| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | Polyprenyl sulfone derivatives and process for producing the same | US581763 | 1984-02-21 | US4613571A | 1986-09-23 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Hideaki Watanabe; Tamio Kawamura; Yasushi Nagai |
| There are disclosed polyprenyl sulfone derivatives of the general formula: ##STR1## wherein n represents an integer of 1-4, R.sub.1 represents an aryl group d R.sub.2 represents a hydroxymethyl or carboxyl group. The polyprenyl sulfone derivatives are prepared by cultivating a microorganism of the genus Nocardia capable of oxidizing a compound of the general formula: ##STR2## wherein n and R.sub.1 have the same meanings as defined above, in a culture medium containing a compound of the above general formula (II), and then collecting the oxidation product from the culture mixture. The polyprenyl sulfone derivatives are useful as intermediates for preparing various useful polyprenyl compounds. | ||||||
| 122 | Erythromycin D and esters thereof by fermentation with Nocardia sp. ATCC 39043 | US600612 | 1984-04-16 | US4582796A | 1986-04-15 | Walter D. Celmer; Walter P. Cullen; Paul C. Watts; Riichiro Shibakawa; Junsuke Tone |
| Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3",4"-di-O-acetylerythromycin D, 3"-O-acetyl-4"-O-propionylerythromycin D and 4"-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D. | ||||||
| 123 | Process for production of A-51568B antibiotic | US561008 | 1983-12-13 | US4558008A | 1985-12-10 | LaVerne D. Boeck; Gary G. Marconi; Marvin M. Hoehn |
| The novel glycopeptide antibiotic A-51568B is produced by submerged, aerobic fermentation of Nocardia orientalis NRRL 15232. A-51568B demonstrates antibiotic activity against gram-positive bacteria. | ||||||
| 124 | Process for producing rebeccamycin | US599918 | 1984-04-13 | US4552842A | 1985-11-12 | Donald E. Nettleton, Jr.; James A. Bush; William T. Bradner; Terrence W. Doyle |
| A novel antitumor agent designated herein as rebeccamycin is produced by fermentation of Nocardia aerocolonigenes (ATCC 39243). Rebeccamycin and its 5'-N-methyl and 5',2",3",6"-tetraacetate derivatives exhibit activity against experimental animal tumor systems. | ||||||
| 125 | Antibiotic M43A, pharmaceutical composition and method of use | US600729 | 1984-04-16 | US4548925A | 1985-10-22 | Harvey M. Higgins, Jr.; Kurt E. Merkel; Mack H. McCormick |
| Antibiotic M43A, a new glycopeptide antibiotic of the vancomycin class, is produced by Nocardia orientalis strains NRRL 2450 and NRRL 2452. M43A has excellent antibacterial activity comparable to that of vancomycin. | ||||||
| 126 | Antibiotics M43B and M43C, pharmaceutical composition and method of use | US600726 | 1984-04-16 | US4548924A | 1985-10-22 | Karl H. Michel |
| Antibiotics M43B and M43C, new glycopeptide antibiotics of the vancomycin class, are produced by Nocardia orientalis NRRL 2452. M43B and M43C have antibacterial activity. | ||||||
| 127 | Antibiotic M43D, pharmaceutical compositions and method of use | US600725 | 1984-04-16 | US4547488A | 1985-10-15 | Kurt E. Merkel |
| Antibiotic M43D, a new glycopeptide antibiotic of the vancomycin class, is produced by Nocardia orientalis NRRL 2450. M43D has excellent antibacterial activity comparable to that of vancomycin. | ||||||
| 128 | Process for preparing 3-hydroxy-ML-236B derivatives known as M-4 and M-4' | US442840 | 1982-11-18 | US4537859A | 1985-08-27 | Akira Terahara; Minoru Tanaka |
| Compounds of formula (I): ##STR1## (wherein OH represents OH or OH), that is to say M-4 carboxylic acid and M-4' carboxylic acid, as well as pharmaceutically acceptable salts and esters thereof and the corresponding ring-closed lactones may be prepared by contacting an ML-236B compound with a microorganism of the genus Nocardia or a cell-free, enzyme-containing extract thereof and then, if necessary, subjecting the resulting product to one or more of the following reactions: hydrolysis, salification, esterification and lactonisation. The resulting M-4 and M-4' derivatives have the ability to inhibit the biosynthesis of cholesterol and are therefore of value in the therapy and/or prophylaxis of hyperlipaemia and arteriosclerosis. | ||||||
| 129 | Fermentation of bile | US597813 | 1984-04-09 | US4528272A | 1985-07-09 | Robert J. Park; Raymond A. Leppik |
| This invention relates to a process for the fermentation of bile which includes the step of cultivating one or more aerobic microorganisms which have the ability to selectively degrate bile acids or bile acid conjugates contained in bile. The fermentation is carried out in a cultivation medium containing or consisting of unfractionated bile under aerobic conditions to prepare a compound of the formula ##STR1## wherein .about. is a bond chosen from one which is alpha or beta to the ring, X is chosen from hydrogen, hydroxyl or oxo, may be either a double or single bond, and R is selected from oxo, hydroxy or a propionic acid residue, attached at the 2-position ##STR2## The invention also includes within its scope certain compounds as described herein prepared by the process of the invention. | ||||||
| 130 | Two-functional-group-containing terpenoids, processes for the preparation of the same, and anti-ulcer agents containing the same | US360519 | 1982-03-22 | US4468458A | 1984-08-28 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Noriaki Kuwana; Shinya Abe; Kouzi Yamada |
| A process for the preparation of a two-functional-group-containing terpenoid having the general formula: ##STR1## in which n is an integer of from 1 to 5, R represents a hydroxymethyl, formyl or carboxyl group, and A represents the hydrogen atom, or a 2-tetrahydropyranyl, benzyl, methoxymethol or methoxyethoxymethyl group comprising the oxidation with a microorganism belonging to the genus Nocardia. Some of the terpenoids are of value as anti-ulcer agents, while others are useful as intermediates. | ||||||
| 131 | Polyprenyl sulfones | US368475 | 1982-04-14 | US4449002A | 1984-05-15 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Hideaki Watanabe; Tamio Kawamura; Yasushi Nagai |
| There are disclosed polyprenyl sulfone derivatives of the general formula: ##STR1## wherein n represents an integer of 1-4, R.sub.1 represents an aryl group d R.sub.2 represents a hydroxymethyl or carboxyl group. The polyprenyl sulfone derivatives are prepared by cultivating a microorganism of the genus Nocardia capable of oxidizing a compound of the general formula: ##STR2## wherein n and R.sub.1 have the same meanings as defined above, in a culture medium containing a compound of the above general formula (II), and then collecting the oxidation product from the culture mixture. The polyprenyl sulfone derivatives are useful as intermediates for preparing various useful polyprenyl compounds. | ||||||
| 132 | Process for preparing maytansinol | US313974 | 1981-10-22 | US4360462A | 1982-11-23 | Eiji Higashide; Mitsuko Asai; Seiichi Tanida |
| A novel Antibiotic C-15003 is produced by cultivating a microorganism of the genus Nocardia.The Antibiotic C-15003 is useful as an antifungal agent or an antiprotozoan agent. | ||||||
| 133 | Method for the production of antibiotic C-15003 P-3 | US209983 | 1980-11-24 | US4356265A | 1982-10-26 | Kazunori Hatano; Masanari Nakamichi; Shun-ichi Akiyama |
| Antibiotic C-15003 P-3 is specifically produced by cultivating a microorganism belonging to the genus Nocardia in a culture medium to which isobutyl aldehyde, isobutyl alcohol or a fatty acid ester of isobutyl alcohol is added.The Antibiotic C-15003 P-3 is useful as an antifungal, antiprotozoan or antitumor agent. | ||||||
| 134 | Antibiotics produced from the microorganism nocardice | US815050 | 1977-07-12 | US4187292A | 1980-02-05 | Eiji Higashide; Mitsuko Asai; Toru Hasegawa |
| The present invention relates to antibiotics C-14919 E-1 and E-2 produced by cultivating a microorganism of the genus Nocardia. These antibiotics display a wide activity against e.g. Gram-positive bacteria, fungi and yeast and are useful as germicides or disinfectants. | ||||||
| 135 | Method for decomposition of phthalic acid esters by use of microorganisms | US783283 | 1977-03-31 | US4133752A | 1979-01-09 | Ryuichiro Kurane; Tomoo Suzuki; Yoshimasa Takahara |
| Microorganisms of a species selected from the group consisting of the specific species belonging to genus Nocardia, genus Pseudomonas, genus Brevibacterium and genus Corynebacterium, when cultured in a culture medium containing a phthalic acid ester as a carbon source, assimilate the phthalic acid ester and decompose it into carbon dioxide gas and water. | ||||||
| 136 | Production of fatty acid esters of fructose | US50072074 | 1974-08-26 | US3909356A | 1975-09-30 | SUZUKI TAKEO; ITO SEIGA |
| A process for producing fatty acid esters of fructose including the steps of (a) culturing a fructose-utilizing microorganism capable of producing fatty acid esters of fructose and belonging to the genus Arthrobacter, Corynebacterium, Nocardia or Mycobacterium in a medium containing fructose as a carbon source, (b) forming the fatty acid esters of fructose intracellularly and (c) recovering the esters from the microbial cells.
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| 137 | Microbiological hydroxylation of aromatic acids | US3645847D | 1968-02-08 | US3645847A | 1972-02-29 | ELTZ ROBERT W |
| A benzoic acid having from zero to three methyl and/or halo substituents and having at least two adjacent unsubstituted ring carbon atoms can be converted to the corresponding dihydroxybenzoic acid derivative by the action of various species of Nocardia which are normally incapable of performing such a conversion. This is accomplished by first contacting the Nocardia cells with an aromatic or halogenated aromatic hydrocarbon for a time sufficient to induce the enzyme system of said cells to perform such an hydroxylation, and thereafter contacting the induced cells with the benzoic acid substrate under aerobic conditions.
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| 138 | Beta-substituted propionic acids and method of making the same | US3616228D | 1969-03-12 | US3616228A | 1971-10-26 | SCHUBERT KURT; BOHME KARL-HEINZ ADAND; HORHOLD CLARE |
| A Beta -substituted propionic acid of the general formula
WHEREIN W is CH2, O or NH and wherein X and Y may be the same or different and are H, OH, O, OAc, lower alkyl, hydroxy- or oxosubstituted lower alkyl, and wherein X and Y may be interconnected. The acids are made by dissolving 3-keto-steroids in an organic water-soluble solvent and fermenting it with an aerobic culture of Nocardia SPEC and recovering the product from the fermentation medium. |
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| 139 | Microbial catalyst for desulfurization of fossil fuels | US131685 | 1998-08-10 | US06124130A | 2000-09-26 | Gregory J. Olson |
| Sulfur is removed from fossil fuels containing sulfur by incubation of the fuel with microbes isolated and purified from soil or water that selectively extract the sulfur without apparently utilizing the fuel as a carbon or energy source. Preferred biodesulfurization microbes remove at least about 20% of the sulfur. The microbes are obtained in a multi-step screen that first selects microorganisms that utilize dibenzothiophene (DBT) as a sole source of sulfur, and then tests these in incubations with fossil fuels; organisms that desulfurize DBT without metabolizing the DBT phenyl ring structures and desulfurize fuels only when a second carbon source devoid of sulfur is present are identified and employed in desulfurization processes. Two cultures, CDT-4 and CDT-4b, were particularly efficacious in the desulfurization of liquid fossil fuels. | ||||||
| 140 | Zearalenone detoxification compositions and methods | US315917 | 1999-05-20 | US6074838A | 2000-06-13 | Jon Duvick; Tracy A. Rood |
| The present invention provides a bacterial microorganism having the ability to degrade or detoxify zearalenone or derivatives or analogs of zearalenone. The present invention also provides a method for the isolation and utilization of a zearalenone-degradation gene encoding a gene product having the ability to degrade or detoxify zearalenone or derivatives or analogs of zearalenone. In another embodiment, the present invention provides for the generation of transformants into which the zearalenone-degradation gene has been introduced, thereby providing the ability to degrade or detoxify zearalenone or derivatives or analogs of zearalenone to said transformants. The present invention further provides a method for detoxification of plants pre- or post-harvest using microbes having the ability to degrade or detoxify zearalenone or derivatives or analogs of zearalenone. The invention also provides a method for detoxification of plants pre- or post-harvest using the zearalenone-degradation gene. | ||||||
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