
| 152 | Array cytometry | US10109980 | 2002-03-27 | US07056746B2 | 2006-06-06 | Michael Seul; Alice Xiang Li |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. This invention is also for a method and apparatus to direct the lateral motion and induce the assembly into planar arrays of cells on semiconductor surfaces in response to temporally and spatially varying electric fields and to projected patterns of illumination. | ||||||
| 153 | System and method for programmable illumination pattern generation | US09768414 | 2001-01-24 | US07041510B2 | 2006-05-09 | Michael Seul; Chiu Wo Chau |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. The invention is also for a system and method for programmable illumination pattern generation, including a novel method and apparatus to generate patterns of illumination and project them onto planar surfaces or onto planar interfaces such as the interface formed by an electrolyte-insulator-semiconductor (EIS), e.g., as described herein. This enables the creation of patterns or sequences of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest. The use of the LCD technology provides flexibility and control over spatial layout, temporal sequences and intensities (“gray scales”) of illumination patterns. The latter capability permits the creation of patterns with abruptly changing light intensities or patterns with gradually changing intensity profiles. | ||||||
| 154 | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles | US11272593 | 2005-11-11 | US20060060767A1 | 2006-03-23 | Mark Wang; Eugene Tu; Luis Pestana; Andrew Senyei; James O'Connell; Tina Nova; Kristie Lykstad; Jeffrey Hall; William Butler |
| Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a particle may be characterized by determining its optophoretic constant or signature. For example, a diseased cell has a different optophoretic constant from a healthy cell, thereby providing information, or the basis for sorting. In the event of physical sorting, various forces may be used for separation, including fluidic forces, such as through the use of laminar flow, or optical forces, or mechanical forces, such as through adhesion. Various techniques for measuring the dielectric constant of particles are provided. | ||||||
| 155 | Use of multiple optical vortices for pumping, mixing and sorting | US11266989 | 2005-11-04 | US20060054793A1 | 2006-03-16 | Jennifer Curtis; Brian Koss; David Grier |
| A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations. The method also involves employing the rotation induced in trapped particles by optical vortices to assemble clusters of particles into functional micromachines, to drive previously assembled micromachines, to pump fluids through microfluidics channels, to control flows of fluids through microfluidics channels, to mix fluids within microfluidics channels, to transport particles, to sort particles and to perform other related manipulations and transformations on matter over length scales | ||||||
| 156 | Method and device for measuring, calibrating and using laser tweezers | US09582609 | 1998-12-21 | US06991906B1 | 2006-01-31 | Günter Fuhr; Thomas Schnelle; Torsten Müller; Hermine Hitzler; Karl-Otto Greulich; Shamoi Monajembashi |
| To measure or exert optically-induced forces on at least one particle in the focus of an optical cage, the following steps are taken: a) the focus is positioned in a microelectrode arrangement with a three-dimensional electrical field that has a field gradient which forms an electrical capture area, and the focus is at a distance from the capture are and b) the amplitude of the electrical field, the light power of the light beam forming the optical cage, and/or the distance of the capture area from the focus are varied to detect which varied field property moves the particle from the focus to the capture area or vice versa, or at least to temporarily move the particle into the capture area. | ||||||
| 157 | System and method for separating micro-particles | US11087174 | 2005-03-22 | US20050164372A1 | 2005-07-28 | Osman Kibar |
| A system and method for separating particles is disclosed in which the particles are exposed to a moving light intensity pattern which causes the particles to move at a different velocities based on the physical properties of the particles. This system and method allows particles of similar size and shape to be separated based on differences in the particles dielectric properties. | ||||||
| 158 | Method and apparatus for a solid-state atomic frequency standard | US10929100 | 2004-08-26 | US20050088248A1 | 2005-04-28 | Christopher White |
| The present invention relates generally to frequency standards. More specifically, the present invention relates to a method and apparatus for solid-state atomic frequency standard based on the hyperfine spectrum of paramagnetic dopants in solids. | ||||||
| 159 | Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices | US09998012 | 2001-11-28 | US06778724B2 | 2004-08-17 | Mark Wang; Erhan Polatkon Ata; Sadik C. Esener |
| Small particles, for example 5 &mgr;m diameter microspheres or cells, within, and moving with, a fluid, normally water, that is flowing within microfluidic channels within a radiation-transparent substrate, typically molded PDMS clear plastic, are selectively manipulated, normally by being pushed with optical pressure forces, with laser light, preferably as arises from VCSELs operating in Laguerre-Gaussian mode, at branching junctions in the microfluidic channels so as to enter into selected downstream branches, thereby realizing particle switching and sorting, including in parallel. Transport of the small particles thus transpires by microfluidics while manipulation in the manner of optical tweezers arises either from pushing due to optical scattering force, or from pulling due to an attractive optical gradient force. Whether pushed or pulled, the particles within the flowing fluid may be optically sensed, and highly-parallel, low-cost, cell- and particle-analysis devices efficiently realized, including as integrated on bio-chips. | ||||||
| 160 | System and method of sorting materials using holographic laser steering | US10630904 | 2003-07-31 | US20040089798A1 | 2004-05-13 | Lewis Gruber; Kenneth Bradley; Ward Lopes; Robert W. Lancelot; Joseph S. Plewa; David G. Grier |
| The present invention employs a beam steering apparatus to isolate valuable cells from other cells, tissues, and contaminants. In one embodiment, the system balances optical trapping against biasing flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation. | ||||||
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