| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 通过抑制蛋氨酸硫氧化物还原酶A(MSRA)的天然反义转录物而治疗MSRA相关疾病 | CN201180024561.X | 2011-05-25 | CN102971423A | 2013-03-13 | J·克拉德; O·霍克瓦舍曼 |
| 本发明涉及调节蛋氨酸硫氧化物还原酶A(MSRA)的表达和/或功能的反义寡核苷酸，尤其是通过靶向蛋氨酸硫氧化物还原酶A(MSRA)的天然反义多核苷酸。本发明还涉及这些反义寡核苷酸的鉴定和它们在治疗MSRA表达相关的疾病和病症中的用途。 | ||||||
| 2 | REDUCTION OF OXIDATED METHIONINE PEPTIDES FOR MASS SPECTROMETRY | US15360662 | 2016-11-23 | US20170152541A1 | 2017-06-01 | Michael Sweredoski; Annie Moradian; Tanya R. Yakushi; Sonja Hess; Roxana Eggleston-Rangel |
| A method for preparing a methionine-containing peptide or protein for analysis by mass spectrometry includes incubating the methionine-containing peptide or protein with a heterologous methionine sulfoxide reductase A (MsrA), MsrB, or MsrAB enzyme resulting in the reduction of oxidized methionine-containing peptides or proteins. | ||||||
| 3 | TREATMENT OF METHIONINE SULFOXIDE REDUCTASE A (MSRA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO MSRA | US14618150 | 2015-02-10 | US20150152425A1 | 2015-06-04 | Joseph COLLARD; Olga Khorkova Sherman |
| The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Methionine Sulfoxide Reductase A (MSRA), in particular, by targeting natural antisense polynucleotides of Methionine Sulfoxide Reductase A (MSRA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of MSRA. | ||||||
| 4 | Treatment of methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA | US13699356 | 2011-05-25 | US08980858B2 | 2015-03-17 | Joseph Collard; Olga Khorkova Sherman |
| The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Methionine Sulfoxide Reductase A (MSRA), in particular, by targeting natural antisense polynucleotides of Methionine Sulfoxide Reductase A (MSRA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of MSRA. | ||||||
| 5 | TREATMENT OF METHIONINE SULFOXIDE REDUCTASE A (MSRA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO MSRA | US13699356 | 2011-05-25 | US20130072546A1 | 2013-03-21 | Joseph Collard; Olga Khorkova Sherman |
| The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Methionine Sulfoxide Reductase A (MSRA), in particular, by targeting natural antisense polynucleotides of Methionine Sulfoxide Reductase A (MSRA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of MSRA. | ||||||
| 6 | TREATMENT OF METHIONINE SULFOXIDE REDUCTASE A (MSRA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO MSRA | EP11787293.7 | 2011-05-25 | EP2576784A2 | 2013-04-10 | COLLARD, Joseph; KHORKOVA SHERMAN, Olga |
| The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Methionine Sulfoxide Reductase A (MSRA), in particular, by targeting natural antisense polynucleotides of Methionine Sulfoxide Reductase A (MSRA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of MSRA. | ||||||
| 7 | メチオニンスルホキシドレダクターゼA(MSRA)に対する天然アンチセンス転写物の阻害によるMSRA関連疾患の治療 | JP2013512185 | 2011-05-25 | JP5917497B2 | 2016-05-18 | コラド,ジョゼフ; コルコワ シャーマン,オルガ |
| 8 | Treatment of msra-related diseases due to the inhibition of natural antisense transcript for the methionine sulfoxide reductase a (msra) | JP2013512185 | 2011-05-25 | JP2013534412A | 2013-09-05 | コラド，ジョゼフ; シャーマン，オルガ コルコワ |
| The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Methionine Sulfoxide Reductase A (MSRA), in particular, by targeting natural antisense polynucleotides of Methionine Sulfoxide Reductase A (MSRA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of MSRA. | ||||||
| 9 | TREATMENT OF METHIONINE SULFOXIDE REDUCTASE A (MSRA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO MSRA | EP11787293.7 | 2011-05-25 | EP2576784B1 | 2017-11-15 | COLLARD, Joseph; KHORKOVA SHERMAN, Olga |
| 10 | TREATMENT OF METHIONINE SULFOXIDE REDUCTASE A (MSRA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO MSRA | EP11787293 | 2011-05-25 | EP2576784A4 | 2014-11-12 | COLLARD JOSEPH; KHORKOVA SHERMAN OLGA |
| 11 | 메티오닌 설폭시드 환원효소 A (MSRA)에 대한 자연 안티센스 전사체의 저해에 의한 메티오닌 설폭시드 환원효소 A (MSRA) 관련된 질환의 치료 | KR1020127031570 | 2011-05-25 | KR101902197B1 | 2018-10-01 | 콜라드,조셉; 크로코바셔만,올가 |
| 본발명은특히, 메티오닌설폭시드환원효소 A (MSRA)의자연안티센스폴리뉴클레오티드를표적으로함으로써, 메티오닌설폭시드환원효소 A (MSRA)의발현및/또는기능을조정하는안티센스올리고뉴클레오티드에관계한다. 본발명은또한, 이들안티센스올리고뉴클레오티드의확인및 메티오닌설폭시드환원효소 A (MSRA)의발현과연관된질환과장애의치료에서그들의용도에관계한다. | ||||||
| 12 | 메티오닌 설폭시드 환원효소 A (MSRA)에 대한 자연 안티센스 전사체의 저해에 의한 메티오닌 설폭시드 환원효소 A (MSRA) 관련된 질환의 치료 | KR1020127031570 | 2011-05-25 | KR1020130077830A | 2013-07-09 | 콜라드,조셉; 크로코바셔만,올가 |
| 본 발명은 특히, 메티오닌 설폭시드 환원효소 A (MSRA)의 자연 안티센스 폴리뉴클레오티드를 표적으로 함으로써, 메티오닌 설폭시드 환원효소 A (MSRA)의 발현 및/또는 기능을 조정하는 안티센스 올리고뉴클레오티드에 관계한다. 본 발명은 또한, 이들 안티센스 올리고뉴클레오티드의 확인 및 메티오닌 설폭시드 환원효소 A (MSRA)의 발현과 연관된 질환과 장애의 치료에서 그들의 용도에 관계한다.
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| 13 | TREATMENT OF METHIONINE SULFOXIDE REDUCTASE A (MSRA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO MSRA | PCT/US2011037835 | 2011-05-25 | WO2011150007A3 | 2012-04-05 | COLLARD JOSEPH; KHORKOVA SHERMAN OLGA |
| The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Methionine Sulfoxide Reductase A (MSRA), in particular, by targeting natural antisense polynucleotides of Methionine Sulfoxide Reductase A (MSRA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of MSRA. | ||||||
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