专利检索_ ..白细胞弹性蛋白酶专利检索_ ..白细胞弹性蛋白酶专利检索查询

序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
21	Pro-elastase and preparation thereof	US53824155	1955-10-03	US2893920A	1959-07-07	GRANT NORMAN H; ROBBINS KENNETH C

22	RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF	US15726607	2017-10-06	US20180273928A1	2018-09-27	F. Nicholas FRANANO; Kimberly S. Bland; Marco D. Wong; Bee C. Ding
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
23	NUCLEIC ACID MOLECULES ENCODING AUTOACTIVATING TYPE I PANCREATIC PROELASTASE PROTEINS	US15919814	2018-03-13	US20180208918A1	2018-07-26	F. Nicholas Franano; Kimberly Bland; Marco D. Wong; Bee C. Ding
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
24	RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF	US14957765	2015-12-03	US20160243205A1	2016-08-25	F. Nicholas FRANANO; Kimberly S. Bland; Marco D. Wong; Bee C. Ding
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
25	NOVEL USES OF ELAFIN	US14299266	2014-06-09	US20140287985A1	2014-09-25	Oliver Wiedow; Birge Bargmann; Barbara Kahlke; Lee Shaw; Nils Wichmann
The invention relates to novel uses of the polypeptide elafin, and/or homologues, derivatives or fragments thereof having inhibitory activity against leukocyte elastase for the prevention and treatment of medical conditions like SIRS.
26	RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF	US13957954	2013-08-02	US20130336956A1	2013-12-19	F. Nicholas Franano; Kimberly S. Bland; Marco D. Wong; Bee C. Ding
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
27	RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF	EP17150627	2008-12-04	EP3176262A1	2017-06-07	FRANANO NICHOLAS F; BLAND KIMBERLY; WONG MARCO D; DING BEE C
Methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
28	Recombinant elastase proteins and methods of manufacturing and use thereof	EP13181046.7	2008-12-04	EP2666854B1	2017-03-15	Franano, F. Nicholas; Bland, Kimberly; Wong, Marco D.; Ding, Bee C.
Methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
29	RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF	EP08861467.2	2008-12-04	EP2229440B9	2013-11-13	FRANANO, F. Nicholas; BLAND, Kimberly; WONG, Marco D.; DING, Bee C.
Methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
30	RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF	EP08861467.2	2008-12-04	EP2229440B1	2013-08-28	FRANANO, F. Nicholas; BLAND, Kimberly; WONG, Marco D.; DING, Bee C.
Methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
31	RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF	EP08861467.2	2008-12-04	EP2229440A2	2010-09-22	FRANANO, F. Nicholas; BLAND, Kimberly; WONG, Marco D.; DING, Bee C.
Methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
32	재조합 엘라스타아제 단백질, 및 이의 제조 방법 및 용도	KR20187002034	2008-12-04	KR20180011860A	2018-02-02
본발명은생물학적으로활성인재조합엘라스타아제단백질의제조, 정제, 제형화방법및 용도에관한것이다. 치료학적으로유용한엘라스타아제단백질을생산하기위한재조합방법, 및이러한엘라스타아제단백질을포함하는약학조성물이기재되어있다. 신규재조합엘라스타아제단백질및 단백질제조물이또한개시되어있다. 본발명의엘라스타아제단백질을함유하는약학조성물을사용하여생물학적전달관의질환을치료하고예방하기위한방법이기재되어있다.
33	재조합 엘라스타아제 단백질, 및 이의 제조 방법 및 용도	KR1020167020627	2008-12-04	KR1020160095184A	2016-08-10	프라나노에프니콜라스; 블랜드킴벌리; 옹마르코디; 딩비씨
본발명은생물학적으로활성인재조합엘라스타아제단백질의제조, 정제, 제형화방법및 용도에관한것이다. 치료학적으로유용한엘라스타아제단백질을생산하기위한재조합방법, 및이러한엘라스타아제단백질을포함하는약학조성물이기재되어있다. 신규재조합엘라스타아제단백질및 단백질제조물이또한개시되어있다. 본발명의엘라스타아제단백질을함유하는약학조성물을사용하여생물학적전달관의질환을치료하고예방하기위한방법이기재되어있다.
34	재조합 엘라스타아제 단백질, 및 이의 제조 방법 및 용도	KR1020167020627	2008-12-04	KR101824350B1	2018-01-31	프라나노에프니콜라스; 블랜드킴벌리; 옹마르코디; 딩비씨
본발명은생물학적으로활성인재조합엘라스타아제단백질의제조, 정제, 제형화방법및 용도에관한것이다. 치료학적으로유용한엘라스타아제단백질을생산하기위한재조합방법, 및이러한엘라스타아제단백질을포함하는약학조성물이기재되어있다. 신규재조합엘라스타아제단백질및 단백질제조물이또한개시되어있다. 본발명의엘라스타아제단백질을함유하는약학조성물을사용하여생물학적전달관의질환을치료하고예방하기위한방법이기재되어있다.
35	재조합 엘라스타아제 단백질, 및 이의 제조 방법 및 용도	KR1020107014799	2008-12-04	KR101732190B1	2017-05-04	프라나노에프니콜라스; 블랜드킴벌리; 옹마르코디; 딩비씨
본발명은생물학적으로활성인재조합엘라스타아제단백질의제조, 정제, 제형화방법및 용도에관한것이다. 치료학적으로유용한엘라스타아제단백질을생산하기위한재조합방법, 및이러한엘라스타아제단백질을포함하는약학조성물이기재되어있다. 신규재조합엘라스타아제단백질및 단백질제조물이또한개시되어있다. 본발명의엘라스타아제단백질을함유하는약학조성물을사용하여생물학적전달관의질환을치료하고예방하기위한방법이기재되어있다
36	재조합 엘라스타아제 단백질, 및 이의 제조 방법 및 용도	KR1020107014799	2008-12-04	KR1020100120639A	2010-11-16	프라나노에프니콜라스; 블랜드킴벌리; 옹마르코디; 딩비씨
본 발명은 생물학적으로 활성인 재조합 엘라스타아제 단백질의 제조, 정제, 제형화 방법 및 용도에 관한 것이다. 치료학적으로 유용한 엘라스타아제 단백질을 생산하기 위한 재조합 방법, 및 이러한 엘라스타아제 단백질을 포함하는 약학 조성물이 기재되어 있다. 신규 재조합 엘라스타아제 단백질 및 단백질 제조물이 또한 개시되어 있다. 본 발명의 엘라스타아제 단백질을 함유하는 약학 조성물을 사용하여 생물학적 전달관의 질환을 치료하고 예방하기 위한 방법이 기재되어 있다
37	CRYSTAL STRUCTURE OF ENZYME AND USES THEREOF	PCT/EP2005013370	2005-12-13	WO2006063792A2	2006-06-22	REINEMER PETER; GIELEN-HAERTWIG HEIKE; ROSENTRETER ULRICH; LI VOLKHART; HARRENGA AXEL; SCHOMBURG DIETMAR; NIEFIND KARSTEN; HANSEN GUIDO
This invention relates to crystallised human neutrophil elastase and the use of its three-dimensional structure to design modulators for human neutrophil elastase.
38	RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF	PCT/US2008085559	2008-12-04	WO2009079220A2	2009-06-25	FRANANO F NICHOLAS; BLAND KIMBERLY; WONG MARCO D; DING BEE C
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.

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