| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen nicht-humanen Organismen | EP09175509.0 | 2007-10-04 | EP2182056A1 | 2010-05-05 | Bauer, Jörg, Dr.; Wetjen, Tom, Dr.-Ing. |
Die vorliegende Erfindung betrifft Polynucleotide aus Ostreococcus lucimarinus, die Desaturasen und Elongasen kodieren und zur rekombinanten Herstellung von mehrfach ungesättigten Fettsäuren eingesetzt werden können. Weiterhin betrifft die Erfindung Vektoren, Wirtszellen und transgene nicht-humane Organismen, die die Polynucleotide enthalten, sowie die von den Polynucleotiden kodierten Polypeptide. Schließlich betrifft die Erfindung noch Herstellungsverfahren für die mehrfach ungesättigten Fettsäuren und für Öl-, Lipid- und Fettsäurezusammensetzungen. |
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| 182 | CERTAIN PLANTS WITH NO SATURATE OR REDUCED SATURATE LEVELS OF FATTY ACIDS IN SEEDS, AND OIL DERIVED FROM THE SEEDS | EP05802517 | 2005-10-07 | EP1799027A4 | 2008-08-27 | THOMPSON MARK; REDDY SAM |
| The subject invention provides "no sat" canola oil. The subject invention also provides seeds that can be used to produce such oils. Plants that produce these seeds are also included within the subject invention. All of this was surprisingly achieved by using a delta-9 desaturase gene in canola. This technology can be applied to other plants as disclosed herein. Oils of the subject invention have particularly advantageous characteristics and fatty acid profiles, which were not heretofore attained. The subject invention still further provides a plant-optimized delta-9 desaturase gene. The subject invention still further provides a plant-optimized delta-9 desaturase gene. In some preferred embodiments, a preferred plant comprises at least two copies of a delta-9 desaturase gene of the subject invention. Seeds produced by such plants surprisingly do not exhibit effects of gene silencing but rather have further surprising reductions in levels of total saturates. | ||||||
| 183 | ANTISENSE MODULATION OF STEAROYL-COA DESATURASE EXPRESSION | EP04776556 | 2004-07-15 | EP1648910A4 | 2008-02-27 | CROOKE ROSANNE M; GRAHAM MARK J |
| Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided. | ||||||
| 184 | RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA) | EP06075998.2 | 2003-02-18 | EP1741781A3 | 2007-06-06 | McSwiggen, James; Beigelman, Leonid |
The present invention concerns methods and reagents useful in modulating BACE gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against beta-secretase (BACE), amyloid precurson protein (APP), pin-1, presenillin 1 (PS-1) and/or presenillin 2 (PS-2) gene expression and/or activity. The small nucleic acid molecules are useful in the treatment of Alzheimer's disease and any other condition that responds to modulation of BACE, APP, pin-1, PS-1 and/or PS-2 expression or activity. |
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| 185 | RNA INTERFERANCE MEDIATED INHIBITION OF CHOLINERGIC MUSCARINIC RECEPTOR (CHRM3) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | EP04781956.0 | 2004-08-20 | EP1682660A2 | 2006-07-26 | RICHARDS, Ivan; MACSWIGGEN, James |
| This invention relates to compounds, compositions, and methods useful for modulating cholinergic muscarinic receptor gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of cholinergic muscarinic receptor gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of cholinergic muscarinic receptor genes, such as M3 muscarinic acetylcholine receptor or cholinergic receptor muscarinic 3 (CHRM3). | ||||||
| 186 | METHODS OF IDENTIFYING AGENTS THAT INHIBIT THE GROWTH OF CANCER CELLS | EP04816110.3 | 2004-08-24 | EP1677739A2 | 2006-07-12 | HU, Xiuyuan; LI, Henry; KE, Ning; GRIFMAN, Mirta; ROGERS, Cheryl; DEFIFE, Kristin; HABITA, Cellia; FAN, Wufang; RHOADES, Kristina; TAN, Philip; TRITZ, Richard; WONG-STAAL, Flossie |
| The present invention is directed to methods of identifying agents useful for inhibiting cancer cells. The agents bind to one of the proteins described herein, or to a gene or mRNA encoding such protein. The invention is also directed to methods for inhibiting cancer cells by administering an agent that binds to one of the proteins described herein, or to a gene or mRNA encoding such protein. | ||||||
| 187 | ANTISENSE MODULATION OF STEAROYL-COA DESATURASE EXPRESSION | EP04776556.5 | 2004-07-15 | EP1648910A2 | 2006-04-26 | CROOKE, Rosanne, M.; GRAHAM, Mark, J. |
| Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided. | ||||||
| 188 | RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER'S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA) | EP04756160.0 | 2004-06-25 | EP1644498A2 | 2006-04-12 | MCSWIGGEN, James; BEIGELMAN, Leonid |
| This invention relates to compounds, compositions, and methods useful for modulating beta-secretase (BACE), amyloid precurson protein (APP), PIN-1, presenillin 1 (PS-1) and/or presenillin 2 (PS-2)gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of BACE, APP, PIN-1, PS-1 and/or PS-2 gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), doublestranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of BACE, APP, PIN-1, PS-1 and/or PS-2 genes. | ||||||
| 189 | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (sina) | EP04077740.1 | 2004-10-08 | EP1522583A3 | 2005-10-12 | Pavco, Pamela; McSwiggen, James; Beigelman, Leonid |
The present invention concerns methods and reagents useful in modulating placental growth factor (e.g., PGF-1 or PIGF-1, PGF-2 or PIGF-2, and/or PGF-3 or PIGF-3) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against PGF gene expression and/or activity. The small nucleic acid molecules are useful in the diagnosis and treatment of cancer, proliferative diseases, and any other disease or condition that responds to modulation of PGF expression or activity. |
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| 190 | RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIN D1 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | EP03743117 | 2003-02-06 | EP1436314A4 | 2005-08-10 | THOMPSON JAMES; MCSWIGGEN JAMES; BEIGELMAN LEONID |
| 191 | RNA INTERFERENCE MEDIATED INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | EP03742833 | 2003-02-20 | EP1521768A4 | 2005-07-06 | MCSWIGGEN JAMES; BEIGELMAN LEONID; PAVCO PAMELA |
| 192 | Methods for efficient production of polyunsaturated fatty acids (PUFA) in Rhodosporidium and Rhodotorula species | US15326077 | 2015-08-21 | US10081821B2 | 2018-09-25 | Yanbin Liu; Chong Mei Koh; Lianghui Ji |
| The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of polyunsaturated fatty acids (PUFA) in fungal hosts selected from Rhodosporidium and Rhodotorula genera. The present invention further relates to a modified fungal host cell having reduced native aldehyde dehydrogenase (ALD 1) enzyme activity, and methods for producing omega-3 and omega-6 fatty acids and triacylglycerides, by growing said fungal host cell under suitable conditions. | ||||||
| 193 | Recombinant microalgae including keto-acyl ACP synthase | US14819117 | 2015-08-05 | US10006034B2 | 2018-06-26 | Scott Franklin; Aravind Somanchi; Janice Wee; George Rudenko; Jeffrey L. Moseley; Walt Rakitsky |
| Methods and compositions for the production of food compositions, oils, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing food compositions, and transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants. | ||||||
| 194 | CERTAIN PLANTS WITH "NO SATURATE" OR REDUCED SATURATE LEVELS OF FATTY ACIDS IN SEEDS, AND OIL DERIVED FROM THE SEEDS | US15606470 | 2017-05-26 | US20180030463A1 | 2018-02-01 | Mark Allen Thompson; Avutu Sambi Reddy |
| The subject invention provides “no sat” canola oil. The subject invention also provides seeds that can be used to produce such oils. Plants that produce these seeds are also included within the subject invention. All of this was surprisingly achieved by using a delta-9 desaturase gene in canola. This technology can be applied to other plants as disclosed herein. Oils of the subject invention have particularly advantageous characteristics and fatty acid profiles, which were not heretofore attained. The subject invention still further provides a plant-optimized delta-9 desaturase gene. The subject invention still further provides a plant-optimized delta-9 desaturase gene. In some preferred embodiments, a preferred plant comprises at least two copies of a delta-9 desaturase gene of the subject invention. Seeds produced by such plants surprisingly do not exhibit effects of gene silencing but rather have further surprising reductions in levels of total saturates. | ||||||
| 195 | Engineered microbes and methods for microbial oil production | US14547304 | 2014-11-19 | US09862977B2 | 2018-01-09 | Gregory Stephanopoulos; Mitchell Tai; Sagar Chakraborty |
| Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties. | ||||||
| 196 | Altered FAD2 and FAD3 genes in Brassica and the molecular marker assisted detection thereof | US14614284 | 2015-02-04 | US09832942B2 | 2017-12-05 | Xueyi Hu; Mandy Lynne Sullivan-Gilbert; Manju Gupta; Steven Arnold Thompson |
| The present invention provides methods of marker-assisted selection for high oleic/low linolenic traits in canola and in other oil seed crop species, as well as isolated nucleic acids for use as molecular markers in such methods. In particular, molecular markers and Brassica nucleic acid corresponding to fad2 and fad3 gene mutations are disclosed. The markers of the present invention are highly useful for the direct selection of desirable fad2 and fad3 alleles during marker-assisted trait introgression and breeding. In one aspect of the embodiment, two single nucleotide polymorphism (SNP) markers are provided that correspond to the alleles. Thus, the present invention advantageously permits one of skill in the art to breed for the molecular markers described herein, or derivatives thereof, rather than breeding for a high oleic/low linolenic phenotype. | ||||||
| 197 | METHODS FOR EFFICIENT PRODUCTION OF POLYUNSATURATED FATTY ACIDS(PUFA) IN RHODOSPORIDIUM AND RHODOTORULA SPECIES | US15326077 | 2015-08-21 | US20170198315A1 | 2017-07-13 | Yanbin LIU; Chong Mei KOH; Lianghui JI |
| The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of polyunsaturated fatty acids (PUFA) in fungal hosts selected from Rhodosporidium and Rhodotorula genera. The present invention further relates to a modified fungal host cell having reduced native aldehyde dehydrogenase (ALD 1) enzyme activity, and methods for producing omega-3 and omega-6 fatty acids and triacylglycerides, by growing said fungal host cell under suitable conditions. | ||||||
| 198 | INCREASING LIPID PRODUCTION AND OPTIMIZING LIPID COMPOSITION | US15313187 | 2015-05-29 | US20170191073A1 | 2017-07-06 | Elena E. Brevnova; Arthur J. Shaw, IV; Johnnes P. Van Dijken |
| Disclosed are nucleotide sequences and corresponding amino acid sequences of Arxula adeninivorans genes that can be utilized to manipulate the lipid content and/or composition of a cell. Methods and compositions for utilizing this information are disclosed to increase the lipid content or modify the lipid composition of a cell by either increasing or decreasing the activity of certain genetic targets. | ||||||
| 199 | Tailored oils produced from recombinant heterotrophic microorganisms | US14975016 | 2015-12-18 | US09657299B2 | 2017-05-23 | Scott Franklin; Aravind Somanchi; Janice Wee; George Rudenko; Jeffrey L. Moseley; Walter Rakitsky |
| Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants. | ||||||
| 200 | ISOBUTANOL TOLERANCE IN YEAST WITH AN ALTERED LIPID PROFILE | US15108845 | 2014-12-22 | US20160326551A1 | 2016-11-10 | Tina K. VAN DYK; Zhixiong XUE; Narendra S. YADAV; Hongxiang ZHANG |
| Provided herein are recombinant yeast host cells and methods for their use for production of fermentation products from an engineered pyruvate utilizing pathway. The yeast host cells provided herein comprise an altered lipid profile, which confers resistance to butanol. | ||||||
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