子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | 组蛋白脱乙酰酶抑制剂 | CN200880019410.3 | 2008-04-09 | CN101679220A | 2010-03-24 | 皮埃尔·特西尔; 西尔瓦纳·利特; 戴维·斯米尔; 罗伯特·德齐尔; 阿兰·阿杰米恩; 伊维斯·A·钱蒂格尼; 西莉亚·多明格斯 |
| 本发明涉及抑制组蛋白脱乙酰酶的化合物。更具体而言，本发明提供式(I)化合物及其N-氧化物、水合物、溶剂合物、可药用的盐、前体药物和复合物，及其外消旋混合物和呈比例混合物、非对映异构体和对映异构体，其中基团L、M、X及Y均如本说明书中的定义。 | ||||||
| 22 | 含硫不饱和羧酸酯化合物及其应用 | CN00120123.9 | 2000-06-01 | CN100341852C | 2007-10-10 | 今井雅夫; 杉本贤一; 藤井谦一; 大迁淳夫; 大熊正; 高木正利; 铃木理穗子; 诧摩启辅 |
| 本发明涉及一种含硫不饱和羧酸酯，其含有一个含硫的取代基和至少两个经一个氧原子结合在仲或叔碳原子上的α，β-不饱和羧酸残基；一种含有含硫不饱和羧酸酯化合物的可聚合组合物；一种聚合该可聚合组合物制备的固化产品；一种由固化产品组成的光学元件；一种制备上述羧酸酯的新中间体化合物。 | ||||||
| 23 | 2－（二苯基甲基亚硫酰基）乙酰胺的合成方法 | CN200510049330.0 | 2005-03-10 | CN1721400A | 2006-01-18 | 裴文; 孙莉; 陶文伟 |
| 本发明涉及一种2－(二苯基甲基亚硫酰基)乙酰胺的合成方法，包括在离子液体中，先由二苯甲硫醇和氯乙酸酯反应制得式(I)化合物，再由式(I)化合物经氨解制得如式(II)的酰胺化合物，最后对酰胺化合物进行氧化得所述产物；所述的合成方法操作简单、收率高、对环境污染小。 | ||||||
| 24 | 含硫不饱和羧酸酯化合物及其应用 | CN00120123.9 | 2000-06-01 | CN1283614A | 2001-02-14 | 今井雅夫; 杉本贤一; 藤井谦一; 大迁淳夫; 大熊正; 高木正利; 铃木理穗子; 诧摩启辅 |
| 本发明涉及一种含硫不饱和羧酸酯,其含有一个含硫的取代基和至少两个经一个氧原子结合在仲或叔碳原子上的α,β－不饱和羧酸残基;一种含有含硫不饱和羧酸酯化合物的可聚合组合物;一种聚合该可聚合组合物制备的固化产品:一种由固化产品组成的光学元件;一种制备上述羧酸酯的新中间体化合物。 | ||||||
| 25 | 制备3-(甲硫基)丙醛的方法 | CN95194068.6 | 1995-07-06 | CN1152913A | 1997-06-25 | Y·C·苏; D·A·鲁斯特 |
| 一种连续制备3-(甲硫基)丙醛的方法。将液体反应介质与气态丙烯醛进料物流在气/液接触段接触。反应介质含3-甲硫基丙醛、甲基硫醇和用于甲基硫醇与丙烯醛反应的催化剂。气态丙烯醛进料物流含丙烯醛蒸汽和不凝气。丙烯醛从丙烯醛进料物流转移到反应介质中，并与甲基硫醇在反应介质中反应，生成含有3-甲硫基丙醇的液体反应产物。不凝气从液体反应产物中分出。将反应产物分成产品馏分和循环馏分，将循环馏分循环回气/液接触段。 | ||||||
| 26 | CYSTINE DIAMIDE ANALOGS FOR CYSTINURIA | PCT/US2020/064583 | 2020-12-11 | WO2021119475A1 | 2021-06-17 | HU, Longqin; ALBANYAN, Haifa |
This document discloses novel cystine analogs, methods of making cystine analogs, compositions containing cystine analogs and methods of using such analogs for inhibiting cystine stone formation and treatment of cystinuria. |
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| 27 | DICARBOXYLIC ACID COMPOUNDS. INORGANIC PARTICLES TREATED WITH THE DICARBOXYLIC ACID COMPOUNDS, AND COMPOSITIONS THEREOF | PCT/IB2020/058985 | 2020-09-25 | WO2021064530A1 | 2021-04-08 | ARMSTRONG, Paul B.; ANIM-ADDO, Jonathan A.; HUNT, Bryan V.; SCHWARTZ, Evan L. |
Described herein is a dicarboxylic acid compound of formula (I): Wherein: R3 comprises an aryl group, R2 is an alkylene group comprising 1 to 6 carbon atoms, n is 0 or 1, R1 is H or CH3, and X is S or NZ, wherein Z is H, an alkyl group comprising 1 to 4 carbon atoms or a phenyl group. Such compounds can be used to modify the surface of inorganic particles. These modified inorganic particles may then be advantageously used in polymerizable resins to increase the refractive index of the resulting composite, while enabling good flow properties of the polymerizable composition |
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| 28 | PROCESS FOR PRODUCING 2-HYDROXY-4-(METHYLTHIO)BUTYRATE COMPOUNDS AND INTERMEDIATES THEREOF | PCT/JP2007/064717 | 2007-07-20 | WO2008010609A1 | 2008-01-24 | HAGIYA, Koji |
A process for producing a 2-hydroxy-4-(methylthio)butyrate compound represented by the formula (2): wherein A is a hydrogen atom or a group represented by R-CH2-, wherein R is a hydrogen atom or an alkyl group, which comprises the step of : reacting 4-(methylthio)-2-oxo-1-butanol with oxygen and a compound represented by the formula (1) : wherein A is as defined above, in the presence of a copper compound. |
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| 29 | PESTICIDAL SUBSTITUTED THIOETHERS | PCT/EP2006/000476 | 2006-01-20 | WO2006079480A1 | 2006-08-03 | SCHNATTERER, Stefan; DOELLER, Uwe; MAIER, Michael; PETRY, Friederike; KNAUF, Werner; SEEGER, Karl |
The invention relates to the use of thioether derivatives of formula (I) wherein: R1 is an unsubstituted or substituted (C1-C6) alkyl, A is a divalent unit taken from the group CO, CR3(OR4), CR3(O-CO-R4), CR3(COOR4), C(=CR3R4), C(=CR3R4), C(=CR3-COOR4), C(=CR3-CN); X is an unsubstituted or substituted (C1-C3) alkylen, R2 is an unsubstituted or substituted (C1-C10) alkyl, (C3-C7) cycloalkyl, (C3-C7) cycloalkenyl, (C3-C7) cycloalkyl-(C1-C6) alkyl, (C3-C7) cycloalkenyl-(C1-C6) alkyl, (C2-C10) alkenyl, (C2-C10) alkinyl, (C6-C12)-aryl, heteroaryl, heterocyclyl, (C6-C12)-aryl-(C1-C3) alkyl, heteroaryl-(C1-C3) alkyl or heterocyclyl-(C1-C3) alkyl residue and wherein R1 , X and A may form a 3 to 10 membered cycloalkyl ring or a pesticidally acceptable salt thereof, for the control of pests, for controlling pests. |
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| 30 | Processes for preparing 3-arylsulfur hydroxamic acids | US09991143 | 2001-11-09 | US20020038037A1 | 2002-03-28 | Jeffrey Allen Campbell; Lawrence Emerson Fisher; Charles Alois Dvorak; Paul Leo McGrane |
| This invention provides processes for the preparation of a compound of Formula I: YnullC(nullO)nullC(R1)(R2)nullCH2nullS(O)nR3 wherein: Y is hydroxy or XONX, where each X is independently hydrogen, lower alkyl or lower acyl; R1 is hydrogen or lower alkyl; R2 is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, or R1 and R2 together with the carbon atom to which they are attached form a cycloalkyl or heterocyclo group; R3 is aryl; and n is 0, 1 or 2. The invention also provides novel aryl haloalkyl sulfide intermediates useful for the preparation of compounds of Formula I and novel methods of preparing aryl alkyl sulfides. | ||||||
| 31 | Use of a cationic amphipathic compound as a transfection agent, vaccine additive or drug | US750503 | 1997-03-03 | US6124270A | 2000-09-26 | Jean Haensler |
| A cationic amphipathic compound of formula (I), ##STR1## wherein A is a single bond, an NH--R' grouping or (a), wherein --R'-- is a straight or branched, optionally substituted, saturated or unsaturated C.sub.1-22 aliphatic chain optionally interrupted by one or more O, S or N heteroatoms and one or more saturated, unsaturated or aromatic carbocyclic or heterocyclic radicals; each of R.sub.1, R.sub.2 and R.sub.3, which are the same or different, is a higher acyl or alkyl grouping; each of R.sub.7, R.sub.8 and R.sub.9, which are the same or different, is a (CH.sub.2).sub.n alkylene radical where 1.ltoreq.N.ltoreq.6; each of R.sub.4, R.sub.5 and R.sub.6, which are the same or different, is a hydrogen atom or an optionally substituted C.sub.1-22 alkyl, alkenyl, alkynyl or acyl radical optionally interrupted by one or more heteroatoms selected from), S and N, or one or more saturated, unsaturated or aromatic carbocyclic or heterocyclic radicals, or else at least two of the groupings R.sub.4, R.sub.5 and R.sub.6, taken together with the nitrogen atom to which they are attached, form a quinuclidino, piperidino, pyrrolidino or morpholino grouping, and X is a non-toxic anion. For use as a drug, a transfection agent or an additive in a vaccine composition. | ||||||
| 32 | Perfluoroalkyl halides and derivatives | US794798 | 1997-02-04 | US6048952A | 2000-04-11 | Frederick E. Behr; Rudolf J. Dams; Johan E. DeWitte; Donald F. Hagen |
| Novel mixtures of perfluoroalkyl halides and derivatives thereof are described. These mixtures contain some compounds with a straight perfluoroalkyl group and some with a branched perfluoroalkyl group. Methods of preparation and use are also described. | ||||||
| 33 | Process for the preparation of 3-(methylthio) propanal | US102025 | 1998-06-22 | US06031138A | 2000-02-29 | Yung C. Hsu; Dennis A. Ruest |
| A process for the continuous preparation of 3-(methylthio)propanal. A liquid reaction medium is contacted with a gaseous acrolein feed stream in a gas/liquid contact zone. The reaction medium contains 3-(methylthio)propanal, methyl mercaptan and a catalyst for the reaction between methyl mercaptan and acrolein. The gaseous acrolein feed stream comprises acrolein vapor and non-condensable gas. Acrolein is transferred from the acrolein feed stream to the reaction medium and reacts with methyl mercaptan in that medium to produce a liquid reaction product containing 3-(methylthio)propanal. The non-condensable gas is separated from the liquid reaction product. The reaction product is divided into a product fraction and a circulating fraction, and the circulating fraction is recycled to the gas/liquid contact zone. | ||||||
| 34 | Acetic acid derivatives | US963413 | 1997-11-03 | US5973188A | 1999-10-26 | Leo Alig; Paul Hadvary; Marianne Hurzeler Muller; Marcel Muller; Beat Steiner; Thomas Weller |
| Acetic acid derivatives of the formula ##STR1## wherein L, M, T and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell--cell adhesion, and are manufactured by cleaving protecting groups in the corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitrites. | ||||||
| 35 | Adamantyl-substituted biaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | US757638 | 1996-12-02 | US5877342A | 1999-03-02 | Jean-Michel Bernardon; Bruno Charpentier |
| Novel pharmaceutically/cosmetically-active adamantyl-substituted biaromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a')-(f'): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders. | ||||||
| 36 | Carbamoylcarboxamides | US793447 | 1997-03-03 | US5847194A | 1998-12-08 | Frank Wetterich; Oliver Wagner; Karl Eicken; Eberhard Ammermann; Gisela Lorenz |
| Carbamoylcarboxamides of the general formula I ##STR1## and their salts (R.sup.1 is unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl or an unsubstituted or substituted nonaromatic carbo- or heterocycle; R.sup.2 is H or unhalogenated or halogenated alkyl or cycloalkyl; R.sup.3 is unsubstituted or substituted alkyl, cycloalkyl or phenylalkyl; R.sup.4 is H or one of the radicals R.sup.3 or R.sup.3 and R.sup.4, together with the C atom to which they are bonded, are an unsubstituted or substituted carbo- or heterocycle; R.sup.5 independently of these is one of the radicals R.sup.2 ; X independently of one another is hydrogen, unsubstituted or substituted alkyl and/or alkenyl; Y independently of one another and of these is one of the radicals X; p,q independently of one another are 0, 1 or 2; R.sup.6 is halogen, cyano, nitro or unsubstituted or substituted alkyl, alkoxy, alkylthio or an unsubstituted or substituted phenyl group bonded via oxygen or sulfur; r is 0, 1, 2 or 3), and compositions containing them, processes for preparation, and the use of the compounds I and the compositions are described. | ||||||
| 37 | Benzyloxy-substituted phenylglycinolamides | US833824 | 1997-04-10 | US5750783A | 1998-05-12 | Siegfried Goldmann; Ulrich Muller; Richard Connell; Hilmar Bischoff; Dirk Denzer; Rudi Grutzmann; Martin Beuck |
| Benzyloxy-substituted phenylglycinolamides are prepared by reaction of benzyloxy-substituted phenylacetic acids with phenylglycinols. The benzyloxy-substituted phenylglycinolamides are suitable as active compounds in medicaments, in particular in medicaments for the treatment of atherosclerosis. | ||||||
| 38 | Process for the preparation of 3-(methylthio)propanal | US73763 | 1993-06-08 | US5352837A | 1994-10-04 | Yung C. Hsu; Dennis A. Ruest |
| A process for the continuous preparation of 3-(methylthio)propanal. A liquid reaction medium is contacted with a gaseous acrolein feed stream in a gas/liquid contact zone. The reaction medium contains 3-(methylthio)propanal, methyl mercaptan and a catalyst for the reaction between methyl mercaptan and acrolein. The gaseous acrolein feed stream comprises acrolein vapor and non-condensable gas. Acrolein is transferred from the acrolein feed stream to the reaction medium and reacts with methyl mercaptan in that medium to produce a liquid reaction product containing 3-(methylthio)propanal. The non-condensable gas is separated from the liquid reaction product. The reaction product is divided into a product fraction and a circulating fraction, and the circulating fraction is recycled to the gas/liquid contact zone. | ||||||
| 39 | Combination heat stabilizer/lubricant for PVC processing and method for producing the same | US57724 | 1993-05-05 | US5332772A | 1994-07-26 | George F. Beekman; Lionel R. Price; Keith A. Mesch |
| The preparation of a zinc mercaptoacid ester by the reaction of zinc oxide with the mercaptoacid ester in a wax matrix provides an improved heat stabilizer for halogen-containing polymer compositions. The process obviates the necessity of isolating and transporting the normally very viscous zinc mercaptoacid esters. The zinc mercaptoacid ester/wax matrix is also an expedient medium for the preparation and utilization of calcium stearate as a lubricant in the heat stabilizer composition and the stabilized polymer composition containing it. A paraffin wax is the preferred matrix for the preparation and use of the heat stabilizer and lubricant. | ||||||
| 40 | Compounds for inhibition of protein methylation | US685597 | 1991-04-15 | US5202456A | 1993-04-13 | Robert R. Rando |
| The invention features a compound of the formulaW-Y-Q-Z or W-Y-ZwhereinW is a farnesyl group, a geranylgeranyl group, a substituted farnesyl group or a substituted geranylgeranyl group; ##STR1## wherein n=1, 2, 3, 4, 5, or 6; each of T.sub.1' . . . T.sub.n' and T.sub.1" . . . T.sub.n" is independently: Fl, Br, --NHCOCH.sub.3, --NH.sub.2, a peptide, an alkane group, an alkene group, an polyethyleneglycol group, a saturated fatty acid, an unsaturated fatty acid, a monosaccharide, or a disaccharide; andZ is --COOH or salts or esters thereof, --CONH.sub.2, --NO.sub.2, --PO.sub.3 or salts or esters thereof, --C N, or --SO.sub.3 or salts or esters thereof, provided that when W is farnesyl, Y is --S--, n=2, and either T.sub.2' or T.sub.2" is --NHCOCH.sub.3, then Z is not --COOH.The compounds of the invention are capable of interfering with enzymatic methylation of a peptide having the carboxyl-terminal motif --CAAX wherein C=cysteine, A=aliphatic amino acid, and X=any amino acid. | ||||||
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