| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | Bifunctional terpenoid, its preparation, and ulcer preventive agent comprising it | JP239580 | 1980-01-12 | JPS56113718A | 1981-09-07 | SATOU AKIO; NAKASHIMA KENJI; TAKAHARA YOSHIMASA; KIJIMA SHIZUMASA; KUWANA NORIAKI; ABE SHINYA; YAMADA KOUJI |
| NEW MATERIAL:A compound shown by the formula I (n is integer of 1W5; R is hydroxymethyl, formyl, or carboxyl). EXAMPLE: 8-Hydroxy-2,6-dimethyl-2,6-octadienoic acid. USE: An ulcer preventive agent. PROCESS: A bacterium belonging to the genus Nocardia having an oxidative ability on a compound shown by the formula II (A is hydroxy-protecting group) is cultivated in a medium consisting of the compound shown by the formula II as a main carbon source, a compound shown by the formula III is collected from the culture, and the protecding group is removed, to give a compound shown by the formula I. A strain (BPM 1613, FERM-P 1609) is cited as the typical bacterium. COPYRIGHT: (C)1981,JPO&Japio | ||||||
| 42 | JPS5635156B2 - | JP4372477 | 1977-04-15 | JPS5635156B2 | 1981-08-14 | |
| Prodn. of indane cpds., i.e. 3a-H-4-(3'-propionic acido)-5-hydroxy-7a-methyl-hexanhydro-1-indanone and 3a-H-4-(3'-propionic acido)-5-hydroxy-7a-methyl-hexahydro-1-indanone-8-lactone (HIL), comprises culturing a strain of Nocardia on a medium contg. sterols (e.g. cholesterol, beta-sitosterol, campesterol, liethocholic acid, cholic acid) or their dehydrogenated derivs., and recovering the prods. HIL is useful as an intermediate and recovering the prods. hormones, e.g. oestradiol. Suitable microorganism strains are e.g. Nocardia corallina NG-511 (FERM-P 4018), Nocardia corallina NG-34 (FERM-P 4017). | ||||||
| 43 | Preparation of antibiotic substance c-15003p-4 | JP13938477 | 1977-11-18 | JPS5473193A | 1979-06-12 | HIGASHIDE EIJI; HATANO KAZUNORI; ASAI MITSUKO |
| PURPOSE: To prepare the title antibiotic substance in high efficiency, useful as an anti- tomor agent, anti-fugnal agent, and anti-protozoal agent, by culturing antibiotic C-15003-producing microbials belinging to Nocardia genus in a medium containing isovaleroyl CoA precursor. CONSTITUTION: Antibiotic substance C-15003P-4 of formula (R is isovaleroyl) is prepared by culturing microbials belonging to Nocardia genus and capable of producing antibiotic substance C-15003, e.g. Nocardia sp. C- 15003 (FERM-P No. 3992), in a medium containing 0.01-1.0 W/V%, pref. 0.1-0.5 W/V%, of an isovlaleroyl CoA precursor, e.g. α-ketoisocaprylic acid, leucine, etc., at 20W35°C. The temperature in the middle culturing stage is pref. 23W30°C, and the pH at the beginning of the culturing is pref. 6.5W7.5. The culturing is conducted for 2W10 days in case of aerated and agitated culturing. COPYRIGHT: (C)1979,JPO&Japio | ||||||
| 44 | Enzymatic hydrolysis method for the preparation of C-13 hydroxyl-bearing taxanes, and use thereof in the preparation of C-13 acyloxy-bearing taxanes | US445120 | 1995-05-19 | US5739016A | 1998-04-14 | Ronald L. Hanson; Ramesh N. Patel; Laszlo J. Szarka |
| An enzymatic hydrolysis method for the preparation of compounds useful as intermediates in the preparation of taxanes such as taxol, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. | ||||||
| 45 | Phenylalanine dehydrogenase production | US618755 | 1996-03-20 | US5714364A | 1998-02-03 | Peter Michael Hammond; Graham Mark Brearley; Christopher Philip Price |
| A method for producing in culture phenylalanine dehydrogenase at yields of 50+ units of enzyme per litre of culture, one unit measured as the amount required to convert one micro-mole of phenylalanine to phenyl pyrovic acid at 25.degree. C. and pH 10.8, in a growth medium comprising a nitrogen source, a buffer, phenylalanine or phenylpyruvic acid or a salt thereof at 20 mM and optionally a vitamin solution. Using phenylalanine at about 100 mM gives yields of phenylalanine dehydrogenase enzyme of 350+ units per liter of culture. | ||||||
| 46 | Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom | US77979 | 1993-06-15 | US5516676A | 1996-05-14 | Ronald L. Hanson; Ramesh N. Patel; Laszlo J. Szarka |
| Compounds useful as intermediates in the preparation of taxanes such as taxol are prepared by contacting one or more C-13 acyloxy-bearing taxanes with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. In a preferred embodiment the microorganism is Nocardioides albus ATCC55424, Nocardioides albus ATCC55425 or Nocardioides luteus ATCC55426 or the hydrolase enzyme is isolated from the microorganisms. | ||||||
| 47 | Novel glycopeptide antibiotics | US3252 | 1987-01-14 | US4946941A | 1990-08-07 | Eiji Kondo; Naoki Tsuji; Koichi Matsumoto; Yoshimi Kawamura; Tadashi Yoshida; Shinzo Matsuura |
| The compounds of the formula: ##STR1## wherein R is ##STR2## or H, wherein X is NH.sub.2 and Y is CH.sub.3 ; or X is OH and Y is H, and their pharmaceutically acceptable salts. The compounds have a potent activity against gram-positive bacteria, especially, methicillin-resistant bacteria. | ||||||
| 48 | Preparation and method for bioprecipitation of soluble pigment in aqueous solution | US31373 | 1987-03-30 | US4772333A | 1988-09-20 | Ryuichiro Kurane; Tomoo Kazuo |
| From the aqueous solution of a soluble pigment, removal of the soluble pigment is attained by intimately mixing the aqueous solution, in the presence of an inorganic salt, with the product of microorganic culture obtained by culturing a bacterium belonging to genus Rhodococcus and allowing the resultant mixture to stand at rest thereby causing the pigment to flocculate and precipitate therein. | ||||||
| 49 | Anthelmintic fermentation products of a microorganism | US857670 | 1986-04-30 | US4766112A | 1988-08-23 | Robert T. Goegelman; Edward S. Inamine; Raymond F. White |
| There are disclosed macrolides isolated from the fermentation broth, with avermectin Bla, avermectin Blb or 22,23-dihydro avermectin Bla as a substrate, of a known microorganism identified as MA-6181. The structure of the novel compounds isolated from the microorganism are presented based upon analytical studies. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents. Compositions for such uses are also disclosed. | ||||||
| 50 | A-51568B antibiotic | US775071 | 1986-09-12 | US4717714A | 1988-01-05 | LaVerne D. Boeck; Gary G. Marconi; Marvin M. Hoehn |
| The novel glycopeptide antibiotic A-51568B is produced by submerged, aerobic fermentation of Nocardia orientalis NRRL 15232. A-51568B demonstrates antibiotic activity against gram-positive bacteria. | ||||||
| 51 | Polyprenyl carboxylic acid derivatives | US259772 | 1981-05-01 | US4500463A | 1985-02-19 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Yuichi Inai; Yoshiyuki Kohara; Yoshiyuki Kawakami; Tomio Tsurugi |
| Polyprenyl carboxylic acid derivatives having the general formula (I): ##STR1## in which n is an integer of from 2 to 4, R.sub.1 represents the hydrogen atom or a protecting group for the carboxylic acid group, and R.sub.2 represents a hydroxymethyl, formyl or carboxyl group, are disclosed. A process for the preparation of the polyprenyl carboxylic acid derivative involving microbiological oxidation using a strain belonging to the genus Nocardia is disclosed. The compounds have anti-ulcer activity and hypotensive activity. The compounds also are useful as intermediates for preparing polyprenyl carboxylic acids of the formula ##STR2## and esters thereof, wherein l is an integer of from 4 to 11. The polyprenyl carboxylic acids and esters thereof have hypotensive activity and anti-ulcer activity. | ||||||
| 52 | Erythromycin D and esters thereof | US367820 | 1982-04-12 | US4496546A | 1985-01-29 | Walter D. Celmer; Walter P. Cullen; Paul C. Watts; Riichiro Shibakawa; Junsuke Tone |
| Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3",4"-di-O-acetylerythromcyin D, 3"-O-acetyl-4"-O-propionylerythromycin D and 4"-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D. | ||||||
| 53 | Rebeccamycin and process for its preparation | US461817 | 1983-01-28 | US4487925A | 1984-12-11 | Donald E. Nettleton, Jr.; James A. Bush; William T. Bradner; Terrence W. Doyle |
| A novel antitumor agent designated herein as rebeccamycin is produced by fermentation of Nocardia aerocolonigenes (ATCC 39243). Rebeccamycin and its 5'-N-methyl and 5',2",3",6"-tetraacetate derivatives exhibit activity against experimental animal tumor systems. | ||||||
| 54 | Process for the preparation of polyprenyl ketone derivatives | US446817 | 1982-12-03 | US4468459A | 1984-08-28 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Isao Yamatsu; Kouichi Suzuki; Takeshi Suzuki; Toshihiko Nakamura |
| Longer carbon chain polyprenyl ketone derivatives are prepared by cultivag Nocardia strain FERM-P No. 1609 in the presence of shorter carbon chain polyprenyl ketones. | ||||||
| 55 | Polyprenyl ketone derivatives | US312068 | 1981-10-16 | US4456558A | 1984-06-26 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Isao Yamatsu; Kouichi Suzuki; Takeshi Suzuki; Toshihiko Nakamura |
| This invention relates to novel polyprenyl ketone derivatives having the eral formula: ##STR1## in which n is an integer of 1-5, and R represents a hydroxymethyl, formyl or carboxyl group, and a process for the preparation of the same. | ||||||
| 56 | Antibiotic C-15003 PHM and production thereof | US347724 | 1982-02-10 | US4450234A | 1984-05-22 | Toru Hasegawa; Motowo Izawa; Seiichi Tanida |
| Novel antibiotic C-15003 PHM, which is produced by cultivating a microorganism belonging to the genus Nocardia and being capable of producing antibiotic C-15003 PHM, and novel C-15003 PHM acylate, which is produced by subjecting C-15003 PHM thus obtained to acylation reaction with an acylating agent, have antiprotozoan and antitumor activities. | ||||||
| 57 | Anti-ulcer composition comprising terpenoid containing two functional groups and method of treating ulcers | US360722 | 1982-03-22 | US4435423A | 1984-03-06 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Noriaki Kuwana; Shinya Abe; Kouzi Yamada |
| A process for the preparation of a two-functional-group-containing terpenoid having the general formula: ##STR1## in which n is an integer of from 1 to 5, R represents a hydroxymethyl, formyl or carboxyl group, and A represents the hydrogen atom, or a 2-tetrahydropyranyl, benzyl, methoxymethol or methoxyethoxymethyl group comprising the oxidation with a microorganism belonging to the genus Nocardia. Some of the terpenoids are of value as anti-ulcer agents, while others are useful as intermediates. | ||||||
| 58 | Macbecin derivatives | US414031 | 1982-09-02 | US4421687A | 1983-12-20 | Toru Hasegawa; Masayuki Muroi; Seiichi Tanida |
| Macbecin derivatives are produced by cultivating a microorganism of the genus Actinosynnema in a culture medium.The Macbecin derivatives are useful as antibacterial, antifungal or antiprotozoal agent. | ||||||
| 59 | Rifamycins, their compositions and use as antibiotics | US397379 | 1982-07-12 | US4411896A | 1983-10-25 | Thomas Schupp; Peter Traxler; Jakob Nuesch |
| New antibiotically active compounds having the basic structure of rifamycin S, namely 3-hydroxyrifamycin S (formula A: X=>C.dbd.O; R.sup.1 =OH; R.sup.2 =H), 3,31-dihydroxy-rifamycin S (formula A: X=>C.dbd.O; R.sup.1 =R.sup.2 =OH) and 1-desoxy-1-oxarifamycin S (formula A: X=--O--; R.sup.1 =R.sup.2 =H) ##STR1## are formed by cultivating, under aerobic conditions, a strain of Nocardia mediterranei which is derived from Streptomyces mediterranei ATCC 13 685 as the parent strain and is characterized by the ability to produce at least one of the mentioned compounds. The recombinant strain Nocardia mediterranei DSM 1415 has proved suitable. The mentioned rifamycin S analogues have analogous antibiotic properties to this but have a wider range of action, especially against gram-negative bacteria. | ||||||
| 60 | Two-functional-group-containing terpenoids | US360520 | 1982-03-22 | US4386227A | 1983-05-31 | Akio Sato; Kenji Nakajima; Yoshimasa Takahara; Shizumasa Kijima; Noriaki Kuwana; Shinya Abe; Kouzi Yamada |
| A process for the preparation of a two-functional-group-containing terpen having the general formula: ##STR1## in which n is an integer of from 1 to 5, R represents a hydroxymethyl, formyl, or carboxyl group, and A represents the hydrogen atom, or a 2-tetrahydropyranyl, benzyl, methoxymethol or methoxyethoxymethyl group comprising the oxidation with a microorganism belonging to the genus Nocardia. Some of the terpenoids are of value as anti-ulcer agents, while others are useful as intermediates. | ||||||
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