| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 具有增强特性的硫叶菌磷酸三酯酶样(PLL)内酯酶活性及其用途 | CN201480027328.0 | 2014-04-14 | CN105209061A | 2015-12-30 | E·查波里雷; M·埃利亚斯; J·海波洛特; D·劳特 |
| 本发明提供了突变的极端嗜热PTE，其具有内酯酶活性，并且衍生自对应于SEQ ID NO:1的共有序列的极端嗜热磷酸二酯酶，所述的突变的PTE包含选自53个推定的位置中的至少一个突变，并且所述的突变的PTE具有增强的特性。此外，本发明提供了包含突变的极端嗜热PTE的组合物及其用途，尤其是作为有机磷酸酯化合物的生物清除剂或者作为使用内酯进行通讯的细菌的群体猝灭剂。 | ||||||
| 2 | NOVEL PHOSPHOTRIESTERASE ENZYMES, METHODS AND COMPOSITIONS RELATED THERETO | US14804277 | 2015-07-20 | US20160083702A1 | 2016-03-24 | Jin Kim MONTCLARE; Richard Bonneau; P. Douglas Renfrew; Ching-Yao Yang; Carlo Yuvienco |
| The instant invention provides methods and related compositions for identifying polypeptides with improved stability and/or enzymatic activity in comparison to native forms, wherein the identified polypeptides comprise one or more non-natural amino acids. In certain embodiments, the present invention relates to novel phosphotriesterase enzymes comprising one or more non-natural amino acids. In a particular embodiment, the instant invention provides novel phosphotriesterase enzymes with greater stability and/or enhanced activity in comparison to native forms of the enzyme. The present invention also relates to compositions comprising novel phophotriesterase enzymes, such as prophylactics, decontaminants, animal feedstocks, and assay kits. | ||||||
| 3 | Sulfolobal phosphotriesterase-like (PLL) lactonases activity having enhanced properties and the uses thereof | US14782703 | 2014-04-14 | US10072252B2 | 2018-09-11 | Eric Chabriere; Mikael Elias; Julien Hiblot; Didier Raoult |
| Mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 53 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate. | ||||||
| 4 | Phosphotriesterase enzymes, methods and compositions related thereto | US14804277 | 2015-07-20 | US09617525B2 | 2017-04-11 | Jin Kim Montclare; Richard Bonneau; P. Douglas Renfrew; Ching-Yao Yang; Carlo Yuvienco |
| The instant invention provides methods and related compositions for identifying polypeptides with improved stability and/or enzymatic activity in comparison to native forms, wherein the identified polypeptides comprise one or more non-natural amino acids. In certain embodiments, the present invention relates to novel phosphotriesterase enzymes comprising one or more non-natural amino acids. In a particular embodiment, the instant invention provides novel phosphotriesterase enzymes with greater stability and/or enhanced activity in comparison to native forms of the enzyme. The present invention also relates to compositions comprising novel phophotriesterase enzymes, such as prophylactics, decontaminants, animal feedstocks, and assay kits. | ||||||
| 5 | SULFOLOBAL PHOSPHOTRIESTERASE-LIKE (PLL) LACTONASES ACTIVITY HAVING ENHANCED PROPERTIES AND THE USES THEREOF | US14782703 | 2014-04-14 | US20160115462A1 | 2016-04-28 | Eric CHABRIERE; Mikael ELIAS; Julien HIBLOT; Didier RAOULT |
| Mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 53 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate. | ||||||
| 6 | Sulfolobal Phosphotriesterase-Like (PLL) lactonases activity having enhanced properties and the uses thereof | EP13305483.3 | 2013-04-12 | EP2789344A1 | 2014-10-15 | Chabriere, Eric; Elias, Mikael; Hiblot, Julien; Raoult, Didier |
The present invention provides mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, said mutated PTE comprising the at least one mutation choosen amongst 53 putative positions and said mutated PTE having enhanced properties. Also provided are compositions comprising the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate. |
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| 7 | SULFOLOBAL PHOSPHOTRIESTERASE-LIKE (PLL) LACTONASES ACTIVITY HAVING ENHANCED PROPERTIES AND THE USES THEREOF | EP14716874.4 | 2014-04-14 | EP2983699A1 | 2016-02-17 | CHABRIERE, Eric; ELIAS, Mikael; HIBLOT, Julien; RAOULT, Didier |
| The present invention provides mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, said mutated PTE comprising the at least one mutation choosen amongst 53 putative positions and said mutated PTE having enhanced properties. Also provided are compositions comprising the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate. | ||||||
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