| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 241 | Calcium receptor-active molecules | US484719 | 1995-06-07 | US6031003A | 2000-02-29 | Edward F. Nemeth; Bradford C. Van Wagenen; Manuel F. Balandrin; Eric G. DelMar; Scott T. Moe |
| The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies. | ||||||
| 242 | Ferritin formation as an predictor of iron availability in foods | US266950 | 1999-03-12 | US6017713A | 2000-01-25 | Raymond P Glahn |
| An in vitro system has been developed capable of effectively predicting the iron (Fe) availability of foods and food products. The system utilizes the formation of ferritin in intestinal epithelial cells as an indicator of Fe uptake from peptic and intestinal food digests. | ||||||
| 243 | Fluorescent conjugates of metal-chelating nitrogen heterocycles | US798390 | 1997-02-07 | US6013802A | 2000-01-11 | Brian Matthew Hoyland; Michael A. Kuhn; Richard P. Haugland |
| The present invention describes a family of fluorescent indicators for metal cations. The indicators are fluorophore conjugates of pyridyl-based metal ion chelators. The indicators are very sensitive detection as quantification reagents for a variety of metals, in a variety of oxidation states, even in the presence of high concentrations of Ca.sup.2+, Na.sup.+, or K.sup.+ or other ions, such as is found in seawater, making them highly useful for assaying physiological samples, biological samples, or environmental samples. | ||||||
| 244 | Calcium receptor-active molecules | US469204 | 1995-06-06 | US6001884A | 1999-12-14 | Edward F. Nemeth; Bradford C. Van Wagenen; Manuel F. Balandrin; Eric G. Delmar; Scott T. Moe |
| The present invention features molecules which can modulate one or activities of an inorganic ion receptor. Preferably, the molecule can mimic or block the effect of extracellular Ca.sup.2+ on a calcium receptor. The preferred use of such molecules is to treat diseases or disorders by altering inorganic ion receptor activity, preferably calcium receptor activity. | ||||||
| 245 | Dried chemical compositions | US951617 | 1997-10-16 | US5998031A | 1999-12-07 | Steven N. Buhl; Bhaskar Bhayani; Chi-Sou Yu; Thuy N. Tang |
| The present invention provides dried chemical compositions comprising dried beads. Typically, the beads comprise reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers. | ||||||
| 246 | Method for determining total chlorine amount and a kit for determining total chlorine amount | US706892 | 1996-09-03 | US5972713A | 1999-10-26 | Noriyasu Kuzuhara; Minoru Takada; Masayuki Numa |
| A method for determining total chlorine amount present in a sample by mixing the sample with a benzidine indicator solution comprising a benzidine compound capable of forming a dye by a reaction with a chlorine, wherein the hue of the formed dye changes depending upon the mole ratio of the chlorine to benzidine compound and determining the total chlorine amount from the hue. A kit for practicing the method incudes the indicator and a color scale for the hues of the dye. | ||||||
| 247 | Composition and method for manufacturing ion selective electrode sensors | US999835 | 1997-11-21 | US5964994A | 1999-10-12 | Alan Robert Craig; James David Hamerslag |
| This invention pertains to fluorophoric compositions and methods of their use for enhancing visualization of various constituents of ion selective electrodes. | ||||||
| 248 | Method for the determination of iodide | US894926 | 1997-09-03 | US5939328A | 1999-08-17 | Wolfgang Fischer; Thomas Groh; Stefanie Beil |
| A method for the determination of iodide in aqueous solutions, preferably in urine. The process is characterized in that the sample solution is admixed with a chromogen and a peracid solution and the color reaction is evaluated visually or photometrically. In the determination of iodide in urine, the sample is pretreated by means of a purified activated carbon. | ||||||
| 249 | Method of measuring metals in samples of living body | US885629 | 1997-06-30 | US5925570A | 1999-07-20 | Kazuyoshi Nishidate; Hiroshi Suzuki; Youko Suzuki; Youko Koga |
| A method and a reagent for highly accurate measuring of trace amount of metals in a sample of living body. The method and the reagent for measuring metals in a sample of living body includes:(1) a method for measuring metals in sample of living body, in which metals other than the objective metals of measurement are added to the measurement system to release the objective metals bonding to co-existing substances in the sample from the co-existing substances; and(2) a reagent for the measurement, in which metals other than the objective metals of the measurement are contained in a reagent for measuring metals in a sample of living body in order to release the objective metals bonding to the co-existing substances in the sample from the co-existing substances. | ||||||
| 250 | Method and apparatus for making an improved resilient packing product | US459495 | 1995-06-02 | US5921907A | 1999-07-13 | Edwin P. Beierlorzer |
| The present invention relates of a method and apparatus for making an improved resilient packing material by forming, resiliently folding and crimping shredded strips of moistened paper material into an improved interlocking, bulk, packaging material. The method and apparatus includes a wetting or dampening system which can be selectively varied to regulate the moisture content of moistened paper material. | ||||||
| 251 | Monoclonal antibody against complexed and non-complexed complexing agents for removing heavy metals from aqueous solutions and for analysis | US440354 | 1995-05-12 | US5907034A | 1999-05-25 | Klaus Bosslet; Peter Hermentin; Gerhard Seemann |
| The invention relates to monoclonal antibodies (mAB) which bind to water-soluble complexones such as ethylenediamine tetraacetate (EDTA) or diethylenetriamine pentaacetate (DTPA) with high specificity and avidity and retain their high avidity and specificity for these complexones after complexing of EDTA or DTPA with metal ions. These mAB can therefore be used, e.g. coupled on filters or other supports, for removing toxic heavy metals which are complexed with EDTA or DTPA. Furthermore, these mAB are suitable as components of immunoassays (RIA, ELISA etc.) for the quantitative determination of EDTA or DTPA in aqueous solutions. | ||||||
| 252 | Reagent for calcium ion level determination | US53701 | 1993-04-29 | US5902730A | 1999-05-11 | Tatsuya Mihara; Hitoshi Kondo; Kazuhiko Nagata |
| A reagent for calcium ion level determination comprising a phospholipid, phospholipase D, choline oxidase, a surfactant and a divalent metal salt. The reagent can easily be prepared and with which quantitative determination of calcium ion can be made over a broad range of a calcium ion concentration with ease and accuracy in a continuous manner. | ||||||
| 253 | pH test elements | US819790 | 1997-03-18 | US5897834A | 1999-04-27 | Paul J. Lawrence; Peter U. Ly; David R. Shockey |
| Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable means rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls. | ||||||
| 254 | Broad range total available chlorine test strip | US25676 | 1998-02-18 | US5888758A | 1999-03-30 | Wen H. Wu |
| A composition, method, and test device for determining the total available chlorine concentration, and the relative amounts of free and bound chlorine, of a test sample are disclosed. The test device includes a test pad having a suitable carrier matrix incorporating an indicator reagent composition capable of converting combined available chlorine to free available chlorine and of interacting with free available chlorine to produce a detectable and measurable response for total available chlorine over a range of 0 to over 5000 ppm total available chlorine in the test sample. An indicator reagent composition contains: (a) an indicator dye that is responsive to free available chlorine, such as tetramethylbenzidine, (b) a buffer, (c) a surfactant, (d) an optional catalyst, and (e) an optional polymer. An indicator reagent composition is incorporated into a carrier matrix, like filter paper, to provide a test pad useful in a dry phase total available chlorine assay of a test sample, such as a sanitizing solution for a hemodialysis unit. | ||||||
| 255 | Calix�4!arene compounds for detection of calcium | US949891 | 1997-10-14 | US5883235A | 1999-03-16 | Allan Milton Byrnard; Rocco Ungaro; Andrea Pochini |
| Calix�4!arene compounds are disclosed that can be used as active components in a calcium sensitive sensor. The compounds exhibit strong calcium ion binding selectivity over sodium and potassium ions and they are stable during sterilization. | ||||||
| 256 | Methods for the preparation of antibodies directed against dithiocarbamates and the use thereof for detection of nitric oxide in body fluids | US644961 | 1996-05-15 | US5869348A | 1999-02-09 | Ching-San Lai |
| In accordance with the present invention, ELISA methods for the measurement of NO levels in mammalian body fluids utilizing monoclonal antibodies directed against dithiocarbamates and related iron complexes are described. It has been found that conjugation of dithiocarbamates to a macromolecule produces immunogenic dithiocarbamate-macromolecule derivatives. Such derivatives can be used for the production (e.g., in rodents) of monoclonal antibodies directed against different forms of dithiocarbamates (e.g., free dithiocarbamates, as well as complexes thereof with iron and, optionally, nitric oxide). In contrast, non-derivatized dithiocarbamates alone are not immunogenic. The simple, easy and non-invasive ELISA methods for measurement of NO levels in body fluids will find a variety of uses, e.g., for diagnosis and monitoring of NO overproduction that has been associated with many inflammatory and infectious diseases. | ||||||
| 257 | Method for measurement of ionized calcium | US553512 | 1996-04-03 | US5840512A | 1998-11-24 | Toshio Tadano; Akira Miike; Norihiko Kayahara; Jun Umemoto |
| The present invention relates to a method for quantitatively determining ionized calcium in a sample by using a phospholipase, which comprises carrying out an enzyme reaction with the phospholipase in a buffer comprising a nitrogen heterocycle-binding sulfonic acid having a pK ranging 6.6 to 7.6 or a salt thereof. According to the method of the invention, the amount of ionized calcium in a sample, such as serum, can be accurately determined. | ||||||
| 258 | Method and apparatus for detecting amine producing organisms in the vagina | US789484 | 1997-01-27 | US5827200A | 1998-10-27 | James C. Caillouette |
| In the method of detecting pathogenic bacteria in the vagina, the steps that include providing an elongated assembly including an elongated carrier and a flexible outer container supported on the carrier; providing a vaginal moisture absorbing or porous material swab at one end of the assembly to communicate with the interior of the outer container; providing a frangible inner container protectively located within the outer container, and providing a flowable aqueous alkaline fluid reactant within the inner container, bending or exerting pressure on the outer container sufficient to rupture the inner container; thereby releasing reactant into the interior of the outer container to enable reactant fluid flow to the swab or porous material, for reaction with bacteria containing vaginal moisture absorbed into the swab or porous material, whereby a gaseous product of the reaction may be detected, by characteristic odor. The outer container may be defined in whole or in part by the porous material which may be woven. | ||||||
| 259 | Method and compositions for enhancing aminolevulinic acid dehydratase assay | US507168 | 1995-07-26 | US5821074A | 1998-10-13 | Martin Wong; David M. Finley |
| The present invention provides a method of improving the sensitivity and accuracy of a lead assay. The method enhances the recovery of lead during isolation of the lead from interfering compounds by maintaining the lead in a sample solution and making the recovered lead available for detection by the assay. An enhancing reagent complexes with the lead isolated in the sample solution. The enhancer includes a chelator having a lead equilibrium binding constant in the range of about 4 log K to about 13 log K. A kit for performing such a lead assay is also provided. | ||||||
| 260 | Method of using automated analyzer testing of urine for presence of a pH abnormality with single reagent indicator | US924421 | 1997-08-27 | US5801060A | 1998-09-01 | Jack V. Smith |
| In an automated analyzer containing a spectrophotometer for determining color changes in a urine sample the urine is admixed with a litmus, methyl red or azolitmin indicator effecting the color change, a surfactant and water. The spectrophotometer determines and prints whether a color change has occurred. | ||||||
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