序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
41 GLUCOSE DEHYDROGENASE EP12863747 2012-12-28 EP2799545A4 2016-01-20 SODE KOJI; MORI KAZUSHIGE
Amino acid mutation(s) can be introduced to Sclerotinia sclerotiorum- or Aspergillus niger-derived glucose dehydrogenase to obtain a glucose dehydrogenase variant with significantly enhanced productivity in E. coli. The glucose dehydrogenase of the present invention is low reactive with xylose.
42 BIOCATALYSTS FOR EZETIMIBE SYNTHESIS EP11778262.3 2011-05-04 EP2566497B1 2015-07-29 CROWE, Michael, A.; ALVIZO, Oscar; BEHROUZIAN, Behnaz; BONG, Yong Koy; COLLIER, Steven, J.; GOHEL, Anupam; MAVINAHALLI, Jagadeesh; MODUKURU, Naga; MUNDORFF, Emily; SMITH, Derek; SONG, Shiwei; YEO, Wan Lin
The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
43 GLUCOSE DEHYDROGENASE EP12863747.7 2012-12-28 EP2799545A1 2014-11-05 SODE, Koji; MORI, Kazushige

Amino acid mutation(s) can be introduced to Sclerotinia sclerotiorum- or Aspergillus niger-derived glucose dehydrogenase to obtain a glucose dehydrogenase variant with significantly enhanced productivity in E. coli. The glucose dehydrogenase of the present invention is low reactive with xylose.

44 BIOCATALYSTS FOR EZETIMIBE SYNTHESIS EP11778262.3 2011-05-04 EP2566497A1 2013-03-13 CROWE, Michael, A.; ALVIZO, Oscar; BEHROUZIAN, Behnaz; BONG, Yong Koy; COLLIER, Steven, J.; GOHEL, Anupam; MAVINAHALLI, Jagadeesh; MODUKURU, Naga; MUNDORFF, Emily; SMITH, Derek; SONG, Shiwei; YEO, Wan Lin
The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
45 MYCOTOXIN-REDUCING COMPOSITION EP07824430.8 2007-11-01 EP2094107B1 2010-12-29 Mann, Stephen Philip; Parfitt, David
A composition comprising an enzyme, a mycotoxin-binding agent and a microorganism capable of taking up a mycotoxin.
46 MYCOTOXIN-REDUCING COMPOSITION EP07824430.8 2007-11-01 EP2094107A2 2009-09-02 Mann, Stephen Philip; Parfitt, David
A composition comprising an enzyme, a mycotoxin-binding agent and a microorganism capable of taking up a mycotoxin.
47 CONVERSION OF METHYLGLYOXAL INTO HYDROXYACETONE USING ENZYMES AND APPLICATIONS THEREOF EP16306848.9 2016-12-29 EP3342873A1 2018-07-04 FAURE, Laetitia; BESTEL-CORRE, Gwenaëlle; RAYNAUD, Céline; DUMON-SEIGNOVERT, Laurence

The present invention relates to new methylglyoxal reductase (MGR) enzymes which are useful for efficiently converting methylglyoxal into hydroxyacetone. The invention more particularly relates to a method for efficiently converting methylglyoxal into hydroxyacetone using said enzymes, to a method for producing 1,2-propanediol using a microorganism overexpressing said enzymes, and to said microorganism.

48 BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF EP12771861.7 2012-04-12 EP2697662B1 2018-06-06 GOHEL, Anupam; SMITH, Derek; WONG, Brian; SUKUMARAN, Joly; YEO, Wan Lin; COLLIER, Steven, J.; NOVICK, Scott
The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
49 MANUFACTURING METHOD FOR IMPROVED PROTEIN-CONTAINING FOOD AND FORMULATION FOR IMPROVING PROTEIN-CONTAINING FOOD EP15734961.4 2015-01-07 EP3092907A1 2016-11-16 SATO, Hiroaki; NAKAGOSHI, Hiroyuki; KOTANI, Masao; KOBAYASHI, Yoshie

A method for producing a modified food containing a protein and a preparation for modifying a food containing a protein are provided. A food raw material containing a protein is treated by using an oxidizing agent and/or an oxidoreductase in combination with a metal and/or a metal-containing substance to produce a food containing a protein.

50 METHODS OF PRODUCING OMEGA-HYDROXYLATED FATTY ACID DERIVATIVES EP14738962.1 2014-06-16 EP2984490A1 2016-02-17 SCHIRMER, Andreas, W.; WANG, Haibo; DEL CARDAYRE, Stephen, B.; HU, Zhihao; HOM, Louis, G.; ZHU, Baolong; CHANG, Cindy; POPOVA, Emanuela, E.
The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.
51 BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF EP12771861 2012-04-12 EP2697662A4 2015-07-01 GOHEL ANUPAM; SMITH DEREK; WONG BRIAN; SUKUMARAN JOLY; YEO WAN LIN; COLLIER STEVEN J; NOVICK SCOTT
The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
52 BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF EP12771861.7 2012-04-12 EP2697662A2 2014-02-19 GOHEL, Anupam; SMITH, Derek; WONG, Brian; SUKUMARAN, Joly; YEO, Wan Lin; COLLIER, Steven, J.; NOVICK, Scott
The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
53 포도당 탈수소 효소 KR1020147020334 2012-12-28 KR101766522B1 2017-08-08 소데,코지; 모리,카즈시게
및유래의포도당탈수소효소에서특정아미노산변이를도입하여대장균의생산성이현저하게높아진변이포도당탈수소효소를얻을수 있다. 본발명의포도당탈수소효소는크실로오스대해반응성이낮다.
54 오메가-수산화 지방산 유도체를 생성하는 방법들 KR1020167000963 2014-06-16 KR1020160020516A 2016-02-23 셔머,안드레아스,더블유.; 왕,하이보; 델카다이레,스티븐,비.; 흐,지하오; 홈,루이스,지.; 주,바오롱; 창,신디; 포포바,엠마누엘라,이.
본발명은오메가-수산화지방산유도체들및 이들을생성하는방법들에관한것이다. 본명세서에서, 본발명은높은순도및 수율로오메가-수산화지방산유도체들을제공하는신규하고환경친화적인생성방법을포함한다. 또한, 선택발효를통해오메가-수산화지방산유도체들을생성하는재조합미생물들이포함된다.
55 PROCESSES USING AMINO ACID DEHYDROGENASES AND KETOREDUCTASE-BASED COFACTOR REGENERATING SYSTEM PCT/US2011024102 2011-02-08 WO2011100265A3 2011-12-29 CABIROL FABIEN L; COLLIER STEVEN J; DAUSSMANN THOMAS; MODUKURU NAGA
The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a leucine dehydrogenase.
56 MYCOTOXIN-REDUCING COMPOSITION PCT/GB2007004191 2007-11-01 WO2008053232A3 2008-08-21 MANN STEPHEN PHILIP; PARFITT DAVID
A composition comprising an enzyme, a mycotoxin-binding agent and a microorganism capable of taking up a mycotoxin.
57 MANUFACTURING METHOD FOR IMPROVED PROTEIN-CONTAINING FOOD AND FORMULATION FOR IMPROVING PROTEIN-CONTAINING FOOD PCT/JP2015050211 2015-01-07 WO2015105112A9 2016-06-02 SATO HIROAKI; NAKAGOSHI HIROYUKI; KOTANI MASAO; KOBAYASHI YOSHIE
Provided is a manufacturing method for an improved protein-containing food and a formulation for improving protein-containing food. A protein-containing food is manufactured by processing a food raw material containing protein with an oxidizer and/or an oxidoreductase, and a metal and/or a metal-containing material.
58 COMPOSITIONS, METHODS, AND DEVICES FOR DIALYSIS PCT/US2014041318 2014-06-06 WO2014197806A3 2015-01-08 MARGOLIN ALEXEY; GRUJIC DANICA; PIERZYNOWSKI STEFAN
Compositions of peritoneal dialysis solutions and metabolizing enzymes, and their uses to treat disorders associated with elevated levels of metabolites are disclosed. Animal models of hyperoxalemia are also disclosed.
59 BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF PCT/US2012033347 2012-04-12 WO2012142302A3 2014-05-01 GOHEL ANUPAM; SMITH DEREK; WONG BRIAN; SUKUMARAN JOLY; YEO WAN LIN; COLLIER STEVEN J; NOVICK SCOTT
The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
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