The present invention relates to a compound represented by the following formula (1): [wherein, X¹ represents a carboxyl group which may be esterified or the like group;

• Y¹ represents a single bond, -O- or -N(R¹)-;
• at least one of A¹, A² and A³ is a group represented by the following formula (2): $${\text{-R}}^{\text{2}}{\text{-a}}^{\text{1}}{\text{-R}}^{\text{3}}{\text{-a}}^{\text{2}}\text{→}$${wherein, R² represents a divalent C_2-12 hydrocarbon group, R³ represents a single bond or a divalent C_1-12 hydrocarbon group, a¹ and a² individually represent a single bond, -S-, -SO-, -SO₂-, -SO₂NH-, -O-, -N(R⁴)-, -CON(R⁵)-, -C(=O)- or - Si(R⁶)(R⁷)- and → means bonding with Q¹, Q² or Q³}, the remaining one or two of A¹, A² and A³ are the same or different and each independently represents a group represented by the following formula (3): $${\text{-R}}^{\text{8}}{\text{-a}}^{\text{3}}{\text{-R}}^{\text{9}}{\text{-a}}^{\text{4}}\text{→}$${wherein, R⁸ and R⁹ individually represent a single bond or a divalent C_1-12 hydrocarbon group, a³ and a⁴ individually represent a single bond, -S-, -SO-, -SO₂-, -SO₂NH-, -O-, - N(R¹⁰)-, -CON(R¹¹)-, -C(=O)- or -SI(R¹²)(R¹³)- and → means bonding with Q¹, Q² or Q³},;
• at least one of Q¹, Q² and Q³ represents a cyclic hydrocarbon group or heterocyclic group and the remaining one or two of Q¹, Q² and Q³ individually represent a hydrogen atom, a carboxyl group which may be esterified, a hydrocarbon group or a heterocyclic group] or salt thereof; and a pharmaceutical comprising the same as an effective ingredient. The compound exhibits strong squalene synthetase inhibitory action and is therefore useful as a pharmaceutical for the treatment·prevention of hypercholesterolemia, hyperlipemia or arteriosclerosis.

Verfahren zur Schwefelung von ungesättigten Fettalkoholen mit Schwefel und gegebenenfalls Schwefelwasserstoff bei erhöhter Temperatur und gegebenenfalls in Anwesenheit eines Katalysators und die Verwendung des Schwefelungsprodukts zur Herstellung von Schmiermitteln.

Phosphoramidites of the formula

   where R is a base-labile protecting group, R¹ and R² are individually alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, or aryl of 6 to 20 carbon atoms or are joined together to form with the nitrogen atom a cyclic structure of 4-7 carbon atoms and 0 to 1 annular chalcogen atoms of atomic number 8 to 16, G is a hydrocarbylene group of 1 to 20 carbon atoms and Z is a hydroxy-protected vicinal diol group bound to G by one of the vicinal diol carbon atoms or a disulfide group and bound to G by one of the sulfur atoms of the disulfide group, with the proviso that G is of at least 4 carbon atoms when Z is said disulfide group are used in conventional automated oligonucleotide synthesis to introduce a functional aldehyde or thiol group on the 5′ end of the oligonucleotide to thereby provide a reactive site on the oligonucleotide that may be used to conjugate the oligonucleotide to molecules that contain a free amino group or an electrophilic center reactive with a thiol group.

A sulfur-containing acryl oligomer composition represented by formula (I): wherein R₁ represents a hydrogen atom or a methyl group; R₂ and R₃ each represents an alkylene group having from 1 to 12 carbon atoms; R₄ represents an alkylene group having from 1 to 12 carbon atoms, an oxydialkylene group having from 2 to 12 carbon atoms, or an aralkylene group having from 6 to 20 carbon atoms; X represents a chlorine, bromine or iodine atom; m represents 0 or an integer of from 1 to 4; and n represents an average degree of oligomerization of 10 or smaller.

The oligomer composition provides on polymerization a cured product having a refractive indices of 1.60 or higher, excellent transparency, and optical uniformity and is therefore useful as a material for plastic lenses.