STREPTOMYCETE AND BIOACTIVE COMPOUND PRODUCED THEREBY |
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申请号 | PCT/IB2007052468 | 申请日 | 2007-06-26 | 公开(公告)号 | WO2008001306B1 | 公开(公告)日 | 2008-10-09 |
申请人 | SOUTH AFRICAN MEDICAL RESEARCH COUNCIL; UNIV CAPE TOWN; MEYERS PAUL ROBERT; LE ROES MARILIZE; GAMMON DAVID W; | 发明人 | MEYERS PAUL ROBERT; LE ROES MARILIZE; GAMMON DAVID W; | ||||
摘要 | The present invention relates to an isolated microorganism of the strain type SPR T (=DSM 44925 T = NRRL B-24448 T ). The microorganism preferably includes genetic material of GenBank accession number DQ141528 (16S-rDNA-sequence). The invention extends to a method of producing 2,5-diphenyloxazole or variants or derivatives thereof, the method comprising recovering the 2,5-diphenyloxazole or variants or derivatives thereof from a microorganism of the strain typeSPR T (=DSM44925 T = NRRL B-24448 T ). | ||||||
权利要求 | 1. An isolated microorganism of the strain type SPR T (= DSM 44925 T = NRRL B-24448 T). 2. A microorganism according to claim 1 which is an actinomycete strain. 3. A microorganism according to either one of claims 1 and 2 from the genus Streptomyces, 4. A microorganism according to claim 3 from the family Streptomycetaceae. 5. A microorganism according to claim 4 wherein the microorganism is Streptomyces polyantibioticus. 6. A microorganism according to claim 5 including genetic material of GenBank accession number DQ141528 (16S-rDNA-sequence) (SEQ ID NO:4). 7. A biologically pure culture having identifying characteristics of GenBank accession number DQ141528 (16S-rDNA-sequence). 8. Actinomycete strain SPR T (= DSM 44925 T = NRRL B-24448 T). 9. A method of producing 2,5-diphenyloxazole or variants or derivatives thereof, the method comprising recovering the 2,5-diphenyloxazole or variants or derivatives thereof from a microorganism of the strain type SPR T (= DSM 44925 T = NRRL B-24448 T). 10. 2,5-diphenyloxazole or variants or derivatives thereof recovered from an isolated microorganism of the strain type SPR T (= DSM 44925 T = NRRL B-24448 T) having identifying characteristics of GenBank accession number DQ141528 (16S-rDNA-sequence). 11. Use of 2,5-diphenyloxazole or variants or derivatives thereof which are recovered from an isolated microorganism of the strain type SPR T (= 39 DSM 44925 T = NRRL B-24448 T), as an antimicrobial agent including use in the treatment of influenza, tuberculosis and/or other bacterial infections. 12. A composition for use as an antimicrobial agent, the composition comprising an effective amount of 2,5-diphenyloxazole or variants or derivatives thereof which are recovered from an isolated microorganism of the strain type SPR T(= DSM 44925 T = NRRL B-24448 T). 13. 2,5-diphenyloxazole or variants or derivatives thereof which are recovered from an isolated microorganism of the strain type SPR T (= DSM 44925 T = NRRL B-24448 T) for use as an antimicrobial agent. 14. 2,5-diphenyloxazole or variants or derivatives thereof which are recovered from an isolated microorganism of the strain type SPR T (= DSM 44925 T = NRRL B-24448 T) for use in the manufacture of a medicament for use as an antimicrobial agent including use in the treatment of influenza, tuberculosis and/or other bacterial infections. 15. Use of 2,5-diphenyloxazole or variants or derivatives thereof which are recovered from an isolated microorganism of the strain type SPR T (= DSM 44925 1" = NRRL B-24448 T) in the manufacture of a medicament for use as an antimicrobial agent including use in the treatment of influenza, tuberculosis and/or other bacterial infections. 16. An isolated polynucleotide of GenBank accession number DQ141528 (16S-rDNA-sequence). 17. An isolated polynucleotide sequence comprising a polynecleotide of GenBank accession number DQ141528 (16S-rDNA-sequence). 18. An isolated microorgansim according to the invention, substantially as hereinbefore described or exemplified. 19. An isolated polynucleotide sequence according to the invention, substantially as hereinbefore described or exemplified. |
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