STREPTOMYCETE AND BIOACTIVE COMPOUND PRODUCED THEREBY

申请号 PCT/IB2007052468 申请日 2007-06-26 公开(公告)号 WO2008001306B1 公开(公告)日 2008-10-09
申请人 SOUTH AFRICAN MEDICAL RESEARCH COUNCIL; UNIV CAPE TOWN; MEYERS PAUL ROBERT; LE ROES MARILIZE; GAMMON DAVID W; 发明人 MEYERS PAUL ROBERT; LE ROES MARILIZE; GAMMON DAVID W;
摘要 The present invention relates to an isolated microorganism of the strain type SPR T (=DSM 44925 T = NRRL B-24448 T ). The microorganism preferably includes genetic material of GenBank accession number DQ141528 (16S-rDNA-sequence). The invention extends to a method of producing 2,5-diphenyloxazole or variants or derivatives thereof, the method comprising recovering the 2,5-diphenyloxazole or variants or derivatives thereof from a microorganism of the strain typeSPR T (=DSM44925 T = NRRL B-24448 T ).
权利要求 38AMENDED CLAIMS [Received by the International Bureau on 08 August 2008 (.08.08.08)]CLAIMS
1. An isolated microorganism of the strain type SPR T (= DSM 44925 T = NRRL B-24448 T).
2. A microorganism according to claim 1 which is an actinomycete strain.
3. A microorganism according to either one of claims 1 and 2 from the genus Streptomyces,
4. A microorganism according to claim 3 from the family Streptomycetaceae.
5. A microorganism according to claim 4 wherein the microorganism is Streptomyces polyantibioticus.
6. A microorganism according to claim 5 including genetic material of GenBank accession number DQ141528 (16S-rDNA-sequence) (SEQ ID NO:4).
7. A biologically pure culture having identifying characteristics of GenBank accession number DQ141528 (16S-rDNA-sequence).
8. Actinomycete strain SPR T (= DSM 44925 T = NRRL B-24448 T).
9. A method of producing 2,5-diphenyloxazole or variants or derivatives thereof, the method comprising recovering the 2,5-diphenyloxazole or variants or derivatives thereof from a microorganism of the strain type SPR T (= DSM 44925 T = NRRL B-24448 T).
10. 2,5-diphenyloxazole or variants or derivatives thereof recovered from an isolated microorganism of the strain type SPR T (= DSM 44925 T = NRRL B-24448 T) having identifying characteristics of GenBank accession number DQ141528 (16S-rDNA-sequence).
11. Use of 2,5-diphenyloxazole or variants or derivatives thereof which are recovered from an isolated microorganism of the strain type SPR T (= 39
DSM 44925 T = NRRL B-24448 T), as an antimicrobial agent including use in the treatment of influenza, tuberculosis and/or other bacterial infections.
12. A composition for use as an antimicrobial agent, the composition comprising an effective amount of 2,5-diphenyloxazole or variants or derivatives thereof which are recovered from an isolated microorganism of the strain type SPR T(= DSM 44925 T = NRRL B-24448 T).
13. 2,5-diphenyloxazole or variants or derivatives thereof which are recovered from an isolated microorganism of the strain type SPR T (= DSM 44925 T = NRRL B-24448 T) for use as an antimicrobial agent.
14. 2,5-diphenyloxazole or variants or derivatives thereof which are recovered from an isolated microorganism of the strain type SPR T (= DSM 44925 T = NRRL B-24448 T) for use in the manufacture of a medicament for use as an antimicrobial agent including use in the treatment of influenza, tuberculosis and/or other bacterial infections.
15. Use of 2,5-diphenyloxazole or variants or derivatives thereof which are recovered from an isolated microorganism of the strain type SPR T (= DSM 44925 1" = NRRL B-24448 T) in the manufacture of a medicament for use as an antimicrobial agent including use in the treatment of influenza, tuberculosis and/or other bacterial infections.
16. An isolated polynucleotide of GenBank accession number DQ141528 (16S-rDNA-sequence).
17. An isolated polynucleotide sequence comprising a polynecleotide of GenBank accession number DQ141528 (16S-rDNA-sequence).
18. An isolated microorgansim according to the invention, substantially as hereinbefore described or exemplified.
19. An isolated polynucleotide sequence according to the invention, substantially as hereinbefore described or exemplified.
说明书全文
QQ群二维码
意见反馈