| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | Perfume composition or impart aroma characteristic of aromatic products, improvement, how to strengthen or modified, and the perfume composition or fragrance products | JP18600793 | 1993-07-28 | JP3609845B2 | 2005-01-12 | ドゥモール エデュアール; マエム シリル; ブラン ピエール−アラン |
| 42 | Method for producing trifluoromethyl-substituted 2-alkoxyacetophenone derivative | JP2002261160 | 2002-09-06 | JP2004099481A | 2004-04-02 | ISHII AKIHISA; KANAI MASATOMI; KURIYAMA KATSU; YASUMOTO MANABU; INOMIYA NORITO; OTSUKA TAKASHI; UEDA KOJI |
| <P>PROBLEM TO BE SOLVED: To provide a method for industrially producing a trifluoromethyl-substituted 2-alkoxyacetoxyphenone derivative used as an important intermediate for medicines and agrochemicals. <P>SOLUTION: This method for producing the trifluoromethyl-substituted 2-alkoxyacetoxyphenone derivative comprises brominating a trifluoromethyl-substituted acetophenone with Br<SB>2</SB>in the presence of an alkylenediol, subjecting the obtained brominated acetal to a substitution reaction with a metal alkoxide, and then hydrolyzing the etherized compound in the presence of an acid catalyst to remove the protecting group. By the method, the trifluoromethyl-substituted 2-alkoxyacetoxyphenone derivative can be produced in a remarkably better yield than by conventional methods. <P>COPYRIGHT: (C)2004,JPO | ||||||
| 43 | Improved process for the preparation of alkyl aldehyde intermediate or aryl aldehyde intermediate | JP52366797 | 1996-12-10 | JP2000502344A | 2000-02-29 | モンテ，ウイリアム・テイ |
| (57)【要約】 グリニャール保護アルデヒドとハロゲン化アルキルまたはハロゲン化ベンジルとを使用するアルキルアルデヒドまたはアリールアルデヒドの調製のための方法が提供される。 グリニャール保護アルデヒドを銅触媒の存在下で上記ハロゲン化物と反応させ、この反応の生成物を加水分解によって選択的に脱保護する。 | ||||||
| 44 | Alkylidenecarbonyl-substituted benzopyranoisoxazolidine compound | JP26742395 | 1995-10-16 | JPH09110874A | 1997-04-28 | ABIKO ATSUSHI |
| PROBLEM TO BE SOLVED: To obtain the subject new compound obtained by the reaction of a specific benzopyranoisoxazolidine compound with a ketone and giving an optically active alcohol and carbonyl compound useful as a raw material for pharmaceuticals, agrochemicals, cosmetics, liquid crystals, etc., in high yield and selectivity. SOLUTION: This new alkylidenecarbonyl-substituted benzopyranoisoxazolidine compound is expressed by formula I [R<1> is H or an alkyl; R<2> and R<3> are each a (substituted) alkyl or R<2> and R<3> together with adjacent C atom form a (substituted) cycloalkylidene]. It is useful for the production of an optically active alcohol, aldehyde and ketone useful as a raw material for pharmaceuticals, agrochemicals, cosmetics, liquid crystal, etc., in high yield and selectivity. The compound can be produced by reacting a benzopyranoisoxazolidine compound expressed by formula II [R<4> is a (substituted) alkyl or a (substituted) aryl] with a ketone expressed by formula III. | ||||||
| 45 | Method of manufacturing a superconductor | JP24701387 | 1987-09-30 | JP2603482B2 | 1997-04-23 | 辰視 日置; 久 杉本; 博純 東 |
| 46 | Benzo cycloalkenyl dihydroxy alkanoic acid compounds, their preparation and pharmaceutical compositions containing them | JP1274690 | 1990-01-24 | JP2561354B2 | 1996-12-04 | DEIDEIE FUESUTARU; JANNIBE NIOSHU; DENISU DESUKUURU; ROBERU BERUMAN; JATSUKU DESERUPURITSUTO |
| Derivatives of benzocycloalkenyldihydroxyalkanoic acids, inhibitors of HMG CoA reductase, antagonists of thromoboxane A2 receptors and antifungals, denoted by the formula I <IMAGE> 1 in which X=CH2, O or S; R1 and R2, identical or different, =H, C1-3 alkyl or together from a -(CH2)n- chain (n=4,5) optionally substituted symmetrically by one or two C1-3 alkyl radicals. R3 and R4, identical or different, =H, CF3, halogen (Cl, F, Br), C1-5 N,N-dialkylamino, C1-4 alkyl, C1-5-alkoxy, C1-3 alkylthio, or phenyl optionally substituted by at most two substitutents which may be identical or different and may denote C1-3 alkyl or C1-3 alkoxy radicals or halogens (F, Cl), it being understood that when one of R3 and R4 denotes the radicals: CF3, N,N-dialkylamino, C6H5 or substituted phenyl, it is present at the vertices 3', 4'or 5' according to formula 1 and the other denotes a hydrogen atom. R5 and R6, (which may be identical or different)=H, halogen (F, Cl, Br), CF3, C1-3 alkyl, C1-3 alkoxy, C6H5, optionally substituted by at most two substitutents which may be identical or different and may denote radicals: C1-3 alkyl or C1-3 alkoxy or halogen atoms (F, Cl), on condition that when one of R5 and R6=CF3, C6H5 or substituted phenyl, it is present at the vertex 6 or 7 and the other denotes a hydrogen atom. The substitutents R3 and R4 or R5 and R6 may also together form, on condition of being at two contiguous vertices, diradicals of formulae: -CH=CH-CH=CH-, -(CH2)m- and -O(CH2)pO-, in which m=3 or 4, p=1 or 2, it being understood that when R3 and R4 or R5 and R6 form the chain sequence -O(CH2)pO-, the latter is linked to the vertices 3' and 4' or 4' and 5' or 6 and 7 according to the formula 1. R7 and R8=H or, together with the existing C-C bond, form a double bond of trans geometry; R9 and R10=H or together form a C1-3 dialkylmethylene residue. In the form of free acids, salts, esters, amides or delta -lactones. Hypocholesterolaemiant, antithrombotic and antifungal medications containing them. | ||||||
| 47 | Method for imparting, improving, strengthening or modifying aromatic characteristics of perfumed composition or aromatic product, and perfumed composition or aromatic product | JP18600793 | 1993-07-28 | JPH06192680A | 1994-07-12 | EDEYUAARU DOUMOORU; SHIRIRU MAEMU; PIEERUUARAN BURAN |
| PURPOSE: To impart, improve, strengthen and modify aromatic characteristics by adding a specified amount of a specified compd. to a perfumed compsn. or aromatic product to impart musky fragrance to the perfumed compsn. or the aromatic product. CONSTITUTION: 3-Methyl-cyclopentadec-5-en-1-one, preferable in its cis- configuration, is added in an effective amount for imparting fragrance to a perfumed compsn. or a aromatic product (such as detergent). COPYRIGHT: (C)1994,JPO | ||||||
| 48 | Method for formylating 5-substituted benzene | JP31860091 | 1991-11-07 | JPH05148176A | 1993-06-15 | SHINKAWA NOBUO; ICHINO TOMIO; TSURUKI TOMIO; KURODA HIROFUMI |
| PURPOSE: To obtain a formyl compound useful as an intermediate for a quinone derivative and a benzothiazole derivative by single process by dissolving a 5-substituted benzene derivative in trifluoroacetic acid and reacting the solution with hexamethylenetetramine. CONSTITUTION: A compound (e.g. 1-methyl-2,3,4,5-tetramethoxytoluene) of formula I (R 1 to R 4 are electron donative group) is dissolved in trifluoroacetic acid and reacted with hexamethylenetetramine preferably at 85-110°C to give the objective compound of formula II. A molar ratio of the compound of formula I to hexamethylenetetramine is preferably 1:1 to 3. 5-25ml trifluoroacetic acid as the solvent is preferably used based on 1g of the compound of formula I. COPYRIGHT: (C)1993,JPO&Japio | ||||||
| 49 | Manufacturing method of thermal head | JP20371387 | 1987-08-17 | JPS6445660A | 1989-02-20 | NAKANO MASAHIRO |
| PURPOSE:To increase the positional precision of an abrasion-resistant layer and enable miniaturization of chips by forming an abrasion-resistant membrane layer which can be etched, over the entire surface of an insulative substrate with a thermal resistor layer and a wiring pattern by using high frequency sputtering process. CONSTITUTION:A thermal resistor layer 3 consisting of a crystal silicon layer added with boron, and an electrode wiring material layer, for instance, are formed on an alumina substrate having a glazed layer 2, and are patterned to a prearranged form. Thus a wiring pattern 4 is obtained. Next, a membrane 5' consisting of a mixture of silicon oxide nitride (SiOxNy) as a main component and a metal is formed in a thickness of more than 5mum by means of high-frequency sputtering process. In this way, highly abrasion-resistant membrane can be obtained. Photoregist is applied over the membrane 5' and is patterned. This patterned photoregist is further selectively etched, as a mask, with dilute hydrofluoric and nitric acid to obtain an abrasion-resistant layer of prearranged form 5. | ||||||
| 50 | JPS6223735B2 - | JP15875978 | 1978-12-25 | JPS6223735B2 | 1987-05-25 | BENJAMIN SHII KURAAKU JUNIA; JOOJI ERU KEI HANTAA |
| 51 | Production of beta-thujaplicin hinokitiol | JP23188785 | 1985-10-17 | JPS6293250A | 1987-04-28 | YOSHIKOSHI AKIRA; KIDO HIDEO; OUCHI HIROYUKI; HARA SUSUMU |
| PURPOSE: To obtain the titled substance, by acetalizing CO group of 2,3-epoxy-2- methyl-5-(1-methylethenyl)cyclohexanone, subjecting the resultant compound to hydrolysis, oxidative cleavage, aldol condensation and esterification, removing an acid and hydrolyzing the formed compound. CONSTITUTION: CO group of a compound expressed by formula I is acetalized, hydrolyzed and oxidatively cleaved with an oxidizing agent, e.g. sodium metaperiodate, to give a dialkoxy compound of a ketoaldehyde expressed by formula II, which is then subjected to aldol condensation to afford a compound expressed by formula III. The resultant compound expressed by formula III is then esterified to remove an acid or the compound expressed by formula III is dehydrated and hydrolyzed to give the aimed substance expressed by formula IV. EFFECT: The aimed substance is obtained from the readily available raw material by a simple method. USE: A trichogenous agent and hair tonic, remedy for pyorrhea, dentifrice, fundamental cosmetic, beautifying and whitening cosmetic, mothproofing agent for clothing and controlling agent against termites. COPYRIGHT: (C)1987,JPO&Japio | ||||||
| 52 | JPS6157294B2 - | JP3515478 | 1978-03-27 | JPS6157294B2 | 1986-12-06 | SHIOIRI TAKAYUKI; KAWAI NOBUTAKA; BAN MASATOSHI |
| 53 | Production of optically active 4-hydroxy-2-cyclopentenone | JP24588384 | 1984-11-22 | JPS61126048A | 1986-06-13 | NOYORI RYOJI; SUZUKI MASAAKI; KUROZUMI SEIJI |
| PURPOSE: Readily available 3,4-epoxycyclopentanone is used as a starting material to effect contact with a metal complex to produce the titled substance which is used as a synthetic intermediate of prostaglandins easily under mild conditions in high yield. CONSTITUTION: 3,4-Epoxycyclopentanone of formula I is brought into contact with a complex of optically active 1,1-bis-2-naphthol in a solvent such as dichloromethane at 0W70°C, preferably 10W40°C. Then, when needed, the hydroxyl is protected to give a compound of formula II (mark * is asymmetric carbon atom; R is H, or protecting group). The complex used in the reaction is prepared by combination of trialkylaluminum as a ligand of of formula III (R 1 is 1W4C alkyl), an alcohol, phenol or sulfonic acid as a coligand and optically active 1,1'-bi-2-naphthol. COPYRIGHT: (C)1986,JPO&Japio | ||||||
| 54 | JPS5914456B2 - | JP10907380 | 1980-08-08 | JPS5914456B2 | 1984-04-04 | TSUKASA HIDETAKA |
| 55 | JPS5834454B2 - | JP5200479 | 1979-04-28 | JPS5834454B2 | 1983-07-27 | KATO KUNIO; KANEKO HAJIME; FUJIMORI MINE; SHIGA MIKIO; MIUCHI AKYOSHI |
| 56 | Preparation of glutaraldehyde | JP386782 | 1982-01-13 | JPS58121234A | 1983-07-19 | IMAI HIROSUKE; MATSUNO MITSUO; YUASA HITOSHI |
| PURPOSE: To prepare the titled substance useful as various intermediates, tanning agent, curing agent, fungicide, crosslinking agent, immobilizing agent for enzyme, etc., with little production of by-products, easily, in high yield and purity, by the thermal decomposition of a cyclopentyl peroxide compound. CONSTITUTION: Glutaraldehyde is prepared by the thermal decomposition of the compound of formulaI(R 1 is H or 1W18C organic residue) or formula II (R 2 and R 3 are H, 1W18C organic residue or together form a ring) at 70W250°C. Since the reaction is exothermic, it is preferable to carry out the decomposition slowly under removal of heat. The raw material is decomposed as it is or after diluting with a solvent such as hydrocarbon, carboxylic acid, phosphoric acid, phosphonic acid, ketone, etc. EFFECT: The degradation of the objective compound can be prevented because there is no contact of the compound with acid, alkali, metallic catalyst, etc. during the preparation process. COPYRIGHT: (C)1983,JPO&Japio | ||||||
| 57 | 4-oxononanal, its intermediate and their preparation | JP14117379 | 1979-11-02 | JPS5665839A | 1981-06-03 | NAKAMURA MIKIO; IDE JIYUNICHI; RIYOU HARUE; FURUHATA AKEMICHI; TAKAGI KEIICHI; IWAMOTO MINORU; KUBOTA NOBORU; TAMURA HIROSHI; KOJIYOU KUNIO |
| NEW MATERIAL:A 4-oxononanal expressed by formula I and its intermediate, an acetal of the 4-oxononanal expressed by formula II (n is 2 or 3). USE: An aromatic or flavoring agent or a modifier having a continuous fruity flavor, used for food and drink, cosmetics, healthful and hygienic goods, medicines, etc. Particularly, a compound expressed by formula I is a key flavor giving a flavor and taste of a water melon. PROCESS: A Grignard reagent expressed by formula III (X is halogen) is reacted with a hexanoic acid or its functional derivative expressed by formula IV (Y is OH, halogen, or O; when Y is OH or halogen, m=1, and when Y is O, m=2) to prepare a compound expressed by formula II. The resultant compound is reacted with an acid, e.g. sulfuric acid, to give the compound of formula I. COPYRIGHT: (C)1981,JPO&Japio | ||||||
| 58 | Process for preparing 3-methylcyclopentadecane-1,5-diol | US15761699 | 2016-09-20 | US10196332B2 | 2019-02-05 | Miriam Bru Roig; Stefan Rüdenauer |
| The present invention relates to a process for preparing 3-methylcyclopentadecane-1,5-diol (I) by hydrogenolysis of 14-methyl-16,17,18-trioxatricyclo[10.3.2.1]octadecane (II). The invention further relates to a process for preparing 3-methylcyclopentadecane-1,5-diol is a macrocyclic diol that can serve as precursor for a macrocyclic odorant, such as muscone and muscenone. | ||||||
| 59 | PROCESS FOR PREPARING 3-METHYLCYCLOPENTADECANE-1,5-DIOL | US15761699 | 2016-09-20 | US20180346397A1 | 2018-12-06 | Miriam BRU ROIG; Stefan RÙDENAUER |
| The present invention relates to a process for preparing 3-methylcyclopentadecane-1,5-diol (I) by hydrogenolysis of 14-methyl-16,17,18-trioxatricyclo[10.3.2.1]octadecane (II). The invention further relates to a process for preparing 3-methylcyclopentadecane-1,5-diol is a macrocyclic diol that can serve as precursor for a macrocyclic odorant, such as muscone and muscenone. | ||||||
| 60 | Process for preparing ketones from epoxides | US14192269 | 2014-02-27 | US09000223B2 | 2015-04-07 | Kevin Micoine; Martin Roos; Peter Hannen; Harald Haeger; Klaus Bartosch |
| A process for preparing a ketone by conversion of a compound E which contains an epoxy group to the ketone in the presence of a mixture comprising at least one noble metal and at least one metal oxide as a catalyst system, wherein the metal oxide in the catalyst system is at least one of titanium dioxide and zirconium dioxide, and the process is conducted at 0 to 0.9 bar of hydrogen. | ||||||
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