| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | Intermediate 1-(2-nitro-1-imidazolyl)-3-substituted amino-2-propanols and the corresponding 2,3-butanediols | US929095 | 1986-11-10 | US4757148A | 1988-07-12 | Israr Ahmed; Gerald E. Adams; Ian J. Stratford; David Gibson |
| A compound of formula I ##STR1## in which formula: R.sub.1 represents hydrogen or an alkyl group;R.sub.2 -R.sub.5 represent hydrogen, alkyl aryl, aralkyl or alkaryl group; andn is 1 or 2. | ||||||
| 22 | Useful in radiotherapy of chemotherapy 4-aziridino-1-nitroimidazol-1-yl-2,3-butanediols | US498827 | 1983-05-27 | US4631289A | 1986-12-23 | Israr Ahmed; Gerald E. Adams; Ian J. Stratford; David Gibson |
| A compound of formula I ##STR1## in which formula: R.sub.1 represents hydrogen or an alkyl group;R.sub.2 -R.sub.5 represent hydrogen, alkyl aryl, aralkyl or alkaryl group; andn is 2.The compounds are used as a radiation sensitizing agent or a chemopotentiating agent for administration to a patient undergoing radiation therapy or chemotherapy for the treatment of cancer. | ||||||
| 23 | Aziridino containing nitro imidazoles and pharmaceutical compositions | US498826 | 1983-05-27 | US4581368A | 1986-04-08 | Israr Ahmed; Gerald E. Adams; Ian J. Stratford |
| A compound of formula I ##STR1## in which formula: R.sub.1 represents hydrogen or an alkyl group;R.sub.2 -R.sub.5 represent hydrogen, alkyl aryl, aralkyl or alkaryl group; andn is 1. | ||||||
| 24 | Immune-stimulating and cancerostatic 1-acyl-2-cyanoaziridines | US916389 | 1978-06-16 | US4267174A | 1981-05-12 | Herbert Berger; Rudi Gall; Wolfgang Kampe; Uwe Bicker; Rolf Kuhn |
| 1-Acyl-2-cyanoaziridines of the formula ##STR1## wherein R is an acyl radical of a carboxylic, sulphonic, sulphinic, sulphenic, phosphonic or phosphoric acid,exhibit immune-stimulating and cancerostatic activities. | ||||||
| 25 | Aminophenyl-cycloamidines | US3769274D | 1971-06-09 | US3769274A | 1973-10-30 | WOLLWEBER H; FLUCKE W |
| DERIVATIVES OF 2-(4-(SUBSTITUTED AMINO) AMINOPHENYLIMINO) PYRROLIDINE, -PIPERIDINE OR HEXAHYDROAZEPINE, OPTIONALLY BEARING ALKYL OR ALKENYL SUBSTITUTION IN THE 1-POSITION OF THE SPECIFIED HETEROCYCLIC GROUPS, ARE ANTHELMINTICS. A NUMBER OF PROCESSES FOR THE PREPARATION OF THESE COMPOUNDS, OF WHICH 2-(4-CARBETHOXYAMINOPHENYLIMINO)-1METHYLPYRROLIDINE IS A TYPICAL EMBODIMENT, ARE DISCLOSED.
|
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| 26 | Amide derivative | JP2000605582 | 2000-03-13 | JP4619545B2 | 2011-01-26 | ブラウン，ディアーグ・サザーランド |
| 27 | 12,13-qualified epothilone derivative | JP2000544658 | 1999-04-05 | JP4476483B2 | 2010-06-09 | グレゴリー・ディ・バイト; ゲルハルト・ホフレ; スーン−フーン・キム・キム |
| 28 | Amide derivative | JP2000605582 | 2000-03-13 | JP2002539207A | 2002-11-19 | ブラウン，ディアーグ・サザーランド |
| (57)【要約】 本発明は式（Ｉａ）［式中、Ｘは−ＮＨＣＯ−または−ＣＯＮＨ−であり、ｍは０−３であり、Ｒ 1は例えばヒドロキシ、ハロゲノ、トリフルオロメチル、シアノ、メルカプト、ニトロ、アミノ、カルボキシおよびカルバモイルの如き基であり、ｎは０−２であり、Ｒ 2は例えばヒドロキシ、ハロゲノ、トリフルオロメチル、シアノ、メルカプト、ニトロ、アミノおよびカルボキシの如き基であり、Ｒ 3は水素、ハロゲノ、（１−６Ｃ）アルキルまたは（１−６Ｃ）アルコキシであり、ｑは０−４であり、そしてＱは例えばアリール、アリールオキシ、アリール−（１−６Ｃ）アルコキシ、アリールアミノおよびＮ−（１−６Ｃ）アルキル−アリールアミノの如き基である］のアミド誘導体、またはそれらの医薬上容認されうる塩類もしくは生体内で分解可能なエステル類、それらの製造方法、それらを含有する薬剤組成物並びにサイトカイン類が介在する疾病または医学的症状の処置におけるそれらの使用に関する。 【化１】 | ||||||
| 29 | Radiation therapy or compounds useful for chemotherapy | JP9475283 | 1983-05-27 | JPH0649697B2 | 1994-06-29 | イアン・ジエイムズ・ストラツトフオ−ド; イスラ−・ア−メツド; ジエラルド・エドワ−ド・アダムス; デビツド・ギブソン |
| 30 | JPH0447667B2 - | JP16667784 | 1984-08-10 | JPH0447667B2 | 1992-08-04 | REN FUANGU RII |
| 31 | JPH0370690B2 - | JP17675683 | 1983-09-24 | JPH0370690B2 | 1991-11-08 | HASHIDA MITSURU; SEZAKI HITOSHI |
| 32 | Imidazolonebenzoic acid ester and herbicide containing said ester as active component | JP1219585 | 1985-01-25 | JPS61171472A | 1986-08-02 | OKADA ITARU; NAKAZAWA MAKOTO; WATANABE HISAO; HANABE HIROSHI |
| NEW MATERIAL:The compound of formula I [X is H, halogen or 1W4C alkyl; Y is alkylene; R 1 is mono- or dialkylamino, N-alkyl-N-alkoxyamino, (O-contain ing) saturated cyclic amino, or pyridyl; R 2 and R 3 are 1W4C alkyl]. EXAMPLE: 2-( 5-Isopropyl-5-methyl-4-oxo-2-imidazolin-2-yl )benzoic acid 2- dimethylaminoethyl ester. USE: A selective herbicide. It exhibits excellent herbicidal effect against various weeds in plowed land, e.g. barnyard grass, smooth pigweed, etc. and in paddy field, e.g. false pimpernel, menochoria, etc. It has no phytotoxicity to crops, especially graminaceous crops such as wheat, corn, etc., and has high safety. PREPARATION: The compound of formula I can be produced by reacting the compound of formula II with excess alcohol of formula III in a solvent or in the absence of solvent, in the presence of an alkali metal hydride, etc., in an inert gas atmosphere, preferably in N 2 gas, etc., at 5W50°C for 1W10hr. COPYRIGHT: (C)1986,JPO&Japio | ||||||
| 33 | Pyridinedicarboxylic acid derivative, manufacture, herbicidal composition and herbicidal method | JP16667784 | 1984-08-10 | JPS6078965A | 1985-05-04 | REN FUANGU RII |
| 34 | JPS5939424B2 - | JP2676875 | 1975-03-05 | JPS5939424B2 | 1984-09-22 | OKAMOTO AKYOSHI; KIKUMOTO RYOJI; TAMAO YOSHIKUNI; TONOMURA SHINJI; OOKUBO KAZUO; TEZUKA TOORU; HIJIKATA AKIKO |
| 35 | Compound useful for radiotherapy or chemical therapy | JP9475283 | 1983-05-27 | JPS58225086A | 1983-12-27 | ISURAA AAMETSUDO; JIERARUDO EDOWAADO ADAMUSU; IAN JIEIMUZU SUTORATSUTOFUOODO; DEBITSUDO GIBUSON |
| 36 | Manufacture of aminophenyllcycloamidine and its salts | JP10193878 | 1978-08-23 | JPS5444663A | 1979-04-09 | HARUTOMUNTO UORUUEEBAA; UINFURIITO FURUTSUKE |
| 37 | ORGANIC REACTION UTILIZING AN α,β-UNSATURATED COMPOUND | PCT/US2016/041816 | 2016-07-11 | WO2017011418A1 | 2017-01-19 | NJARDARSON, Jon; CHOGII, Isaac |
The present invention provides a various organic reaction that utilize an α,β-unsaturated compound to produce aziridine compounds and dihydrofuran compounds. In particular, the present invention provides a method for producing an aziridine compounds of the formula : (I) or a dihydrofuran compound of the formula: (II) by reacting an α,β-unsaturated compound of the formula: (III) with an appropriate compound. In this manner a wide variety of aziridine compounds and dihydrofuran compounds can be produced using the method of the invention. |
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| 38 | AMIDE DERIVATIVES | PCT/GB2000/000912 | 2000-03-13 | WO00055153A1 | 2000-09-21 | |
| The invention concerns amide derivatives of Formula (Ia) wherein X is - NHCO- or -CONH-; m is 0-3; R<1> is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-2; R<2> is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino and carboxy; R<3> is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy; q is 0-4; and Q is a group such as aryl, aryloxy, aryl-(1-6C)alkoxy, arylamino and N-(1-6C)alkyl-arylamino; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines. | ||||||
| 39 | 12,13-CYCLOPROPANE EPOTHILONE DERIVATIVES | PCT/US1999/007448 | 1999-04-05 | WO99054318A1 | 1999-10-28 | |
| The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor. | ||||||
| 40 | 5-HYDROXYTRYPTAMINE RECEPTOR 7 MODULATORS AND THEIR USE AS THERAPEUTIC AGENTS | PCT/US2018/022581 | 2018-03-15 | WO2018175190A1 | 2018-09-27 | BLASS, Benjamin E.; CANNEY, Daniel J.; BLATTNER, Kevin M. |
Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity. |
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