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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
121	有抗生作用的KSB-1939化合物、其制法及含有这类化合物的杀虫剂	CN88104219	1988-07-07	CN1030790A	1989-02-01	加藤秀树; 小林岑右; 津朋德; 铃木昭; 矶贝彰; 多田修
本文描述了由下述通式(I)表示的KSB-1939化合物，其中R是-(CH2)2CH3，或这里n表示整数0～2，m表示整数0或1，R表示甲基或乙基。本文还描述了制备KSB-1939化合物的方法，和含一种KSB-1939化合物作为有效成份的农药。
122	A-21978C衍生物生产方法改进	CN85107552	1985-10-08	CN85107552A	1987-05-20	弗洛伊德·米尔顿·休伯; 理查德·路易斯·皮珀; 安东尼·约瑟夫·蒂尔特斯; 汤姆·爱德华·伊顿; 林达·马克辛·福特; 小奥蒂斯·韦伯斯特·戈弗雷; 马丽·路易丝·布朗·休伯; 小米尔顿·约瑟夫·兹米朱斯基
提供一种用于制备具有2个碳原子到14个碳原子的链烷酰基侧链的A-21978C环状肽衍生物的经过改进的方法，包括在发酵生产步骤中，把某种2个碳原子到14个碳原子的链烷酸，或者它们的一种酯或盐，加入到产生A-21978C的培养物中。此外，提供了制备A-21978C抗菌素的新方法，包括在需氧条件下培养一种新的微生物菌种。
123	REDUCTION OF NON-STARCH POLYSACCHARIDES AND ALPHA-GALACTOSIDES IN SOY FLOUR BY MEANS OF SOLID-STATE FERMENTATION USING CELLULOLYTIC BACTERIA ISOLATED FROM DIFFERENT ENVIRONMENTS	PCT/IB2013050763	2013-01-29	WO2013114282A3	2013-10-31	ROMERO ORMAZABAL JAIME MOISES; OPAZO SALAS RAFAEL JOSE DANIEL
The invention relates to a method for fermenting soy flour in the solid state in order to reduce non-starch polysaccharides and alpha-galactosides, said method comprising the following steps: a) preparation of the fermentation substrate; b) inoculation of the substrate with selected celluloytic bacterial strains; c) incubation; and, optionally, d) drying of the product, which generates a product with: an increase in protein of between 12 and 15% compared to non-fermented soy flour, degradation of the alpha-galactosides of more than 90% compared to non-fermented soy flour, a reduction in non-starch polysaccharides (NSPs) of between 15 and 25%, an amino acid profile similar to that of non-fermented soy flour, and immune-stimulating effects.
124	GENE CLUSTER FOR BIOSYNTHESIS OF GRISELIMYCIN AND METHYLGRISELIMYCIN	PCT/EP2012070213	2012-10-11	WO2013053857A3	2013-08-01	BROENSTRUP MARK; KOENIG CAUDIA; TOTI LUIGI; WINK JOACHIM; LEUSCHNER WULF; GASSENHUBER JOHANN; MUELLER ROLF; WENZEL SILKE; BINZ TINA; VOLZ CARSTEN
The present invention refers to the gene cluster and genes comprised by the gene cluster which are involved in the biosynthesis of griselimycin and methylgriselimycin and to the use of the gene cluster, genes comprised thereby and proteins encoded thereby for the production of antibiotic agents.
125	NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF	PCT/US2011043028	2011-07-06	WO2012006321A3	2013-08-01	CARR GRANT J; MANNING DAVID D; YANG ZHICAI; GUO CHENG; MAENG JUN-HO; RABENSTEIN JOHN; MICHELS PETER C; CHASE MATTHEW W
The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
126	STAMBOMYCIN AND DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS DRUGS	PCT/EP2010060707	2010-07-23	WO2011009938A3	2011-05-05	AIGLE BERTRAND; CHALLIS GREGORY; LAURETI LUISA; SONG LIJIANG; LEBLOND PIERRE
The present invention relates to Stambomycin compounds, their derivatives and their pharmaceutically acceptable salt thereof.
127	NEW STREPTOMYCES BARAKATEI STRAIN, CULTURE FILTRATE, DERIVED ACTIVE COMPOUNDS AND USE THEREOF IN THE TREATMENT OF PLANTS	PCT/FR2009051180	2009-06-19	WO2009156687A3	2010-04-01	LEBRIHI AHMED; ERRAKHI RAFIK; BARAKATE MUSTAPHA
The subject matter of the invention is a new Streptomyces barakatei strain deposited with the CNCM under number I-3640 and with the LMG under number P-23734. The invention also relates to the use of this strain or of a mutant strain for obtaining a composition (culture filtrate) and active compounds (secondary metabolites) by fermentation. Finally, the invention also relates to the use of the new strain, of a mutant strain, of the culture filtrate or of the active compounds, for plant protection and the biological control of phytopathogenic agents and/or for stimulating plant growth.
128	METHODS	PCT/GB2009000935	2009-04-09	WO2009125190A2	2009-10-15	RAY MICHAEL JASON; MURPHY RICHARD JAMES
A method of pre-treating lignocellulosic and cellulosic biomass for utilisation of carbohydrate or Iignin from the biomass, the method comprising the steps of inoculating the lignocellulosic biomass with lignocellulose degrading brown rot fungus and incubating the inoculated biomass under conditions in which growth of the lignocellulose degrading brown rot is promoted. The incubation may be under conditions in which growth of the lignocellulose degrading brown rot is promoted is terminated after less than 50, 40, 30, 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5 or 4 days, or before substantial depletion of glucose in the biomass occurs.
129	ELAIOPHYLIN BIOSYNTHETIC GENE CLUSTER	PCT/US2005041273	2005-11-14	WO2006053313A3	2009-05-07	HALTLI BRADLEY A
The present invention relates especially to a DNA fragment that is obtainable from the gene cluster within the genome of streptomycete that is responsible for elaiophylin biosynthesis and that contains at least one gene or part of a gene that codes for a polypeptide that is involved directly or indirectly in the biosynthesis of elaiophylin and to methods of preparing said DNA fragment. The present invention relates furthermore to recombinant DNA molecules containing one of the DNA fragments according to the invention and to the plasmids and vectors derived therefrom. Also included are host organisms transformed with the said plasmid or vector DNA.
130	STREPTOMYCETE AND BIOACTIVE COMPOUND PRODUCED THEREBY	PCT/IB2007052468	2007-06-26	WO2008001306B1	2008-10-09	MEYERS PAUL ROBERT; LE ROES MARILIZE; GAMMON DAVID W
The present invention relates to an isolated microorganism of the strain type SPR^T(=DSM 44925^T = NRRL B-24448^T). The microorganism preferably includes genetic material of GenBank accession number DQ141528 (16S-rDNA-sequence). The invention extends to a method of producing 2,5-diphenyloxazole or variants or derivatives thereof, the method comprising recovering the 2,5-diphenyloxazole or variants or derivatives thereof from a microorganism of the strain typeSPR^T (=DSM44925^T = NRRL B-24448^T).
131	TRIOXACARCINS AND THEIR USE AGAINST INFECTIONS	PCT/EP2005001696	2005-02-18	WO2005080549A3	2005-12-08	KAYSER OLIVER; LAATSCH HARTMUT; MASKEY RAJENDRA PRASAD; HANSSKE FRIEDRICH; GRUEN-WOLLNY IRIS; HELMKE ELISABETH
The invention relates to the use of trioxacarcins as agents for treating infections caused by fungi, parasites, viruses or bacteria. The invention also relates to the novel trioxacarcin derivatives as such, to drugs containing them or the salts thereof and to the use thereof in the treatment of tumors and inflammatory diseases or in the treatment of infections that are caused by fungi, parasites, viruses or bacteria.
132	SUBSTITUTED HETEROCYCLES	PCT/EP2004001097	2004-02-06	WO2004071382A3	2005-01-06	STADLER MARC; SEIP STEPHAN; MUELLER HARTWIG; MAYER-BARTSCHMID ANKE; BRUENING MICHAEL-ALEXANDER; BENET-BUCHHOLZ JORDI; TOGAME HIROKO; DODO REIKO; REINEMER PETER; BACON KEVIN; FUCHIKAMI KINJI; MATSUKAWA SATOKO; URBAHNS KLAUS
The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.
133	CONVERSION OF RED BLOOD CELLS A, B, AND AB USING a-N-ACETYLGALACTOSAMINIDASES AND a-GALACTOSIDASE	PCT/US0230403	2002-09-25	WO03027245A3	2003-07-10	CLAUSEN HENRIK; DE LA VEGA HUMBERTO; HILL CHERYL; LIU QIYONG PETER
This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique a-N-acetylgalactosaminidases and a-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells.
134	A NOVEL STRAIN OF STREPTOMYCES FOR CONTROLLING PLANT DISEASES	PCT/US0130393	2001-09-27	WO0226041A2	2002-04-04	LEHMAN LORI JO; YUAN CAIYAO; ORJALA JIMMY ENCIO; MCCOY RANDY JAY; MANKER DENISE CAROL; MARRONE PAMELA GAIL; SANTAMARIA JORGE ISAAC JIMENEZ
A novel antibiotic-producing Streptomyces sp. is provided that exhibits antifungal activity only on certain specific plant pathogens. Also provided is a method of treating or protecting plants from fungal infections comprising applying an effective amount of an antibiotic-producing Streptomyces sp. having all the identifying characteristics of NRRL Accession number B-30145. The invention also relates to fungicidal compositions comprising this novel Streptomyces strain and the antibiotics and metabolites produced by this strain either alone, or in combination with other chemical and biological pesticides.
135	REDUCTION OF NON-STARCH POLYSACCHARIDES AND ALPHA-GALACTOSIDES IN SOY FLOUR BY MEANS OF SOLID-STATE FERMENTATION USING CELLULOLYTIC BACTERIA ISOLATED FROM DIFFERENT ENVIRONMENTS	PCT/IB2013050763	2013-01-29	WO2013114282A9	2014-01-09	ROMERO ORMAZABAL JAIME MOISES; OPAZO SALAS RAFAEL JOSE DANIEL
The invention relates to a method for fermenting soy flour in the solid state in order to reduce non-starch polysaccharides and alpha-galactosides, said method comprising the following steps: a) preparation of the fermentation substrate; b) inoculation of the substrate with selected celluloytic bacterial strains; c) incubation; and, optionally, d) drying of the product, which generates a product with: an increase in protein of between 12 and 15% compared to non-fermented soy flour, degradation of the alpha-galactosides of more than 90% compared to non-fermented soy flour, a reduction in non-starch polysaccharides (NSPs) of between 15 and 25%, an amino acid profile similar to that of non-fermented soy flour, and immune-stimulating effects.
136	A METHOD TO GENERATE NOVEL BIOACTIVE MOLECULES	PCT/US2011058450	2011-10-28	WO2012058630A3	2012-08-16	PALSSON BERNHARD; CHARUSANTI PEP
The present invention describes a method to generate new chemical entities (NCEs) that have well-defined activities such as, but not limited to, anti-bacterial, antifungal and anthelmintic effects. The NCEs are generated through adaptive evolution of one microbe (the producer) against another organism or cell type (the target). The producer is made to compete against the target over time by co-culturing the two together and serially passing the producer organism until the producer adaptively evolves by synthesizing an NCE(s) that inhibits growth of or kills the target. The molecular structure of the chemical entity (or entities) is then elucidated using tools from genomics, molecular biology, computational biology, analytical chemistry, organic chemistry and related fields.
137	GROWTH ENHANCEMENT AND CONTROL OF BACTERIAL AND FUNGAL PLANT DISEASES WITH STREPTOMYCES SCOPULIRIDIS	PCT/US2011045886	2011-07-29	WO2012016140A2	2012-02-02	SCOTT NICOLE J; MARTIN WILLIAM R
Methods of controlling plant diseases mediated by bacterial or fungal plant pathogens. The method comprises providing Streptomyces scopuliridis strain RB72 or an isolated protein or polypeptide comprising the amino acid of SEQ ID NO: 1 and applying the Streptomyces scopuliridis strain RB72 or the isolated protein or polypeptide comprising the amino acid of SEQ ID NO: l to plants or plant seeds under conditions effective to treat plant diseases mediated by bacterial or fungal plant pathogens. Also disclosed is a plant or plant seed treated by this method, a planting composition, and a method of enhancing growth.
138	NOVEL STRAIN OF STREPTOMYCES SPOROCLIVATUS WHICH SUPPRESSES GINSENG ROOT ROT	PCT/KR2010004456	2010-07-08	WO2011005044A9	2011-07-07	RHO MUN-CHUAL; LEE WOO-SONG; PARK CHAN-SUN; KIM MIN-SOO
The present invention relates to a novel strain of Streptomyces sporoclivatus rho-49 having an antagonist action with respect to micro-organic plant pathogens, and more specifically it relates to: a novel strain of Streptomyces sporoclivatus rho-49 having an antagonist action with respect to micro-organisms which cause ginseng root rot; to a microbial preparation for preventing micro-organic plant pathogens, which contains cells or spores or a culture fluid of the strain or a mixture thereof as an active ingredient; and to a production method for the microbial preparation for preventing micro-organic plant pathogens, comprising the step of culturing the Streptomyces sporoclivatus rho-49.
139	MICROORGANISMS, MICROBIAL PHOSPHATE FERTILIZERS AND METHODS FOR PREPARING SUCH MICROBIAL PHOSPHATE FERTILIZERS	PCT/CN2008001850	2008-11-06	WO2009070966A8	2010-07-01	HO BIU; HUANG EN-HSIUNG; HO TING KWOK; HO TING WING
Microorganisms, microbial phosphate fertilizers and methods for preparing such microbial phosphate fertilizers, wherein microorganisms are Strepotmyces cellulosae, whose deposit number is CGMCC No. 2167 or Aspergillus versicolor, whose deposit number is CGMCC No. 2171. The microbial phosphate fertilizers comprise the fermentation products of microbial flora consisting of the following four microorganisms: Bacillus subtilis strain WH2, Bacillus licheniformis strain WH4, Streptomyces cellulosae strain WH9 and Aspergillus versicolor strain WH13. The methods for preparing such microbial phosphate fertilizers are provided, wherein the methods mayutilize the phosphorus rocks which the content of phosphorus pentoxideis 8%-12%.
140	STREPTOMYCETE AND BIOACTIVE COMPOUND PRODUCED THEREBY	PCT/IB2007052468	2007-06-26	WO2008001306A3	2008-08-14	MEYERS PAUL ROBERT; LE ROES MARILIZE; GAMMON DAVID W
The present invention relates to an isolated microorganism of the strain type SPR^T(=DSM 44925^T = NRRL B-24448^T). The microorganism preferably includes genetic material of GenBank accession number DQ141528 (16S-rDNA-sequence). The invention extends to a method of producing 2,5-diphenyloxazole or variants or derivatives thereof, the method comprising recovering the 2,5-diphenyloxazole or variants or derivatives thereof from a microorganism of the strain typeSPR^T (=DSM44925^T = NRRL B-24448^T).

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