Anaplasmosis vaccines
阅读：38发布：2022-01-15
专利汇可以提供Anaplasmosis vaccines专利检索，专利查询，专利分析的服务。并且An anaplasmosis vaccine containing an avirulent Anaplasma marginale mutant in a red blood cell carrier is provided. The virulent form is exposed to radiation to accelerate the rate of dissociation of the virulent form to an avirulent form and the irradiated organism is subsequently passed through at least one nonbovine ruminant host.，下面是Anaplasmosis vaccines专利的具体信息内容。
2. A method according to claim 1 wherein said radiation is X-ray.
2. inoculating said radiated blood into anaplasmosis susceptible non-bovine ruminant sheep, goat or deer host;
3. harvesting blood from said non-bovine ruminant host, said blood containing attenuated Anaplasma marginale
3. A method according to claim 1 wherein said radiation is from a radioactive cobalt source.
4. A method according to claim 2 wherein said X-ray radiation is administered in a quantum about 60,000 roentgens.
4. serially inoculating with said harvested blood into each of a plurality of said hosts;
5. continuing said serial inoculation until attenuated Anaplasma marginale organisms are confirmable in harvested blood by direct blood smear examination and a positive serologic reaction in the capillary tube agglutination test or complement fixation test; and
5. The method of claim 1 including the step of storing the blood under preserving conditions.
6. The method of claim 5 in which the withdrawn blood is freeze-dried and the powder is stored.
6. harvesting the blood from said hosts with the confirmed attenuated Anaplasma marginale organisms of step 5; whereby said blood of step 6 contains attenuated Anaplasma marginale within the red blood cells and is useful as vaccine, said vaccine being characterizable by at least one of the following tests: a. an anaplasmosis susceptible ruminant host, vaccinated with said vaccine, becomes positive to capillary agglutination and complement fixation tests approximately five to six weeks after vaccination; b. an anaplasmosis susceptible ruminant host, vaccinated with said vaccine, develops erythrocytic inclusions and shows a drop in packed cell volume, without concurrent gross symptoms of anaplasmosis; c. an anaplasmosis susceptible ruminant host, vaccinated with said vaccine, maintains a high level of antibody for at least six months, at which time the host resist challenge with Anaplasma marginale; d. an anaplasmosis susceptible ruminant host, vaccinated with said vaccine, remains free of observable symptoms of the anaplasmosis, in the face of a natural challenge when the host is placed in a herd of anaplasmosis susceptible ruminant hosts containing known Anaplasma marginale carriers; e. said attenuated strain of Anaplasma marginale, which is on deposit in the American Type Culture Collection under ATCC Number VR 554, remains avirulent for at least five serial passages through anaplasmosis susceptible ruminant hosts and each host exhibits strong immunity to clinical symptoms of anaplasmosis; and f. the blood of a vaccinated anaplasmosis susceptible reuminant host is useful as a vaccine for anaplasmosis without further treatment.
7. The method of claim 5 in which the withdrawn blood is frozen and the frozen liquid is stored.
8. The method of claim 5 in wHich the preserving condition for the lyophilized vaccine is brought about by desiccating the vaccine in admixture with polyvinylpyrrolidone.
9. The method of claim 5 in which the preserving condition for the frozen vaccine is brought about by freezing the vaccine in admixture with glycerol.
10. A method of immunizing cattle against Anaplasma marginale comprising inoculating the cattle with at least one of: (1) the blood of step 6 of claim 29; (2) the blood of a cow which has been immunized directly with the blood of step 6 of claim 29; and (3) the blood of a cow which has been immunized with the said attenuated Anaplasma marginale organism.
11. A method according to claim 1 wherein the vaccine is harvested from a passage not earlier than the second animal passage.
12. A method according to claim 1 wherein the quantum is in a range from 40,000 to 85,000 roentgens.
13. The Anaplasma marginale vaccine comprising the blood of step 6 of claim 1.
14. The Anaplasma marginale vaccine comprising the blood of the said cows of claim 10.
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