子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | AMINOBUTANOIC ACID DERIVATIVES | PCT/JP9804529 | 1998-10-07 | WO9919296A8 | 2000-11-02 | TAKAHASHI KANJI; SUGIURA TSUNEYUKI |
| Aminobutanoic acid derivatives represented by general formula (I) and salts thereof (wherein each symbol is as defined in the description). The derivatives inhibit matrix metalloproteinases and are therefore useful for the prevention and/or treatment of rheumatism, osteoarthritis, pathologic bone resorption, osteoporosis, periodontal diseases, interstitial nephritis, arteriosclerosis, pulmonary emphysema, hepatic cirrhosis, corneal injury, diseases due to metastasis and infiltration of cancer cells or proliferation thereof, autoimmune diseases (such as Crohn's disease and Sjögren's disease), diseases due to transmigration of white blood cells or infiltration thereof, neovascularization, multiple sclerosis, aortic aneurysm, endometritis and so on. | ||||||
| 122 | PROCESS FOR THE BENIGN DIRECT FIXATION AND CONVERSION OF NITROGEN OXIDES | PCT/US2000/001025 | 2000-01-14 | WO00041798A1 | 2000-07-20 | |
| A direct fixation of NO2 and N2O4 at room temperature and atmospheric pressure is described using bis(diorganoamino)magnesium compounds formed from reactions between donor-solvent free diorganomagnesium compounds and primary or secondary amines, yielding new compositions of matter having the general formulas [(R2N)i(R2NNxOy)jMg]m and [(R2N)i(R2NNxOy)j(NxOy)kMg]m. Methods are also described to convert these new compositions of matter into useful organic compounds and nitrogen gas. | ||||||
| 123 | FREE RADICAL INHIBITORS FOR QUENCHING AQUEOUS PHASE POLYMER GROWTH AND RELATED METHODS | PCT/US9919355 | 1999-08-24 | WO0011039A2 | 2000-03-02 | |
| An aqueous phase inhibitor for quenching free radical polymerization comprising a free radical quenching agent having a hydrophilic tail is disclosed, as well as a coating and related methods. In one embodiment, the free radical quenching agent can either be an N-hydroxylamine or an N-nitrosonamine, the hydrophilic tail can be a polyhydric alcohol tail and the inhibitor can be a concentrate in a liquid medium such as water, alcohol and mixture thereof. | ||||||
| 124 | AMINOBUTANOIC ACID DERIVATIVES | PCT/JP1998/004529 | 1998-10-07 | WO99019296A1 | 1999-04-22 | |
| Aminobutanoic acid derivatives represented by general formula (I) and salts thereof (wherein each symbol is as defined in the description). The derivatives inhibit matrix metalloproteinases and are therefore useful for the prevention and/or treatment of rheumatism, osteoarthritis, pathologic bone resorption, osteoporosis, periodontal diseases, interstitial nephritis, arteriosclerosis, pulmonary emphysema, hepatic cirrhosis, corneal injury, diseases due to metastasis and infiltration of cancer cells or proliferation thereof, autoimmune diseases (such as Crohn's disease and Sjögren's disease), diseases due to transmigration of white blood cells or infiltration thereof, neovascularization, multiple sclerosis, aortic aneurysm, endometritis and so on. | ||||||
| 125 | ΑΝΑΛΟΓΑ ΥΠΟΚΑΤΕΣΤΗΜΕΝΟΥ (Ε)-Ν'-(1-ΦΑΙΝΥΛΑΙΘΥΛΙΔΕΝΟ) ΒΕΝΖΟΫΔΡΑΖΙΔΙΟΥ ΩΣ ΑΝΑΣΤΟΛΕIΣ ΑΠΟΜΕΘΥΛΑΣΗΣ ΙΣΤΟΝΗΣ | CY201100866 | 2020-09-14 | CY1123345T1 | 2022-03-24 | VANKAYALAPATI HARIPRASAD; SORNA VENKATASWAMY; WARNER STEVEN L; BEARSS DAVID J; SHARMA SUNIL; STEPHENS BRET |
| Σεμίαάποψη, ηεφεύρεσηαφοράσευποκατεστημένου (Ε)-Ν'-(1-φαινυλαιθυλιδενο)βενζοϋδραζιδίουανάλογα, παράγωγααυτών, καισχετικέςενώσεις, πουείναιχρήσιμεςωςαναστολείςλυσίνης-εδικήςαπομεθυλάσηςιστόνης, συμπεριλαμβανομένης LSD1•συνθετικέςμεθόδουςγιακατασκευήτωνενώσεων•φαρμακευτικέςσυνθέσειςπουπεριλαμβάνουντιςενώσεις•καιμεθόδουςχρήσηςτωνενώσεωνκαιτωνσυνθέσεωνγιαναθεραπεύονταιδιαταραχέςπουσυνδυάζονταιμεδυσλειτουργίατης LSD1. Ηπερίληψηαυτήπροορίζεταιωςεργαλείοσάρωσηςγιασκοπούςέρευναςστησυγκεκριμένητέχνηκαιδενπροτίθεταιναείναιπεριοριστικήτηςπαρούσαςεφεύρεσης. | ||||||
| 126 | Análogos de (e)-n-(1-feniletilideno) benzo-hidrazida substituída como inibidores de histona desmetilase e composições farmacêuticas compreendendo-os | BR112014003382 | 2012-08-15 | BR112014003382B1 | 2022-03-15 | STEPHENS BRET; DAVID J BEARSS; VANKAYALAPATI HARIPRASAD; STEVE L WARNER; SHARMA SUNIL; SORNA VENKATASWAMY |
| análogos de (e)-n'-(1-feniletilideno)benzo-hidrazida substituída como inibidores de histona desmetilase. em um aspecto, a invenção refere-se a análogos de (e)-n'-(1-feniletilideno)benzoidrazida substituída, derivados dos mesmos, e compostos relacionados, que são úteis como inibidores de histona desmetilase específica de lisina, incluindo lsd1; métodos sintéticos para preparar os compostos; composição farmacêuticas compreendendo os compostos; e métodos de usar os compostos e composições para tratar distúrbios associados com disfunção da lsd1. o resumo é pretendido como uma ferramenta de varredura para propósitos de investigação na técnica particular e não é pretendido ser limitante da presente invenção. | ||||||
| 127 | PODSTAWIONE ANALOGI (E)-N'-(1-FENYLOETYLIDENO)BENZOHYDRAZYDU JAKO INHIBITORY DEMETYLAZY HISTONOWEJ | PL12823540 | 2012-08-15 | PL2744330T3 | 2020-12-14 | VANKAYALAPATI HARIPRASAD; SORNA VENKATASWAMY; WARNER STEVE L; BEARSS DAVID J; SHARMA SUNIL; STEPHENS BRET |
| 128 | SUPSTITUIRANI (E)-N´- (1-FENILETILIDEN) ANALOZI BENZOHIDRAZIDA KAO INHIBITORI HISTONSKE DEMETILAZE | HRP20201433 | 2020-09-08 | HRP20201433T1 | 2020-12-11 | VANKAYALAPATI HARIPRASAD; SORNA VENKATASWAMY; WARNER STEVE L; BEARSS DAVID J; SHARMA SUNIL; STEPHENS BRET |
| 129 | Metoda za pripravo diazoalkanov | SI201330689 | 2013-01-23 | SI2807145T1 | 2017-09-29 | PROCTOR LEE |
| 130 | HIDRAZIDAS DE ÁCIDO CARBOXÍLICO ARILO Y HETEROARILO SUSTITUIDAS O SUS SALES Y SU USO PARA AUMENTAR LA TOLERANCIA AL ESTRÉS EN PLANTAS | UY36800 | 2016-07-19 | UY36800A | 2017-01-31 | BRÜNJES DR MARCO; FRACKENPOHL DR JENS; BOJACK DR GUIDO; HELMKE DR HENDRIK; ADELT DR ISABELLE; LEHR DR STEFAN; BRÜCHNER DR PETER; DITTGEN DR JAN; DIRK SCHMUTZLER; HEINEMANN DR INES; BICKERS DR UDO; HILLS MARTIN JEFFREY; MORENO DR JUAN PEDRO RUIZ-SANTAELLA; STREK DR HARRY; PHILIPPE DESBORDES |
| La invención se refiere a hidrazidas de ácido carboxílico arilo y heteroarilo sustituidas de la fórmula general (I) o sales de los mismos, en el que los radicales de la fórmula (I) tienen las definiciones mencionadas en la descripción, para aumentar la tolerancia al estrés abiótico, así como para aumentar el crecimiento de las plantas y/o para aumentar el rendimiento de la planta. | ||||||
| 131 | PREPARACIÓN DE CIERTAS MOLÉCULAS DE (FENILO SUSTITUIDO)-TRIAZOLIL-(FENILO SUSTITUIDO), INTERMEDIARIOS E INSECTICIDAS RELACIONADOS CON DICHAS MOLÉCULAS | ARP140100673 | 2014-02-28 | AR094958A1 | 2015-09-09 | JAMES M RENGA; ANNE M WILSON; PETER BORROMEO; CARL DEAMICIS; JEROD PATZNER |
| Reivindicación 1: Un proceso que comprende: (1a) hacer reaccionar una sal de arilalcoxiimidato de fórmula (1) con formilhidrazina para producir una iminohidrazina de fórmula (2); y (1b) ciclar dicha iminohidrazina de fórmula (2) para producir un ariltriazol de fórmula (3); en donde X es F, Cl, Br, o I; R¹ es NO₂, C(=O)OH o un C(=O)O-alquilo C₁₋₆; R² es un alquilo C₁₋₆. | ||||||
| 132 | Energetické materiály na bázi bismutu | CZ2013858 | 2013-11-07 | CZ305403B6 | 2015-09-02 | NESVEDA JIŘÍ |
| Energetická sloučenina se sníženou toxicitou na bázi bismutité soli, která má vlastnosti iniciálních výbušnin, získaná reakcí rozpustných solí bismutu s rozpustnými solemi anorganických a organických energetických sloučenin, přičemž rozpustná sůl bismutu je na bázi chloristanu bismutu. Dále je popsán způsob její přípravy a použití. | ||||||
| 133 | СПОЛУКА, СКЛАД І СПОСІБ БОРОТЬБИ З ПАТОГЕННИМ ГРИБОМ | UAA201112633 | 2009-04-01 | UA107572C2 | 2015-01-26 | PEARSON NORMAN; ROSS RONALD; EHR ROBERT |
| Винахідналежитьдоацилгідразоновихі семікарбазоновихпохіднихальдегідіві кетонів, якіможутьвиступатиякатрактантирослиннихпатогеннихзооспор. Привпливіводоюсполукививільняютьальдегідиабокетони, якіможутьприваблюватизооспори. Запропонованісполукиможутьоб'єднуватисяз фунгіцидамидляотриманняфунгіциднихпрепаратів, якіособливоефективнівідносноооміцетів, щопродукуютьпатогеннігриби. | ||||||
| 134 | Compositions and methods for treatment of inflammatory bowel disease | AU2013264894 | 2013-05-15 | AU2013264894A1 | 2014-11-27 | KANDULA MAHESH |
| The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing inflammatory bowel disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of gastrointestinal diseases and inflammation such as inflammatory bowel disease, ulcerative colitis, mild-to-moderate Crohn's disease, rheumatoid arthritis, inflammatory arthritis, psoriatic arthritis, liver cirrhosis and idiopathic urticaria. | ||||||
| 135 | Compounds with antibacterial activity against clostridium | NZ60585011 | 2011-08-04 | NZ605850A | 2014-07-25 | GUILLEMONT JERÔME EMILE GEORGES; RABOISSON PIERRE JEAN-MARIE BERNARD; LOUNIS NACER |
| The disclosure relates to family of chemical compounds, or their therapeutic salts thereof, than contain and chroman moiety (with an (R)-configuration at the 4-position) and a pyrazolo triazine moiety that linked by an amine containing alkyl chain. The family differ from each other by various substituents, including halogens, hydroxyl groups and alkly chains, attached to the ring structures. The disclosure also relates to the process of their formation, their intermediates, their use as a medicine for the use in the treatment of a bacterial, Clostridium based, infection. | ||||||
| 136 | ANALOGOS SUSTITUIDOS DE LA (E)-N' -(1-FENILETILIDEN)BENZOHIDRAZIDA COMO INHIBIDORES DE LA HISTONA DESMETILASA. | MX2014001842 | 2012-08-15 | MX2014001842A | 2014-07-24 | BEARSS DAVID J; VANKAYALAPATI HARIPRASAD; SORNA VENKATASWAMY; WARNER STEVE L; SHARMA SUNIL; STEPHENS BRET |
| En un aspecto, la invención se relaciona con análogos de (E)-N'-(1 -feniletiliden)benzohidrazida sustituidos, derivados de los mismos, y compuestos relacionados, que son útiles como inhibidores de la histona desmetilasa específica de la lisina, incluyendo LSD1; métodos sintéticos para hacer los compuestos; composiciones farmacéuticas que comprenden los compuestos; y métodos para utilizar los compuestos y composiciones para tratar trastornos asociados con la disfunción de la LSD1; este resumen se pretende como una herramienta de exploración para los propósitos de investigación en la técnica particular, y no pretende ser limitante de la presente invención. | ||||||
| 137 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS | SG2014009609 | 2012-08-15 | SG2014009609A | 2014-05-29 | VANKAYALAPATI HARIPRASAD; SORNA VENKATASWAMY; WARNER STEVE L; BEARSS DAVID J; SHARMA SUNIL; STEPHENS BRET |
| 138 | Substituted (E)-N'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhiitors | AU2012296639 | 2012-08-15 | AU2012296639A1 | 2014-03-06 | VANKAYALAPATI HARIPRASAD; SORNA VENKATASWAMY; WARNER STEVE L; BEARSS DAVID J; SHARMA SUNIL; STEPHENS BRET |
| In one aspect, the invention relates to substituted (E)-N'-(1- phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | ||||||
| 139 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | CA2873096 | 2013-05-15 | CA2873096A1 | 2013-11-28 | KANDULA MAHESH |
| Disclosed are compounds of Formula (I) and Formula (II) or their pharmaceutical acceptable salts. The pharmaceutical compositions comprising an effective amount of compounds of Formula (I) or Formula (II) may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used for treatment of gastrointestinal diseases and inflammation such as inflammatory bowel disease, ulcerative colitis, mild-to-moderate Crohn's disease, rheumatoid arthritis, inflammatory arthritis, psoriatic arthritis, liver cirrhosis and idiopathic urticaria. | ||||||
| 140 | NAFTENSKE KISELINE I NJIHOVI DERIVATI KAO SREDSTVO ZA OŽIVLJAVANJE BILJAKA | YUP93402 | 2002-12-10 | RS51867B | 2012-02-29 | KEVRESAN SLAVKO DR; CIRIN-NOVTA VERA DR; KANDRAC JULIJAN DR; PETROVIC NOVICA DR; KUHAJDA KSENIJA DR; RADIC LJUBICA MR; VASIC DRAGANA MR; KOVACEVIC BRANISLAV DR; VUJIC DURA |
| NAFTENSKE KISELINE I NJIHOVI DERIVATI KAO SREDSTVO ZA OŽIVLJAVANJE BILJAKA. Sredstvo za indukciju adventivnih korenova koje se sastoji od naftenskih kiselina i/ili njihovih derivata opšte formule CnH2n-k COR gde je n = 2-26 a k= 1 u slučaju monocikličnih struktura, k =3 u slučaju bicikličnih struktura odnosno u slučaju pol icikličnih struktura je k = više od 3, a R = OX gde je X alkil radikal ili supstituisani alkil radikal u slučaju estara, R = OM gde je M alkalni ili zemnoalkalni metal u slučaju soli, R = NH2 u slučaju amida, R = NHNH2 u slučaju hidrazida, R = N3 u slučaju azida a izolovane su iz frakcije nafte intervaladestilacije od 216-390°C.Prijava sadrži još 3 patentna zahteva. | ||||||
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