| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | Anthelmintic fermentation products of a microorganism | US857670 | 1986-04-30 | US4766112A | 1988-08-23 | Robert T. Goegelman; Edward S. Inamine; Raymond F. White |
| There are disclosed macrolides isolated from the fermentation broth, with avermectin Bla, avermectin Blb or 22,23-dihydro avermectin Bla as a substrate, of a known microorganism identified as MA-6181. The structure of the novel compounds isolated from the microorganism are presented based upon analytical studies. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents. Compositions for such uses are also disclosed. | ||||||
| 62 | A-51568B antibiotic | US775071 | 1986-09-12 | US4717714A | 1988-01-05 | LaVerne D. Boeck; Gary G. Marconi; Marvin M. Hoehn |
| The novel glycopeptide antibiotic A-51568B is produced by submerged, aerobic fermentation of Nocardia orientalis NRRL 15232. A-51568B demonstrates antibiotic activity against gram-positive bacteria. | ||||||
| 63 | Polyprenyl carboxylic acid derivatives | US259772 | 1981-05-01 | US4500463A | 1985-02-19 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Yuichi Inai; Yoshiyuki Kohara; Yoshiyuki Kawakami; Tomio Tsurugi |
| Polyprenyl carboxylic acid derivatives having the general formula (I): ##STR1## in which n is an integer of from 2 to 4, R.sub.1 represents the hydrogen atom or a protecting group for the carboxylic acid group, and R.sub.2 represents a hydroxymethyl, formyl or carboxyl group, are disclosed. A process for the preparation of the polyprenyl carboxylic acid derivative involving microbiological oxidation using a strain belonging to the genus Nocardia is disclosed. The compounds have anti-ulcer activity and hypotensive activity. The compounds also are useful as intermediates for preparing polyprenyl carboxylic acids of the formula ##STR2## and esters thereof, wherein l is an integer of from 4 to 11. The polyprenyl carboxylic acids and esters thereof have hypotensive activity and anti-ulcer activity. | ||||||
| 64 | Erythromycin D and esters thereof | US367820 | 1982-04-12 | US4496546A | 1985-01-29 | Walter D. Celmer; Walter P. Cullen; Paul C. Watts; Riichiro Shibakawa; Junsuke Tone |
| Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3",4"-di-O-acetylerythromcyin D, 3"-O-acetyl-4"-O-propionylerythromycin D and 4"-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D. | ||||||
| 65 | Rebeccamycin and process for its preparation | US461817 | 1983-01-28 | US4487925A | 1984-12-11 | Donald E. Nettleton, Jr.; James A. Bush; William T. Bradner; Terrence W. Doyle |
| A novel antitumor agent designated herein as rebeccamycin is produced by fermentation of Nocardia aerocolonigenes (ATCC 39243). Rebeccamycin and its 5'-N-methyl and 5',2",3",6"-tetraacetate derivatives exhibit activity against experimental animal tumor systems. | ||||||
| 66 | Process for the preparation of polyprenyl ketone derivatives | US446817 | 1982-12-03 | US4468459A | 1984-08-28 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Isao Yamatsu; Kouichi Suzuki; Takeshi Suzuki; Toshihiko Nakamura |
| Longer carbon chain polyprenyl ketone derivatives are prepared by cultivag Nocardia strain FERM-P No. 1609 in the presence of shorter carbon chain polyprenyl ketones. | ||||||
| 67 | Polyprenyl ketone derivatives | US312068 | 1981-10-16 | US4456558A | 1984-06-26 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Isao Yamatsu; Kouichi Suzuki; Takeshi Suzuki; Toshihiko Nakamura |
| This invention relates to novel polyprenyl ketone derivatives having the eral formula: ##STR1## in which n is an integer of 1-5, and R represents a hydroxymethyl, formyl or carboxyl group, and a process for the preparation of the same. | ||||||
| 68 | Antibiotic C-15003 PHM and production thereof | US347724 | 1982-02-10 | US4450234A | 1984-05-22 | Toru Hasegawa; Motowo Izawa; Seiichi Tanida |
| Novel antibiotic C-15003 PHM, which is produced by cultivating a microorganism belonging to the genus Nocardia and being capable of producing antibiotic C-15003 PHM, and novel C-15003 PHM acylate, which is produced by subjecting C-15003 PHM thus obtained to acylation reaction with an acylating agent, have antiprotozoan and antitumor activities. | ||||||
| 69 | Anti-ulcer composition comprising terpenoid containing two functional groups and method of treating ulcers | US360722 | 1982-03-22 | US4435423A | 1984-03-06 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Noriaki Kuwana; Shinya Abe; Kouzi Yamada |
| A process for the preparation of a two-functional-group-containing terpenoid having the general formula: ##STR1## in which n is an integer of from 1 to 5, R represents a hydroxymethyl, formyl or carboxyl group, and A represents the hydrogen atom, or a 2-tetrahydropyranyl, benzyl, methoxymethol or methoxyethoxymethyl group comprising the oxidation with a microorganism belonging to the genus Nocardia. Some of the terpenoids are of value as anti-ulcer agents, while others are useful as intermediates. | ||||||
| 70 | Macbecin derivatives | US414031 | 1982-09-02 | US4421687A | 1983-12-20 | Toru Hasegawa; Masayuki Muroi; Seiichi Tanida |
| Macbecin derivatives are produced by cultivating a microorganism of the genus Actinosynnema in a culture medium.The Macbecin derivatives are useful as antibacterial, antifungal or antiprotozoal agent. | ||||||
| 71 | Rifamycins, their compositions and use as antibiotics | US397379 | 1982-07-12 | US4411896A | 1983-10-25 | Thomas Schupp; Peter Traxler; Jakob Nuesch |
| New antibiotically active compounds having the basic structure of rifamycin S, namely 3-hydroxyrifamycin S (formula A: X=>C.dbd.O; R.sup.1 =OH; R.sup.2 =H), 3,31-dihydroxy-rifamycin S (formula A: X=>C.dbd.O; R.sup.1 =R.sup.2 =OH) and 1-desoxy-1-oxarifamycin S (formula A: X=--O--; R.sup.1 =R.sup.2 =H) ##STR1## are formed by cultivating, under aerobic conditions, a strain of Nocardia mediterranei which is derived from Streptomyces mediterranei ATCC 13 685 as the parent strain and is characterized by the ability to produce at least one of the mentioned compounds. The recombinant strain Nocardia mediterranei DSM 1415 has proved suitable. The mentioned rifamycin S analogues have analogous antibiotic properties to this but have a wider range of action, especially against gram-negative bacteria. | ||||||
| 72 | Two-functional-group-containing terpenoids | US360520 | 1982-03-22 | US4386227A | 1983-05-31 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Noriaki Kuwana; Shinya Abe; Kouzi Yamada |
| A process for the preparation of a two-functional-group-containing terpen having the general formula: ##STR1## in which n is an integer of from 1 to 5, R represents a hydroxymethyl, formyl, or carboxyl group, and A represents the hydrogen atom, or a 2-tetrahydropyranyl, benzyl, methoxymethol or methoxyethoxymethyl group comprising the oxidation with a microorganism belonging to the genus Nocardia. Some of the terpenoids are of value as anti-ulcer agents, while others are useful as intermediates. | ||||||
| 73 | Two-functional-group-containing terpenoids, processes for the preparation of the same, and anti-ulcer agents containing the same | US221163 | 1980-12-29 | US4338251A | 1982-07-06 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Noriaki Kuwana; Shinya Abe; Kouzi Yamada |
| A process for the preparation of a two-functional-group-containing terpenoid having the general formula: ##STR1## in which n is an integer of from 1 to 5, R represents a hydroxymethyl, formyl or carboxyl group, and A represents the hydrogen atom, or a 2-tetrahydropyranyl, benzyl, methoxymethol or methoxyethoxymethyl group comprising the oxidation with a microorganism belonging to the genus Nocardia. Some of the terpenoids are of value as anti-ulcer agents, while others are useful as intermediates. | ||||||
| 74 | Antibiotic X-14868A, B, C and D | US116696 | 1980-01-30 | US4278663A | 1981-07-14 | Chao-Min Liu; Barbara Prosser; John Westley |
| Antibiotic X-14868A having the following chemical structure ##STR1## and the pharmaceutically acceptable salts thereof is presented. Also presented is a fermentative method of producing the above antibiotic.Antibiotic X-14868A exhibits anticoccidiostatic activity. | ||||||
| 75 | 3,4-Dihydro-4-hydroxy-5-(3-hydroxy-2-pyridinyl)-4-me thyl-2H-pyrrole-2-carboxamide | US70287 | 1979-08-27 | US4249008A | 1981-02-03 | Richard B. Sykes; Jerry S. Wells; Wen-Chih Liu |
| Cultivation of a strain of the microorganism Nocardia sp. 11,340, which has been deposited in the American Type Culture Collection as A.T.C.C. No. 31531, yields a novel antibiotic substance EM 4940, having activity against a range of gram-positive and gram-negative bacteria, yeasts, fungi, acholeplasma, and the protozoan Trichomanas vaginalis. | ||||||
| 76 | Antibiotics produced from the microorganism nocardia | US66823 | 1979-08-14 | US4245047A | 1981-01-13 | Eiji Higashide; Mitsuko Asai; Toru Hasegawa |
| The present invention relates to a method of producing the antibiotics C-14919 E-1 and/or E-2 by cultivating an antibiotic C-14919 E-1 and/or E-2 producing strain of the genus Nocardia in a culture medium and accumulating said antibiotics. These antibiotics have a wide range of antibiotic activity and they are useful as germicides or disinfectants. | ||||||
| 77 | Antibacterial antibiotic BM782 | US17000 | 1979-03-02 | US4234717A | 1980-11-18 | Homer D. Tresner; Amedeo A. Fantini; Donald B. Borders; William J. McGahren |
| This disclosure describes three new antibiotics designated BM782.alpha.1, BM782.alpha.2, and BM782.alpha.1a which are produced in a microbiological fermentation under controlled conditions using a new strain of an undetermined species of the genus Nocardia or mutants thereof. These new antibacterial agents are active against Mycobacterium tuberculosis as well as both gram-positive and gram-negative microorganisms and thus are useful for inhibiting the growth of such bacteria and bacilli wherever they may be found. | ||||||
| 78 | Method for producing antibiotic C-15003 P-3 | US959602 | 1978-11-13 | US4228239A | 1980-10-14 | Eiji Higashide; Kazunori Hatano; Mitsuko Asai |
| A novel Antibiotic C-15003 P-3 is specifically produced by cultivating a microorganism of the genus Nocardia in a culture medium containing valine or isobutyric acid and/or their derivatives.The Antibiotic C-15003 P-3 is useful as an antifungal, antiprotozoan and antitumor agent. | ||||||
| 79 | Method for producing Antibiotic C-15003 by culturing nocardia | US811448 | 1977-06-29 | US4162940A | 1979-07-31 | Eiji Higashide; Mitsuko Asai; Seiichi Tanida |
| A novel Antibiotic C-15003 is produced by cultivating a microorganism of the genus Nocardia.The Antibiotic C-15003 is useful as an antifungal agent or an antiprotozoan agent. | ||||||
| 80 | Production of carboxylic acids by microbiological oxidation of hydrocarbons | US51254365 | 1965-12-08 | US3419469A | 1968-12-31 | HUMPHREY ARTHUR E; RAYMOND RICHARD L |
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