| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | METHOD FOR SYNTHESIZING DIARYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, INCLUDING TETRAHYDROFURANS | PCT/US1999/024441 | 1999-10-15 | WO00023409A1 | 2000-04-27 | |
| A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (+/-)trans-2- [5-(N'-methyl- N'-hydroxyureidyl- methyl)-3-methoxy- 4-p-chlorophenylthioethoxyphenyl]- 5-(3,4,5- trimethoxyphenyl)- tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed. | ||||||
| 182 | RETINYL ETHERS, DERIVATIVES AND ANALOGUES AND INHIBITION OF BREAST CARCINOGENESIS | PCT/US9907946 | 1999-04-12 | WO9952846A3 | 2000-01-27 | SHEALY Y FULMER |
| The present invention is directed to retinyl ethers, derivatives and analogues and their use in inhibiting breast carcinogenesis or breast cancer cell growth. | ||||||
| 183 | PROCESS FOR PRODUCING ALKOXYBUTENES | PCT/EP9704704 | 1997-08-29 | WO9812165A3 | 1999-07-22 | KANAND JUERGEN; ROEPER MICHAEL |
| In a process for producing alkoxybutenes, 1,3-butadiene or a butadiene-containing hydrocarbon mixture is reacted with an alcohol of formula ROH (I) at an increased temperature and pressure in the presence of a Brönsted acid, yielding a mixture of addition products of formulas (II) and (III), in which the radical R is a C2-C20 alkyl, alkenyl, cycloalkyl or cycloalkenyl group substituted or not with 1 to 2 C1-C10 alkoxy or hydroxy groups, or is a C2-C10 aryl or C7-C11 aralkyl group or a methyl group. The disclosed improvement consists in that the reaction is carried out in the presence of water. | ||||||
| 184 | O-DERIVATIVES OF HALOGENATED DIPHENYL ETHER COMPOUNDS | PCT/EP9807997 | 1998-12-09 | WO9931036A2 | 1999-06-24 | HOELZL WERNER; HUEGLIN DIETMAR; MAIER THOMAS; MAO JIANWEN; OCHS DIETMAR |
| The invention describes O-derivatives of halogenated diphenyl ether compounds of formula (1), in which R1 and R2 independently of one another are F, Cl or Br; Y is a radical of formula (1a); (1b); (1c); (1d); (1e) or (1f); R3 is C1-C22alkyl; C1-C22alkoxy; phenyl; phenyl-C1-C4alkyl; --(CH2)p4-A<+>R5R6R7; the radical of formula (I); R4 C1-C22alkyl; R5, R6, R7 and R8 independently of one another are hydrogen; C1-C4alkyl; sulfo-C1-C4alkyl; or R5 and R6 together with A form a cyclic radical unsubstituted or substituted by sulfo groups; or R7 and R8 together with N form a cyclic radical unsubstituted or substituted by sulfo groups; A is N or P; Z1 is fluorine, chlorine, the radical of formula (1g); Z2 is fluorine, chlorine, C1-C22alkoxy, C1-C22alkylthio or C1-C22-monoalkylamino or C1-C22dialkylamino; each of which is unsubstituted or substituted by OH, NH2 or sulfo; C6-C12aryloxy, C6-C12arylthio or C6-C12monoarylamino or C6-C12diarylamino, each of which is unsubstituted or substituted by OH, NH2 or sulfo; m is from 1 to 3; n is 1 or 2; and p1, p2, p3, p4 and p5 independently of one another are 1-4. The diphenyl ether derivatives according to the invention have excellent antimicrobial properties and are stable to migration. | ||||||
| 185 | SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS AND ANALOGUES THEREOF USEFUL FOR THE TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION | PCT/US1998/024819 | 1998-11-20 | WO99026611A1 | 1999-06-03 | |
| The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer. | ||||||
| 186 | PREPARATION OF ISOFLURANE BY REACTION OF 2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER AND CHLORINE IN ADDED WATER, AT LOW TEMPERATURES AND/OR AT HIGHER CONVERSIONS | PCT/US1998/021997 | 1998-10-15 | WO99020588A1 | 1999-04-29 | |
| A process for preparing isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether) by reacting PFE (2,2,2-trifluoroethyl difluoromethyl ether) with chlorine in the presence of ultraviolet light and added water, at a low temperature and/or at a high conversion. | ||||||
| 187 | PROCESS FOR PRODUCING n-BUTYLALKYL ETHERS | PCT/EP9704703 | 1997-08-29 | WO9812164A3 | 1999-04-01 | KANAND JUERGEN; ROEPER MICHAEL |
| In a process for producing n-butylalkyl ethers, (a) 1,3-butadiene or a butadiene-containing hydrocarbon mixture is reacted with an alcohol of formula ROH (I), in which the radical R is a C2-C20 alkyl or alkenyl group substituted or not with 1 to 2 C1-C10 alkoxy or hydroxy groups, a C6-C10 aryl or C7-C11 aralkyl group or a methyl group, at an increased temperature and pressure in the presence of a Brönsted acid or in the presence of a complex of an element of groups Ib, VIIb or VIIIb of the periodic table of elements with a phosphorus- or nitrogen-containing ligand, yielding a mixture of addition products of formulas (II) and (III); (b) the isomers are separated; (c) addition product III is isomerised into addition product II; (d) addition product II is hydrogenated in the presence of a homogeneous or heterogeneous transition metal element catalyst in the liquid phase or in the presence of a heterogeneous, transition metal element-containing catalyst in the gas phase, yielding n-butylalkyl ether of formula (IV). | ||||||
| 188 | PROCESS FOR PRODUCING ALKOXYBUTENES | PCT/EP1997004704 | 1997-08-29 | WO1998012165A2 | 1998-03-26 | BASF AKTIENGESELLSCHAFT |
| In a process for producing alkoxybutenes, 1,3-butadiene or a butadiene-containing hydrocarbon mixture is reacted with an alcohol of formula ROH (I) at an increased temperature and pressure in the presence of a Brönsted acid, yielding a mixture of addition products of formulas (II) and (III), in which the radical R is a C2-C20 alkyl, alkenyl, cycloalkyl or cycloalkenyl group substituted or not with 1 to 2 C1-C10 alkoxy or hydroxy groups, or is a C2-C10 aryl or C7-C11 aralkyl group or a methyl group. The disclosed improvement consists in that the reaction is carried out in the presence of water. | ||||||
| 189 | PROCESS FOR PRODUCING n-BUTYLALKYL ETHERS | PCT/EP1997004703 | 1997-08-29 | WO1998012164A2 | 1998-03-26 | BASF AKTIENGESELLSCHAFT |
| In a process for producing n-butylalkyl ethers, (a) 1,3-butadiene or a butadiene-containing hydrocarbon mixture is reacted with an alcohol of formula ROH (I), in which the radical R is a C2-C20 alkyl or alkenyl group substituted or not with 1 to 2 C1-C10 alkoxy or hydroxy groups, a C6-C10 aryl or C7-C11 aralkyl group or a methyl group, at an increased temperature and pressure in the presence of a Brönsted acid or in the presence of a complex of an element of groups Ib, VIIb or VIIIb of the periodic table of elements with a phosphorus- or nitrogen-containing ligand, yielding a mixture of addition products of formulas (II) and (III); (b) the isomers are separated; (c) addition product III is isomerised into addition product II; (d) addition product II is hydrogenated in the presence of a homogeneous or heterogeneous transition metal element catalyst in the liquid phase or in the presence of a heterogeneous, transition metal element-containing catalyst in the gas phase, yielding n-butylalkyl ether of formula (IV). | ||||||
| 190 | PURIFICATION OF FLUORINATED DIMETHYL ETHERS | PCT/US1996008221 | 1996-05-31 | WO1996039370A1 | 1996-12-12 | HAMPSHIRE CHEMICAL CORP.; O'NEILL, Gerald, J.; BULKA, Robert, J. |
| A process for the purification of bis(difluoromethyl)ether. Bis(difluoromethyl)ether is exposed to molecular sieves in order to reduce or completely remove impurities. In a further embodiment, the present invention optionally includes means for preferentially inhibiting the formation of CF2HOCC13 in the formation of bis(difluoromethyl)ether prior to exposing the bis(difluoromethyl)ether to the molecular sieves. | ||||||
| 191 | METHOD FOR SYNTHESIS OF ARYL DIFLUOROMETHYL ETHERS AND THE LIKE | PCT/US1996001327 | 1996-01-29 | WO1996023754A1 | 1996-08-08 | SMITHKLINE BEECHAM CORPORATION; SMITHKLINE BEECHAM PLC |
| This invention relates to a method for preparing difluoromethyl ethers, thiols and amines without using chlorofluorocarbon gases. The intermediates prepared by this method can be used to make certain compounds which act as PDE IV inhibitors which are useful for treating asthma and other diseases implicated with the PDE IV isozyme. | ||||||
| 192 | PROCESS FOR PREPARING ISETHIONATE ETHOXYLATES | PCT/US1995004178 | 1995-04-04 | WO1995029144A1 | 1995-11-02 | VISTA CHEMICAL COMPANY; WEERSOORIYA, Upali; LIN, John |
| A process for producing alkali metal isethionate ethoxylates by reacting an alkali metal isethionate and a polyol, the mole ratio of polyol to alkali metal isethionate being greater than about 7:1, the reaction mixture produced being neutralized with a non-oxidizing inorganic acid to produce a neutralized reaction mixture from which the alkali metal isethionate ethoxylate is recovered. | ||||||
| 193 | PROCESS FOR MAKING PROPARGYL ETHERS OF HYDROXYAROMATIC COMPOUNDS | PCT/US1988001734 | 1988-05-25 | WO1988009782A1 | 1988-12-15 | THE DOW CHEMICAL COMPANY; INBASEKARAN, Muthiah, N.; DIRLIKOV, Stoil, K. |
| A process for preparing an aromatic propargyl ether, preferably bispropargyl ether, from hydroxyaromatic compounds comprising vigorously stirring a propargyl halide, preferably propargyl chloride, with a hydroxyaromatic compound, such as bisphenol A, in an aqueous sodium hydroxide solution at a temperature of from 0C to 100C, in the presence of a phase transfer catalyst such as tetrabutylammonium bromide. The mixture is then filtered to recover a solid product. That product is washed with water and propanol. This process provides a product having greater than 95 percent purity in yields ranging from 85 to 97 percent of theoretical. | ||||||
| 194 | VINYLBENZYL ETHERS OF POLYHYDRIC HALOGENATED PHENOLIC COMPOUNDS | PCT/US1987002024 | 1987-08-14 | WO1988001262A1 | 1988-02-25 | THE DOW CHEMICAL COMPANY; GODSCHALZ, James, P.; WOO, Edmund, P.; SCHRADER, Patricia, A.; ALDRICH, Peter, D. |
| The polyfunctional vinylbenzyl ethers of formula (I), wherein Ar is an aromatic nucleus of from 6 to 24 carbon atoms, X is a halogen moiety, R is hydrogen or an alkyl group of from 1 to 6 carbon atoms, n is an integer of at least 1; o is an integer of at least 2 and p is the remaining number of sites available on the aromatic nucleus which are not substituted with the halogen or oxygen containing moiety are prepared. These polyfunctional vinylbenzyl ethers can be copolymerized with polycyanate ester compounds to provide copolymers having dielectric constants below 3 and a V-O rating in a UL-94 test. | ||||||
| 195 | HEXASUBSTITUTED CYCLOHEXANE COMPOUNDS | PCT/EP8700318 | 1987-06-19 | WO8800940A3 | 1988-02-25 | PRAEFCKE KLAUS; KOHNE BERND; DORSCH DIETER; RIEGER BERNHARD |
| Hexasubstituted cyclohexane compounds which are suitable as components of discotic liquid crystal phases. | ||||||
| 196 | 一种蒸汽辅助热解木质素制备愈创木酚类产物的方法 | PCT/CN2019/111078 | 2019-10-14 | WO2021012411A1 | 2021-01-28 | 蒋剑春; 叶俊; 徐俊明; 王奎; 李静; 周铭昊; 夏海虹; 刘朋; 王瑞珍; 赵佳平 |
本发明公开了一种蒸汽辅助热解木质素制备愈创木酚类产物的方法，属于生物质资源利用技术领域。该方法中木质素在热解反应器中进行，得到热解产物；利用饱和蒸汽作为萃取溶剂对热解产物进行连续脱除，得到愈创木酚类产物；所述热解温度为220-400℃，饱和蒸汽温度为150-300℃，饱和蒸汽流量为2.5-12.5g/min，反应时间为0.5-2h。本发明通过热解实现木质素组分含氧醚键断键，采用饱和蒸汽萃取实现热解产物连续脱除，提高液化产物产率并选择性制备愈创木酚类产物。本发明获得液化产物纯度高，过程简单，容易实现工业化推广。 |
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| 197 | RECYCLABLE AND REWORKABLE POLYOL (S) | PCT/IB2020/054717 | 2020-05-19 | WO2020260970A1 | 2020-12-30 | DUBEY, Pradip Kumar; SINGH, Chandan Kumar; SITTIPUMMONGKOL, Kanyarat; SRIPET, Weerawat |
Polyol component(s) for a recyclable polyurethane system is disclosed. The recyclable polyurethane system comprises a polyol component having a structural Formula (I), a polyol component having a structural Formula (II) or a polyol component having a structural Formula III and an isocyanate curing agent. A process(es) for preparing the polyol component having the structural Formula (I), the polyol component having the structural Formula (II) and the polyol component having the structural Formula (III) is also disclosed. |
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| 198 | 含氟阳离子聚合单体及其合成和应用 | PCT/CN2019/111675 | 2019-10-17 | WO2020078422A1 | 2020-04-23 | 邹应全; 邓宇飞 |
一种式(I)单体化合物，其中各变量如说明书中所定义。该单体通过硫醇与烯烃之间的点击化学反应以高产率、快速合成，而且将基本上全氟化的烷烃链借助于包含降冰片烷结构部分的连接基引入到氧杂环烷烃类单体中，使得由所得单体阳离子光固化得到的光固化薄膜表面硬度高，表面能低，疏水疏油性能优良，尤其是抗油性沾污非常好。还涉及所述单体的制备方法，该单体开环聚合得到的聚合物，包含该单体的可光固化组合物和由该可光固化组合物光固化得到的光固化材料。 |
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| 199 | PROCESSES FOR TREATING OLEFIN FEEDSTREAMS AND RELATED OLIGOMERIZATION PROCESSES | PCT/EP2013/073400 | 2013-11-08 | WO2014082838A1 | 2014-06-05 | HAMILTON, Paul |
Embodiments disclosed herein relate to a process for the oligomerization of olefins, the process including at least one olefin feedstream that includes ammonia and contacting the at least one olefin feedstream with a liquid including alkaline water to remove at least a portion of the ammonia to produce at least one treated olefin feedstream and subsequently contacting the at least one treated olefin feedstream with a catalyst under oligomerization conditions to produce an oligomer product. In several embodiments disclosed herein, the at least one olefin feedstream includes one or more C3-C15 olefins, preferably, C3-C5 olefins, any isomer thereof, one or more paraffins having the same or different carbon number as the olefins, and mixtures thereof. |
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| 200 | RECYCLING AND REINVESTMENT OF CARBON FROM AGRICULTURAL PROCESSES FOR RENEWABLE FUEL AND MATERIALS USING THERMOCHEMICAL REGENERATION | PCT/US2012050619 | 2012-08-13 | WO2013025627A3 | 2013-05-10 | MCALISTER ROY EDWARD |
| Techniques, systems, apparatus and material are disclosed for regeneration or recycling of carbon substances into renewable fuel and materials. In one aspect, a method of recycling carbon to produce a renewable fuel can include harvesting carbon donors, such as carbon dioxide (CO2), emitted from an agricultural process. Hydrogen donors, such as from biomass waste, can be dissociated under an anaerobic reaction to produce hydrogen. The harvested carbon dioxide can be reacted with the waste-produced hydrogen under pressure and temperature to generate a renewable fuel, such as methanol fuel. | ||||||
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