| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Rhomboid Proteins and Uses Thereof | US14879712 | 2015-10-09 | US20160129078A1 | 2016-05-12 | Kenton Ko; Joshua Powles |
| Compositions and methods for managing the growth, life cycle, functionality, or biological progression of cells, tissues, and organisms by introducing rhomboid proteins or peptides into the internal and external environment of the cells, tissues, and organisms. In particular, embodiments comprise compositions and methods for overcoming drug resistance in disease, and for sensitizing cells, tissues, and organisms to agents to treat disease, and methods for producing such compositions. The compositions and methods include rhomboid proteins, polypeptides, and/or peptides, and nucleic acids encoding such proteins, polypeptides, and/or and peptides, corresponding to the Arabidopsis At1g74130 or At1g25290 gene or human UBAC2 gene. The rhomboid proteins, polypeptides, and/or and peptides or nucleic acids may be derived from natural genetic sources, from different species, different genes of the rhomboid family, through alternative splicing of encoding transcripts, through laboratory manipulations, using recombinant protein production techniques, fermentation, mutagenesis approaches, synthesis, peptides, or other methods of generation and production. | ||||||
| 2 | METHODS AND USES RELATED TO RHBDL4 | US12595367 | 2008-04-11 | US20100173972A1 | 2010-07-08 | Marius Kasper Lemberg; Matthew Freeman |
| The invention relates to a method of identifying a modulator of RHBDL4, said method comprising (i) providing a first and second sample of cells; (ii) contacting said first sample of cells with a candidate modulator of RHBDL4; (iii) measuring epidermal growth factor receptor (EGFR) transactivation in said first and second samples of cells, wherein a difference between the transactivation measured in said first and second samples of cells identifies said candidate modulator of RHBDL4 as a modulator of RHBDL4. The invention also relates to RHBDL4 protease assays and to uses of RHBDL4 protease and methods of cleavage of RHBDL4 substrates. | ||||||
| 3 | METHODS AND USES RELATED TO RHBDL4 | EP08736959.1 | 2008-04-11 | EP2155895A2 | 2010-02-24 | LEMBERG, Marius, Kasper; FREEMAN, Matthew |
| The invention relates to a method of identifying a modulator of RHBDL4, said method comprising (i) providing a first and second sample of cells; (ii) contacting said first sample of cells with a candidate modulator of RHBDL4; (iii) measuring epidermal growth factor receptor (EGFR) transactivation in said first and second samples of cells, wherein a difference between the transactivation measured in said first and second samples of cells identifies said candidate modulator of RHBDL4 as a modulator of RHBDL4. The invention also relates to RHBDL4 protease assays and to uses of RHBDL4 protease and methods of cleavage of RHBDL4 substrates. | ||||||
| 4 | METHODS AND USES RELATED TO RHBDL4 | PCT/GB2008001295 | 2008-04-11 | WO2008125836A3 | 2008-12-04 | LEMBERG MARIUS KASPER; FREEMAN MATTHEW |
| The invention relates to a method of identifying a modulator of RHBDL4, said method comprising (i) providing a first and second sample of cells; (ii) contacting said first sample of cells with a candidate modulator of RHBDL4; (iii) measuring epidermal growth factor receptor (EGFR) transactivation in said first and second samples of cells, wherein a difference between the transactivation measured in said first and second samples of cells identifies said candidate modulator of RHBDL4 as a modulator of RHBDL4. The invention also relates to RHBDL4 protease assays and to uses of RHBDL4 protease and methods of cleavage of RHBDL4 substrates. | ||||||
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