专利检索_ .二硫化物作为受体专利检索_ .二硫化物作为受体专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	Host cells and methods of use	US14772436	2014-03-06	US09926570B2	2018-03-27	Yonghwan Jin; Yuan Zhu
The present invention relates to genetically modified host cells, in particular yeast cells, comprising at least one isolated polynucleotide encoding a Killer Expression protease (Kex2p) or a fragment and/or variant thereof which has at least one Kex2p functional activity and at least one isolated polynucleotide encoding a Protein Disulfide-Isomerase (Pdi1) or a fragment and/or variant thereof which has at least one Pdi functional activity. Also provided herein are genetically modified host cells comprising at least one isolated polynucleotide encoding a Killer Expression protease (Kex2p) or a fragment and/or variant thereof which has at least one Kex2p functional activity, at least one isolated polynucleotide encoding a Protein Disulfide-Isomerase (Pdi1) or a fragment and/or variant thereof which has at least one Pdi1 functional activity and at least one isolated polynucleotide encoding a Endoplasmic Reticulum Oxidoreductin (Ero1) or a fragment and/or variant thereof which has at least one Ero1 functional activity.
2	HOST CELLS AND METHODS OF USE	US14772436	2014-03-06	US20160017343A1	2016-01-21	Yonghwan JIN; Yuan ZHU
The present invention relates to genetically modified host cells, in particular yeast cells, comprising at least one isolated polynucleotide encoding a Killer Expression protease (Kex2p) or a fragment and/or variant thereof which has at least one Kex2p functional activity and at least one isolated polynucleotide encoding a Protein Disulfide-Isomerase (Pdi1) or a fragment and/or variant thereof which has at least one Pdi functional activity. Also provided herein are genetically modified host cells comprising at least one isolated polynucleotide encoding a Killer Expression protease (Kex2p) or a fragment and/or variant thereof which has at least one Kex2p functional activity, at least one isolated polynucleotide encoding a Protein Disulfide-Isomerase (Pdi1) or a fragment and/or variant thereof which has at least one Pdi1 functional activity and at least one isolated polynucleotide encoding a Endoplasmic Reticulum Oxidoreductin (Ero1) or a fragment and/or variant thereof which has at least one Ero1 functional activity.
3	宿主細胞および使用方法	JP2015561647	2014-03-06	JP2016514957A	2016-05-26	ヨンファン、ジン; ユアン、チュー
本発明は、キラーエクスプレッションプロテアーゼ(Kex2p)または少なくとも1つのKex2pの機能活性を有するその断片および/もしくは変異体をコードする少なくとも1つの単離されたポリヌクレオチドと、タンパク質ジスルフィドイソメラーゼ(Pdi1)または少なくとも1つのPdiの機能活性を有するその断片および/もしくは変異体をコードする少なくとも1つの単離されたポリヌクレオチドとを含んでなる、遺伝子改変宿主細胞、特に、酵母細胞に関する。また、本明細書では、キラーエクスプレッションプロテアーゼ(Kex2p)または少なくとも1つのKex2pの機能活性を有するその断片および/もしくは変異体をコードすると、少なくとも1つの単離されたポリヌクレオチドと、タンパク質ジスルフィドイソメラーゼ(Pdi1)または少なくとも1つのPdi1の機能活性を有するその断片および/もしくは変異体をコードする少なくとも1つの単離されたポリヌクレオチドと、小胞体オキシドレダクチン(Ero1)または少なくとも1つのEro1の機能活性を有するその断片および/もしくは変異体をコードする少なくとも1つの単離されたポリヌクレオチドを含んでなる遺伝子改変宿主細胞も提供される。
4	HOST CELLS AND METHODS OF USE	EP14760330	2014-03-06	EP2964666A4	2016-08-10	JIN YONGHWAN; ZHU YUAN
The present invention relates to genetically modified host cells, in particular yeast cells, comprising at least one isolated polynucleotide encoding a Killer Expression protease (Kex2p) or a fragment and/or variant thereof which has at least one Kex2p functional activity and at least one isolated polynucleotide encoding a Protein Disulfide-Isomerase (Pdi1) or a fragment and/or variant thereof which has at least one Pdi functional activity. Also provided herein are genetically modified host cells comprising at least one isolated polynucleotide encoding a Killer Expression protease (Kex2p) or a fragment and/or variant thereof which has at least one Kex2p functional activity, at least one isolated polynucleotide encoding a Protein Disulfide-Isomerase (Pdi1) or a fragment and/or variant thereof which has at least one Pdi1 functional activity and at least one isolated polynucleotide encoding a Endoplasmic Reticulum Oxidoreductin (Ero1) or a fragment and/or variant thereof which has at least one Ero1 functional activity.
5	숙주 세포 및 사용방법	KR1020157023780	2014-03-31	KR1020150126839A	2015-11-13	진,용환; 주,유안
본발명은킬러발현프로테아제 (Kex2p) 또는적어도하나의 Kex2p 기능적활성을갖는그의단편및/또는변이체를코딩하는적어도하나의단리된폴리뉴클레오티드및 단백질디술피드-이소머라제 (Pdi1) 또는적어도하나의 Pdi1 기능적활성을갖는그의단편및/또는변이체를코딩하는적어도하나의단리된폴리뉴클레오티드를포함하는, 유전자변형된숙주세포, 특히효모세포에관한것이다. 킬러발현프로테아제 (Kex2p) 또는적어도하나의 Kex2p 기능적활성을갖는그의단편및/또는변이체를코딩하는적어도하나의단리된폴리뉴클레오티드, 단백질디술피드-이소머라제 (Pdi1) 또는적어도하나의 Pdi1 기능적활성을갖는그의단편및/또는변이체를코딩하는적어도하나의단리된폴리뉴클레오티드및 소포체옥시도리덕틴 (Ero1) 또는적어도하나의 Ero1 기능적활성을갖는그의단편및/또는변이체를코딩하는적어도하나의단리된폴리뉴클레오티드를포함하는유전자변형된숙주세포가또한본원에제공된다.

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