子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | Nitroethane derivative, production thereof and insecticide | JP20124390 | 1990-07-31 | JPH03204848A | 1991-09-06 | ISHIMITSU KEIICHI; SUZUKI JUNJI; OISHI HARUHITO; YAMADA TOMIO; HATANO RENPEI; TAKAKUSA NOBUO |
| NEW MATERIAL:Compounds of formula I (R 1 and R 2 are halogen; Formula II is formula III or IV; X is alkylene which may be substituted, hetero atom or single bond; R 3 is heterocycle or phenyl which may be substituted; R 4, R 5, R 6 are alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, etc., which may be substituted and R 5 and R 6 may be H or form ring which may contain more hetero atom) and salts thereof. EXAMPLE: N-(2-chloro-5-pyridylmethyl)-N'-methyl-dichloronitroacetamidine. USE: An insecticide having an excellent insecticidal action not only for sensitive- group insect pests but for organophosphorous and carbamate-resistant group insect pests. PREPARATION: A compound of formula V or VI is reacted with a halogenation agent to obtain the objective compound of formula I. COPYRIGHT: (C)1991,JPO&Japio | ||||||
| 22 | Imino((3-fluorophenyl)amino)acetic acid derivative and herbicide | JP16771788 | 1988-07-07 | JPH0219353A | 1990-01-23 | SUGIYAMA YUICHI; ISONO TAKU; NAKAMURA YUKIHIRO; TAKAIWA AKIHIRO; KOMATSUBARA KENICHI |
| NEW MATERIAL:The compound of formula I (X 1-X 4 are H, halogen or methyl; R is H or lower alkyl). USE: A herbicide exhibiting excellent herbicidal effect especially against paddy field weeds such as water chestnut, flatstage, cockspur-grass and bulrush and free from phytotoxicity to paddy rice plant. It also exhibits excellent effect against cockspur-grass of 3-leaved stage. PREPARATION: The compound of formula I having the form of an alkyl ester derivative can be produced by reacting an amine of formula II with a compound of formula III and neutralizing the product. The hydrolysis of the obtained compound of formula I gives another compound of formula I wherein R is H. The starting compound of formula III can be produced by reacting H 2NC(S)C (O)OR' with a Meerwein reagent (triethyloxonium tetrafluoroborate) in methylene chloride. COPYRIGHT: (C)1990,JPO&Japio | ||||||
| 23 | JPS60502204A - | JP50273684 | 1984-07-06 | JPS60502204A | 1985-12-19 | |
| 24 | Zz22acylaminoo33monosubstituted propenoate | JP9335079 | 1979-07-24 | JPS5540669A | 1980-03-22 | DONARUDO DABURIYU GURAHAMU; EDOWAADO EFU ROJIYAASU; FUREDERITSUKU EMU KEEHAN |
| 25 | Antithrombotic agent | JP52300795 | 1995-03-03 | JP4081138B2 | 2008-04-23 | シャハト，アロン・リー; シューマン，ロバート・セオドア; スミス，ジェラルド・フロイド; ワイリー，マイケル・ロバート |
| 26 | Compounds having a selectivity for retinoid x receptor | JP51870893 | 1993-04-22 | JP3727334B2 | 2005-12-14 | ジ，リン; ヘイマン，リチャード・エイ; ベーム，マーカス・エフ |
| 27 | N-aryl hydrazine derivative as insecticide and acaricide | JP2005134574 | 2005-05-02 | JP2005263809A | 2005-09-29 | FURCH JOSEPH A; KUHN DAVID GEORGE; HUNT DAVID ALLEN; LEW ALBERT CHIEH; GRONOSTAJSKI CYNTHIA EMMA |
| PROBLEM TO BE SOLVED: To provide a method for protecting important agronomic crops from harmful and damaging action caused by noxious organisms of insects and ticks. SOLUTION: The N-aryl hydrazine derivative is represented by formula I [for example, 2,2-dimethyl propionic acid and 2-(2,6-dichloro-α,α,α-trifluoro-P-tolyl)hydrazido]. This compound controls noxious organisms of insects and ticks and is effective for preventing damage and loss caused by the noxious organisms. COPYRIGHT: (C)2005,JPO&NCIPI | ||||||
| 28 | Aminoalkylbenzene compound | JP2001158596 | 2001-05-28 | JP2002047264A | 2002-02-12 | ANTONSSON KARL THOMAS; BYLUND RUTH ELVY; GUSTAFSSON NILS DAVID; NILSSON NILS OLOV INGEMAR |
| PROBLEM TO BE SOLVED: To provide an intermediate for synthesis of serine protease inhibitor and a method for producing the same. SOLUTION: In order to produce a compound represented by general formula (I) [W1 is a protecting group for N-terminus; A2 represents structural fragments of formulas IIIa, IIIb or IIIc (wherein (p) is an integer of 0-2; (m) is an integer of 1-4; Y is methylene or the like; R3 is a 1-4C alkyl or the like; R5 is H or a 1-4C alkyl), (n) is an integer of 0-4; and Q1 is a protected amidino group or the like], an N-terminus-protected amino acid represented by the general formula: W1-A2-OH (W1 and A2 are defined as stated above) is allowed to react with a compound represented by general formula (II) (wherein (n) and Q1 are defined as stated above). | ||||||
| 29 | New peptide derivatives | JP50166595 | 1994-06-02 | JP3205558B2 | 2001-09-04 | アントンソン，カール・トーマス; グスタヴソン，ニルス・ダーヴイツド; ニルソン，ニルス・オーロヴ・インゲマル; ビユルンド，ルート・エルヴユー |
| 30 | β- sulfonamide hydroxamic acid as inhibitors for matrix metal Purotenaize and TACE | JP51842498 | 1997-10-08 | JP2001502326A | 2001-02-20 | グ，ヤンソン; ザスク，アリー; レビン，ジェレミー・イアン |
| (57)【要約】 本発明は、マトリクス金属プロテイナーゼ(例えば、ゼラチナーゼ、ストロメリシンおよびコラゲナーゼ)およびＴＮＦ-α変換酵素(ＴＡＣＥ、腫瘍壊死因子-α変換酵素)に対する新規な低分子量非ペプチド系阻害薬の発見に関する。 かかる阻害薬は、これらの酵素が関係している疾患、例えば、関節炎、腫瘍の増殖や転移、血管形成、組織潰瘍、異常創傷治癒、歯周疾患、骨疾患、蛋白尿、大動脈瘤、外傷性関節損傷後の変性軟骨減少、神経系の脱髄疾患、移植後拒絶反応、液液質、食欲不振、炎症、発熱、インスリン抵抗性、敗血症性ショック、うっ血性心不全、中枢神経系の炎症性疾患、炎症性腸疾患、ＨＩＶ感染症、老人性黄斑変性症、糖尿病性網膜症、増殖性硝子体網膜症、未熟児網膜症、眼炎、円錐角膜、シューグレン症候群、近視、眼腫、眼の血管形成/血管新生などの治療に有用である。 ＴＡＣＥおよびＭＭＰを阻害する本発明のオルト-スルホンアミドアリールヒドロキサム酸は、式(１)： ［式中、ヒドロキサム酸部分およびスルホンアミド部分は、Ａ基の隣接炭素に結合している；ここで、Ａは、Ｎ、ＯおよびＳから独立して選択される１〜２個のヘテロ原子を有し、また、所望によりＲ 1 、Ｒ 2 、Ｒ 3およびＲ 4で置換されていてもよい、非芳香族ヘテロ環系の単環式５〜７員環；０〜２個の二重結合を有し、また、所望によりＲ 1 、Ｒ 2 、Ｒ 3およびＲ 4で置換されていてもよい、-Ｃ 3 -Ｃ 7 -シクロアルキル；あるいは、-ＣＨＲ 5 ＝ＣＨＲ 6 -であり；Ｚ、Ｒ 1 、Ｒ 2 、Ｒ 3 、Ｒ 4 、Ｒ 5 、Ｒ 6 、Ｒ 7 、Ｒ 8およびＲ 9は、明細書に記載されている］で示され、また、その医薬上許容される塩、ならびにその光学異性体およびジアステレオマーである。 | ||||||
| 31 | Nitroethane derivative, its production method and insecticide | JP20124390 | 1990-07-31 | JP2836215B2 | 1998-12-14 | ISHIMITSU KEIICHI; SUZUKI JUNJI; OOISHI HARUHITO; YAMADA TOMIO; HATANO RENPEI; TAKAKUSA NOBUO |
| 32 | Amidine derivatives having a nitric oxide synthase activity | JP50681495 | 1994-08-12 | JPH09501918A | 1997-02-25 | シエイクスピア，ウイリアム・カルビン; ジエンテイーレ，ロバート・ジエイムズ; マクドナルド，ジエイムズ・エドウイン; マリー，ロバート・ジヨン |
| (57)【要約】 式(Ｉ) 〔式中、Ｄはフェニル、ピリジニルまたはＯ、ＳおよびＮから選択されるヘテロ原子１〜４個を有する５員複素環式芳香環であり、これら３つの基し場合によりC 1〜6アルキル、C 1〜6アルコキシ、ハロゲンおよびC 1〜6パーフルオロアルキルから選択される基１つ以上で置換されているか；またはC 1〜6パーフルオロアルキルであり；R 1は水素、C 1〜6アルキルまたはハロゲンであり；R 2は-X(CH 2 ) n ZCONR 3 R 4 、-X(CH 2 ) n NHCO(CH 2 ) s NR 3 R 4 、-X(CH 2 ) p NR 3 R 4 、-X(CH 2 ) n NHCOR 5または-(CH 2 ) q NHC(NH)R 6であり；そしてＸ、Ｚ、R 3 、R 4 、R 5 、R 6 、ｎ、ｓ、ｐおよびｑは明細書において定義するものである〕の化合物、並びにその調製方法、およびそれらを含有する組成物を記載する。 式(Ｉ)の化合物は酸化窒素合成酵素阻害作用を有する。 | ||||||
| 33 | Optically active amines, optically active imines and their production | JP5109395 | 1995-03-10 | JPH08245526A | 1996-09-24 | SAKAI TAKASHI; UNEYAMA KENJI |
| PURPOSE: To obtain optically active new amines or imines having C 2 symmetry functioning as asymmetric sources of important highly selective asymmetric synthesis in synthesis of intermediates for medicines or agrochemicals. CONSTITUTION: This compound is expressed by formula I or II (R 1 and R 2 are each H, an alkyl, an alkoxy, a halogen or trifluoromethyl; * is an asymmetric carbon atom), e.g. N-(2,2,2-trifluoro-1-phenylethylidene)-2,2,2-trifluoro-1- phenylethanamine. Furthermore, the imines of formula II are obtained by reacting ketones of formula III with amines of formula IV in the presence of a catalyst such as titanium tetrachloride and the amines of formula I are obtained by reducing the imines of formula II. COPYRIGHT: (C)1996,JPO | ||||||
| 34 | Imino((3-chloro-2-methylphenyl)amino) acetic acid derivative herbicide | JP16679888 | 1988-07-06 | JPH0217103A | 1990-01-22 | SUGIYAMA YUICHI; ISONO TAKU; NAKAMURA YUKIHIRO |
| PURPOSE: To provide a herbicide capable of controlling Eleocharis Kuroguwai and Cyperus serotinus without giving any chemical damage against paddy rice and exhibiting a herbicial acting also on the treatment of 3 leaf stage Panicum Crus-galli L. by containing the subject compound as an active ingredient. CONSTITUTION: A herbicide contains a compound of the formula (R is H or lower alkyl) as an active ingredient. The compound of the formula exhibits a strong herbicidal activity against a wide range of weeds and can kill or control the weeds within 1-2 weeks by being applied just before the weeds germinate or at the early or medium period stage of the growth thereof in an amount of 0.1-10kg/ha. The compound of the formula can selecting control the weeds on the cultivation of a specific crop such as corn, potato, cane, peanut, soybean, barley or fruit tree by restricting the amount of the herbicide to be applied or by changing the method of the application. COPYRIGHT: (C)1990,JPO&Japio | ||||||
| 35 | 44*monoalkylamino*phenyl compound 44*monoarukiruamino*fuenirukagobutsu | JP11756578 | 1978-09-26 | JPS5466637A | 1979-05-29 | ROBAATO GOOTON SHIEPAADO |
| 36 | IMPROVED COLOR STABILITY OF ISOCYANATES | PCT/US2004022759 | 2004-07-14 | WO2005089085A3 | 2007-02-01 | ROSEN RICHARD; BERNARD JEAN-MARIE; WO SHIMING; VARRON CORINNE |
| A hardener composition for use as a component of a two component polyurethane coating composition, comprising a polyisocyanate, a catalyst for promoting reaction of the polyisocyanate with a reactive hydrogen compound, and one or more antioxidants selected from: a first antioxidant comprising one or more of sterically hindered phenol antioxidants and secondary aryl amine antioxidants, and a second antioxidant comprising one or more organophosphite antioxidant, exhibits improved color stability. | ||||||
| 37 | INHIBITORS OF TRANSTHYRETIN AMYLOID FIBRIL FORMATION | PCT/US2006/004512 | 2006-02-08 | WO2006086517A3 | 2006-08-17 | KELLY, Jeffery, W.; JOHNSON, Steven, M.; PETRASSI, H., Michael |
Bisaryloxime ethers and bisarylhydroazones are shown to be effective for inhibiting formation of amyloid fibrils of transthyretin. |
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| 38 | NOVEL AMIDINE COMPOUNDS FOR TREATING MICROBIAL INFECTIONS | PCT/US2003/027963 | 2003-09-05 | WO2005033065A1 | 2005-04-14 | TIDWELL, Richard, R.; BOYKIN, David; BRUN, Reto; STEPHENS, Chad, E.; KUMAR, Arvind |
Novel amidine and diamidine compounds are useful in the treatment of microbial infections, including mycobacterial, fungal and protozoal infections. Pharmaceutical formulations comprising these compounds can be used in methods of treating microbial infections. |
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| 39 | AMIDINES AND DERIVATIVES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PCT/EP2004/052201 | 2004-09-16 | WO2005028425A2 | 2005-03-31 | ALLEGRETTI, Marcello; CESTA, Maria, Candida; NANO, Giuseppe; BERTINI, Riccardo; BIZZARRI, Cinzia; COLOTTA, Francesco |
Amidines and derivatives thereof of formula (I) are described. The process for their preparation and pharmaceutical compositions thereof are also described. The amidines of the invention are useful in the inhibition of chemotaxis of neutrophils induced by IL- 8. The compounds of the invention are used in the treatement of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion. |
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| 40 | 1-아릴-5-(트리플루오로메틸)-1Ｈ-테트라졸의 제조 방법 | KR1020067006822 | 2004-09-30 | KR100780906B1 | 2007-11-30 | 하기야가즈타케; 사토야스히로; 고구로기요토; 미츠이스나오 |
| 본 발명은, 화학식 1로 표기되는 2,2,2-트리플루오로-N-아릴-아세트이미드와, 옥시염화인 및 디페닐인산 클로라이드로 이루어진 군으로부터 선택된 적어도 1종과, 제삼급 아민을, 유기용매 중에서 반응시키는, 화학식 2로 표기되는 N-아릴-2,2,2-트리플루오로아세트이미도일 클로라이드의 제조방법에 관한 것이다. 또한 본 발명은, 화학식 2로 표기되는 N-아릴-2,2,2-트리플루오로아세트이미도일 클로라이드와 아지드화물을, 아민염의 존재하에서 방향족 탄화수소 용매 중에서 반응시키는, 화학식 4로 표기되는 1-아릴-5-(트리플루오로메틸)-1H-테트라졸의 제조방법에 관한 것이다. (1) (2) (4) N-아릴-2,2,2-트리플루오로아세트이미도일 클로라이드, 1-아릴-5-(트리플루오로메틸)-1H-테트라졸 | ||||||
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