| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 来自加州海兔的DFP酶 | CN201610806428.4 | 2010-05-06 | CN106434596A | 2017-02-22 | S.丹尼尔森; L.K.斯科夫; R.莱特; V.莱兹; M.L.C.达方塞卡 |
| 本发明涉及来自加州海兔的DFP酶，具体地涉及具有有机磷水解酶活性的分离的多肽和编码所述多肽的分离的多核苷酸。本发明还涉及包含所述多核苷酸的核酸构建体、载体和宿主细胞，以及用于产生和使用所述多肽的方法。 | ||||||
| 2 | OPAA FL—a mutant enzyme with increased catalytic efficiency on organophosphorus compound GD | US15395412 | 2016-12-30 | US09976130B1 | 2018-05-22 | Mark A Guelta; Melissa M. Dixon; Steven P. Harvey |
| This invention is directed toward a non-wild-type organophosphorus acid anhydrolase enzyme having two site mutations, method of production, and method of use to more effectively degrade toxic organophosphorus compounds and, in particular, toxic chemical GD (3,3-Dimethylbutan-2-ylmethylphosphonofluoridate), than the wild type organophosphorus acid anhydrolase. | ||||||
| 3 | Enzymes for degrading organophosphates | US14233878 | 2012-07-20 | US09796990B2 | 2017-10-24 | Colin Scott; John Oakeshott; Robyn Russell; Nigel French; Steven Kotsonis; Kaiyan Liu |
| The present invention relates to enzymes capable of hydrolysing organophosphate (OP) molecules. In particular, the invention relates to variants of the OpdA enzyme from Agrobacterium that display improved activity when compared to the naturally occurring OpdA. The invention is also towards polypeptides that have organophosphate hydrolysing activity for the organophosphates chlorpyrifos methyl, diazinon and parathion ethyl. | ||||||
| 4 | Mutated organophosphorus acid anhydrolases and their uses thereof | US14946276 | 2015-11-19 | US09587232B1 | 2017-03-07 | Steven P. Harvey; Mark A. Guelta |
| The invention is directed toward non-wild-type organophosphorus acid anhydrolases having three site mutations, method of production, and method of use to effectively degrade toxic chemicals such as N,N-diethyl-2-(methyl-(2-methylpropoxy)phosphoryl)sulfanylethanamine) (“VR”). | ||||||
| 5 | ENGINEERED ORGANOPHOSPHORUS ACID ANHYDROLASES AND METHODS OF USE THEREOF | US15174719 | 2016-06-06 | US20160355792A1 | 2016-12-08 | Scott Pegan; Steven P. Harvey |
| Genetically engineered organophosphorus acid anhydrolases (OPAA) with improved catalytic efficiency and relaxed stereospecificity are provided. The variants typically include a mutation at the residue corresponding to H343 of wildtype Alteromonas sp. OPAA. The mutation allows the OPAA enzyme to effectively process both VR enantiomers. The OPAA optionally include one or more mutations selected the residues corresponding to Y212, V342, and I215 of wildtype Alteromonas sp. OPAA which improve the enzyme's catalytic efficiency for VX and VR. A particularly preferred OPAA includes mutations at the residues corresponding Y212F, V342L, I215Y, and H343D relative to wildtype Alteromonas sp. OPAA. Compositions including an effective amount of OPAA to increase hydrolysis of an organophosphate, and methods of use thereof for treating subjects exposed to an organophosphate, or a surface or liquid contaminated with an organophosphate are also provided. | ||||||
| 6 | POLYPEPTIDES HAVING ORGANOPHOSPHOROUS HYDROLASE ACTIVITY | US14403949 | 2013-05-30 | US20150152397A1 | 2015-06-04 | Bjarne Gram Hansen; Steffen Danielsen; Lars Kobberoee Skov; Leonardo De Maria; Julie Bille Rannes |
| The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | ||||||
| 7 | DFPASE ENZYMES FROM APLYSIA CALIFORNICA | US13319282 | 2010-05-06 | US20120195874A1 | 2012-08-02 | Steffen Danielsen; Lars Kobberoee Skov; Ricardo Leite; Vincent Laize; M. Leonor Cancela Da Fonseca |
| The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | ||||||
| 8 | POLYPEPTIDES HAVING ORGANOPHOSPHOROUS HYDROLASE ACTIVITY | EP13726224.2 | 2013-05-31 | EP2855670A2 | 2015-04-08 | HANSEN, Bjarne, Gram; DANIELSEN, Steffen; SKOV, Lars, Kobberoee; DE MARIA, Leonardo; RANNES, Julie, Bille |
| The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | ||||||
| 9 | DFPASE ENZYMES FROM APLYSIA CALIFORNICA | EP10721013.0 | 2010-05-06 | EP2427555A1 | 2012-03-14 | DANIELSEN, Steffen; SKOV, Lars, Kobberoee; LEITE, Ricardo; LAIZE, Vincent; DA FONSECA, M., Leonor, Cancela |
| The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | ||||||
| 10 | Mutant OPAA enzymes with increased catalytic efficiency on organophosphorus compound EA1356 | US15896833 | 2018-02-14 | US10124043B1 | 2018-11-13 | Steven P Harvey; Mark A Guelta; Leslie R McMahon |
| The invention comprises isolated, mutant, non-wild-type organophosphorus acid anhydrolase (OPAA) enzymes having three site mutations, methods of production, and methods of use to effectively degrade organophosphorus compound EA1356 (2-methylcyclohexyl methylphosphonofluoridate) with greater catalytic efficiency than the wild-type OPAA enzyme. | ||||||
| 11 | POTENTIAL GRADIENT AMPLIFIED DETECTION OF CHEMICAL AGENTS | US15880815 | 2018-01-26 | US20180217085A1 | 2018-08-02 | Paul V. BRAUN; Mohammad Amdad Ali |
| New approaches for selective detection of chemical agents such as sarin are necessary because of the high toxicity of sarin and related compounds, the potential of these compounds to be used as weapons of mass destruction, and the limitations of current detection methodologies. Herein is described an apparatus and a method for selective and amplified detection of sarin simulants deposited via an aerosol process. The simulant absorbs into a hydrogel, where it hydrolyzes upon contact with water producing elemental ions. The elemental ions are then concentrated via an ionic chemical potential gradient to a sensor, where it is detected. This technique has potential to amplify the capture efficiency of a sensor by a 1000-fold within couple of minutes. | ||||||
| 12 | DFPase enzymes from aplysia californica | US14209463 | 2014-03-13 | US09447392B2 | 2016-09-20 | Steffen Danielsen; Lars Kobberoee Skov; Ricardo Leite; Vincent Laize; M. Leonor Cancela Da Fonseca |
| The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | ||||||
| 13 | ENZYMES FOR DEGRADING ORGANOPHOSPHATES | US14233878 | 2012-07-20 | US20140342387A1 | 2014-11-20 | Colin Scott; John Oakeshott; Robyn Russell; Nigel French; Steven Kotsonis; Kaiyan Liu |
| The present invention relates to enzymes capable of hydrolysing organophosphate (OP) molecules. In particular, the invention relates to variants of the OpdA enzyme from Agrobacterium that display improved activity when compared to the naturally occurring OpdA. The invention is also towards polypeptides that have organophosphate hydrolysing activity for the organophosphates chlorpyrifos methyl, diazinon and parathion ethyl. | ||||||
| 14 | DFPASE ENZYMES FROM APLYSIA CALIFORNICA | US14209463 | 2014-03-13 | US20140193879A1 | 2014-07-10 | Steffen Danielsen; Lars Kobberoee Skov; Ricardo Leite; Vincent Laize; M. Leonor Cancela Da Fonseca |
| The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | ||||||
| 15 | ENZYME CATALYSTS FOR DIELS-ALDER REACTIONS | US13130260 | 2009-11-19 | US20120100594A1 | 2012-04-26 | David Baker; Alexandre Zangellini; Justin Siegel; Jennifer St. Clair |
| The present invention provides enzyme catalysts for Diels-Alder reactions, including intermolecular Diels-Alder reactions, as well as protein scaffolds for making such enzyme catalysts. In other aspects, the invention provides methods of making the enzyme catalysts, including by de novo computational design. The present invention thereby provides enzyme catalysts capable of catalyzing a desired Diels-Alder reaction, including with a specified or desired stereo-selectivity. | ||||||
| 16 | DFPASE ENZYMES FROM APLYSIA CALIFORNICA | EP10721013.0 | 2010-05-06 | EP2427555B1 | 2016-10-19 | DANIELSEN, Steffen; SKOV, Lars, Kobberoee; LEITE, Ricardo; LAIZE, Vincent; DA FONSECA, M., Leonor, Cancela |
| 17 | ENZYMES FOR DEGRADING ORGANOPHOSPHATES | EP12815284 | 2012-07-20 | EP2734620A4 | 2014-12-24 | SCOTT COLIN; OAKESHOTT JOHN; RUSSELL ROBYN; FRENCH NIGEL; KOTSONIS STEVEN; LIU KAIYAN |
| The present invention relates to enzymes capable of hydrolysing organophosphate (OP) molecules. In particular, the invention relates to variants of the OpdA enzyme from Agrobacterium that display improved activity when compared to the naturally occurring OpdA. The invention is also towards polypeptides that have organophosphate hydrolysing activity for the organophosphates chlorpyrifos methyl, diazinon and parathion ethyl. | ||||||
| 18 | ENZYMES FOR DEGRADING ORGANOPHOSPHATES | EP12815284.0 | 2012-07-20 | EP2734620A1 | 2014-05-28 | SCOTT, Colin; OAKESHOTT, John; RUSSELL, Robyn; FRENCH, Nigel; KOTSONIS, Steven; LIU, Kaiyan |
| The present invention relates to enzymes capable of hydrolysing organophosphate (OP) molecules. In particular, the invention relates to variants of the OpdA enzyme from Agrobacterium that display improved activity when compared to the naturally occurring OpdA. The invention is also towards polypeptides that have organophosphate hydrolysing activity for the organophosphates chlorpyrifos methyl, diazinon and parathion ethyl. | ||||||
| 19 | Polypeptides Having Organophosphorous Hydrolase Activity | US16057501 | 2018-08-07 | US20180346892A1 | 2018-12-06 | Bjarne Gram Hansen; Steffen Danielsen; Lars Kobberosee Skov; Leonardo De Maria; Julie Bille Rannes |
| The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | ||||||
| 20 | Polypeptides having organophosphorous hydrolase activity | US15342856 | 2016-11-03 | US10066220B2 | 2018-09-04 | Bjarne Gram Hansen; Steffen Danielsen; Lars Kobberoee Skov; Leonardo De Maria; Julie Bille Rannes |
| The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | ||||||
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