序号 | 专利名 | 申请号 | 申请日 | 公开(公告)号 | 公开(公告)日 | 发明人 |
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41 | METHODS AND COMPOSITIONS FOR IDENTIFYING METHYLATED CYTOSINES | PCT/US2022074999 | 2022-08-16 | WO2023023500A1 | 2023-02-23 | BROWN COLIN; LIU XIAOHAI; WU XIAOLIN; BRUSTAD ERIC; SHULTZABERGER SARAH E |
Disclosed herein include methods, compositions, reaction mixtures, kits and systems for identification of methylated cytosines in nucleic acids using a bisulfite-free, one-step chemoenzymatic modification of methylated cytosines. | ||||||
42 | ACILHIDRAZONAS PARA EL TRATAMIENTO DE ENFERMEDADES NEUROLÓGICAS | PCT/ES2019/070649 | 2019-09-27 | WO2020065119A1 | 2020-04-02 | PÉREZ FERNÁNDEZ, Ruth; CANAL MARTÍN, Andrea; SANCHEZ BARRENA, María José; MANSILLA APARICIO, Alicia |
La presente invención se refiere a un grupo de compuestos con un núcleo estructural de acilhidrazona que presentan capacidad moduladora de la interacción entre las proteínas NCS-1 y Ric8a, implicadas en el proceso de regulación del número de sinapsis y la probabilidad de liberación de neurotransmisores.Estos compuestos, por tanto, son útiles para el tratamiento de enfermedades neurológicas en las que está afectado el número de sinapsis, tales como enfermedad de Alzheimer, enfermedad de Huntington o enfermedad de Parkinson. |
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43 | TUNABLE NITRIC OXIDE-RELEASING MACROMOLECULES HAVING MULTIPLE NITRIC OXIDE DONOR STRUCTURES | PCT/US2012/052350 | 2012-08-24 | WO2013029009A1 | 2013-02-28 | SCHOENFISCH, Mark; LU, Yuan; STASKO, Nathan; BAO, Jian |
Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein. |
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44 | POLYMER SUPPORTED REAGENTS AND METHODS OF REDUCING AROMATIC NITRO COMPOUNDS BY USING THE SAME | PCT/KR2012001928 | 2012-03-16 | WO2012128515A3 | 2013-02-07 | HAN YANG-KYOO; CHO JIN; LEE SANG-MI; SHIN SEUNG-HOON |
The present invention relates to a polymer supported reagent comprising a novel crosslinked mesoporous polymer, enabling a simple and easy production of an azoxy compound or an azo compound from an aromatic nitro compound, and a method of selectively reducing an aromatic nitro compound by using the same. The polymer supported reagent comprises a certain acrylamide mesoporous crosslinked polymer. | ||||||
45 | POLYMER SUPPORTED REAGENTS AND METHODS OF REDUCING AROMATIC NITRO COMPOUNDS BY USING THE SAME | PCT/KR2012/001928 | 2012-03-16 | WO2012128515A2 | 2012-09-27 | HAN, Yang-Kyoo; CHO, Jin; LEE, Sang-Mi; SHIN, Seung-Hoon |
The present invention relates to a polymer supported reagent comprising a novel crosslinked mesoporous polymer, enabling a simple and easy production of an azoxy compound or an azo compound from an aromatic nitro compound, and a method of selectively reducing an aromatic nitro compound by using the same. The polymer supported reagent comprises a certain acrylamide mesoporous crosslinked polymer. |
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46 | METHOD FOR SORTING CARBON NANOTUBES (CNTS) AND DEVICE FOR CNTS SORTING | PCT/KR2010/007781 | 2010-11-05 | WO2011062388A1 | 2011-05-26 | LEE, Kwangyeol |
A method for sorting carbon nanotubes (CNTs) is disclosed. In one embodiment, a method for sorting CNTs of the present disclosure comprises providing to a surface of a substrate, the surface modified with a trans isomer of photo-isomerization-reactive diazo compound, a dispersion containing a mixture of conducting CNTs and semiconducting CNTs removing CNTs which are not associated with the modified surface from the surface; and irradiating the modified surface to detach the CNTs associated with the modified surface. |
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47 | FLUORESCENT XANTHENES AND WHITE LIGHT FLUOROPHORES | PCT/US2007/073864 | 2007-07-19 | WO2008011508A1 | 2008-01-24 | STRONGIN, Robert, M.; WARNER, Isiah, M.; YANG, Youjun; LOWRY, Mark; FAKAYODE, Sayo, O.; ESCOBEDO CORDOVA, Jorge, O.; XU, Xiangyang |
Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in "multiplexing" techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges. |
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48 | IMMUNOREGULATORY COMPOUNDS AND DERIVATIVES AND METHODS OF TREATING DISEASES THEREWITH | PCT/US2001/026697 | 2001-08-28 | WO02018324A2 | 2002-03-07 | |
Compounds are disclosed having the structure of Formula (I), where R<1>, R<3>, and R<4> are independently hydrogen or C1 to C4 alkyl, and R<2> is (II), where R<5> is selected from the group consisting of hydrogen and C1 to C4 alkyl, or (III), where R<6>, R<7> and R<8> are independently hydrogen or C1 to C4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed (IV), where R<9>, R<10> and R<11> are independently selected from the group consisting of hydrogen and C1 to C4 alkyl, and R<12> is selected from the group consisting of hydrogen and -C(O)R<13>, where R<13> is a C1 to C6 alkyl or an aryl group. | ||||||
49 | AZOPHENOLS AS ERG ONCOGENE INHIBITORS | EP16845184.7 | 2016-09-09 | EP3347001B1 | 2023-07-26 | DOBI, Albert L.; DALGARD, Clifton; SRIVASTAVA, Shiv |
50 | ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES | EP19813064.3 | 2019-09-27 | EP3858342A1 | 2021-08-04 | PÉREZ FERNÁNDEZ, Ruth; CANAL MARTÍN, Andrea; SANCHEZ BARRENA, María José; MANSILLA APARICIO, Alicia |
The present invention relates to a group of compounds with an acylhydrazone structural core having the capacity to modulate interaction between NCS-1 and Ric8a proteins involved in the process of regulating the number of synapses and the neurotransmitter release probability. These compounds are therefore useful for the treatment of neurological diseases in which the number of synapses is affected, such as Alzheimer's disease, Huntington's disease, or Parkinson's disease. |
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51 | TUNABLE NITRIC OXIDE-RELEASING MACROMOLECULES HAVING MULTIPLE NITRIC OXIDE DONOR STRUCTURES | EP12825927.2 | 2012-08-24 | EP2748141B1 | 2017-12-06 | SCHOENFISCH, Mark; LU, Yuan; STASKO, Nathan; BAO, Jian |
52 | TUNABLE NITRIC OXIDE-RELEASING MACROMOLECULES HAVING MULTIPLE NITRIC OXIDE DONOR STRUCTURES | EP12825927.2 | 2012-08-24 | EP2748141A4 | 2015-04-08 | SCHOENFISCH, Mark; LU, Yuan; STASKO, Nathan; BAO, Jian |
53 | A REAGENT, A KIT, AND A METHOD FOR DETECTING AND IDENTIFYING A WIDE RANGE OF ILLICIT DRUGS | EP08789821.9 | 2008-08-21 | EP2200972A4 | 2013-05-29 | AMISAR, Shai |
54 | Herstellung von Diazo-und Azoverbindungen | EP88109835.4 | 1988-06-21 | EP0297397A3 | 1991-08-21 | Lorenz, Manfred, Dr. |
Herstellung von Diazoverbindungen durch Diazogruppenübertragung auf aktivierte Methylenverbindungen, dadurch gekennzeichnet, daß man ein Azidoformamidiniumsalz als Diazogruppenüberträger verwendet sowie Herstellung von Azoverbindungen auf diesem Wege. |
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55 | Aromatische Säuren | EP89810336.1 | 1989-05-01 | EP0342157A2 | 1989-11-15 | Chang, Jui Yoa, Dr. |
Die Erfindung betrifft neue aromatische Säuren, insbesondere Verbindungen der Formel
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56 | Herstellung von Diazo-und Azoverbindungen | EP88109835.4 | 1988-06-21 | EP0297397A2 | 1989-01-04 | Lorenz, Manfred, Dr. |
Herstellung von Diazoverbindungen durch Diazogruppenübertragung auf aktivierte Methylenverbindungen, dadurch gekennzeichnet, daß man ein Azidoformamidiniumsalz als Diazogruppenüberträger verwendet sowie Herstellung von Azoverbindungen auf diesem Wege. |
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57 | Anti-inflammatory agents | EP88300163.8 | 1988-01-11 | EP0276065A1 | 1988-07-27 | Bollinger, Nancy Grace; Goodson, Theodore, Jr.; Herron, David Kent |
This invention provides benzene derivatives of the Formula I
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58 | AZOPHENOLS AS ERG ONCOGENE INHIBITORS | EP16845184.7 | 2016-09-09 | EP3347001A4 | 2019-05-08 | DOBI, Albert L.; DALGARD, Clifton; SRIVASTAVA, Shiv |
59 | AZOPHENOLS AS ERG ONCOGENE INHIBITORS | EP16845184.7 | 2016-09-09 | EP3347001A1 | 2018-07-18 | DOBI, Albert L.; DALGARD, Clifton; SRIVASTAVA, Shiv |
60 | PEPTIDE DEFORMYLASE INHIBITORS | EP02748375.9 | 2002-03-01 | EP1363873A4 | 2006-01-04 | XIANG, JIA-NING; CHRISTENSEN, Siegfried, B.; LEE, Jinhwa; MERCER, Daniel, J. |
Nobel PDF inhibitors and novel methods for their use are provided. |