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序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
41 BIOREACTOR WITH FEED AND HARVEST FLOW THROUGH FILTER ASSEMBLY US13984937 2012-02-22 US20130316396A1 2013-11-28 Patric Fricking
The present invention relates to a bioreactor and a method for operating a bioreactor which comprises a chamber (100) capable of receiving a liquid media, and a filter assembly (200) comprising a perfusion filter (210; 212; 214). The filter assembly (200) is disposed in the chamber (100) and the filter assembly (200) is free to move within the chamber (100). The filter assembly (200) comprises means for coupling a harvesting flow through said filter (210; 212; 214) and means for coupling a feed flow through said filter in an opposite direction compared to the harvesting flow. Through this arrangement, the clogging prevention of the perfusion filter can be improved.
42 Ensiling biomass for biofuels production and multiple phase apparatus for hydrolyzation of ensiled biomass US12633555 2009-12-08 US08529765B2 2013-09-10 Jerry Wayne Horton
A method, apparatus and system for the hydrolyzation of ensiled biomass is disclosed. Ensiled biomass is processed in multiple phases, resulting in a liquid precursor hydrozate and a solid precursor hydrozate. The liquid precursor having significant economic value, and being suitable for uses such as, for example, lower cost and improved efficiency ethanol production. A method for lower cost, improved efficiency alcohol production that uses the resulting liquid precursor hydrozate being produced at distributed sources is further disclosed.
43 CULTURE CONTAINER FOR ADHERENT CELLS AND METHOD FOR PRODUCING CULTURE CONTAINER FOR ADHERENT CELLS US13862966 2013-04-15 US20130230914A1 2013-09-05 Takahiko Totani; Yoichi Ishizaki; Satoshi Tanaka; Ryo Suenaga; Kyohei Ota; Masahiro Kuninori
A culture bag for culturing adherent cells is provided without requiring a highly clean production environment and a complex production step such as a masking step. An adherent cell culture vessel that is formed of a polyolefin is configured so that part or the entirety of the inner surface of the culture vessel has a static water contact angle of 95° or more, and has an advancing contact angle and a receding contact angle that satisfy the inequality “advancing contact angle−receding contact angle>25°” when water runs down along the inner surface.
44 AUTOMATED CELL CULTURE SYSTEM US13642269 2011-04-20 US20130210130A1 2013-08-15 Yves Larcher; Rupert Hagg
The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module.
45 FERMENTER FOR A BIOGAS PLANT US13255534 2010-03-03 US20130122579A1 2013-05-16 Eric Priller
A fermenter for a biogas plant which operates with wet fermentation includes a fixed casing which surrounds a reaction space, an inlet for biomass and an outlet for the fermentation reside. A wall is arranged inside the casing, which separates the inlet from the outlet.
46 SOLAR HYBRID PHOTOBIOREACTOR US12968591 2010-12-15 US20120156762A1 2012-06-21 István Csányi; Laszlo Balazs; Janos Sneider; Erazmus Gerencser
A photobioreactor system is provided that comprises a bioreactor including at least two bioreactor tubes, each having an end and a hollow interior, the ends being connectively joined by one or more connector units having a hollow portion defined by a circumference, a solar concentrator configured to collect and concentrate solar power, at least one light guide associated with the solar concentrator to illuminate the hollow portion of the one or more connector units, and at least one LED illuminating the one or more connector units.
47 Gas Scrubbed Perfusion Filter US13093859 2011-04-26 US20110201050A1 2011-08-18 Sarfaraz K. Niazi
Fine gas bubbles traveling at fast speed are employed to scrub a hard-surface filter for harvesting liquids from suspensions including those consisting of nutrient media and cell culture, on a continuous basis without clogging the filters.
48 Apparatus for treating garbage US599229D US599229A 1898-02-15
49 FEEDER-FREE METHOD FOR CULTURE OF BOVINE AND PORCINE SPERMATOGONIAL STEM CELLS EP17172768.8 2013-02-11 EP3243903A1 2017-11-15 OATLEY, Jon Michael; OATLEY, Melissa Joan

The present invention relates to the production and culture of undifferentiated spermatogonial stem cells that can be maintained long term and are feeder free. The resultant feeder-free populations can be used in any of a number of protocols including the generation of progeny bulls. The present invention includes novel methods required for the successful enrichment of bovine spermatogonial stem cells, novel cell lines and other components used for the same, as well as the resultant stem cell compositions.

50 DEVICE FOR MANUFACTURING ORGANIC SUBSTANCE AND METHOD FOR MANUFACTURING ORGANIC SUBSTANCE EP14843678 2014-09-12 EP3045538A4 2017-05-10 SATOU KANETOMO; FUJIMORI YOJI; ISHII TETSUYA; HAMACHI KOKORO; DOYAMA KAZUO
Provided is a novel apparatus capable of suitably manufacturing an organic substance from a syngas. An apparatus 1 for manufacturing an organic substance includes a syngas producing furnace (11), an organic substance synthesis unit (16), a moisture content raising unit (12), and a moisture content lowering unit (13). The syngas producing furnace (11) is configured to produce a syngas containing carbon monoxide by partly oxidizing a carbon source. The organic substance synthesis unit (16) is configured to produce an organic substance from the syngas. The moisture content raising unit (12) is disposed between the syngas producing furnace (11) and the organic substance synthesis unit (16). The moisture content raising unit (12) is configured to raise a moisture content of the syngas. The moisture content lowering unit (13) is disposed between the moisture content raising unit (12) and the organic substance synthesis unit (16). The moisture content lowering unit (13) is configured to lower the moisture content of the syngas.
51 REACTOR FOAM SENSOR SYSTEMS AND METHODS OF USE EP15704123.7 2015-01-16 EP3094716A1 2016-11-23 KJAR, Steven R.; BROWN, Jeffery O.; BROWN, Jason D.; BRAU, Christopher D.
A foam sensor system includes a flexible bag comprised of a polymeric material and bounding a compartment. A foam sensor assembly is mounted on the flexible bag and includes a foam contact disposed within the compartment of the flexible bag. A ground assembly is mounted on the flexible bag and includes a ground contact disposed within the compartment of the flexible bag, the foam sensor assembly and the ground assembly being configured so that an electrical potential can be applied between the foam contact and the ground contact.
52 CONCENTRATOR FILTER EP12777319.0 2012-05-23 EP2714885A2 2014-04-09 Niazi, Sarfaranz K.
A method and an apparatus for separating suspended matter from liquid includes a concentrator filter that draws the liquid out of the suspension while the filter kept unblocked by a sparging filter that allows scrubbing of the concentrator filter by gas bubbles. This invention can be used to replace cross-flow filtration and centrifugation in the bioprocess industry and to reduce the volume of suspensions to concentrate the yield of the end product in the chemical industry.
53 SELECTION OF IMPROVED MICROBIAL STRAINS FOR PRODUCTION OF SUCCINIC ACID FROM GLYCEROL EP12718739.1 2012-04-20 EP2699701A1 2014-02-26 THEODOROPOULOS, Constantinos
Provided are methods for generating a microorganism with improved ability to convert glycerol to succinic acid. These methods comprise combining a microorganism with ability to convert glycerol to succinic acid and a medium containing glycerol to produce a fermentation mixture; allowing fermentation to occur such that succinic acid is produced; and assaying for an indication of glycerol metabolism. These latter two steps may be repeated as necessary. Also provided are microorganisms generated in this manner, particularly bacteria deposited at the NCIMB on 13 th April 2011 with the Accession Number NCIMB 41825. A method of producing succinic acid from glycerol is also provided, this method comprising: mixing a microorganism according to claim of the invention with a medium comprising glycerol to produce a fermentation mixture; and incubating the fermentation mixture, under conditions that promote fermentation to produce succinic acid, until succinic acid is produced. Succinic acid produced by such methods is also provided.
54 FERMENTER FÜR EINE BIOGASANLAGE EP10706553.4 2010-03-03 EP2406368A1 2012-01-18 PRILLER, Eric
A fermenter (10) for a wet fermentation biogas plant, comprising a fixed jacket (12) which surrounds a reaction space, an inlet (18) for biomass and an outlet (20) for the fermentation residue, is characterized in that a wall (16) separating the inlet (18) from the outlet (20) is arranged inside the jacket (12).
55 METHOD FOR PRODUCING WINE WITH A LOW ALCOHOL CONTENT, AND FERMENTING-DESUGARING UNIT FOR THE IMPLEMENTATION THEREOF US16310182 2017-06-13 US20190249124A1 2019-08-15 René CHELLE
According to the invention, an aliquot of must is sent from a wine making vat into an air-lift-type fermenting-desugaring unit, wherein homogenization of the aliquot and aeration of the yeasts are carried out with controlled heating in order to achieve aerobic fermentation until all the sugar in the aliquot has been consumed completely.
56 OLIVE DERIVED CELL CULTURE AND METHODS FOR PREPARING AND USING THE SAME US16072886 2017-01-26 US20190231837A1 2019-08-01 Yoheved HAGAY; Malkit AZACHI
The present application describes a large process for the in vitro production of an olive cell culture.The application further describes a composition in a form of a powder comprising olive fruit/leaf cells grown in vitro and a method of treating metabolic syndrome disorders, such as, high cholesterol level, comprising administering an effective amount of the composition. The cell line callus culture of olive cells manufactured according to the process of the invention includes high level of hydroxytyrosoll, tyrosol, oleoropein and verbascoside.
57 CULTURE CONTAINER, AND SYSTEM AND METHOD OF TRANSFERRING A CULTURED ORGANISM BETWEEN CULTURE CONTAINERS US15692520 2017-08-31 US20180332842A1 2018-11-22 Chia-Kang TSAO
A culture container includes a tube having a first and a second opening respectively provided at two opposite ends thereof, and a cover attachable to and removable from the first opening of the tube, the cover including an inlet port for passage of a fluid substance and a receptacle for holding a substance consumable by an organism of interest, the receptacle being enclosed inside the tube and the inlet port communicating with a hollow interior of the tube when the cover is attached to the first opening of the tube. Moreover, a system and a method of transferring a cultured organism of interest include switching the covers between two culture containers.
58 Process for improved fermentation of a microorganism US15774658 2016-11-08 US20180327710A1 2018-11-15 Subir Kumar NANDY
A method for improving biomass production and/or growth rate of a microorganism in a fermentation process is shown, and includes: (i) providing one or more microorganisms; (ii) providing a fermentation substrate suitable for fermenting the one or more microorganisms; (iii) mixing the one or more microorganisms and the fermentation substrate providing a fermentation broth; (iv) adding the fermentation broth to a fermentation tank; (v) injecting at least one gaseous substrate into the fermentation broth; (vi) running the fermentation process for a fermentation period of at least 1 hour; wherein the at least one gaseous substrate comprises one or more greenhouse gases, such as carbon dioxide (CO2).
59 Bioreactor vessels and associated bioreactor systems US14417739 2013-07-29 US10041030B2 2018-08-07 Adrian Neil Bargh
A bioreactor vessel (100) is provided with a rigid ledge projecting to a side thereof and defining fluid conduits (136a-c) between three respective externally-facing ports (132a-c) and a vessel chamber (105). A bioreactor system includes a cell culture module (10) having a receiving station (14) in which the vessel (100) is received, in use. Three fluid connection ports (314a-c) are located adjacent to the receiving station (14) and are in fluid connection with associated gas and/or liquid input lines (302a-c, 316, via a valve assembly (300). When the vessel (100) is inserted into the receiving station, the rigid nature of the ledge and the defined positions of the receiving station connection ports (314a-c) mean that the externally-facing ports (132a-c) on the vessel are brought into registration with the receiving station connection ports (314a-c), thereby forming respective fluid connections automatically, without having to manually couple fluid lines on the vessel (100) to ports on the cell culture base (12).
60 DEVICES, SYSTEMS AND METHODS FOR INHIBITING INVASION AND METASTASES OF CANCER US15474214 2017-03-30 US20170285003A1 2017-10-05 Geraldine A. Hamilton; Norman Wen; Catherine Karalis; Antonio Varone; Daniel Levner; Riccardo Barrile
The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.
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