| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 201 | Multiple laminar flow-based particle and cellular separation with laser steering | US14829993 | 2015-08-19 | US09335295B2 | 2016-05-10 | Daniel Mueth; Joseph Plewa; Jessica Shireman; Amy Anderson; Lewis Gruber; Neil Rosenbaum |
| The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage. | ||||||
| 202 | MULTIPLE LAMINAR FLOW-BASED PARTICLE AND CELLULAR SEPARATION WITH LASER STEERING | US14829993 | 2015-08-19 | US20160047777A1 | 2016-02-18 | Daniel MUETH; Joseph PLEWA; Jessica SHIREMAN; Amy ANDERSON; Lewis GRUBER; Neil ROSENBAUM |
| The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage. | ||||||
| 203 | Multiple laminar flow-based particle and cellular identification | US14317738 | 2014-06-27 | US09000357B2 | 2015-04-07 | Daniel Mueth; Joseph Plewa; Jessica Shireman; Amy Anderson; Lewis Gruber; Neil Rosenbaum |
| An apparatus and method to identify at least one component from a plurality of components in a fluid mixture, includes a first input channel containing the fluid mixture of components; at least one buffer input channel, into which at least one additional flow of buffer solution is introduced; a plurality of regions disposed at the other end of the apparatus, which are adapted to receive outputs of at least one selected component of the plurality of components, the selected component which is selectively removed from the first flow to one of the regions; a waste channel through which unselected components are removed from the first flow; a plurality of pumps connected to at least one reservoir, to control flow rates of the first flow and the additional flow(s); and a computer which controls a selection of one of the plurality of components from the fluid mixture. | ||||||
| 204 | METHOD OF MAKING A MICROBEAD ARRAY WITH ATTACHED BIOMOLECULES | US14181028 | 2014-02-14 | US20140262782A1 | 2014-09-18 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 205 | Method of making a microbead array with attached biomolecules | US13664953 | 2012-10-31 | US08691594B2 | 2014-04-08 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 206 | Multiple laminar flow-based particle and cellular separation with laser steering | US13412969 | 2012-03-06 | US08653442B2 | 2014-02-18 | Daniel Mueth; Joseph Plewa; Jessica Shireman; Amy Anderson; Lewis Gruber; Neil Harris Rosenbaum |
| The invention provides a method, apparatus and system for separating cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One exemplary method includes providing a first flow having a plurality of components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first cellular component of the plurality of components into the second flow while concurrently maintaining a second cellular component of the plurality of components in the first flow. The second flow having the first cellular component is then differentially removed from the first flow having the second cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage. | ||||||
| 207 | AtomChip device | US11816172 | 2006-01-29 | US08309909B2 | 2012-11-13 | Valery Dikovsky; Ron Folman; Yoni Japha |
| An AtomChip device and a method for trapping, manipulating and measuring atoms in ultra high vacuum chamber, and for increasing the lifetime of the trapped atoms, the AtomChip device including at least one conductive element, made of metal, wherein at least part of the metal is a dilute alloy metal, and wherein the at least one conductive element has a low working temperature. | ||||||
| 208 | Multiple laminar flow-based particle and cellular separation with laser steering | US12659277 | 2010-03-02 | US08158927B2 | 2012-04-17 | Daniel Mueth; Joseph Plewa; Jessica Shireman; Amy Anderson; Lewis Gruber; Neil Harris Rosenbaum |
| The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage. | ||||||
| 209 | METHOD AND DEVICE FOR ACCURATELY MEASURING THE INCIDENT FLUX OF AMBIENT PARTICLES IN A HIGH OR ULTRA-HIGH VACUUM ENVIRONMENT | US13116982 | 2011-05-26 | US20110290991A1 | 2011-12-01 | James Lawrence Booth; David Erik Fagnan; Bruce George Klappauf; Kirk William Madison; Jicheng Wang |
| An apparatus and method that can measure flux density in-situ under high vacuum conditions includes a means for confining a collection of identical, elemental sensor particles to a volume of space by initial cooling by laser or another method, then confinement in a sensor volume using externally applied magnetic and/or optical fields. | ||||||
| 210 | STATIC ELECTROMAGNETIC APPARATUS FOR ACCELERATING ELECTRICALLY NEUTRAL MOLECULES UTILIZING THEIR DIPOLAR ELECTRIC MOMENT | US13129346 | 2009-11-13 | US20110253542A1 | 2011-10-20 | Achille Zanzucchi |
| An electromagnetic device for accelerating electrically neutral molecules of a substance is characterized by the fact of comprising: a Treating Tube (14) in non-conducting material, into which the substance to treat is introduced; static electromagnetic circuits that surround the above Treating Tube exerting on the substance to treat electromagnetic actions which push it axially, with utilization of the dipolar electric moment of the molecules. The treating method of the molecules accelerates these molecules utilizing their weak dipolar electric moment, subjecting them to a combination of a magnetic field and an electric one or, in alternative, of a magnetic field and one at Hertz waves, alternating and isofrequential, utilizing the Lorentz force of electrology. | ||||||
| 211 | Neutral atom trapping device | US11714557 | 2007-03-06 | US07816643B2 | 2010-10-19 | Masaharu Hyodo |
| A neutral atom trapping device with a multipole-magnetic field-generating electrode is provided with a main current electrode through which main current flows, and a pair of sub-current electrodes through which sub-current flows, and which is located in parallel to and both sides of said main current electrode; a neutral atom trapping device with an S-shaped multipole-magnetic field-generating electrode. | ||||||
| 212 | Multiple laminar flow-based particle and cellular separation with laser steering | US12659277 | 2010-03-02 | US20100216208A1 | 2010-08-26 | Daniel Mueth; Joseph Plewa; Jessica Shireman; Amy Anderson; Lewis Gruber; Neil Harris Rosenbaum |
| The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage. | ||||||
| 213 | Arrays formed of encoded beads having ligands attached | US10645426 | 2003-08-21 | US07749774B2 | 2010-07-06 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 214 | ATOMCHIP DEVICE | US11816172 | 2006-01-29 | US20100154570A1 | 2010-06-24 | Valery Dikovsky; Ron Folman; Yoni Japha |
| An AtomChip device and a method for trapping, manipulating and measuring atoms in ultra high vacuum chamber, and for increasing the lifetime of the trapped atoms, the AtomChip device including at least one conductive element, made of metal, wherein at least part of the metal is a dilute alloy metal, and wherein the at least one conductive element has a low working temperature. | ||||||
| 215 | Arrays formed of encoded beads having oligonucleotides attached | US11436009 | 2006-05-16 | US07615345B2 | 2009-11-10 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 216 | Single-Shot Spatially-Resolved Imaging Magnetometry using Ultracold Atoms | US12434005 | 2009-05-01 | US20090272887A1 | 2009-11-05 | Fredrik K. Fatemi; Mark Bashkansky; Matthew L. Terraciano |
| A method and system for remotely imaging a magnetic field within an atom cloud is provided. An atom sample held in a magneto-optical trap is released, and the released atom cloud is illuminated by a Raman beam. Resonant atoms having certain velocities will absorb photon momenta from the Raman beam. The velocities of those resonant atoms will change in response to the absorbed momenta, causing a change in the travel distance of those atoms as compared with non-resonant atoms. The atom cloud is imaged by an imaging device such as a CCD camera and the presence of the resonant atoms is shown in the images as bright lines in the atom cloud. The distance traveled by the resonant atoms and therefore the separation of the lines in the image is a function of the magnetic fields in the atom cloud. The system and method of the present invention can image the magnetic fields within an atom cloud with a high spatial resolution over the entire atom cloud in a single imaging cycle, and analysis of the image provides information regarding the magnetic fields. | ||||||
| 217 | Multiple laminar flow-based particle and cellular separation with laser steering | US12213109 | 2008-06-13 | US20090032449A1 | 2009-02-05 | Daniel Mueth; Joseph Plewa; Jessica Shireman; Amy Anderson; Lewis Gruber; Neil Harris Rosenbaum |
| The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage. | ||||||
| 218 | System and method of sorting materials using holographic laser steering | US11808677 | 2007-06-12 | US07482577B2 | 2009-01-27 | Lewis Gruber; Kenneth Bradley; Ward Lopes; Robert Lancelot; Joseph Plewa; David Grier |
| The present invention employs a beam steering apparatus to isolate valuable cells from other cells, tissues, and contaminants. In one embodiment, the system balances optical trapping against biasing flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation. | ||||||
| 219 | Apparatus and method for coating objects using an optical system | US10790115 | 2004-03-02 | US07425345B2 | 2008-09-16 | Jan Weber |
| An apparatus comprises a dispenser, a coherent energy source and an beam steering system. The dispenser defines a path of a droplet. The beam steering system is coupled to the coherent energy source and is configured to define a beam path of the coherent energy source. The beam path of the coherent energy source is disposable across the dispenser path at an interaction location. The beam steering system and coherent energy source are collectively configured such that at least one of a direction, a velocity and an acceleration of the droplet is modified within the interaction location. | ||||||
| 220 | Neutral atom trapping device | US11714557 | 2007-03-06 | US20080073494A1 | 2008-03-27 | Masaharu Hyodo |
| A neutral atom trapping device with a multipole-magnetic field-generating electrode is provided with a main current electrode through which main current flows, and a pair of sub-current electrodes through which sub-current flows, and which is located in parallel to and both sides of said main current electrode; a neutral atom trapping device with an S-shaped multipole-magnetic field-generating electrode-. | ||||||
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