| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 潜在免疫原性降低的乳蛋白水解产物 | CN200780047281.4 | 2007-12-03 | CN101594785B | 2014-01-08 | 马诺耶·库马尔; 大卫·王 |
| 本发明提供了水解产物组合物，其包含被至少一种蛋白水解酶水解的至少一种乳蛋白或乳清蛋白。所述水解产物降低了乳蛋白或乳清蛋白在易于对所述蛋白产生免疫反应的受试者体内的免疫原性。本发明还提供了所述组合物的制备方法，以及包含所述组合物的食品和非食品。 | ||||||
| 2 | 一种高效表达V8蛋白酶的方法 | CN201410261929.X | 2014-06-12 | CN104059898A | 2014-09-24 | 周小满; 高敏奇; 吴家权; 萧国平 |
| 本发明公开了一种高效表达V8蛋白酶的方法，属于酶工程技术领域。本发明将融合了SUMO标签的V8蛋白酶基因，在大肠杆菌中进行表达，获得含有SUMO标签的V8蛋白酶，然后利用SUMO蛋白酶移除SUMO标签，获得具有活性的V8蛋白酶。酶活可达15.5U/mg，已经适用于重组蛋白制备和肽指纹图谱鉴定。 | ||||||
| 3 | 一种获得蛋白质水解物的方法 | CN97194838.0 | 1997-05-20 | CN1099839C | 2003-01-29 | P·M·尼尔森 |
| 本发明涉及一种获得用作调味剂的蛋白质水解物的方法。更特别的，本发明提供了从蛋白质底物获得富含游离谷氨酸和/或肽结合的谷氨酸残基的水解物的一种方法，该方法包括将该底物进行脱酰胺处理且将该底物经过一种特异性作用蛋白水解酶的作用的步骤。 | ||||||
| 4 | 表达耐热谷胺酰内肽酶的工程菌、制备方法及应用 | CN201511025337.9 | 2015-12-31 | CN105567617A | 2016-05-11 | 唐兵; 唐晓峰; 刘丰 |
| 本发明公开了将一种表达耐热谷胺酰内肽酶基因插入到表达质粒pET-26b（+）中，构建出重组表达质粒，将此重组表达质粒转化到大肠杆菌中，获得高效表达耐热谷胺酰内肽酶的基因工程菌。表达耐热谷胺酰内肽酶具有良好的热稳定性，并且在高温条件下具有专一的底物特异性。在生产、储存和运输过程中稳定，具有较长的货架期。 | ||||||
| 5 | 潜在免疫原性降低的乳蛋白水解产物 | CN200780047281.4 | 2007-12-03 | CN101594785A | 2009-12-02 | 马诺耶·库马尔; 大卫·王 |
| 本发明提供了水解产物组合物，其包含被至少一种蛋白水解酶水解的至少一种乳蛋白或乳清蛋白。所述水解产物降低了乳蛋白或乳清蛋白在易于对所述蛋白产生免疫反应的受试者体内的免疫原性。本发明还提供了所述组合物的制备方法，以及包含所述组合物的食品和非食品。 | ||||||
| 6 | 一种获得蛋白质水解物的方法 | CN01119457.X | 1997-05-20 | CN1326687A | 2001-12-19 | P·M·尼尔森 |
| 本发明涉及一种获得用作调味剂的蛋白质水解物的方法。更特别的,本发明提供了从蛋白质底物获得富含游离谷氨酸和/或肽结合的谷氨酸残基的水解物的一种方法,该方法包括将该底物进行脱酰胺处理且将该底物经过一种特异性作用蛋白水解酶的作用的步骤。 | ||||||
| 7 | 一种获得蛋白质水解物的方法 | CN97194838.0 | 1997-05-20 | CN1219106A | 1999-06-09 | P·M·尼尔森 |
| 本发明涉及一种获得用作调味剂的蛋白质水解物的方法。更特别的,本发明提供了从蛋白质底物获得富含游离谷氨酸和/或肽结合的谷氨酸残基的水解物的一种方法,该方法包括将该底物进行脱酰胺处理且将该底物经过一种特异性作用蛋白水解酶的作用的步骤。 | ||||||
| 8 | METHOD FOR ENZYMATICALLY PREPARING PEPTIDES FOR USE IN IMPROVEMENT OF BRAIN FUNCTION | US13495581 | 2012-06-13 | US20120329722A1 | 2012-12-27 | Naoto Uchida; Hiroaki Goto; Kazuhito Ohsawa; Kohji Ohki |
| The invention provides a method for preparing a peptide for improving brain function, comprising hydrolyzing milk casein with an enzymatic catalyst comprising a protease to produce a hydrolysate comprising: (i) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 1 or a variant thereof; (ii) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 2 or a variant thereof; or (iii) a mixture of the peptides of (i) and (ii), wherein the production yield of each of the peptides is 2% or more, or the total production yield of the mixture is 10% or more. The invention also provides a food or drink or a pharmaceutical composition containing the hydrolysate. | ||||||
| 9 | Method for enzymatically preparing peptides for use in improvement of brain function | US13495581 | 2012-06-13 | US09523109B2 | 2016-12-20 | Naoto Uchida; Hiroaki Goto; Kazuhito Ohsawa; Kohji Ohki |
| The invention provides a method for preparing a peptide for improving brain function, comprising hydrolyzing milk casein with an enzymatic catalyst comprising a protease to produce a hydrolysate comprising: (i) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 1 or a variant thereof; (ii) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 2 or a variant thereof; or (iii) a mixture of the peptides of (i) and (ii), wherein the production yield of each of the peptides is 2% or more, or the total production yield of the mixture is 10% or more. The invention also provides a food or drink or a pharmaceutical composition containing the hydrolysate. | ||||||
| 10 | Carboxypeptidases and nucleic acids encoding same | US11073247 | 2005-03-04 | US20050175736A1 | 2005-08-11 | Alexander Blinkovsky; Randy Berka; Michael Rey; Elizabeth Golightly; Alan Klotz; Thomas Mathisen; Claus Dambmann |
| The present invention relates to polypeptides having carboxypeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to methods of obtaining protein hydrolysates useful as flavor improving agents. | ||||||
| 11 | Method of obtaining protein hydrolysates | US188985 | 1998-11-09 | US6036983A | 2000-03-14 | Per Munk Nielsen |
| The present invention relates to a method of obtaining protein hydrolysates useful as flavoring agents. More specifically, the invention provides a method of obtaining from a proteinaceous sustrate a hydrolysate enriched in free glutamic acid and/or peptide bound glutamic acid residues, which method comprises the steps of subjecting the substrate to a deamidation process, and subjecting the substrate to the action of a specific acting proteolytic enzyme. | ||||||
| 12 | Milk Protein Hydrolyzates with Reduced Immunogenic Potential | US12519317 | 2007-12-03 | US20100273718A1 | 2010-10-28 | Manoj Kumar; David Wong |
| Hydrolyzate compositions comprising at least one milk protein or whey hydrolyzed with at least one proteolytic enzyme are provided. The hydrolyzates reduce the immunogenicity of the milk or whey protein in a subject predisposed to having an immune reaction to the protein. Methods for making the compositions are also provided, as food products and nonfood products comprising the compositions. | ||||||
| 13 | Carboxypeptidases and nucleic acids encoding same | US11073247 | 2005-03-04 | US07091002B2 | 2006-08-15 | Alexander Blinkovsky; Randy Berka; Michael Rey; Elizabeth Golightly; Alan Klotz; Thomas Erik Mathisen; Claus Dambmann |
| The present invention relates to polypeptides having carboxypeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to methods of obtaining protein hydrolysates useful as flavor improving agents. | ||||||
| 14 | Carboxypeptidases and nucleic acids encoding the same | US08943714 | 1997-10-03 | US06187578B1 | 2001-02-13 | Alexander Blinkovsky; Randy Berka; Michael Rey; Elizabeth Golightly; Alan Klotz; Thomas Erik Mathisen; Claus Dambmann; Kimberly M. Brown |
| The present invention relates to polypeptides having carboxypeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to methods of obtaining protein hydrolysates useful as flavor improving agents. | ||||||
| 15 | How to obtain a protein hydrolyzate | JP54141497 | 1997-05-20 | JP2000515003A | 2000-11-14 | ムンク ニエルセン，ペール |
| (57)【要約】 本発明はフレーバリング剤として有用なタンパク質加水分解物を得る方法に関する。 より詳細には、本発明はタンパク性基質から遊離グルタミン酸及び／またはグルタミン酸残基含有ペプチドに富んだ加水分解物を得る方法を提供し、その方法は前記基質を脱アミド化過程にかける工程及び前記基質を特異的に作用するタンパク質分解性酵素の作用にかける工程を含むものである。 | ||||||
| 16 | A METHOD OF OBTAINING PROTEIN HYDROLYSATES | EP97921649.6 | 1997-05-20 | EP0969736A1 | 2000-01-12 | NIELSEN, Per, Munk |
| The present invention relates to a method of obtaining protein hydrolysates useful as flavoring agents. More specifically, the invention provides a method of obtaining from a proteinaceous substrate a hydrolysate enriched in free glutamic acid and/or peptide bound glutamic acid residues, which method comprises the steps of subjecting the substrate to a deamidation process, and subjecting the substrate to the action of a specific acting proteolytic enzyme. | ||||||
| 17 | MILK PROTEIN HYDROLYZATES WITH REDUCED IMMUNOGENIC POTENTIAL | EP07862429.3 | 2007-12-03 | EP2124603B1 | 2014-11-19 | KUMAR, Manoj; WONG, David |
| 18 | MILK PROTEIN HYDROLYZATES WITH REDUCED IMMUNOGENIC POTENTIAL | EP07862429.3 | 2007-12-03 | EP2124603A2 | 2009-12-02 | KUMAR, Manoj; WONG, David |
| Hydrolyzate compositions comprising at least one milk protein or whey hydrolyzed with at least one proteolytic enzyme are provided. The hydrolyzates reduce the immunogenicity of the milk or whey protein in a subject predisposed to having an immune reaction to the protein. Methods for making the compositions are also provided, as food products and nonfood products comprising the compositions. | ||||||
| 19 | A METHOD OF OBTAINING PROTEIN HYDROLYSATES | EP97921649.6 | 1997-05-20 | EP0969736B1 | 2006-06-28 | NIELSEN, Per, Munk |
| The present invention relates to a method of obtaining protein hydrolysates useful as flavoring agents. More specifically, the invention provides a method of obtaining from a proteinaceous substrate a hydrolysate enriched in free glutamic acid and/or peptide bound glutamic acid residues, which method comprises the steps of subjecting the substrate to a deamidation process, and subjecting the substrate to the action of a specific acting proteolytic enzyme. | ||||||
| 20 | MILK PROTEIN HYDROLYZATES WITH REDUCED IMMUNOGENIC POTENTIAL | PCT/US2007024723 | 2007-12-03 | WO2008088472A3 | 2008-10-02 | KUMAR MANOJ; WONG DAVID |
| Hydrolyzate compositions comprising at least one milk protein or whey hydrolyzed with at least one proteolytic enzyme are provided. The hydrolyzates reduce the immunogenicity of the milk or whey protein in a subject predisposed to having an immune reaction to the protein. Methods for making the compositions are also provided, as food products and nonfood products comprising the compositions. | ||||||
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