| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | RNA interference mediated inhibition of protein tyrosine phosphatase type IVA (PRL3) gene expression using short interfering nucleic acid (siNA) | US10897902 | 2004-07-23 | US20050176663A1 | 2005-08-11 | James McSwiggen; Leonid Beigelman; Nassim Usman |
| This invention relates to compounds, compositions, and methods useful for modulating protein tyrosine phosphatase type IVA (PRL3) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of protein tyrosine phosphatase type IVA (PRL3) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of protein tyrosine phosphatase type IVA (PRL3) genes. | ||||||
| 162 | RNA interference mediated inhibition of type 1 insulin-like growth factor receptor gene expression using short interfering nucleic acid (siNA) | US10918896 | 2004-08-16 | US20050164966A1 | 2005-07-28 | James McSwiggen; Leonid Beigelman; Bharat Chowrira |
| This invention relates to compounds, compositions, and methods useful for modulating type 1 insulin-like growth factor receptor gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of type 1 insulin-like growth factor receptor gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of type 1 insulin-like growth factor receptor genes. | ||||||
| 163 | RNA interference mediated inhibition of chromosome translocation gene expression using short interfering nucleic acid (siNA) | US10923522 | 2004-08-20 | US20050159381A1 | 2005-07-21 | James McSwiggen; Leonid Beigelman; Bharat Chowrira |
| This invention relates to compounds, compositions, and methods useful for modulating chromosomal translocation gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of chromosomal translocation gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of BCR-ABL, ERG, EWS-ERG, TEL-AML1, EWS-FLI1, TLS-FUS, PAX3-FKHR, and/or AML1-ETO fusion genes. | ||||||
| 164 | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) | US10915896 | 2004-08-11 | US20050159378A1 | 2005-07-21 | James McSwiggen; Leonid Beigelman |
| This invention relates to compounds, compositions, and methods useful for modulating Myc and/or Myb gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of Myc and/or Myb gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of Myc and/or Myb (e.g., c-Myc, N-Myc, L-Myc, c-Myb, a-Myb, b-Myb, and v-Myb) genes. The small nucleic acid molecules are useful in the treatment of cancer and other diseases and disorders. | ||||||
| 165 | RNA interference mediated inhibition of proliferating cell nuclear antigen (PCNA) gene expression using short interfering nucleic acid (siNA) | US10916095 | 2004-08-11 | US20050158735A1 | 2005-07-21 | James McSwiggen; Leonid Beigelman; Bharat Chowrira |
| This invention relates to compounds, compositions, and methods useful for modulating PCNA gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of PCNA gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of PCNA genes. The small nucleic acid molecules are useful in the treatment of cancer or restenosis or other proliferative diseases, disorders, or conditions. | ||||||
| 166 | RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA) | US10923330 | 2004-08-20 | US20050153916A1 | 2005-07-14 | James McSwiggen; Leonid Beigelman |
| This invention relates to compounds, compositions, and methods useful for modulating telomerase gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of telomerase gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of telomerase genes, such as telomerase template RNA (TERC/TR), or a telomerase protein (TERT). | ||||||
| 167 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) | US10758155 | 2004-01-12 | US20050075304A1 | 2005-04-07 | James McSwiggen; Leonid Beigleman; Pamela Pavco |
| The present invention concerns methods and reagents useful in modulating vascular endothelial growth factor (VEGF, VEGF-A, VEGF-B, VEGF-C, VEGF-D) and/or vascular endothelial growth factor receptor (e.g., VEGFr1, VEGFr2 and/or VEGFr3) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against VEGF and/or VEGFr gene expression and/or activity. The small nucleic acid molecules are useful in the diagnosis and treatment of cancer, proliferative diseases, and any other disease or condition that responds to modulation of VEGF and/or VEGFr expression or activity. | ||||||
| 168 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) | US10764957 | 2004-01-26 | US20050054596A1 | 2005-03-10 | James McSwiggen; Leonid Beigleman; Pamela Pavco |
| The present invention concerns methods and reagents useful in modulating vascular endothelial growth factor (VEGF, VEGF-A, VEGF-B, VEGF-C, VEGF-D) and/or vascular endothelial growth factor receptor (e.g., VEGFr1, VEGFr2 and/or VEGFr3) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against VEGF and/or VEGFr gene expression and/or activity. The small nucleic acid molecules are useful in the diagnosis and treatment of cancer, proliferative diseases, and any other disease or condition that responds to modulation of VEGF and/or VEGFr expression or activity. | ||||||
| 169 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) | US10826966 | 2004-04-16 | US20050032733A1 | 2005-02-10 | James McSwiggen; Dennis Macejak; David Morrissey |
| The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism. | ||||||
| 170 | Nucleic acid-based modulation of gene expression in the vascular endothelial growth factor pathway | US10726236 | 2003-12-02 | US20040142895A1 | 2004-07-22 | Jennifer Lockridge; Pamela Pavco |
| The present invention relates to nucleic acid molecules, including dsRNA, siRNA, antisense, 2,5-A chimeras, aptamers, and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, and allozymes, which modulate the expression of vascular endothelial growth factor receptor (VEGF) and/or vascular endothelial growth factor receptor (VEGFr) genes for the treatment and/or diagnosis of female reproductive disorders and conditions, including but not limited to endometriosis, endometrial carcinoma, gynecologic bleeding disorders, irregular menstrual cycles, ovulation, premenstrual syndrome (PMS), and menopausal dysfunction. | ||||||
| 171 | INCREASING LIPID PRODUCTION AND OPTIMIZING LIPID COMPOSITION | EP15800544 | 2015-05-29 | EP3149152A4 | 2018-03-07 | BREVNOVA ELENA E; SHAW ARTHUR J IV; VAN DIJKEN JOHANNES P |
| Disclosed are nucleotide sequences and corresponding amino acid sequences of Arxula adeninivorans genes that can be utilized to manipulate the lipid content and/or composition of a cell. Methods and compositions for utilizing this information are disclosed to increase the lipid content or modify the lipid composition of a cell by either increasing or decreasing the activity of certain genetic targets. | ||||||
| 172 | Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms | EP13180237.3 | 2009-12-08 | EP2669380B1 | 2017-09-27 | Senger, Toralf; Bauer, Jörg; Napier, Johnathan A. |
| 173 | Certain plants with no saturate or reduced saturate levels of fatty acids in seeds, and oil derived from the seeds | EP11000857.0 | 2005-10-07 | EP2338328B1 | 2017-09-20 | Thompson, Mark; Reddy, Sam |
| The subject invention provides "no sat" canola oil. The subject invention also provides seeds that can be used to produce such oils. Plants that produce these seeds are also included within the subject invention. All of this was surprisingly achieved by using a delta-9 desaturase gene in canola. This technology can be applied to other plants as disclosed herein. Oils of the subject invention have particularly advantageous characteristics and fatty acid profiles, which were not heretofore attained. The subject invention still further provides a plant-optimized delta-9 desaturase gene. The subject invention still further provides a plant-optimized delta-9 desaturase gene. In some preferred embodiments, a preferred plant comprises at least two copies of a delta-9 desaturase gene of the subject invention. Seeds produced by such plants surprisingly do not exhibit effects of gene silencing but rather have further surprising reductions in levels of total saturates. | ||||||
| 174 | METHODS FOR EFFICIENT PRODUCTION OF POLYUNSATURATED FATTY ACIDS (PUFA) IN RHODOSPORIDIUM AND RHODOTORULA SPECIES | EP15840158.8 | 2015-08-21 | EP3191577A1 | 2017-07-19 | LIU, Yanbin; KOH, Chong Mei; JI, Lianghui |
| The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of polyunsaturated fatty acids (PUFA) in fungal hosts selected from Rhodosporidium and Rhodotorula genera. The present invention further relates to a modified fungal host cell having reduced native aldehyde dehydrogenase (ALD 1) enzyme activity, and methods for producing omega-3 and omega-6 fatty acids and triacylglycerides, by growing said fungal host cell under suitable conditions. | ||||||
| 175 | ACID-TOLERANT YEAST CELL, METHOD OF PRODUCING ORGANIC ACID USING THE SAME, AND METHOD OF PRODUCING THE YEAST CELL | EP16180739.1 | 2016-07-22 | EP3124604A2 | 2017-02-01 | CHU, Hunsu; CHO, Hwayoung; PARK, Jinhwan; YANG, Dongsik; RHEE, Hongsoon; CHO, Kwangmyung |
Provided are an acid-tolerant yeast cell, a method of producing an organic acid by using the yeast cell, and a method of producing the yeast cell resistant to acid.
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| 176 | FOOD COMPOSITIONS COMPRISING TAILORED OILS | EP11787552 | 2011-05-27 | EP2575486A4 | 2016-03-23 | FRANKLIN SCOTT; SOMANCHI ARAVIND; WEE JANICE; RUDENKO GEORGE; MOSELEY JEFFREY L; RAKITSKY WALT |
| 177 | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen nicht-humanen Organismen | EP09175509.0 | 2007-10-04 | EP2182056B1 | 2015-12-23 | Bauer, Jörg, Dr.; Wetjen, Tom, Dr.-Ing. |
| 178 | ENGINEERED MICROBES AND METHODS FOR MICROBIAL OIL PRODUCTION | EP12840947 | 2012-10-19 | EP2768954A4 | 2015-09-23 | STEPHANOPOULOS GREGORY; TAI MITCHELL; CHAKRABORTY SAGAR |
| Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties. | ||||||
| 179 | Altered FAD2 and FAD3 genes in brassica and the molecular marker-assisted detection thereof | EP12150075.5 | 2004-02-11 | EP2457922A1 | 2012-05-30 | Hu, Xueyi; Gupta, Manju; Sullivan-Gilbert, Mandy Lynne; Thompson, Steven Arnold |
The present invention provides methods of marker assisted selection for high oleic/low linolenic traits in canola and in other oil seed crop species, as well as isolated nucleic acids for use as molecular markers in such methods. In particular, molecular markers and Brassica nucleic acid corresponding to fad2 and fad3 gene mutations are disclosed. The markers of the present invention are highly useful for the direct selection of desirable fad2 and fad3 alleles during marker-assisted trait introgression and breeding. In a one aspect of the embodiment, two single nucleotide polymorphism (SNP) markers are provided which correspond to the alleles.Thus, the present invention advantageously permits one of skill in the art to breed for the molecular markers described herein, or derivatives thereof, rather than breeding for a high oleic/low linolenic phenotype. |
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| 180 | Verfahren und Marker zur einfachen Transformation und Selektion von rekombinanten Ciliaten | EP03007098.1 | 2003-03-28 | EP1357190B1 | 2011-06-29 | Rüsing, Matthias, Dr. |
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