| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | ASX-SPECIFIC PROTEIN LIGASE | US15306249 | 2015-03-24 | US20170044515A1 | 2017-02-16 | Kien Truc Giang Nguyen; James P. Tam |
| The present invention is directed to enzymes having Asx-specific ligase and cyclase activity and to nucleic acids encoding those as well as methods of the manufacture of said enzymes. Further encompassed are methods and uses of these enzymes. | ||||||
| 2 | A Salmonella Paratyphi A with an O-Antigen Having an Extended Carbohydrate Chain and Use Thereof | US15532823 | 2015-09-07 | US20180050100A1 | 2018-02-22 | Jun WU; Peng SUN; Bo LIU; Shaohong CHANG; Xin GONG; Hengliang WANG; Li ZHU; Chao PAN; Erling FENG |
| The present invention discloses a Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cldLT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB45733-OPSSpty50973 and rEPA4573-OPSSpty50973 as prepared by using Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved. | ||||||
| 3 | ＡＳＸ特異的なタンパク質リガーゼ | JP2016563922 | 2015-03-24 | JP2017515468A | 2017-06-15 | トリュック ジャン グエン、キーン; ピー． タム、ジェームズ |
| 本発明は、Asx特異的なリガーゼ活性とシクラーゼ活性とを有する酵素およびこれをコードする核酸、ならびに前記酵素の製造の方法に関する。これらの酵素の方法および使用がさらに包含される。 | ||||||
| 4 | ASX-SPECIFIC PROTEIN LIGASE | EP15782456.6 | 2015-03-24 | EP3134427A1 | 2017-03-01 | NGUYEN, Kien Truc Giang; TAM, James P. |
| The present invention is directed to enzymes having Asx-specific ligase and cyclase activity and to nucleic acids encoding those as well as methods of the manufacture of said enzymes. Further encompassed are methods and uses of these enzymes. | ||||||
| 5 | O-ANTIGEN CARBOHYDRATE CHAIN EXTENDED SALMONELLA PARATYPHI A AND USE THEREOF | EP15867235 | 2015-09-07 | EP3231868A4 | 2018-05-23 | WU JUN; SUN PENG; LIU BO; CHANG SHAOHONG; GONG XIN; WANG HENGLIANG; ZHU LI; PAN CHAO; FENG ERLING |
| The present invention discloses a Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cld LT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB4573 3 -OPS Spty 50973 and rEPA4573-OPS Spty 50973 as prepared by using Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved. | ||||||
| 6 | O-ANTIGEN CARBOHYDRATE CHAIN EXTENDED SALMONELLA PARATYPHI A AND USE THEREOF | EP15867235.2 | 2015-09-07 | EP3231868A1 | 2017-10-18 | WU, Jun; SUN, Peng; LIU, Bo; CHANG, Shaohong; GONG, Xin; WANG, Hengliang; ZHU, Li; PAN, Chao; FENG, Erling |
The present invention discloses a Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cldLT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB45733-OPSSpty50973 and rEPA4573-OPSSpty50973 as prepared by using Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved. |
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| 7 | ASX-SPECIFIC PROTEIN LIGASE | EP15782456 | 2015-03-24 | EP3134427A4 | 2017-09-13 | NGUYEN KIEN TRUC GIANG; TAM JAMES P |
| The present invention is directed to enzymes having Asx-specific ligase and cyclase activity and to nucleic acids encoding those as well as methods of the manufacture of said enzymes. Further encompassed are methods and uses of these enzymes. | ||||||
