子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | Chiral compound | JP24114098 | 1998-08-13 | JP4452338B2 | 2010-04-21 | ルイーズ・ファランド |
| 162 | 2- and 2,5-substituted phenylketoenols | JP2008202324 | 2008-08-05 | JP2009079035A | 2009-04-16 | LIEB FOLKER; FISCHER REINER; BRETSCHNEIDER THOMAS; RUTHER MICHAEL; GRAFF ALAN; SCHNEIDER UDO; ERDELEN CHRISTOPH; WACHENDORF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; TURBERG ANDREAS |
| <P>PROBLEM TO BE SOLVED: To provide compounds which are 1-H-3-aryl-2,4-dione derivatives and are highly active against plant pests. <P>SOLUTION: Provided are compounds of formula (I') (wherein X is chlorine, bromine, or methyl; Z is chlorine or methyl; and A and B are each a 1-8C alkyl, a 2-4C alkenyl, a (1-6C)alkoxy(1-4C)alkyl, a poly(1-4C)alkoxy(1-4C)alkyl, or a (1-6C)alkylthio(1-4C)alkyl, or a like group, provided that A and B may be combined with each other to form a ring). <P>COPYRIGHT: (C)2009,JPO&INPIT | ||||||
| 163 | A novel amino acid derivative, its production method, its application to the treatment | JP18774894 | 1994-07-18 | JP3584496B2 | 2004-11-04 | リュッソン クリストフ; グロ クロード; シュワルツ ジャン−シャルル; ルコント ジャンヌ−マリー; モンテル ティエリ; ダンヴィ ドゥニ; ノエル ナディーヌ; デュアメル ピエール; デュアメル リュセット |
| 164 | 3- (Het) arylcarboxylic acid derivatives, their preparation and intermediates therefor | JP52140894 | 1994-04-13 | JP3483254B2 | 2004-01-06 | ヴァルター，ヘルムート; ヴェストファレン，カール−オットー; ゲルバー，マティアス; テーオバルト，ハンス; バウマン，エルンスト; フォーゲルバッハー，ウヴェ、ヨーゼフ; ブラッツ，マティアス; ラーデマハー，ヴィルヘルム; ラインハイマー，ヨーアヒム |
| 165 | Preparation of 10-Death acetoxymethyl baccatin iii | JP51632994 | 1994-01-14 | JP3431155B2 | 2003-07-28 | ソモサ、カーメン; チャイ、キ‐ビュン; ホルトン、ロバート・エイ |
| 166 | Metal protease inhibitor | JP51941795 | 1995-01-20 | JP3297053B2 | 2002-07-02 | マーク ウィッタカー; レイモンド ポール ベケット; フィオンナ ミッチェル マーティン; アンドリュー ミラー |
| 167 | Hydroxamic acid derivative compound, method for producing the same and medicament with the same as active ingredient | JP2000288615 | 2000-09-22 | JP2002080445A | 2002-03-19 | KONNO YOSHITOSHI; SAKAKI KATSUTO; NAKA MASAO; KONISHI MIKIO; KISHIMOTO CHUZO |
| PROBLEM TO BE SOLVED: To provide a compound capable of inhibiting IL-6 production and useful as a prophylactic and/or therapeutic agent for various inflammatory diseases, septicemia, multiple myeloma, plasmacytic leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi sarcoma, chronic articular rheumatism, hypergammaglobulinemia, Castleman's disease, intra-atrial myxoma, diabetes, autoimmune diseases, hepatitis, colitis, graft-versus-host diseases, infectious diseases and endometriosis. SOLUTION: This compound is a hydroxamic acid derivative of the formula (1) ( the respective meanings of symbols are as described in the specification), a nontoxic salt thereof or a prodrug form thereof. COPYRIGHT: (C)2002,JPO | ||||||
| 168 | Long acting, chemically resistant skin emollients, moisturizers, and reinforcing agents | JP2000523966 | 1998-09-10 | JP2001525353A | 2001-12-11 | カーメン チョウ; ローズマリー エフ． ハートマン; キャスリン エム． ローズ; ケー．ダニエル ローズ; セス ディー． ローズ |
| (57)【要約】 本発明は、２部分分子である化合物およびそのような化合物を含む組成物に関し、２部分分子の一方の部分は、皮膚に共有結合するようにデザインされ(結合剤)、他方の部分(特性用途剤)は、幾つかの特性用途、例えば、エモリエント性、モイスチャライジング効果、抗アクネ、抗シワ、抗疼痛、抗菌、殺真菌、抗ウイルス、抗刺激、皮膚日焼けおよび皮膚明化効果、皮膚の長時間保護(例えば、日焼け止め成分の混入により紫外線から；毒性および／または刺激性物質から；殺虫剤および／または昆虫忌避剤の混入により昆虫および皮膚寄生虫から；抗酸化剤の混入により加齢におけるようなフリーラジカルまたは他の物質から)、または頭髪、皮膚、爪、羊毛もしくは毛皮の染色を付与するようにデザインされている。 共有結合された部分は、(例えば、剪断力からの)皮膚強化効果を付与するのに、または創傷治癒剤として有用でもあり得る。 | ||||||
| 169 | O- benzyl - oxime ether and fungicides containing said compound | JP15656091 | 1991-06-27 | JP3009505B2 | 2000-02-14 | アルブレヒト、ハロイス; ウヴェ、カルドルフ; エーバーハルト、アマーマン; ギーゼラ、ロレンツ; クラウス、オーベルドルフ; クリストフ、キュナスト; ズィークベルト、ブラント; フーベルト、ザウター; ブラント、ミュラー; ラインハルト、キルストゲン |
| 170 | Production of stabilized and deodorized organic polysulfide | JP827199 | 1999-01-14 | JPH11279142A | 1999-10-12 | DEVAUX JEAN-FRANCOIS; FREMY GEORGES; LABAT YVES |
| PROBLEM TO BE SOLVED: To produce the subject compound without using a reactant having strong toxicity and without requiring the employment or distillation of a solvent or a phase-mixing agent by treating a crude organic polysulfide with an alkylene carbonate in the presence of a basic catalyst. SOLUTION: This method for producing a stabilized and deodorized organic polysulfide comprises treating a crude organic polysulfide with an alkylene carbonate {a compound of the formula [(n) is 0-2; R 1-R 4 are each H or an alkyl], concretely, ethylene carbonate, propylene carbonate, butylene carbonate, trimethylene carbonate or the like} in the presence of a basic catalyst (for example, a combination of mercaptan, an alkylene oxide and an alkaline base, an anion exchange resin, etc.), preferably in the coexistence of a sulfur-donor. The weight ratio of the alkylene carbonate: the crude polysulfide is 0.001:1 to 0.2:1, preferably 0.005:1 to 0.1:1. The treatment method preferably comprises adding the alkylene carbonate and the basic catalyst to the crude polysulfide and subsequently stirring the mixture at about 15-150°C for 2 min to 10 hr. COPYRIGHT: (C)1999,JPO | ||||||
| 171 | Phthalic acid diamide derivative, agricultural and horticultural insecticide and its use | JP35076898 | 1998-11-25 | JPH11240857A | 1999-09-07 | TONISHI MASANORI; NAKAO ISAMI; KONO EIJI; NISHIDA TATSUKI; FURUYA TAKASHI; SHIMIZU HISAAKI; SEO AKIRA; SAKATA KAZUYUKI; FUJIOKA NOBUSUKE; SUGANO HIDEO |
| PROBLEM TO BE SOLVED: To obtain the subject new compound useful as an agricultural and horticultural insecticide. SOLUTION: This compound is shown by formula I [R<1> to R<3> are each H, cyano, a 3-6C cycloalkyl, a halo 3-6C cycloalkyl, a 3-6C cycloalkenyl, a halo 3-6C cycloalkenyl or the like; X is H, a halogen, cyano, nitro, a 3-6C cycloalkyl, a halo 3-6C cycloalkyl or the like; (n) is l-4; Y is H, a halogen, cyano, nitro, a 3-6C cycloalkyl, a halo 3-6C cycloalkyl or the like; (m) is 1-5; Z<1> and Z<2> are each O or S]. The compound of formula I is obtained, for example, in the case in which R<3> is H, Z<1> and Z<2> are each O, by reacting a compound of formula II with a compound of formula III in an inert solvent (e.g. benzene or the like) to give a compound of formula IV and reacting the compound of formula IV with a compound of the formula R<1> (R<2> )NH at a room temperature to the reflux temperature of the solvent for several minutes to 48 hours to give a compound of formula V. | ||||||
| 172 | Pentaerythritol derivative and its use as lubricant additive | JP27383398 | 1998-09-28 | JPH11158482A | 1999-06-15 | FRANCISCO MANUEL A; PUCKACE JAMES S; CAMERON STEPHEN D; POLIZZOTTI RICHARD SAMUEL |
| PROBLEM TO BE SOLVED: To improve the oxidation resistance of a lubricating oil by using an oil-soluble antioxidant comprising an oil-soluble mercapto deriv. having an enough sulfur density and an unstable S-C bond. SOLUTION: 0.05-20 wt.% oil-soluble antioxidant comprising a mercapto deriv. of formula I and 75-99.5 wt.% lubricating oil are incorporated into a lubricating oil compsn. In formula I, EWG 1 and EWG 2 are each an electron- attractive group such as a nitro, nitrile, or ketone group and it is pref. a carboxyl group, giving a compd. of formula II. In formula II, R 1 and R 2 are each H or a 1-36C hydrocarbyl; b is 0 or 1; and A is an alkane, alkyne, alkene (e.g. CH 2CH 2 or CH 2), or arom. group or the like. This thiol deriv. is prepd. by heating a mixture of maleic anhydride and an alcohol source to a temp. higher than the m.p. of maleic anhydride, then reacting the mixture with a thiol source (e.g. n-propylmercaptan) and a non-nucleophilic base (e.g. triethylamine), and adding a free-radical initiator to the resultant product to complete the reaction. COPYRIGHT: (C)1999,JPO | ||||||
| 173 | Substituted benzoic acid derivatives, their production and use of the compounds on therapy of disease | JP17517097 | 1997-06-17 | JPH10182551A | 1998-07-07 | HEMMERLE HORST DR; HENKE STEPHAN; BELOW PETER; BURGER HANS-JOERG; HERLING ANDREAS; JAEHNE GERHARD |
| PROBLEM TO BE SOLVED: To obtain the subject new compound especially useful for treating II type diabetes as a glucose-6-phosphatase system inhibitor. SOLUTION: A compound of formula I (R 1 is a 1-10C alkyl, a 2-10C alkenul, an alkinyl, a 6-12C aryl, a 1-10C alkyl-(6-12C) aryl, etc.; R 2 is a 1-10C alkyl, a 2-10C alkenyl, an alkinyl, a 1-9C heteroaryl, a 1-10C alkanoyl, etc.; R 4 is H, a 1-10C alkyl, etc.,). The compound of formula I is obtained by producing a compound of formula III (R a is phenyl, tolyl, alkyl, pyridyl) from 5-nitro-2- iodobenzoic acid of formula II as a starting substance through four processes and subsequently subjecting the compound of formula III to an alkaline hydrolysis reaction. The compound of formula I is contained as an active ingredient in a pharmaceutical preparation in an amount of 0.1-95wt.%, and administered at a daily dose of 10-500mg per 75kg of a body. COPYRIGHT: (C)1998,JPO | ||||||
| 174 | 3- (methylthio) propanal method of manufacturing | JP50440596 | 1995-07-06 | JPH10504812A | 1998-05-12 | シー． シュー，ユン; エイ． リュースト，デニス |
| (57)【要約】 ３−（メチルチオ）プロパナールの連続製造方法。 液体反応媒体を、気／液接触域においてガス状アクロレイン供給流に接触させる。 反応媒体は、３−（メチルチオ）プロパナール、メチルメルカプタン及びアクロレインとメチルメルカプタンとの間で反応させるための触媒を含有する。 ガス状アクロレイン供給流は、アクロレイン蒸気及び非凝縮性ガスを含む。 アクロレインは、供給流から反応媒体に移され、その媒体中のメチルメルカプタンと直接反応して３−（メチルチオ）プロパナールを含有する液体反応生成物を生成する。 非凝縮性ガスを液体反応生成物から分離する。 反応生成物を生成物フラクションと循環フラクションとに分割し、循環フラクションを気／液接触域に循環させる。 | ||||||
| 175 | Transfection agent, the use of cationic amphiphilic compounds as vaccine adjuvant or pharmaceutical | JP53077296 | 1996-04-11 | JPH10501822A | 1998-02-17 | アエンスレ，ジャン |
| (57)【要約】 一般式Ｉ： 式中、−Ａ−は、単結合、ＮＨ−Ｒ'基、−ＮＨ−ＣＯ−Ｒ'−基(Ｒ'は、炭素数１から２２の脂肪族基で、直鎖または分枝で、置換されていることもあり、飽和または不飽和で、１または複数のＯ、Ｓ、Ｎのヘテロ原子で中断され、例えば、１または複数の飽和または不飽和の炭素環または異項環または芳香族基で中断されていることもある）−Ｒ 1 、Ｒ 2 、Ｒ 3は、同一または異なって、アルキルまたは高級アシル基を示す。 −Ｒ 7 、Ｒ 8 、Ｒ 9は、同一または異なって、アルキレン−(ＣＨ 2 ) n −、１≦ｎ≦６を示す。 −Ｒ 4 、Ｒ 5 、Ｒ 6は、同一または異なって、・水素原子・炭素数１から２２のアルキル、アルケニル、アルキニルまたはアシル基（これらは置換されていることもあり、１または複数のＯ、Ｓ、Ｎのヘテロ原子で中断され、例えば、１または複数の飽和または不飽和の炭素環または異項環または芳香族基で中断されていることもある）・Ｒ 4 、Ｒ 5およびＲ 6基の少なくとも２つは、その結合する窒素原子と共に、キヌクリジノ、ピペリジノ、ピロリジノまたはモルホリノ基を形成する・Ｘは非毒性アニオンであるのカチオン性両親媒性化合物。 薬剤として、トランスフェクション剤として、ワクチン組成物の添加剤として使用。 | ||||||
| 176 | Reversible thermosensitive color developing composition and reversible recording medium using it | JP12929896 | 1996-04-26 | JPH09327971A | 1997-12-22 | TORII MASASHI; FURUYA HIROMI; SHIMADA MASARU; TSUTSUI KYOJI |
| PROBLEM TO BE SOLVED: To obtain a reversible thermosensitive color developing composition holding stable color developability and discoloring properties, dealing with wide using and environmental conditions and particularly having rapid erasability by mixing an electron donative coloring compound with electron receptive compound represented by a specific general formula. SOLUTION: A reversible thermosensitive color developing composition is prepared by mixing with electron donative coloring compound and electron receptive compound of carboxylic acid compound represented by a formula I [is integer of 1 to 3, R 1 is hydroxyl group, alkyl group, alkoxy group, halogen atom, or hydrogen atom, R 2 is aliphatic hydrocarbon group having number of carbon atoms of 8 or more, X is a group represented by formula II (p, q are integers of 0 or 1, A is bivalent aliphatic hydrocarbon group, B is a bivalent aromatic group which may have a substituent, or an aliphatic group, and Y, Z are bivalent groups including at least one hetero atom.)]. A recording layer containing this coloring composition is provided on a support to form a reversible thermosensitive recording medium. COPYRIGHT: (C)1997,JPO | ||||||
| 177 | Heat stabilizer/lubricant for processing pvc and its production | JP1517297 | 1997-01-29 | JPH09227742A | 1997-09-02 | JIYOOJI EFU BIIKUMAN; RAIONERU AARU PURAISU; KIISU EE METSUSHIYU |
| PROBLEM TO BE SOLVED: To obtain a thermal stabilizer/lubricant for processing PVC, low in viscosity and giving a good extrusion characteristic, and to provide the same. SOLUTION: This method for producing a zinc mercapto ester stabilizer composition comprises heating the mixture of zinc oxide with a mercapto ester of the formula: HS-[CH 2C(=O)OR] x-(CH 2) y-C(=O)OR] [R is a 1-20C linear or branched saturated or unsaturated alkyl group; (x) is 0 or 1; (y) is 1 or 2; wherein when (x) is 1, (y) is 1] and a paraffin wax up to at least the melting point of the wax and removing the produced water. COPYRIGHT: (C)1997,JPO | ||||||
| 178 | Metal protease inhibitor | JP51941795 | 1995-01-20 | JPH09508361A | 1997-08-26 | マーク ウィッタカー; レイモンド ポール ベケット; フィオンナ ミッチェル マーティン; アンドリュー ミラー |
| (57)【要約】 式中、Ｘが-ＣＯ 2 Ｈ又は-ＣＯＮＨＯＨ基であり；Ｒ 4がフエニル又は5-又は6-員のヘテロアリール環（式中、いずれかの環の窒素原子は、ベンゼン環又は5-、6-又は7-員の複素環式環に任意に縮合されていてもよいＮ-オキシドとして酸化されていてもよく、環のいずれもが任意に置換されていてもよい）である式（Ｉ）のマトリックス金属タンパク質分解酵素阻害化合物。 | ||||||
| 179 | Benzoic acid derivative and phospholipase a2 inhibitor containing the same | JP7419696 | 1996-03-28 | JPH08325154A | 1996-12-10 | YAMASHITA HIROYUKI; OKUMURA KUNIO; MIZOGAMI KENJI; YODA HIROE; FUKAZAWA NOBUYUKI; OOTSUKA KENGO; KAWAMO HIROSHI; KOKUBU YUICHIRO |
| PURPOSE: To obtain a benzoic acid derivative which has strong inhibitory action against PLA2 type I and type II, and is useful as a preventive and/or therapeutic agent for inflammatory diseases such as pancreatitis, rheumatism, allergy, ischemic angiopathy, bronchitic asthma or ulcers and an PLA2 inhibitor. CONSTITUTION: The objective compound is represented by formula I (X is O, S; R1 is H, a lower alkyl; R2 is a 10-30C alkyl; R3 -R6 are each H, hydroxy group, nitro, amino, cyano, a lower alkylamino), for example, 2-(pentadecyloxy) benzoic acid. A benzoic acid derivative of formula II (X is O, S; R9 is H, lower alkyl; R10 is a 10-30C alkyl; R11 and R12 are each H, nitro, amino, a lower alkylsulfonyl-amino) is an unknown compound among the derivatives of formula I. The compound of formula I or formula II is obtained by adding a compound of the formula: R2 -OH, then triphenylphosphine to a compound of formula III, dissolving or suspending them in a solvent and dropping a diethyl azodicarboxylate to effect the reactions. | ||||||
| 180 | Substances as amine imide-containing molecules and molecular recognition agent | JP50340094 | 1993-06-30 | JPH08500339A | 1996-01-16 | シー．ジュニア ホーガン，ジョセフ |
| (57)【要約】 新規なアミンイミドをベースとした分子モジュールの設計および合成、ならびに新たな分子および機能性素材の構築における該モジュールの使用を開示する。 新たな分子および機能性素材は薬剤の設計および合成において有用な分子認識剤であり、分離および材料科学の分野で使用される。 | ||||||
QQ群二维码
意见反馈
意见反馈