子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | SYSTEMS AND METHODS FOR IMMOBILIZING EXTRACELLULAR MATRIX MATERIAL ON ORGAN ON CHIP, MULTILAYER MICROFLUIDICS MICRODEVICES, AND THREE-DIMENSIONAL CELL CULTURE SYSTEMS | US15748066 | 2016-07-27 | US20180223251A1 | 2018-08-09 | Dongeun Huh; Mark Mondrinos; Cassidy Blundell; Jeongyun Seo |
| The presently disclosed subject matter provides an approach to address the needs for microscale control in shaping the spatial geometry and microarchitecture of 3D collagen hydrogels. For example, the disclosed subject matter provides for compositions, methods, and systems employing N-sulfosuccinimidyl-6-(4′-azido-2′-nitro-phenylamino)hexanoate (“sulfo-SANPAH”), to prevent detachment of the hydrogel from the anchoring substrate due to cell-mediated contraction. | ||||||
| 102 | HYDROGEL-BASED MICROFLUIDIC CHIP FOR CO-CULTURING CELLS | US15557224 | 2015-07-21 | US20180172666A1 | 2018-06-21 | Bong Geun CHUNG; Jong Min LEE; Hye In SEO; Jun-Hyuk BAE |
| Provided are a hydrogel-based microfluidic chip for cell co-culture and a use thereof, wherein the microfluidic chip allows the co-culture of cancer cells and vascular endothelial cells; can be widely applied in various studies associated with cancer; is suitable in studies on the photothermal therapy effect on, especially, cancer cells; and has excellent biocompatibility, mechanical properties, and economical feasibility. | ||||||
| 103 | ELECTRONIC DEVICE, WEARABLE DEVICE, AND METHOD OF PROVIDING CONTENT-BASED SOMATIC SENSES USING ULTRASOUND | US15647370 | 2017-07-12 | US20180135001A1 | 2018-05-17 | Seung-ryong JEON; Ki-hyun KIM; Taek-soo KIM; Eun-jung LEE; Gyeong-cheol JANG |
| Provided is an electronic device for providing somatic senses based on content. The electronic device includes: a processor configured to generate an ultrasound driving signal for evoking somatic senses corresponding to somatosensory data by stimulating a certain region of the brain of a user; and a communication interface configured to transmit the generated ultrasound driving signal to an external device, wherein the somatosensory data corresponds to the content. | ||||||
| 104 | AUTOMATIC DEVICE FOR CULTURING CELL AND OPERATING METHOD THEREOF | US15569873 | 2016-07-08 | US20180127695A1 | 2018-05-10 | Dohyun Nam; Gyuha RYU; Jinku LEE |
| Provided herein is an automatic cell culture device including an incubator configured to contain at least one container for culturing cells, a microscope configured to observe a state of the cell in the container, a robot arm configured to move the container, a liquid handler configured to introduce liquid into or discharge liquid from the container, and a control device configured to control an operation of at least one of the incubator, the microscope, the robot arm, and the liquid handler. | ||||||
| 105 | ROTARY DEVICE FOR BIO-PRINTING AND METHOD FOR USING THE SAME | US15562560 | 2015-03-31 | US20180112167A1 | 2018-04-26 | Yujian James KANG; Huixing ZHOU |
| The present invention relates to a rotary rod for 3D bio-printing, in which the rotary rod is arranged horizontally and is driven to rotate, the rotary rod has a hollow structure and provided with at least one hole in a surface thereof, such that during a 3D bio-printing process, a nutrition solution passes through the hollow structure and a portion of the nutrition solution exudes via at least one hole. The present invention further provides a 3D bio-printing platform for supplying nutrition, comprising the rotary rod and a nutrition supply system, and a method of printing a tubular tissue using the bio-printing platform. The present invention, which reduces the possibility of resulting in tissue collapse from the effect of gravity, provides a new method of 3D bio-printing a tubular tissue and supplying nutrition in a printing process, with a wide application prospect. | ||||||
| 106 | ARTIFICIAL SKIN CULTURE CONTAINER AND METHOD FOR PRODUCING ARTIFICIAL SKIN USING SAME | US15562576 | 2016-03-22 | US20180087030A1 | 2018-03-29 | Dae Jin MIN; Sung Hoon LEE; Hae Kwang LEE; Jae Hyun JEONG; Hee Wook RYU; Hee Jin KIM |
| An artificial skin culture container according to the present invention can solve the problems of the contraction of the dermal layer of artificial skin and the detachment thereof from the culture container, which result from an interaction between collagen and fibroblasts existing in the dermal layer of artificial skin during the production of the artificial skin, by using agar and hydrophobically modifying a portion of the agar. Therefore, the use of the culture container enables to stably culture artificial skin and produce artificial skin similar to the human skin. In addition, the artificial skin culture container of the present invention comprises agar, and thus a culture solution can be supplied through a side portion as well as a lower portion of the culture container, which allows to effectively culture artificial skin. | ||||||
| 107 | INCUBATOR AND INCUBATOR SYSTEM WITH CLEAN BENCH FUNCTION | US15563498 | 2016-03-31 | US20180044625A1 | 2018-02-15 | Makoto CHIKUDA; Shinichirou YOSHIDA; Hiroyuki OKAMOTO; Kiyomi ARAI |
| The present invention provides an incubator with a clean bench function to have both function of opened and closed system and a proposal how to use, allowing cells or others to be “closable and openable” manipulated and cultured, as well as an incubator, a globe box, a clean bench. This is implemented in this system has a specific structure and a characteristic component, e.g., a structure classified two units by the inside temperature, an operation cover and a circular fixture, a channel from/to inside or outside etc. to allow such as used, a non-opening operation and supply and observation from outside, or a moving of perfusion culture device and medium storing bags kept on connecting tubes or others. An incubator 100 with a clean bench function mainly includes a chamber 110, 210, 220, 230, a temperature control unit 160, 213 and a gas concentration control and supply unit 140, 240, as well as a CO2 cylinder 170, a N2 cylinder 180, and a N2 gas generator 190. The chamber 210 has an ability of setting on low temperature. The chamber 110 has the shape of a rectangular parallelepiped and includes an opening 111 in the front, and a sensor 161. The opening 111 attached on a sealing door 117 and an inner door 118, and their intervening space with elastic materials 120-122 and channels 126-128 in a peripheral portion 112 around the opening 111. For the closable operation inside the chamber 110 from the outside, an operation cover 136 and a circular fixture 300, a membrane with/without slit 134 and the fixer 134a, b is attached on/off the fixing hole 119 in the inner door 118, and a first hook 114 to hang of the operation cover is attached to each of two inner side surfaces 113 of the chamber 110. A UV lamp 116 adapted to emit UV rays for sterilization is attached on upper site of inner back surface 115 in the chamber 110. The N2 gas supplied in large quantity into the chamber from N2 cylinder 180 that positive pressure is maintained in the chamber 110 relative to outside pressure as used the clean bench function. In particular, this present invention is possible to mostly three new matters as follows: First, the exchange and regulate with gas composition and temperature in this system is both of them different constituent at the same time. Second, this system is an ability to operate under the condition of very low temperature (from 4 degree Celsius) and low O2 concentration (from 1%), too. Third, this system is an ability applied to variety of opened and closed operation etc. under the keeping with condition. | ||||||
| 108 | FREEZING BAG CONTAINER | US15712518 | 2017-09-22 | US20180007890A1 | 2018-01-11 | Masaki MATSUMURA |
| A container for containing a freezing bag filled with biological tissue and for cooling and warming the freezing bag. The container includes a main body possessing an inner surface, a first side surface and a second side surface positioned opposite the first side surface. The main body is substantially rectangular parallelepiped shaped. The container includes at least one opening in at least one of the first side surface and the second side surface of the container, and at least two ridges spaced apart from one another on the inner surface of the container to create an air gap between the spaced apart ridges, the inner surface of the container and the outer surface of the freezing bag. | ||||||
| 109 | SYSTEMS, DEVICES, KITS AND METHODS FOR SEEDING CELLS OR SETS OF MOLECULES IN AN ARRAY ON A SUBSTRATE | US15536584 | 2015-12-15 | US20170362557A1 | 2017-12-21 | Yehoshua SHEINMAN; Revital SHARIVKIN; Merav BELENKOVICH |
| The present disclosure provides systems, devices and methods for seeding cells or sets of molecules on a substrate by utilizing a seeding mesh, to obtain an essentially homogenous patterned seeding of the cells or sets of molecules on the mesh. | ||||||
| 110 | FIBER STRUCTURE FOR USE AS CELL SCAFFOLD MATERIAL | US15521985 | 2015-10-30 | US20170342376A1 | 2017-11-30 | Koji Kadowaki; Chisa Kuga; Masaki Fujita; Kazuhiro Tanahashi; Satoshi Yamada; Takayuki Kaneko; Hiroshi Tsuchikura |
| A fiber structure can be used as a cell scaffold material, which fiber structure includes a multifilament formed by bundling monofilaments having an average fiber diameter of 1 to 15 μm, wherein each of the monofilaments satisfies Formula (1): (Y/X)×100>50 . . . (1) wherein, in Formula (1), X represents the number of monofilaments for which the average crossing angle is investigated, and Y represents the number of monofilaments having an average crossing angle of not more than 25° in X. | ||||||
| 111 | METHOD FOR PREPARING BONE MARROW CELL AGGREGATE | US15661654 | 2017-07-27 | US20170321191A1 | 2017-11-09 | Nobuhiko KOJIMA |
| The present invention provides a technique which enables organization of bone marrow cells by a simple method in a short period of time.A method for preparing a bone marrow cell aggregate, comprising adding a liquid containing a bone marrow cell population to a medium containing a swellable material and culturing the bone marrow cell population in the presence of the swellable material. A method for reassembling a bone marrow tissue, comprising adding a liquid containing a bone marrow cell population to a medium containing a swellable material and culturing the bone marrow cell population in the presence of the swellable material.According to common knowledge in the art, it has been considered difficult to reorganize once disintegrated bone marrow tissue without changing the cell composition (that is, without adding any adherent cell or extracellular matrix which will work as a “connecting material (binder)”). Indeed, it was impossible to aggregate bone marrow cells by conventional methods. As a result of its achievement, the present invention changes such conventional thought and results and provides a major breakthrough technique pertaining to 3D culture of bone marrow cells. It has also been confirmed that culture of a bone marrow-like tissue reassembled by the method of the present could be continued up to day 14 in the MC medium. | ||||||
| 112 | CELL SHEET MANUFACTURING DEVICE AND MANUFACTURING METHOD THEREFOR | US15525280 | 2015-11-09 | US20170321176A1 | 2017-11-09 | Daehyeong KIM; Seunghong CHOI; Taeghwan HYEON; Seokjoo KIM; Hyerim CHO; Kyoungwon CHO |
| The present invention relates to a cell sheet manufacturing device and a manufacturing method therefor. More specifically, the present invention relates to a cell sheet manufacturing device comprising a support layer made of silicon rubber, a patterned electrode formed adjacent to the support layer and a graphene layer formed adjacent to the electrode, and a manufacturing method therefor. | ||||||
| 113 | BILE ACID BIOMARKERS FOR NIEMANN-PICK DISEASES, METHODS AND USES THEREFOR | US15581389 | 2017-04-28 | US20170285015A1 | 2017-10-05 | Daniel ORY; Xuntian JIANG |
| Methods for identification and quantification of bile acids are disclosed. Bile acids in plasma, serum and/or blood such as a dried blood spot are used to identify subjects with a Niemann-Pick disease. The methods include measuring levels of a bile acid, such as 3β,5α,6β-trihydroxycholanic acid, N-(3β,5α,6β-trihydroxy-cholan-24-oyl)glycine, N-(3β,5α,6β-trihydroxy-cholan-24-oyl)taurine, or a combination thereof. Detection of bile acids involve mass spectroscopy and/or a combination of mass spectroscopy and liquid chromatography such as a LC-MS/MS assay. The methods can be used with sphingomyelinase assays to detect, diagnose and differentiate between Niemann-Pick A/B and Niemann-Pick C (NPC) disease. | ||||||
| 114 | METHOD FOR INDUCING THREE-DIMENSIONAL OSTEOGENIC DIFFERENTIATION OF STEM CELLS USING HYDROGEL | US15512455 | 2015-09-15 | US20170283768A1 | 2017-10-05 | Hyun Sook PARK; Sun Ray LEE; Ji Won YANG; Seol CHU; Hyun Jung MO |
| The present invention relates to a method for inducing osteogenic differentiation of mesenchymal stem cells and, more particularly, to a short-time osteogenic differentiation method of culturing cells using a porous membrane and a biodegradable synthetic biogel, whereby the cells do not contact a cell culture container. The present invention can significantly shorten the induction period of osteogenic differentiation, compared to the conventional osteogenic differentiation method, and has an effect of the cells being easily separable after differentiation as well. | ||||||
| 115 | THREE-DIMENSIONAL CELL CULTURE SYSTEM AND CELL CULTURE METHOD USING SAME | US15512466 | 2015-09-15 | US20170283767A1 | 2017-10-05 | Hyun Sook PARK; Sun Ray LEE; Ji Won YANG; Seol CHU; Jang Mi PARK; Hyun Jung MO |
| The present invention relates to a composition for preserving cells and a cell preservation method and, more specifically: to a composition for preserving cells, containing, as active ingredients, a plant-derived recombinant human serum albumin and a plant peptide, which maintain a high cell survival rate while maintaining animal-free and xeno-free properties and are stable without changes in cell morphology or a surface expression factor during the short term preservation of cells such as stem cells or primary cultured cells; and a cell preservation method using the same. | ||||||
| 116 | NEURAL CIRCUIT PROBE | US15521792 | 2015-10-30 | US20170241976A1 | 2017-08-24 | Paul K. Hansma; Kenneth S. Kosik; Luke S.K. Theogarajan; Barney Drake; Daniel C. Bridges; Connor J. Randall; Kenneth R. Tovar |
| A Neural Circuit Probe (NCP) combines a multi-electrode array (MEA) with an automated local probe, wherein the probe is positioned to interact with one or more cells, such as neurons of a neural circuit, grown on or about one or more electrodes of the multi-electrode array. The probe may interact with the cells by electrically recording signals from the multi-electrode array that are assigned to a specific one of the cells. The probe may interact with the cells by locally delivering chemicals to the cells, which transiently and reversibly modulate the electrical behavior of the cells. The probe may interact with the cells by harvesting the cells using a pipette, so that the harvested cells can be sequenced. | ||||||
| 117 | CELL CULTURE MEDIUM AND CULTURE METHOD USING THE SAME | US15515086 | 2015-08-19 | US20170226471A1 | 2017-08-10 | Tomohisa KATO; Yonehiro KANEMURA; Tomoko SHOFUDA; Hayato FUKUSUMI |
| It is an object of the present invention to provide a cell culture medium capable of enhancing cell growth efficiency without using feeder cells, in particular wherein the cell culture medium does not comprise serum. According to the present invention, a cell culture medium comprising fibrin 5 and Zeta polypeptide is provided. | ||||||
| 118 | METHOD FOR CULTURING PLURIPOTENT STEM CELLS | US15515449 | 2015-09-30 | US20170218343A1 | 2017-08-03 | Toshimasa Uemura; Yui Onomura; Takashi Tsumura |
| Provided is a method for efficiently culturing pluripotent stem cells with higher safety. The present invention relates to a method for culturing pluripotent stem cells, the method comprising culturing an isolated pluripotent stem cells in a pseudo-microgravity environment to proliferate the pluripotent stem cells while maintaining the pluripotent stem cells in an undifferentiated state, thereby forming and growing spheroids of the pluripotent stem cells; and a method for inducing differentiation of pluripotent stem cells by using the method. | ||||||
| 119 | Method of loading and distributing cells in a bioreactor of a cell expansion system | US13971500 | 2013-08-20 | US09175259B2 | 2015-11-03 | Brian J. Nankervis |
| One or more embodiments are described directed to a method and system for loading and distributing cells in a bioreactor of a cell expansion system. Accordingly, embodiments include methods and systems that may provide for adding a plurality of cells to a fluid within a bioreactor of the cell expansion system. A first percentage of the plurality of cells is allowed to settle in the bioreactor and a second percentage of the plurality of cells is allowed to settle outside of the bioreactor. The first percentage of cells is then expanded in the bioreactor. The second percentage of cells is wasted. | ||||||
| 120 | Deformable polymer testing device | US13593319 | 2012-08-23 | US08906696B2 | 2014-12-09 | Archit Giridhar |
| A testing device uses a selectively deformable substrate to capture and retain spherical beads for genetic experimentation. A method of fabricating the device is described in which a silicon substrate can be coated with a photosensitive, bio-compatible polymer for photolithographic patterning using a single mask exposure. The polymer is patterned with a matrix of wells, each well capable of expansion to accept placement of a bead in the well, and contraction to secure the bead in the well. The polymer can exhibit piezoelectric properties that cause it to respond mechanically to a selected electrical excitation. | ||||||
QQ群二维码
意见反馈
意见反馈