| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | Technology for the Preparation of Microparticles | US15080399 | 2016-03-24 | US20160235675A1 | 2016-08-18 | Michael P. Malakhov; Fang Fang |
| Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions. | ||||||
| 22 | SOLUBLE BETA-N-ACETYLGLUCOSAMINIDASE BASED ANTIBIOFILM COMPOSITIONS AND USES THEREOF | US13416793 | 2012-03-09 | US20120258089A1 | 2012-10-11 | Srinivasa MADHYASTHA; Nanda Yakandawala; Purushottam V. Gawande; Karen Lovetri; Jeffrey B. Kaplan; Daniel Rhoads; Lasha Gogokhia |
| The present invention provides compositions comprising an antibiofilm enzyme, a soluble β-N-acetylglucosaminidase similar to the dspB gene (DispersinB®), and an antimicrobial for preventing growth and proliferation of biofilm-embedded microorganisms in acute and chronic wounds, and methods of treatment. The invention further provides methods for preparing medical devices, and in particular, wound care devices using soluble β-N-acetylglucosaminidase based antimicrobial compositions. | ||||||
| 23 | Grain wet milling process for producing dextrose | US11121170 | 2005-05-03 | US20060251761A1 | 2006-11-09 | Robert Jansen; John Kerr; Edward Farley; Gordon Walker; Sebastien Camborieux |
| Whole grain, such as wheat, barley, rye, and/or rice, can be processed by (a) steeping the grain or at least partially dehulled grain in an aqueous liquid to produce softened grain, (b) milling the softened grain to produce milled grain, (c) liquefying the milled grain by contacting it with amylase and heating it to a temperature of at least about 50° C., producing a liquefied material, (d) at least partially saccharifying the liquefied material by contacting it with amyloglucosidase at a temperature of at least about 50° C., producing a first saccharified material, and (e) separating fiber and germ from the first saccharified material, producing a screened material that is substantially free of fiber and wheat germ. The process also includes the steps of (f) further saccharifying the screened material by contacting it with amyloglucosidase at a temperature of at least about 50° C., producing a second saccharified material, (g) membrane filtering the second saccharified material, producing a permeate that comprises primarily dextrose and other soluble components and a retentate that comprises insoluble protein, and (h) purifying the permeate by chromatographic separation, producing a purified dextrose stream. The chromatographic separation can also produce a raffinate, and the process can further include the steps of (i) combining the retentate from the membrane filtration and the raffinate from the chromatographic separation to form a fermentation medium, (j) fermenting the fermentation medium aerobically with a microorganism, (k) separating a protein product that comprises insoluble protein and microorganism from the medium, and (l) drying the protein product. | ||||||
| 24 | Microcapsules | US10474432 | 2004-04-21 | US20040170693A1 | 2004-09-02 | Anders Vango Pedersen; Morten Mohr Hansen; Susanne Lund Madsen; Nina Musaeus Jensen; Carsten Lynggaard Hansen; Annette Strarup Kristensen; Karin Meyer Hansen |
| Microcapsules comprising an active substance embedded in a matrix material obtainable by treating a pectic substance with one or more enzymes selected from the group consisting of esterases (E.C.3.1.), glucosidases (E.C.3.2.), peptidases (E.C.3.4.), proteases (E.C.3.4.), and lyases (E.C.4.), a process of preparing microcapsules and products containing such microcapsules. | ||||||
| 25 | Method for preparing flour doughs and products made from such doughs using glycerol oxidase | US10462527 | 2003-06-16 | US20040071853A1 | 2004-04-15 | Jorn Borch Soe; Charlotte Horsmans Poulsen; Preben Rasmussen; Susan Mampusti Madrid; Masoud R. Zargahi |
| Method of improving the rheological properties of a flour dough and the quality of bread, alimentary paste products, noodles and cakes wherein glycerol oxidase or a combination of glycerol oxidase and a lipase is added to the dough and dough improving compositions comprising these enzymes. The strength of (B/C ratio) and the gluten index of the dough was improved and in the resulting products the improvements were higher specific volume, increased crumb pore homogeneity and reduced average crumb pore diameter. | ||||||
| 26 | Pet food | US921414 | 1986-10-22 | US4784860A | 1988-11-15 | Flemming M. Christensen; Hans A. S. Olsen; Columbus O. L. Boyce |
| A pet food containing a proteinaceous vegetable source component treated with an SPS-ase preparation in aqueous medium. Presence of this component imparts a decisive improvement in regard to the elasticity and palatability of the pet food. | ||||||
| 27 | ＦＧＦ23 융합 폴리펩티드를 사용하는 방법 및 조성물 | KR1020127022498 | 2011-01-27 | KR1020130032296A | 2013-04-01 | 글라스,데이비드; 후,쇼우-이 |
| 본 개시내용은 연령-관련 병태 또는 대사 장애를 예방 또는 치료하기 위한 방법, 키트 및 조성물에 관한 것이다. 본 개시내용의 융합 폴리펩티드는 FGF23 또는 그의 활성 단편을 포함한다. 한 실시양태에서, 융합 폴리펩티드는 (a) 위치 Q156, C206 및 C244 중 하나 이상에 돌연변이를 갖는 섬유모세포 성장 인자 23 (FGF23) 또는 그의 기능적 활성 변이체 또는 유도체를 포함하는 폴리펩티드; 및 (b) Fc-감마-수용체에 대한 감소된 친화도 및/또는 증가된 혈청 반감기를 갖는 변형된 Fc 단편, 또는 Klotho 단백질의 하나 이상의 세포외 서브도메인, 또는 그의 기능적 활성 변이체 또는 유도체를 포함하는 폴리펩티드; 및, 임의로 (c) 링커를 포함한다. Klotho 융합 단백질은 다양한 연령-관련 병태 및 대사 장애의 치료 또는 예방에 유용하다. 또 다른 실시양태에서, 융합 폴리펩티드는 FGF (예컨대 FGF23) 또는 그의 기능적 활성 변이체 또는 유도체; 및 변형된 Fc 단편 또는 그의 기능적 활성 변이체 또는 유도체를 포함한다. 융합 폴리펩티드의 다양한 실시양태에서, FGF23은 응집 및 프로테아제-매개 절단을 감소시키는 돌연변이를 갖는다. | ||||||
| 28 | 활성 성분 제제를 위한 개질된 식물 고무 | KR1020077011232 | 2005-11-18 | KR1020070084323A | 2007-08-24 | 베크마르쿠스; 로이엔베르거브루노; 새퍼크리스티안; 바그너게라드; 레베르니그-스타이거크리스티나 |
| The present invention relates to compositions containing (fat-soluble) active ingredients and/or colorants in a matrix based on modified plant gums, i.e. plant gums that have been submitted to hydrolysis to degrade either the protein portion and/or where appropriate, the polysaccharide, and to a process for preparing these compositions as well as to modified plant gums, whose protein part is hydrolysed up to a degree of about 30%, preferably to a degree of from about 0.05 to about 30%, and/or whose polysaccharide part is hydrolysed up to a degree of about 50%, a process for the manufacture thereof and such modified plant gums themselves. The present invention further relates to the use of the compositions of this invention for the enrichment, fortification and/or for the coloration of food, beverages, animal feed, cosmetics and pharmaceutical compositions and to such food, beverages, animal feed, cosmetics and pharmaceutical compositions themselves. | ||||||
| 29 | ADENO-ASSOCIATED VIRUS VECTORS ENCODING MODIFIED G6PC AND USES THEREOF | US15538852 | 2015-12-22 | US20170362670A1 | 2017-12-21 | Janice J. Chou |
| Modified G6PC (glucose-6-phosphatase, catalytic subunit) nucleic acids and glucose-6-phosphatase-α (G6Pase-α) enzymes with increased phosphohydrolase activity are described. Also described are vectors, such as adeno-associated virus (AAV) vectors, and recombinant AAV expressing modified G6Pase-α. The disclosed AAV vectors and rAAV can be used for gene therapy applications in the treatment of glycogen storage disease, particularly glycogen storage disease type Ia (GSD-Ia), and complications thereof. | ||||||
| 30 | Technology for the Preparation of Microparticles | US15369734 | 2016-12-05 | US20170079920A1 | 2017-03-23 | Michael P. Malakhov; Fang Fang |
| Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions. | ||||||
| 31 | Polypeptides having endopeptidase activity and polynucleotides encoding same | US13821168 | 2011-09-30 | US09458446B2 | 2016-10-04 | Peter Rahbek Oestergaard; Carsten P. Sonksen; Tine Hoff; Gitte B. Lynglev |
| The present invention relates to polypeptides having endopeptidase activity and to methods of producing and using the polypeptides. The invention also relates to methods of making a food protein hydrolysate using a trypsin-like endopeptidase derived from a bacterium. | ||||||
| 32 | Use of Acid Stable Proteases in Animal Feed, Preferably to Increase Performance of COCC-Vaccinated Broiler Chickens | US15174082 | 2016-06-06 | US20160271232A1 | 2016-09-22 | Nelson Ward; Inge Knap |
| The invention relates to the use of at least one acid stable protease in poultry feed in combination with anti-coccidial vaccination of birds for increasing the performance of vaccinated animals. It has been found surprisingly that the additions of at least one acid stable protease according to the invention to the diet of “cocci”-vaccinated birds have a significant improvement of animal performance. The inventors found that especially the use of serin proteases improve the performance of vaccinated broiler chickens, in particular the use of serin proteases increases weight gain and improves Feed Conversion Ratio (FCR) of cocci-vaccinated birds. | ||||||
| 33 | NOVEL ANTIBODY-DRUG CONJUGATES AND THE USE OF SAME IN THERAPY | US14904353 | 2014-07-11 | US20160151515A1 | 2016-06-02 | Nicolas JOUBERT; Marie Claude VIAUD-MASSUARD; Renaud RESPAUD |
| Disclosed are novel antibody-drug conjugates and use thereof in therapy, in particular in anticancer or anti-inflammatory therapy, as well as synthetic products useful as linkers, composed of a linker head and a linker body, and also a method for preparing the linkers and the antibody-drug conjugates. | ||||||
| 34 | Technology for the Preparation of Microparticles | US14341502 | 2014-07-25 | US20150050713A1 | 2015-02-19 | Michael P. Malakhov; Fang Fang |
| Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions. | ||||||
| 35 | USE OF ACID STABLE PROTEASES IN ANIMAL FEED, PREFERABLY TO INCREASE PERFORMANCE OF COCC-VACCINATED BROILER CHICKENS | US14357608 | 2012-11-19 | US20140314910A1 | 2014-10-23 | Nelson Ward; Inge Knap |
| The invention relates to the use of at least one acid stable protease in poultry feed in combination with anti-coccidial vaccination of birds for increasing the performance of vaccinated animals. It has been found surprisingly that the additions of at least one acid stable protease according to the invention to the diet of “cocci”-vaccinated birds have a significant improvement of animal performance. The inventors found that especially the use of serin proteases improve the performance of vaccinated broiler chickens, in particular the use of serin proteases increases weight gain and improves Feed Conversion Ratio (FCR) of cocci-vaccinated birds. | ||||||
| 36 | Soluble β-N-acetylglucosaminidase based antibiofilm compositions and uses thereof | US13416793 | 2012-03-09 | US08821862B2 | 2014-09-02 | Srinivasa Madhyastha; Nanda Yakandawala; Purushottam V. Gawande; Karen Lovetri; Jeffrey B. Kaplan; Daniel Rhoads; Lasha Gogokhia |
| The present invention provides compositions comprising an antibiofilm enzyme, a soluble β-N-acetylglucosaminidase similar to the dspB gene (DispersinB®), and an antimicrobial for preventing growth and proliferation of biofilm-embedded microorganisms in acute and chronic wounds, and methods of treatment. The invention further provides methods for preparing medical devices, and in particular, wound care devices using soluble β-N-acetylglucosaminidase based antimicrobial compositions. | ||||||
| 37 | Polypeptides Having Endopeptidase Activity and Polynucleotides Encoding Same | US13821168 | 2011-09-30 | US20130273203A1 | 2013-10-17 | Peter Rahbek Oestergaard; Carsten P. Sonksen; Tine Hoff; Gitte B. Lynglev |
| The present invention relates to polypeptides having endopeptidase activity and to methods of producing and using the polypeptides. The invention also relates to methods of making a food protein hydrolysate using a trypsin-like endopeptidase derived from a bacterium. | ||||||
| 38 | METHODS AND COMPOSITIONS USING KLOTO-FGF FUSION POLYPEPTIDES | US13796711 | 2013-03-12 | US20130224196A1 | 2013-08-29 | David GLASS; Shou-Ih HU |
| The present invention is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The Klotho fusion polypeptides of the invention include at least a Klotho protein or an active fragment thereof. In one embodiment, the fusion polypeptide comprises a Klotho polypeptide, a FGF (such as FGF23) and (optionally) a modified Fc fragment. The Fc fragment can, for example, have decreased binding to Fc-gamma-receptor and increased serum half-life. The Klotho fusion proteins are useful in the treatment and prevention of a variety of age-related conditions and metabolic disorders. In another embodiment, the fusion polypeptide comprises a FGF (such as FGF23) and a modified Fc fragment. | ||||||
| 39 | METHODS OF LYSOSOMAL STORAGE DISEASE THERAPY | US13253005 | 2011-10-04 | US20120082653A1 | 2012-04-05 | Dwight D. KOEBERL |
| Methods of treating a lysosomal storage disorder and methods of increasing cellular uptake of a lysosomal enzyme using β2 agonists or therapeutic agents that increase expression of receptors for a lysosomal enzyme. | ||||||
| 40 | Method for preparing flour doughs and products made from such doughs using lipase | US10462527 | 2003-06-16 | US07371423B2 | 2008-05-13 | Jorn Borch Søe; Charlotte Horsmans Poulsen; Preben Rasmussen; Susan Mampusti Madrid; Masoud R. Zargahi |
| Method of improving the rheological properties of a flour dough and the quality of bread, alimentary paste products, noodles and cakes wherein glycerol oxidase or a combination of glycerol oxidase and a lipase is added to the dough and dough improving compositions comprising these enzymes. The strength of (B/C ratio) and the gluten index of the dough was improved and in the resulting products the improvements were higher specific volume, increased crumb pore homogeneity and reduced average crumb pore diameter. | ||||||
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