专利汇可以提供新型的吡啶并吡嗪衍生物,其制备方法和用途专利检索,专利查询,专利分析的服务。并且本 发明 涉及通式(Ia)和(Ib)所示的新型的吡啶并[2,3-b]吡嗪衍 生物 及其制备方法及其作为药物、特别是作为用于 治疗 恶性 疾病 和治疗其它的基于病理性 细胞增殖 的疾病的药物的用途。,下面是新型的吡啶并吡嗪衍生物,其制备方法和用途专利的具体信息内容。
1.通式(Ia)所示的吡啶并[2,3-b]吡嗪衍生物,
其中
基团R3,R4之一独立地选自、或者基团R3,R4二者彼此独立地选自:
(1)“-NR6R7”;
其中基团R6,R7彼此独立地选自:
(e)“氢,烷基,芳基烷基,杂芳基烷基”;
第一个前提条件是,基团R6,R7不同时为氢,烷基,芳基烷基或杂芳基烷基;
第二个前提条件是,如果基团R6,R7之一独立地是“氢”,则基团R5不选自:“-NH-环
烷基,-NH-杂环基,-NH-芳基,-NH-杂芳基,卤素,-F,-Cl,-Br,-I,-NRaRb”,其中Ra,Rb独立地选自:“H,烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-NRcRd”,其中Rc,Rd又独立地选自:“H,烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”;
(f)“-C(Y1)NR8R9,-C(Y1b)OR9b,-C(=NR10)-R11,-C(Y2)NR12-Y3-R13”;
其中Y1,Y1b,Y2彼此独立地选自:“=O,=S,=NH,=NR14”;
其中Y 3独立地选自:“O,S”;
其中基团R8,R9,R9b,R10,R11,R12,R13,R14彼此独立地选自:
(I)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHX1,-NX2X3,-NO2,-OH,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-X4,-C(O)O-X5,-C(O)NH-X6,-C(O)NX7X8,-O-X9,-O(-X10-O)a-H(a=1,2,3,4,5),-O(-X11-O)b-X12(b= 1,2,3,4,5),-OC(O)-X13,-OC(O)-O-X14,-OC(O)-NHX15,-O-C(O)-NX16X17,-OP(O)(OX18)(OX19),-OSi(X20)(X21)(X22),-OS(O2)-X23,-NHC(O)-NH2,-NHC(O)-X24,-NX25C(O)-X26,-NH-C(O)-O-X27,-NH-C(O)-NH-X28,-NH-C(O)-NX29X30,-NX31-C(O)-O-X32,-NX33-C(O)-NH-X34,-NX35-C(O)-NX36X37,-NHS(O2)-X38,-NX39S(O2)-X40,-S-X41,-S(O)-X42,-S(O2)-X43,-S(O2)NH-X44,-S(O2)NX45X46,-S(O2)O-X47,-P(O)(OX48)(OX49),-Si(X50)(X51)(X52),-C(NH)-NH2,-C(NX53)-NH2,-C(NH)-NHX54,-C(NH)-NX55X56,-C(NX57)-NHX58,-C(NX59)-NX60X61,-NH-C(O)-NH-O-X62,-NH-C(O)-NX63-O-X64,-NX65-C(O)-NX66-O-X67,-N(-C(O)-NH-O-X68)2,-N(-C(O)-NX69-O-X70)2,-N(-C(O)-NH-O-X71)(-C(O)-NX72-O-X73),-C(S)-X74,-C(S)-O-X75,-C(S)-NH-X76,-C(S)-NX77X78,-C(O)-NH-O-X79,-C(O)-NX80-O-X81,-C(S)-NH-O-X82,-C(S)-NX83-O-X84,-C(O)-NH-NH-X85,-C(O)-NH-NX86X87,-C(O)-NX88-NX89X90,-C(S)-NH-NH-X91,-C(S)-NH-NX92X93,-C(S)-NX94-NX95X96,-C(O)-C(O)-O-X97,-C(O)-C(O)-NH2,-C(O)-C(O)-NHX98,-C(O)-C(O)-NX99X100,-C(S)-C(O)-O-X101,-C(O)-C(S)-O-X102,-C(S)-C(S)-O-X103,-C(S)-C(O)-NH2,-C(S)-C(O)-NHX104,-C(S)-C(O)-NX105X106,-C(S)-C(S)-NH2,-C(S)-C(S)-NHX107,-C(S)-C(S)-NX108X109,-C(O)-C(S)-NH2,-C(O)-C(S)-NHX110,-C(O)-C(S)-NX111X112”;
其中X1,X2,X 3,X4,X5,X6,X7,X8,X9,X10,X11,X12,X13,X14,X15,X16,X17,X18,X19,X20,X21,X22,X23,X24,X25,X26,X27,X28,X29,X30,X31,X32,X33,X34,X35,X36,X37,X38,X39,X40,X41,X42,X43,X44,X45,X46,X47,X48,X49,X50,X51,X52,X53,X54,X55,X56,X57,X58,X59,X60,X61,X62,X63,X64,X65,X66,X67,X68,X69,X70,X71,X72,X73,X74,X75,X76,X77,X78,X79,X80,X81,X82,X83,X84,X85,X86,X87,X88,X89,X90,X91,X92,X93,X94,X95,X96,X97,X98,X99,X100,X101,X102,X103,X104,X105,X106,X107,X108,X109,X110,X111,X112彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,X7,X8和/或X16,X17和/或X29,X30和/或X36,X37和/或X45,X46和/或X55,X56和/或
X60,X61和/或X77,X78和/或X86,X87和/或X89,X90和/或X92,X93和/或X95,X96
和/或X99,X100和/或X105,X106和/或X108,X109和/或X111,X112和/或分别一起
还可形成“杂环基”;
其中任选地,上述取代基组(I)的取代基,如果不是氢,又可彼此独立地被至少一个相
同或不同的选自以下的取代基取代:
(i)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHX201,-NX202X203,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-X204,-C(O)O-X205,-C(O)NH-X206,-C(O)NX207X208,-O-X209,-O(-X210-O)c-H(c=1,2,3,4,5),-O(-X211-O)d-X212(d=1,2,3,4,5),-OC(O)-X213,-OC(O)-O-X214,-OC(O)-NHX215,-O-C(O)-NX216X217,-OP(O)(OX218)(OX219),-OSi(X220)(X221)(X222),-OS(O2)-X
223,-NHC(O)-NH2,-NHC(O)-X224,-NX225C(O)-X226,-NH-C(O)-O-X227,-NH-C(O)-NH-X228,-NH-C(O)-NX229X230,-NX231-C(O)-O-X232,-NX233-C(O)-NH-X234,-NX235-C(O)-NX236X237,-NHS(O2)-X238,-NX239S(O2)-X240,-S-X241,-S(O)-X242,-S(O2)-X243,-S(O2)NH-X244,-S(O2)NX245X246,-S(O2)O-X247,-P(O)(OX248)(OX249),-Si(X250)(X251)(X252),-C(NH)-NH2,-C(NX253)-NH2,-C(NH)-NHX254,-C(NH)-NX255X256,-C(NX257)-NHX258,-C(NX259)-NX260X261,-NH-C(O)-NH-O-X262,-NH-C(O)-NX263-O-X264,-NX265-C(O)-NX266-O-X267,-N(-C(O)-NH-O-X268)2,-N(-C(O)-NX269-O-X270)2,-N(-C(O)-NH-O-X271)(-C(O)-NX272-O-X273),-C(S)-X274,-C(S)-O-X275,-C(S)-NH-X276,-C(S)-NX277X278,-C(O)-NH-O-X279,-C(O)-NX280-O-X281,-C(S)-NH-O-X282,-C(S)-NX283-O-X284,-C(O)-NH-NH-X285,-C(O)-NH-NX286X287,-C(O)-NX288-NX289X290,-C(S)-NH-NH-X291,-C(S)-NH-NX292X293,-C(S)-NX294-NX295X296,-C(O)-C(O)-O-X297,-C(O)-C(O)-NH2,-C(O)-C(O)-NHX298,-C(O)-C(O)-NX299X300,-C(S)-C(O)-O-X301,-C(O)-C(S)-O-X302,-C(S)-C(S)-O-X303,-C(S)-C(O)-NH2,-C(S)-C(O)-NHX304,-C(S)-C(O)-NX305X306,-C(S)-C(S)-NH2,-C(S)-C(S)-NHX307,-C(S)-C(S)-NX308X309,-C(O)-C(S)-NH2,-C(O)-C(S)-NHX310,-C(O)-C(S)-NX311X312”;
其中X201,X202,X203,X204,X205,X206,X207,X208,X209,X210,X211,X212,X213,X214,X215,X216,X217,X218,X219,X220,X221,X222,X223,X224,X225,X226,X227,X228,X229,X230,X231,X232,X233,X234,X235,X236,X237,X238,X239,X240,X241,X242,X243,X244,X245,X246,X247,X248,X249,X250,X251,X252,X253,X254,X255,X256,X257,X258,X259,X260,X261,X262,X263,X264,X265,X266,X267,X268,X269,X270,X271,X272,X273,X274,X275,X276,X277,X278,X279,X280,X281,X282,X283,X284,X285,X286,X287,X288,X289,X290,X291,X292,X293,X294,X295,X296,X297,X298,X299,X300,X301,X302,X303,X304,X305,X306,X307,X308,X309,X310,X311,X312彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,X207,X208和/或X216,X217和/或X229,X230和/或X236,X237和/
或X245,X246和/或X255,X256和/或X260,X261和/或X277,X278和/或X286,X287
和/h或X289,X290和/或X292,X293和/或X295,X296和/或X299,X300和/或X305,
X306和/或X308,X309和/或X311,X312和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(i)的取代基又可彼此独立地被至少一个相同或不同的选
自以下的取代基取代:
(ii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHX401,-NX402X403,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-X404,-C(O)O-X405,-C(O)NH-X406,-C(O)NX407X408,-O-X409,-O(-X410-O)e-H(e=1,2,3,4,5),-O(-X411-O)f-X412(f=1,2,3,4,5),-OC(O)-X413,-OC(O)-O-X414,-OC(O)-NHX415,-O-C(O)-NX416X417,-OP(O)(OX418)(OX419),-OSi(X420)(X421)(X422),-OS(O2)-X
423,-NHC(O)-NH2,-NHC(O)-X424,-NX425C(O)-X426,-NH-C(O)-O-X427,-NH-C(O)-NH-X428,-NH-C(O)-NX429X430,-NX431-C(O)-O-X432,-NX433-C(O)-NH-X434,-NX435-C(O)-NX436X437,-NHS(O2)-X438,-NX439S(O2)-X440,-S-X441,-S(O)-X442,-S(O2)-X443,-S(O2)NH-X444,-S(O2)NX445X446,-S(O2)O-X447,-P(O)(OX448)(OX449),-Si(X450)(X451)(X452),-C(NH)-NH2,-C(NX453)-NH2,-C(NH)-NHX454,-C(NH)-NX455X456,-C(NX457)-NHX458,-C(NX459)-NX460X461,-NH-C(O)-NH-O-X462,-NH-C(O)-NX463-O-X464,-NX465-C(O)-NX466-O-X467,-N(-C(O)-NH-O-X468)2,-N(-C(O)-NX469-O-X470)2,-N(-C(O)-NH-O-X471)(-C(O)-NX472-O-X473),-C(S)-X474,-C(S)-O-X475,-C(S)-NH-X476,-C(S)-NX477X478,-C(O)-NH-O-X479,-C(O)-NX480-O-X481,-C(S)-NH-O-X482,-C(S)-NX483-O-X484,-C(O)-NH-NH-X485,-C(O)-NH-NX486X487,-C(O)-NX488-NX489X490,-C(S)-NH-NH-X491,-C(S)-NH-NX492X493,-C(S)-NX494-NX495X496,-C(O)-C(O)-O-X497,-C(O)-C(O)-NH2,-C(O)-C(O)-NHX498,-C(O)-C(O)-NX499X500,-C(S)-C(O)-O-X501,-C(O)-C(S)-O-X502,-C(S)-C(S)-O-X503,-C(S)-C(O)-NH2,-C(S)-C(O)-NHX504,-C(S)-C(O)-NX505X506,-C(S)-C(S)-NH2,-C(S)-C(S)-NHX507,-C(S)-C(S)-NX508X509,-C(O)-C(S)-NH2,-C(O)-C(S)-NHX510,-C(O)-C(S)-NX511X512”;
其中X401,X402,X403,X404,X405,X406,X407,X408,X409,X410,X411,X412,X413,X414,X415,X416,X417,X418,X419,X420,X421,X422,X423,X424,X425,X426,X427,X428,X429,X430,X431,X432,X433,X434,X435,X436,X437,X438,X439,X440,X441,X442,X443,X444,X445,X446,X447,X448,X449,X450,X451,X452,X453,X454,X455,X456,X457,X458,X459,X460,X461,X462,X463,X464,X465,X466,X467,X468,X469,X470,X471,X472,X473,X474,X475,X476,X477,X478,X479,X480,X481,X482,X483,X484,X485,X486,X487,X488,X489,X490,X491,X492,X493,X494,X495,X496,X497,X498,X499,X500,X501,X502,X503,X504,X505,X506,X507,X508,X509,X510,X511,X512彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,X407,X408和/或X416,X417和/或X429,X430和/或X436,X437和/
或X445,X446和/或X455,X456和/或X460,X461和/或X477,X478和/或X486,X487
和/或X489,X490和/或X492,X493和/或X495,X496和/或X499,X500和/或X505,
X506和/或X508,X509和/或X511,X512和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(ii)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(iii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-C1,-Br,-I,-CN,-CF3,-N3,-NH2,-NHX601,-NX602X603,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-X604,-C(O)O-X605,-C(O)NH-X606,-C(O)NX607X608,-O-X609,-O(-X610-O)e-H(e=1,2,3,4,5),-O(-X611-O)f-X612(f=1,2,3,4,5),-OC(O)-X613,-OC(O)-O-X614,-OC(O)-NHX615,-O-C(O)-NX616X617,-OP(O)(OX618)(OX619),-OSi(X620)(X621)(X622),-OS(O2)-X
623,-NHC(O)-NH2,-NHC(O)-X624,-NX625C(O)-X626,-NH-C(O)-O-X627,-NH-C(O)-NH-X628,-NH-C(O)-NX629X630,-NX631-C(O)-O-X632,-NX633-C(O)-NH-X634,-NX635-C(O)-NX636X637,-NHS(O2)-X638,-NX639S(O2)-X640,-S-X641,-S(O)-X642,-S(O2)-X643,-S(O2)NH-X644,-S(O2)NX645X646,-S(O2)O-X647,-P(O)(OX648)(OX649),-Si(X650)(X651)(X652),-C(NH)-NH2,-C(NX653)-NH2,-C(NH)-NHX654,-C(NH)-NX655X656,-C(NX657)-NHX658,-C(NX659)-NX660X661,-NH-C(O)-NH-O-X662,-NH-C(O)-NX663-O-X664,-NX665-C(O)-NX666-O-X667,-N(-C(O)-NH-O-X668)2,-N(-C(O)-NX669-O-X670)2,-N(-C(O)-NH-O-X671)(-C(O)-NX672-O-X673),-C(S)-X674,-C(S)-O-X675,-C(S)-NH-X676,-C(S)-NX677X678,-C(O)-NH-O-X679,-C(O)-NX680-O-X681,-C(S)-NH-O-X682,-C(S)-NX683-O-X684,-C(O)-NH-NH-X685,-C(O)-NH-NX686X687,-C(O)-NX688-NX689X690,-C(S)-NH-NH-X691,-C(S)-NH-NX692X693,-C(S)-NX694-NX695X696,-C(O)-C(O)-O-X697,-C(O)-C(O)-NH2,-C(O)-C(O)-NHX698,-C(O)-C(O)-NX699X700,-C(S)-C(O)-O-X701,-C(O)-C(S)-O-X702,-C(S)-C(S)-O-X703,-C(S)-C(O)-NH2,-C(S)-C(O)-NHX704,-C(S)-C(O)-NX705X706,-C(S)-C(S)-NH2,-C(S)-C(S)-NHX707,-C(S)-C(S)-NX708X709,-C(O)-C(S)-NH2,-C(O)-C(S)-NHX710,-C(O)-C(S)-NX711X712”;
其中X601,X602,X603,X604,X605,X606,X607,X608,X609,X610,X611,X612,X613,X614,X615,X616,X617,X618,X619,X620,X621,X622,X623,X624,X625,X626,X627,X628,X629,X630,X631,X632,X633,X634,X635,X636,X637,X638,X639,X640,X641,X642,X643,X644,X645,X646,X647,X648,X649,X650,X651,X652,X653,X654,X655,X656,X657,X658,X659,X660,X661,X662,X663,X664,X665,X666,X667,X668,X669,X670,X671,X672,X673,X674,X675,X676,X677,X678,X679,X680,X681,X682,X683,X684,X685,X686,X687,X688,X689,X690,X691,X692,X693,X694,X695,X696,X697,X698,X699,X700,X701,X702,X703,X704,X705,X706,X707,X708,X709,X710,X711,X712彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,X607,X608和/或X616,X617和/或X629,X630和/或X636,X637和/
或X645,X646和/或X655,X656和/或X660,X661和/或X677,X678和/或X686,X687
和/或X689,X690和/或X692,X693和/或X695,X696和/或X699,X700和/或X705,
X706和/或X708,X709和/或X711,X712和/或分别一起还可形成“杂环基”;
第一个前提条件是,如果“-C(Y1)-NR8R9”选自:“-C(O)-NRaRb”,其中Ra,Rb彼此独立地选自:“氢,烷基,(C9-C30)烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,环烷基,环烷基烷基,杂环基,杂环基烷基”,或者其中Ra,Rb一起形成“杂环基”,基团R1,R2之一不是“氢”,并且基团R1,R2中的另一个不是“-NRcRd”,其中Rc,Rd彼此独立地选自:“氢,烷基,(C9-C30烷基),环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-C(Ya1)NXa16Xa17,-C(=NXa18)-Xa19,-C(Ya2)NXa20-Ya3-Xa21”;前提条件是Rc,Rd不同时是“氢”或“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,进一步的前提条件是如果基团Rc,Rd之一是“氢”或“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,则基团Rc,Rd中的另一个是“-C(Ya1)NXa16Xa17”,“-C(=NXa18)-Xa19”或“-C(Ya2)NXa20-Ya3-Xa21”,其中Ya1,Ya2,Ya3彼此独立地选自“O,S,=NH,=NXa22”;其中Xa16,Xa17,Xa18,Xa19,Xa20,Z21,Z22彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,3杂芳基烷基,杂环基,杂环基烷基”;
第二个前提条件是,如果基团R1,R2中的至少一个是“-NXa26Xa27”,其中基团Xa26,
Xa27中的至少一个是“-C(O)-NReRf”,其中基团Re,Rf中的至少一个选自:“烷基,环烷基,杂环基,芳基,杂芳基,C(O)-烷基,C(O)-芳基,C(O)-杂芳基,(C9-C30)烷基,环烷基烷基,杂环基烷基,芳基烷基,杂芳基烷基,-C(O)-(C9-C30)烷基,-C(O)-环烷基,-C(O)-环烷基烷基,-C(O)-芳基烷基,-C(O)-杂芳基烷基,-C(O)-杂环基,-C(O)-杂环基烷基,-S(O2)-烷基,-S(O2)-(C9-C30)烷基,-S(O2)-环烷基,-S(O2)-环烷基烷基,-S(O2)-芳基,-S(O2)-芳基烷基,-S(O2)-杂芳基,-S(O2)-杂芳基烷基,-S(O2)-杂环基,-S(O2)-杂环基烷基”,则基团R3,R4不是“-C(O)-NXa1135Xa1136”,其中Xa1135,Xa1136独立地选自:“氢,烷基,(C9-C30烷基),环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,或其中Xa1135,Xa1136一起形成“杂环基”;
第三个前提条件是,如果“-C(Y1)-NR8R9”独立地选自:“-C(O)-N[C(O)-O-烷
基 ]2,-C(O)-N[C(O)- 烷 基 ]2,-C(O)-N[S(O2)- 烷 基 ]2,-C(O)-N[S(O2)- 环 烷
基]2,-C(O)-N[S(O2)-环烷基烷基]2,-C(O)-N[S(O2)-芳基]2,-C(O)-N[S(O2)-杂环基]2”,则基团R1,R2彼此独立地不是“苯基”;
第四个前提条件是,如果“-C(Y2)-NR12-Y3-R13”独立地选自:“-C(O)-N[O-烷基]2”,则基团R1,R2彼此独立地不是“苯基”;
(g)“-C(O)-C(O)-R16”;
其中基团R16独立地选自:
(II)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHZ1,-NZ2Z3,-NO2,-OH,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-Z4,-C(O)O-Z5,-C(O)NH-Z6,-C(O)NZ7Z8,-O-Z9,-O(-Z10-O)a-H(a=1,2,3,4,5),-O(-Z11-O)b-Z12(b= 1,2,3,4,5),-OC(O)-Z13,-OC(O)-O-Z14,-OC(O)-NHZ15,-O-C(O)-NZ16Z17,-OP(O)(OZ18)(OZ19),-OSi(Z20)(Z21)(Z22),-OS(O2)-Z23,-NHC(O)-NH2,-NHC(O)-Z24,-NZ25C(O)-Z26,-NH-C(O)-O-Z27,-NH-C(O)-NH-Z28,-NH-C(O)-NZ29Z30,-NZ31-C(O)-O-Z32,-NZ33-C(O)-NH-Z34,-NZ35-C(O)-NZ36Z37,-NHS(O2)-Z38,-NZ39S(O2)-Z40,-S-Z41,-S(O)-Z42,-S(O2)-Z43,-S(O2)NH-Z44,-S(O2)NZ45Z46,-S(O2)O-Z47,-P(O)(OZ48)(OZ49),-Si(Z50)(Z51)(Z5
2),-C(NH)-NH2,-C(NZ53)-NH2,-C(NH)-NHZ54,-C(NH)-NZ55Z56,-C(NZ57)-NHZ58,-C(NZ59)-NZ60Z61,-NH-C(O)-NH-O-Z62,-NH-C(O)-NZ63-O-Z64,-NZ65-C(O)-NZ66-O-Z67,-N(-C(O)-NH-O-Z68)2,-N(-C(O)-NZ69-O-Z70)2,-N(-C(O)-NH-O-Z71)(-C(O)-NZ72-O-Z73),-C(S)-Z74,-C(S)-O-Z75,-C(S)-NH-Z76,-C(S)-NZ77Z78,-C(O)-NH-O-Z79,-C(O)-NZ80-O-Z81,-C(S)-NH-O-Z82,-C(S)-NZ83-O-Z84,-C(O)-NH-NH-Z85,-C(O)-NH-NZ86Z87,-C(O)-NZ88-NZ89Z90,-C(S)-NH-NH-Z91,-C(S)-NH-NZ92Z93,-C(S)-NZ94-NZ95Z96,-C(O)-C(O)-O-Z97,-C(O)-C(O)-NH2,-C(O)-C(O)-NHZ98,-C(O)-C(O)-NZ99Z100,-C(S)-C(O)-O-Z101,-C(O)-C(S)-O-Z102,-C(S)-C(S)-O-Z103,-C(S)-C(O)-NH2,-C(S)-C(O)-NHZ104,-C(S)-C(O)-NZ105Z106,-C(S)-C(S)-NH2,-C(S)-C(S)-NHZ107,-C(S)-C(S)-NZ108Z109,-C(O)-C(S)-NH2,-C(O)-C(S)-NHZ110,-C(O)-C(S)-NZ111Z112”;
其中Z1,Z2,Z3,Z4,Z5,Z6,Z7,Z8,Z9,Z10,Z11,Z12,Z13,Z14,Z15,Z16,Z17,Z18,Z19,Z20,Z21,Z22,Z23,Z24,Z25,Z26,Z27,Z28,Z29,Z30,Z31,Z32,Z33,Z34,Z35,Z36,Z37,Z38,Z39,Z40,Z41,Z42,Z43,Z44,Z45,Z46,Z47,Z48,Z49,Z50,Z51,Z52,Z53,Z54,Z55,Z56,Z57,Z58,Z59,Z60,Z61,Z62,Z63,Z64,Z65,Z66,Z67,Z68,Z69,Z70,Z71,Z72,Z73,Z74,Z75,Z76,Z77,Z78,Z79,Z80,Z81,Z82,Z83,Z84,Z85,Z86,Z87,Z88,Z89,Z90,Z91,Z92,Z93,Z94,Z95,Z96,Z97,Z98,Z99,Z100,Z101,Z102,Z103,Z104,Z105,Z106,Z107,Z108,Z109,Z110,Z111,Z112彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,Z7,Z8和/或Z16,Z17和/或Z29,Z30和/或Z36,Z37和/或Z45,Z46和/或Z55,Z56和/或
Z60,Z61和/或Z77,Z78和/或Z86,Z87和/或Z89,Z90和/或Z92,Z93和/或Z95,Z96
和/或Z99,Z100和/或Z105,Z106和/或Z108,Z109和/或Z111,Z112和/或分别一起
还可形成“杂环基”;
其中任选地,上述取代基组(II)的取代基,如果不是氢,又可彼此独立地被至少一个
相同或不同的选自以下的取代基取代:
(i)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHZ201,-NZ202Z203,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-Z204,-C(O)O-Z205,-C(O)NH-Z206,-C(O)NZ207Z208,-O-Z209,-O(-Z210-O)c-H(c=1,2,3,4,5),-O(-Z211-O)d-Z212(d=1,2,3,4,5),-OC(O)-Z213,-OC(O)-O-Z214,-OC(O)-NHZ215,-O-C(O)-NZ216Z217,-OP(O)(OZ218)(OZ219),-OSi(Z220)(Z221)(Z222),-OS(O2)-Z
223,-NHC(O)-NH2,-NHC(O)-Z224,-NZ225C(O)-Z226,-NH-C(O)-O-Z227,-NH-C(O)-NH-Z228,-NH-C(O)-NZ229Z230,-NZ231-C(O)-O-Z232,-NZ233-C(O)-NH-Z234,-NZ235-C(O)-NZ236Z237,-NHS(O2)-Z238,-NZ239S(O2)-Z240,-S-Z241,-S(O)-Z242,-S(O2)-Z243,-S(O2)NH-Z244,-S(O2)NZ245Z246,-S(O2)O-Z247,-P(O)(OZ248)(OZ249),-Si(Z250)(Z251)(Z252),-C(NH)-NH2,-C(NZ253)-NH2,-C(NH)-NHZ254,-C(NH)-NZ255Z256,-C(NZ257)-NHZ258,-C(NZ259)-NZ260Z261,-NH-C(O)-NH-O-Z262,-NH-C(O)-NZ263-O-Z264,-NZ265-C(O)-NZ266-O-Z267,-N(-C(O)-NH-O-Z268)2,-N(-C(O)-NZ269-O-Z270)2,-N(-C(O)-NH-O-Z271)(-C(O)-NZ272-O-Z273),-C(S)-Z274,-C(S)-O-Z275,-C(S)-NH-Z276,-C(S)-NZ277Z278,-C(O)-NH-O-Z279,-C(O)-NZ280-O-Z281,-C(S)-NH-O-Z282,-C(S)-NZ283-O-Z284,-C(O)-NH-NH-Z285,-C(O)-NH-NZ286Z287,-C(O)-NZ288-NZ289Z290,-C(S)-NH-NH-Z291,-C(S)-NH-NZ292Z293,-C(S)-NZ294-NZ295Z296,-C(O)-C(O)-O-Z297,-C(O)-C(O)-NH2,-C(O)-C(O)-NHZ298,-C(O)-C(O)-NZ299Z300,-C(S)-C(O)-O-Z301,-C(O)-C(S)-O-Z302,-C(S)-C(S)-O-Z303,-C(S)-C(O)-NH2,-C(S)-C(O)-NHZ304,-C(S)-C(O)-NZ305Z306,-C(S)-C(S)-NH2,-C(S)-C(S)-NHZ307,-C(S)-C(S)-NZ308Z309,-C(O)-C(S)-NH2,-C(O)-C(S)-NHZ310,-C(O)-C(S)-NZ311Z312”;
其中Z201,Z202,Z203,Z204,Z205,Z206,Z207,Z208,Z209,Z210,Z211,Z212,Z213,Z214,Z215,Z216,Z217,Z218,Z219,Z220,Z221,Z222,Z223,Z224,Z225,Z226,Z227,Z228,Z229,Z230,Z231,Z232,Z233,Z234,Z235,Z236,Z237,Z238,Z239,Z240,Z241,Z242,Z243,Z244,Z245,Z246,Z247,Z248,Z249,Z250,Z251,Z252,Z253,Z254,Z255,Z256,Z257,Z258,Z259,Z260,Z261,Z262,Z263,Z264,Z265,Z266,Z267,Z268,Z269,Z270,Z271,Z272,Z273,Z274,Z275,Z276,Z277,Z278,Z279,Z280,Z281,Z282,Z283,Z284,Z285,Z286,Z287,Z288,Z289,Z290,Z291,Z292,Z293,Z294,Z295,Z296,Z297,Z298,Z299,Z300,Z301,Z302,Z303,Z304,Z305,Z306,Z307,Z308,Z309,Z310,Z311,Z312彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,Z207,Z208和/或Z216,Z217和/或Z229,Z230和/或Z236,Z237和/
或Z245,Z246和/或Z255,Z256和/或Z260,Z261和/或Z277,Z278和/或Z286,Z287
和/或Z289,Z290和/或Z292,Z293和/或Z295,Z296和/或Z299,Z300和/或Z305,
Z306和/或Z308,Z309和/或Z311,Z312和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(i)的取代基又可彼此独立地被至少一个相同或不同的选
自以下的取代基取代:
(ii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHZ401,-NZ402Z403,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-Z404,-C(O)O-Z405,-C(O)NH-Z406,-C(O)NZ407Z408,-O-Z409,-O(-Z410-O)e-H(e=1,2,3,4,5),-O(-Z411-O)f-Z412(f=1,2,3,4,5),-OC(O)-Z413,-OC(O)-O-Z414,-OC(O)-NHZ415,-O-C(O)-NZ416Z417,-OP(O)(OZ418)(OZ419),-OSi(Z420)(Z421)(Z422),-OS(O2)-Z
423,-NHC(O)-NH2,-NHC(O)-Z424,-NZ425C(O)-Z426,-NH-C(O)-O-Z427,-NH-C(O)-NH-Z428,-NH-C(O)-NZ429Z430,-NZ431-C(O)-O-Z432,-NZ433-C(O)-NH-Z434,-NZ435-C(O)-NZ436Z437,-NHS(O2)-Z438,-NZ439S(O2)-Z440,-S-Z441,-S(O)-Z442,-S(O2)-Z443,-S(O2)NH-Z444,-S(O2)NZ445Z446,-S(O2)O-Z447,-P(O)(OZ448)(OZ449),-Si(Z450)(Z451)(Z452),-C(NH)-NH2,-C(NZ453)-NH2,-C(NH)-NHZ454,-C(NH)-NZ455Z456,-C(NZ457)-NHZ458,-C(NZ459)-NZ460Z461,-NH-C(O)-NH-O-Z462,-NH-C(O)-NZ463-O-Z464,-NZ465-C(O)-NZ466-O-Z467,-N(-C(O)-NH-O-Z468)2,-N(-C(O)-NZ469-O-Z470)2,-N(-C(O)-NH-O-Z471)(-C(O)-NZ472-O-Z473),-C(S)-Z474,-C(S)-O-Z475,-C(S)-NH-Z476,-C(S)-NZ477Z478,-C(O)-NH-O-Z479,-C(O)-NZ480-O-Z481,-C(S)-NH-O-Z482,-C(S)-NZ483-O-Z484,-C(O)-NH-NH-Z485,-C(O)-NH-NZ486Z487,-C(O)-NZ488-NZ489Z490,-C(S)-NH-NH-Z491,-C(S)-NH-NZ492Z493,-C(S)-NZ494-NZ495Z496,-C(O)-C(O)-O-Z497,-C(O)-C(O)-NH2,-C(O)-C(O)-NHZ498,-C(O)-C(O)-NZ499Z500,-C(S)-C(O)-O-Z501,-C(O)-C(S)-O-Z502,-C(S)-C(S)-O-Z503,-C(S)-C(O)-NH2,-C(S)-C(O)-NHZ504,-C(S)-C(O)-NZ505Z506,-C(S)-C(S)-NH2,-C(S)-C(S)-NHZ507,-C(S)-C(S)-NZ508Z509,-C(O)-C(S)-NH2,-C(O)-C(S)-NHZ510,-C(O)-C(S)-NZ511Z512”;
其中Z401,Z402,Z403,Z404,Z405,Z406,Z407,Z408,Z409,Z410,Z411,Z412,Z413,Z414,Z415,Z416,Z417,Z418,Z419,Z420,Z421,Z422,Z423,Z424,Z425,Z426,Z427,Z428,Z429,Z430,Z431,Z432,Z433,Z434,Z435,Z436,Z437,Z438,Z439,Z440,Z441,Z442,Z443,Z444,Z445,Z446,Z447,Z448,Z449,Z450,Z451,Z452,Z453,Z454,Z455,Z456,Z457,Z458,Z459,Z460,Z461,Z462,Z463,Z464,Z465,Z466,Z467,Z468,Z469,Z470,Z471,Z472,Z473,Z474,Z475,Z476,Z477,Z478,Z479,Z480,Z481,Z482,Z483,Z484,Z485,Z486,Z487,Z488,Z489,Z490,Z491,Z492,Z493,Z494,Z495,Z496,Z497,Z498,Z499,Z500,Z501,Z502,Z503,Z504,Z505,Z506,Z507,Z508,Z509,Z510,Z511,Z512彼此独立地选自“:氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,Z407,Z408和/或Z416,Z417和/或Z429,Z430和/或Z436,Z437和/
或Z445,Z446和/或Z455,Z456和/或Z460,Z461和/或Z477,Z478和/或Z486,Z487
和/或Z489,Z490和/或Z492,Z493和/或Z495,Z496和/或Z499,Z500和/或Z505,
Z506和/或Z508,Z509和/或Z511,Z512和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(ii)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(iii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHZ601,-NZ602Z603,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-Z604,-C(O)O-Z605,-C(O)NH-Z606,-C(O)NZ607Z608,-O-Z609,-O(-Z610-O)e-H(e=1,2,3,4,5),-O(-Z611-O)f-Z612(f-1,2,3,4,5),-OC(O)-Z613,-OC(O)-O-Z614,-OC(O)-NHZ615,-O-C(O)-NZ616Z617,-OP(O)(OZ618)(OZ619),-OSi(Z620)(Z621)(Z622),-OS(O2)-Z6
23,-NHC(O)-NH2,-NHC(O)-Z624,-NZ625C(O)-Z626,-NH-C(O)-O-Z627,-NH-C(O)-NH-Z628,-NH-C(O)-NZ629Z630,-NZ631-C(O)-O-Z632,-NZ633-C(O)-NH-Z634,-NZ635-C(O)-NZ636Z637,-NHS(O2)-Z638,-NZ639S(O2)-Z640,-S-Z641,-S(O)-Z642,-S(O2)-Z643,-S(O2)NH-Z644,-S(O2)NZ645Z646,-S(O2)O-Z647,-P(O)(OZ648)(OZ649),-Si(Z650)(Z651)(Z652),-C(NH)-NH2,-C(NZ653)-NH2,-C(NH)-NHZ654,-C(NH)-NZ655Z656,-C(NZ657)-NHZ658,-C(NZ659)-NZ660Z661,-NH-C(O)-NH-O-Z662,-NH-C(O)-NZ663-O-Z664,-NZ665-C(O)-NZ666-O-Z667,-N(-C(O)-NH-O-Z668)2,-N(-C(O)-NZ669-O-Z670)2,-N(-C(O)-NH-O-Z671)(-C(O)-NZ672-O-Z673),-C(S)-Z674,-C(S)-O-Z675,-C(S)-NH-Z676,-C(S)-NZ677Z678,-C(O)-NH-O-Z679,-C(O)-NZ680-O-Z681,-C(S)-NH-O-Z682,-C(S)-NZ683-O-Z684,-C(O)-NH-NH-Z685,-C(O)-NH-NZ686Z687,-C(O)-NZ688-NZ689Z690,-C(S)-NH-NH-Z691,-C(S)-NH-NZ692Z693,-C(S)-NZ694-NZ695Z696,-C(O)-C(O)-O-Z697,-C(O)-C(O)-NH2,-C(O)-C(O)-NHZ698,-C(O)-C(O)-NZ699Z700,-C(S)-C(O)-O-Z701,-C(O)-C(S)-O-Z702,-C(S)-C(S)-O-Z703,-C(S)-C(O)-NH2,-C(S)-C(O)-NHZ704,-C(S)-C(O)-NZ705Z706,-C(S)-C(S)-NH2,-C(S)-C(S)-NHZ707,-C(S)-C(S)-NZ708Z709,-C(O)-C(S)-NH2,-C(O)-C(S)-NHZ710,-C(O)-C(S)-NZ711Z712”;
其中Z601,Z602,Z603,Z604,Z605,Z606,Z607,Z608,Z609,Z610,Z611,Z612,Z613,Z614,Z615,Z616,Z617,Z618,Z619,Z620,Z621,Z622,Z623,Z624,Z625,Z626,Z627,Z628,Z629,Z630,Z631,Z632,Z633,Z634,Z635,Z636,Z637,Z638,Z639,Z640,Z641,Z642,Z643,Z644,Z645,Z646,Z647,Z648,Z649,Z650,Z651,Z652,Z653,Z654,Z655,Z656,Z657,Z658,Z659,Z660,Z661,Z662,Z663,Z664,Z665,Z666,Z667,Z668,Z669,Z670,Z671,Z672,Z673,Z674,Z675,Z676,Z677,Z678,Z679,Z680,Z681,Z682,Z683,Z684,Z685,Z686,Z687,Z688,Z689,Z690,Z691,Z692,Z693,Z694,Z695,Z696,Z697,Z698,Z699,Z700,Z701,Z702,Z703,Z704,Z705,Z706,Z707,Z708,Z709,Z710,Z711,Z712彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,Z607,Z608和/或Z616,Z617和/或Z629,Z630和/或Z636,Z637和/
或Z645,Z646和/或Z655,Z656和/或Z660,Z661和/或Z677,Z678和/或Z686,Z687
和/或Z689,Z690和/或Z692,Z693和/或Z695,Z696和/或Z699,Z700和/或Z705,
Z706和/或Z708,Z709和/或Z711,Z712和/或分别一起还可形成“杂环基”;
前提条件是基团R16不是“吲哚基”;
(h)“-S(O2)-R18”;
其中基团R18独立地选自:
(III)“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHW1,-NW2W3,-NO2,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-W4,-C(O)O-W5,-C(O)NH-W6,-C(O)NW7W8,-O-W9,-O(-W10-O)a-H(a = 1,2,3,4,5),-O(-W11-O)b-W12(b = 1,
2,3,4,5),-OC(O)-W13,-OC(O)-O-W14,-OC(O)-NHW15,-O-C(O)-NW16W17,-OP(O)(OW18)(OW19),-OSi(W20)(W21)(W22),-OS(O2)-W23,-NHC(O)-NH2,-NHC(O)-W24,-NW25C(O)-W26,-NH-C(O)-O-W27,-NH-C(O)-NH-W28,-NH-C(O)-NW29W30,-NW31-C(O)-O-W32,-NW33-C(O)-NH-W
34,-NW35-C(O)-NW36W37,-NHS(O2)-W38,-NW39S(O2)-W40,-S-W41,-S(O)-W42,-S(O2)-W43,-S(O2)NH-W44,-S(O2)NW45W46,-S(O2)O-W47,-P(O)(OW48)(OW49),-Si(W50)(W51)(W52),-C(NH)-NH2,-C(NW53)-NH2,-C(NH)-NHW54,-C(NH)-NW55W56,-C(NW57)-NHW58,-C(NW59)-NW60W61,-NH-C(O)-NH-O-W62,-NH-C(O)-NW63-O-W64,-NW65-C(O)-NW66-O-W67,-N(-C(O)-NH-O-W68)2,-N(-C(O)-NW69-O-W70)2,-N(-C(O)-NH-O-W71)(-C(O)-NW72-O-W73),-C(S)-W74,-C(S)-O-W
75,-C(S)-NH-W76,-C(S)-NW77W78,-C(O)-NH-O-W79,-C(O)-NW80-O-W81,-C(S)-NH-O-W82,-C(S)-NW83-O-W84,-C(O)-NH-NH-W85,-C(O)-NH-NW86W87,-C(O)-NW88-NW89W90,-C(S)-NH-NH-W91,-C(S)-NH-NW92W93,-C(S)-NW94-NW95W96,-C(O)-C(O)-O-W97,-C(O)-C(O)-NH2,-C(O)-C(O)-NHW98,-C(O)-C(O)-NW99W100,-C(S)-C(O)-O-W101,-C(O)-C(S)-O-W102,-C(S)-C(S)-O-W103,-C(S)-C(O)-NH2,-C(S)-C(O)-NHW104,-C(S)-C(O)-NW105W106,-C(S)-C(S)-NH2,-C(S)-C(S)-NHW107,-C(S)-C(S)-NW108W109,-C(O)-C(S)-NH2,-C(O)-C(S)-NHW110,-C(O)-C(S)-NW111W112”;
其中W1,W2,W3,W4,W5,W6,W7,W8,W9,W10,W11,W12,W13,W14,W15,W16,W17,W18,W19,W20,W21,W22,W23,W24,W25,W26,W27,W28,W29,W30,W31,W32,W33,W34,W35,W36,W37,W38,W39,W40,W41,W42,W43,W44,W45,W46,W47,W48,W49,W50,W51,W52,W53,W54,W55,W56,W57,W58,W59,W60,W61,W62,W63,W64,W65,W66,W67,W68,W69,W70,W71,W72,W73,W74,W75,W76,W77,W78,W79,W80,W81,W82,W83,W84,W85,W86,W87,W88,W89,W90,W91,W92,W93,W94,W95,W96,W97,W98,W99,W100,W101,W102,W103,W104,W105,W106,W107,W108,W109,W110,W111,W112彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,W7,W8和/或W16,W17和/或W29,W30和/或W36,W37和/或W45,W46和/或W55,W56和/或
W60,W61和/或W77,W78和/或W86,W87和/或W89,W90和/或W92,W93和/或W95,W96
和/或W99,W100和/或W105,W106和/或W108,W109和/或W111,W112和/或分别一起
还可形成“杂环基”;
其中任选地,上述取代基组(III)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(i)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHW201,-NW202W203,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-W204,-C(O)O-W205,-C(O)NH-W206,-C(O)NW207W208,-O-W209,-O(-W210-O)c-H(c=1,2,3,4,5),-O(-W211-O)d-W212(d=1,2,3,4,5),-OC(O)-W213,-OC(O)-O-W214,-OC(O)-NHW215,-O-C(O)-NW216W217,-OP(O)(OW218)(OW219),-OSi(W220)(W221)(W222),-OS(O2)-W
223,-NHC(O)-NH2,-NHC(O)-W224,-NW225C(O)-W226,-NH-C(O)-O-W227,-NH-C(O)-NH-W228,-NH-C(O)-NW229W230,-NW231-C(O)-O-W232,-NW233-C(O)-NH-W234,-NW235-C(O)-NW236W237,-NHS(O2)-W238,-NW239S(O2)-W240,-S-W241,-S(O)-W242,-S(O2)-W243,-S(O2)NH-W244,-S(O2)NW245W246,-S(O2)O-W247,-P(O)(OW248)(OW249),-Si(W250)(W251)(W252),-C(NH)-NH2,-C(NW253)-NH2,-C(NH)-NHW254,-C(NH)-NW255W256,-C(NW257)-NHW258,-C(NW259)-NW260W261,-NH-C(O)-NH-O-W262,-NH-C(O)-NW263-O-W264,-NW265-C(O)-NW266-O-W267,-N(-C(O)-NH-O-W268)2,-N(-C(O)-NW269-O-W270)2,-N(-C(O)-NH-O-W271)(-C(O)-NW272-O-W273),-C(S)-W274,-C(S)-O-W275,-C(S)-NH-W276,-C(S)-NW277W278,-C(O)-NH-O-W279,-C(O)-NW280-O-W281,-C(S)-NH-O-W282,-C(S)-NW283-O-W284,-C(O)-NH-NH-W285,-C(O)-NH-NW286W287,-C(O)-NW288-NW289W290,-C(S)-NH-NH-W291,-C(S)-NH-NW292W293,-C(S)-NW294-NW295W296,-C(O)-C(O)-O-W297,-C(O)-C(O)-NH2,-C(O)-C(O)-NHW298,-C(O)-C(O)-NW299W300,-C(S)-C(O)-O-W301,-C(O)-C(S)-O-W302,-C(S)-C(S)-O-W303,-C(S)-C(O)-NH2,-C(S)-C(O)-NHW304,-C(S)-C(O)-NW305W306,-C(S)-C(S)-NH2,-C(S)-C(S)-NHW307,-C(S)-C(S)-NW308W309,-C(O)-C(S)-NH2,-C(O)-C(S)-NHW310,-C(O)-C(S)-NW311W312”;
其中W201,W202,W203,W204,W205,W206,W207,W208,W209,W210,W211,W212,W213,W214,W215,W216,W217,W218,W219,W220,W221,W222,W223,W224,W225,W226,W227,W228,W229,W230,W231,W232,W233,W234,W235,W236,W237,W238,W239,W240,W241,W242,W243,W244,W245,W246,W247,W248,W249,W250,W251,W252,W253,W254,W255,W256,W257,W258,W259,W260,W261,W262,W263,W264,W265,W266,W267,W268,W269,W270,W271,W272,W273,W274,W275,W276,W277,W278,W279,W280,W281,W282,W283,W284,W285,W286,W287,W288,W289,W290,W291,W292,W293,W294,W295,W296,W297,W298,W299,W300,W301,W302,W303,W304,W305,W306,W307,W308,W309,W310,W311,W312彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,W207,W208和/或W216,W217和/或W229,W230和/或W236,W237和/
或W245,W246和/或W255,W256和/或W260,W261和/或W277,W278和/或W286,W287
和/或W289,W290和/或W292,W293和/或W295,W296和/或W299,W 300和/或W305,
W306和/或W 308,W309和/或W311,W312和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(i)的取代基又可彼此独立地被至少一个相同或不同的选
自以下的取代基取代:
(ii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHW401,-NW402W403,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-W404,-C(O)O-W405,-C(O)NH-W406,-C(O)NW407W408,-O-W409,-O(-W410-O)e-H(e=
1,2,3,4,5),-O(-W411-O)f-W412(f =1,2,3,4,5),-OC(O)-W413,-OC(O)-O-W414,-OC(O)-NHW415,-O-C(O)-NW416W417,-OP(O)(OW418)(OW419),-OSi(W420)(W421)(W422),-OS(O2)-W4
23,-NHC(O)-NH2,-NHC(O)-W424,-NW425C(O)-W426,-NH-C(O)-O-W427,-NH-C(O)-NH-W428,-NH-C(O)-NW429W430,-NW431-C(O)-O-W432,-NW433-C(O)-NH-W434,-NW435-C(O)-NW436W437,-NHS(O2)-W438,-NW439S(O2)-W440,-S-W441,-S(O)-W442,-S(O2)-W443,-S(O2)NH-W444,-S(O2)NW445W446,-S(O2)O-W447,-P(O)(OW448)(OW449),-Si(W450)(W451)(W452),-C(NH)-NH2,-C(NW453)-NH2,-C(NH)-NHW454,-C(NH)-NW455W456,-C(NW457)-NHW458,-C(NW459)-NW460W461,-NH-C(O)-NH-O-W462,-NH-C(O)-NW463-O-W464,-NW465-C(O)-NW466-O-W467,-N(-C(O)-NH-O-W468)2,-N(-C(O)-NW469-O-W470)2,-N(-C(O)-NH-O-W471)(-C(O)-NW472-O-W473),-C(S)-W474,-C(S)-O-W475,-C(S)-NH-W476,-C(S)-NW477W478,-C(O)-NH-O-W479,-C(O)-NW480-O-W481,-C(S)-NH-O-W482,-C(S)-NW483-O-W484,-C(O)-NH-NH-W485,-C(O)-NH-NW486W487,-C(O)-NW488-NW489W490,-C(S)-NH-NH-W491,-C(S)-NH-NW492W493,-C(S)-NW494-NW495W496,-C(O)-C(O)-O-W497,-C(O)-C(O)-NH2,-C(O)-C(O)-NHW498,-C(O)-C(O)-NW499W500,-C(S)-C(O)-O-W501,-C(O)-C(S)-O-W502,-C(S)-C(S)-O-W503,-C(S)-C(O)-NH2,-C(S)-C(O)-NHW504,-C(S)-C(O)-NW505W506,-C(S)-C(S)-NH2,-C(S)-C(S)-NHW507,-C(S)-C(S)-NW508W509,-C(O)-C(S)-NH2,-C(O)-C(S)-NHW510,-C(O)-C(S)-NW511W512”;
其中W401,W402,W403,W404,W405,W406,W407,W408,W409,W410,W411,W412,W413,W414,W415,W416,W417,W418,W419,W420,W421,W422,W423,W424,W425,W426,W427,W428,W429,W430,W431,W432,W433,W434,W435,W436,W437,W438,W439,W440,W441,W442,W443,W444,W445,W446,W447,W448,W449,W450,W451,W452,W453,W454,W455,W456,W457,W458,W459,W460,W461,W462,W463,W464,W465,W466,W467,W468,W469,W470,W471,W472,W473,W474,W475,W476,W477,W478,W479,W480,W481,W482,W483,W484,W485,W486,W487,W488,W489,W490,W491,W492,W493,W494,W495,W496,W497,W498,W499,W500,W501,W502,W503,W504,W505,W506,W507,W508,W509,W510,W511,W512彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,W407,W408和/或W416,W417和/或W429,W430和/或W436,W437和/
或W445,W446和/或W455,W456和/或W460,W461和/或W477,W478和/或W486,W487
和/或W489,W490和/或W492,W493和/或W495,W496和/或W499,W500和/或W505,
W506和/或W508,W509和/或W511,W512和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(ii)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(iii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHW601,-NW602W603,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-W604,-C(O)O-W605,-C(O)NH-W606,-C(O)NW607W608,-O-W609,-O(-W610-O)e-H(e=1,2,3,4,5),-O(-W611-O)f-W612(f=1,2,3,4,5),-OC(O)-W613,-OC(O)-O-W614,-OC(O)-NHW615,-O-C(O)-NW616W617,-OP(O)(OW618)(OW619),-OSi(W620)(W621)(W622),-OS(O2)-W62
3,-NHC(O)-NH2,-NHC(O)-W624,-NW625C(O)-W626,-NH-C(O)-O-W627,-NH-C(O)-NH-W628,-NH-C(O)-NW629W630,-NW631-C(O)-O-W632,-NW633-C(O)-NH-W634,-NW635-C(O)-NW636W637,-NHS(O2)-W638,-NW639S(O2)-W640,-S-W641,-S(O)-W642,-S(O2)-W643,-S(O2)NH-W644,-S(O2)NW645W646,-S(O2)O-W647,-P(O)(OW648)(OW649),-Si(W650)(W651)(W652),-C(NH)-NH2,-C(NW653)-NH2,-C(NH)-NHW654,-C(NH)-NW655W656,-C(NW657)-NHW658,-C(NW659)-NW660W661,-NH-C(O)-NH-O-W662,-NH-C(O)-NW663-O-W664,-NW665-C(O)-NW666-O-W667,-N(-C(O)-NH-O-W668)2,-N(-C(O)-NW669-O-W670)2,-N(-C(O)-NH-O-W671)(-C(O)-NW672-O-W673),-C(S)-W674,-C(S)-O-W675,-C(S)-NH-W676,-C(S)-NW677W678,-C(O)-NH-O-W679,-C(O)-NW680-O-W681,-C(S)-NH-O-W682,-C(S)-NW683-O-W684,-C(O)-NH-NH-W685,-C(O)-NH-NW686W687,-C(O)-NW688-NW689W690,-C(S)-NH-NH-W691,-C(S)-NH-NW692W693,-C(S)-NW694-NW695W696,-C(O)-C(O)-O-W697,-C(O)-C(O)-NH2,-C(O)-C(O)-NHW698,-C(O)-C(O)-NW699W700,-C(S)-C(O)-O-W701,-C(O)-C(S)-O-W702,-C(S)-C(S)-O-W703,-C(S)-C(O)-NH2,-C(S)-C(O)-NHW704,-C(S)-C(O)-NW705W706,-C(S)-C(S)-NH2,-C(S)-C(S)-NHW707,-C(S)-C(S)-NW708W709,-C(O)-C(S)-NH2,-C(O)-C(S)-NHW710,-C(O)-C(S)-NW711W712”;
其中W601,W602,W603,W604,W605,W606,W607,W608,W609,W610,W611,W612,W613,W614,W615,W616,W617,W618,W619,W620,W621,W622,W623,W624,W625,W626,W627,W628,W629,W630,W631,W632,W633,W634,W635,W636,W637,W638,W639,W640,W641,W642,W643,W644,W645,W646,W647,W648,W649,W650,W651,W652,W653,W654,W655,W656,W657,W658,W659,W660,W661,W662,W663,W664,W665,W666,W667,W668,W669,W670,W671,W672,W673,W674,W675,W676,W677,W678,W679,W680,W681,W682,W683,W684,W685,W686,W687,W688,W689,W690,W691,W692,W693,W694,W695,W696,W697,W698,W699,W700,W701,W702,W703,W704,W705,W706,W707,W708,W709,W710,W711,W712彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,W607,W608和/或W616,W617和/或W629,W630和/或W636,W637和/
或W645,W646和/或W655,W656和/或W660,W661和/或W677,W678和/或W686,W687
和/或W689,W690和/或W692,W693和/或W695,W696和/或W699,W700和/或W705,
W706和/或W708,W709和/或W711,W712和/或分别一起还可形成“杂环基”;
第一个前提条件是,基团R18不选自:“-O-烷基,-O-(C9-C30)烷基,-O-芳基,-O-芳基烷基,-O-杂芳基,-O-杂芳基烷基,-O-环烷基,-O-环烷基烷基,-O-杂环基,-O-杂环基烷基”;
第二个前提条件是,如果基团R18独立地选自:“-NRaRb”,其中Ra,Rb彼此独立地选自:
“氢,烷基,(C9-C30)烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,环烷基,环烷基烷基,杂环基,杂环基烷基”,则基团R1不选自:“被=O取代的杂环基烷基,其中杂环基是5元杂环基;
被杂环基取代的烷基,其中杂环基是5元杂环基并且被=O取代”;
并且基团R3,R4之一独立地选自或者基团R3,R4二者均不选自:
(2)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHA1,-NA2A3,-NO2,-OH,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-A4,-C(O)O-A5,-C(O)NH-A6,-C(O)NA7A8,-O-A9,-O(-A10-O)a-H(a=1,2,3,4,5),-O(-A11-O)b-A12(b= 1,2,3,4,5),-OC(O)-A13,-OC(O)-O-A14,-OC(O)-NHA15,-O-C(O)-NA16A17,-OP(O)(OA18)(OA19),-OSi(A20)(A21)(A22),-OS(O2)-A23,-NHC(O)-NH2,-NHC(O)-A24,-NA25C(O)-A26,-NH-C(O)-O-A27,-NH-C(O)-NH-A28,-NH-C(O)-NA29A30,-NA31-C(O)-O-A32,-NA33-C(O)-NH-A34,-NA35-C(O)-NA36A37,-NHS(O2)-A38,-NA39S(O2)-A40,-S-A41,-S(O)-A42,-S(O2)-A43,-S(O2)NH-A44,-S(O2)NA45A46,-S(O2)O-A47,-P(O)(OA48)(OA49),-Si(A50)(A51)(A5
2),-C(NH)-NH2,-C(NA53)-NH2,-C(NH)-NHA54,-C(NH)-NA55A56,-C(NA57)-NHA58,-C(NA59)-NA60A61,-NH-C(O)-NH-O-A62,-NH-C(O)-NA63-O-A64,-NA65-C(O)-NA66-O-A67,-N(-C(O)-NH-O-A68)2,-N(-C(O)-NA69-O-A70)2,-N(-C(O)-NH-O-A71)(-C(O)-NA72-O-A73),-C(S)-A74,-C(S)-O-A75,-C(S)-NH-A76,-C(S)-NA77A78,-C(O)-NH-O-A79,-C(O)-NA80-O-A81,-C(S)-NH-O-A82,-C(S)-NA83-O-A84,-C(O)-NH-NH-A85,-C(O)-NH-NA86A87,-C(O)-NA88-NA89A90,-C(S)-NH-NH-A91,-C(S)-NH-NA92A93,-C(S)-NA94-NA95A96,-C(O)-C(O)-O-A97,-C(O)-C(O)-NH2,-C(O)-C(O)-NHA98,-C(O)-C(O)-NA99A100,-C(S)-C(O)-O-A101,-C(O)-C(S)-O-A102,-C(S)-C(S)-O-A103,-C(S)-C(O)-NH2,-C(S)-C(O)-NHA104,-C(S)-C(O)-NA105A106,-C(S)-C(S)-NH2,-C(S)-C(S)-NHA 107,-C(S)-C(S)-NA108A109,-C(O)-C(S)-NH2,-C(O)-C(S)-NHA110,-C(O)-C(S)-NA111A112”;
其中A1,A2,A3,A4,A5,A6,A7,A8,A9,A10,A11,A12,A13,A 14,A15,A16,A17,A18,A19,A20,A21,A22,A23,A24,A25,A26,A27,A28,A29,A30,A31,A32,A33,A34,A35,A36,A37,A38,A39,A40,A41,A42,A43,A44,A45,A46,A47,A48,A49,A50,A51,A52,A53,A54,A55,A56,A57,A58,A59,A60,A61,A62,A63,A64,A65,A66,A67,A68,A69,A70,A71,A72,A73,A74,A75,A76,A77,A78,A79,A80,A81,A82,A83,A84,A85,A86,A87,A88,A89,A90,A91,A92,A93,A94,A95,A96,A97,A98,A99,A100,A101,A102,A103,A104,A105,A106,A107,A108,A109,A110,A111,A112彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,A7,A8和/或A16,A17和/或A29,A 30和/或A 36,A 37和/或A45,A46和/或A55,A56和/
或A60,A61和/或A77,A78和/或A86,A87和/或A89,A90和/或A92,A93和/或A95,
A96和/或A99,A100和/或A105,A106和/或A108,A109和/或A111,A112和/或分别
一起还可形成“杂环基”;
其中任选地,上述取代基组(2)的取代基,如果不是氢,又可彼此独立地被至少一个相
同或不同的选自以下的取代基取代:
(i)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHA201,-NA202A203,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-A204,-C(O)O-A205,-C(O)NH-A206,-C(O)NA207A208,-O-A209,-O(-A210-O)c-H(c=1,2,3,4,5),-O(-A211-O)d-A212(d=1,2,3,4,5),-OC(O)-A213,-OC(O)-O-A214,-OC(O)-NHA215,-O-C(O)-NA216A217,-OP(O)(OA218)(OA219),-OSi(A220)(A221)(A222),-OS(O2)-A
223,-NHC(O)-NH2,-NHC(O)-A224,-NA225C(O)-A226,-NH-C(O)-O-A227,-NH-C(O)-NH-A228,-NH-C(O)-NA229A230,-NA231-C(O)-O-A232,-NA233-C(O)-NH-A234,-NA235-C(O)-NA236A237,-NHS(O2)-A238,-NA239S(O2)-A240,-S-A241,-S(O)-A242,-S(O2)-A243,-S(O2)NH-A244,-S(O2)NA245A246,-S(O2)O-A247,-P(O)(OA248)(OA249),-Si(A250)(A251)(A252),-C(NH)-NH2,-C(NA253)-NH2,-C(NH)-NHA254,-C(NH)-NA255A256,-C(NA257)-NHA258,-C(NA259)-NA260A261,-NH-C(O)-NH-O-A262,-NH-C(O)-NA263-O-A264,-NA265-C(O)-NA266-O-A267,-N(-C(O)-NH-O-A268)2,-N(-C(O)-NA269-O-A270)2,-N(-C(O)-NH-O-A271)(-C(O)-NA272-O-A273),-C(S)-A274,-C(S)-O-A275,-C(S)-NH-A276,-C(S)-NA277A278,-C(O)-NH-O-A279,-C(O)-NA280-O-A281,-C(S)-NH-O-A282,-C(S)-NA283-O-A284,-C(O)-NH-NH-A285,-C(O)-NH-NA286A287,-C(O)-NA288-NA289A290,-C(S)-NH-NH-A291,-C(S)-NH-NA292A293,-C(S)-NA294-NA295A296,-C(O)-C(O)-O-A297,-C(O)-C(O)-NH2,-C(O)-C(O)-NHA298,-C(O)-C(O)-NA299A300,-C(S)-C(O)-O-A301,-C(O)-C(S)-O-A302,-C(S)-C(S)-O-A303,-C(S)-C(O)-NH2,-C(S)-C(O)-NHA304,-C(S)-C(O)-NA305A306,-C(S)-C(S)-NH2,-C(S)-C(S)-NHA307,-C(S)-C(S)-NA308A309,-C(O)-C(S)-NH2,-C(O)-C(S)-NHA310,-C(O)-C(S)-NA311A312”;
其中A201,A202,A203,A204,A205,A206,A207,A208,A209,A210,A211,A212,A213,A214,A215,A216,A217,A218,A219,A220,A221,A222,A223,A224,A225,A226,A227,A228,A229,A230,A231,A232,A233,A234,A235,A236,A237,A238,A239,A240,A241,A242,A243,A244,A245,A246,A247,A248,A249,A250,A251,A252,A253,A254,A255,A256,A257,A258,A259,A260,A261,A262,A263,A264,A265,A266,A267,A268,A269,A270,A271,A272,A273,A274,A275,A276,A277,A278,A279,A280,A281,A282,A283,A284,A285,A286,A287,A288,A289,A290,A291,A292,A293,A294,A295,A296,A297,A298,A299,A300,A301,A302,A303,A304,A305,A306,A307,A308,A309,A310,A311,A312彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,A207,A208和/或A216,A217和/或A229,A230和/或A236,A237和/
或A245,A246和/或A255,A256和/或A260,A261和/或A277,A278和/或A286,A287
和/或A289,A290和/或A292,A293和/或A295,A296和/或A299,A300和/或A305,
A306和/或A308,A309和/或A311,A312和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(i)的取代基又可彼此独立地被至少一个相同或不同的选
自以下的取代基取代:
(ii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHA401,-NA402A403,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-A404,-C(O)O-A405,-C(O)NH-A406,-C(O)NA407A408,-O-A409,-O(-A410-O)e-H(e=1,2,3,4,5),-O(-A411-O)f-A412(f=1,2,3,4,5),-OC(O)-A413,-OC(O)-O-A414,-OC(O)-NHA415,-O-C(O)-NA416A417,-OP(O)(OA418)(OA419),-OSi(A420)(A421)(A422),-OS(O2)-A
423,-NHC(O)-NH2,-NHC(O)-A424,-NA425C(O)-A426,-NH-C(O)-O-A427,-NH-C(O)-NH-A428,-NH-C(O)-NA429A430,-NA431-C(O)-O-A432,-NA433-C(O)-NH-A434,-NA435-C(O)-NA436A437,-NHS(O2)-A438,-NA439S(O2)-A440,-S-A441,-S(O)-A442,-S(O2)-A443,-S(O2)NH-A444,-S(O2)NA445A446,-S(O2)O-A447,-P(O)(OA448)(OA449),-Si(A450)(A451)(A452),-C(NH)-NH2,-C(NA453)-NH2,-C(NH)-NHA454,-C(NH)-NA455A456,-C(NA457)-NHA458,-C(NA459)-NA460A461,-NH-C(O)-NH-O-A462,-NH-C(O)-NA463-O-A464,-NA465-C(O)-NA466-O-A467,-N(-C(O)-NH-O-A468)2,-N(-C(O)-NA469-O-A470)2,-N(-C(O)-NH-O-A471)(-C(O)-NA472-O-A473),-C(S)-A474,-C(S)-O-A475,-C(S)-NH-A476,-C(S)-NA477A478,-C(O)-NH-O-A479,-C(O)-NA480-O-A481,-C(S)-NH-O-A482,-C(S)-NA483-O-A484,-C(O)-NH-NH-A485,-C(O)-NH-NA486A487,-C(O)-NA488-NA489A490,-C(S)-NH-NH-A491,-C(S)-NH-NA492A493,-C(S)-NA494-NA495A496,-C(O)-C(O)-O-A497,-C(O)-C(O)-NH2,-C(O)-C(O)-NHA498,-C(O)-C(O)-NA499A500,-C(S)-C(O)-O-A501,-C(O)-C(S)-O-A502,-C(S)-C(S)-O-A503,-C(S)-C(O)-NH2,-C(S)-C(O)-NHA504,-C(S)-C(O)-NA505A506,-C(S)-C(S)-NH2,-C(S)-C(S)-NHA507,-C(S)-C(S)-NA508A509,-C(O)-C(S)-NH2,-C(O)-C(S)-NHA510,-C(O)-C(S)-NA511A512”;
其中A401,A402,A403,A404,A405,A406,A407,A408,A409,A410,A411,A412,A413,A414,A415,A416,A417,A418,A419,A420,A421,A422,A423,A424,A425,A426,A427,A428,A429,A430,A431,A432,A433,A434,A435,A436,A437,A438,A439,A440,A441,A442,A443,A444,A445,A446,A447,A448,A449,A450,A451,A452,A453,A454,A455,A456,A457,A458,A459,A460,A461,A462,A463,A464,A465,A466,A467,A468,A469,A470,A471,A472,A473,A474,A475,A476,A477,A478,A479,A480,A481,A482,A483,A484,A485,A486,A487,A488,A489,A490,A491,A492,A493,A494,A495,A496,A497,A498,A499,A500,A501,A502,A503,A504,A505,A506,A507,A508,A509,A510,A511,A512彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,A407,A408和/或A416,A417和/或A429,A430和/或A436,A437和/
或A445,A446和/或A455,A456和/或A460,A461和/或A477,A478和/或A486,A487
和/或A489,A490和/或A492,A493和/或A495,A496和/或A499,A500和/或A505,
A506和/或A508,A509和/或A511,A512和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(ii)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(iii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHA601,-NA602A603,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-A604,-C(O)O-A605,-C(O)NH-A606,-C(O)NA607A608,-O-A609,-O(-A610-O)e-H(e=1,2,3,4,5),-O(-A611-O)f-A612(f=1,2,3,4,5),-OC(O)-A613,-OC(O)-O-A614,-OC(O)-NHA615,-O-C(O)-NA616A617,-OP(O)(OA618)(OA619),-OSi(A620)(A621)(A622),-OS(O2)-A
623,-NHC(O)-NH2,-NHC(O)-A624,-NA625C(O)-A626,-NH-C(O)-O-A627,-NH-C(O)-NH-A628,-NH-C(O)-NA629A630,-NA631-C(O)-O-A632,-NA633-C(O)-NH-A634,-NA635-C(O)-NA636A637,-NHS(O2)-A638,-NA639S(O2)-A640,-S-A641,-S(O)-A642,-S(O2)-A643,-S(O2)NH-A644,-S(O2)NA645A646,-S(O2)O-A647,-P(O)(OA648)(OA649),-Si(A650)(A651)(A652),-C(NH)-NH2,-C(NA653)-NH2,-C(NH)-NHA654,-C(NH)-NA655A656,-C(NA657)-NHA658,-C(NA659)-NA660A661,-NH-C(O)-NH-O-A662,-NH-C(O)-NA663-O-A664,-NA665-C(O)-NA666-O-A667,-N(-C(O)-NH-O-A668)2,-N(-C(O)-NA669-O-A670)2,-N(-C(O)-NH-O-A671)(-C(O)-NA672-O-A673),-C(S)-A674,-C(S)-O-A675,-C(S)-NH-A676,-C(S)-NA677A678,-C(O)-NH-O-A679,-C(O)-NA680-O-A681,-C(S)-NH-O-A682,-C(S)-NA683-O-A684,-C(O)-NH-NH-A685,-C(O)-NH-NA686A687,-C(O)-NA688-NA689A690,-C(S)-NH-NH-A691,-C(S)-NH-NA692A693,-C(S)-NA694-NA695A696,-C(O)-C(O)-O-A697,-C(O)-C(O)-NH2,-C(O)-C(O)-NHA698,-C(O)-C(O)-NA699A700,-C(S)-C(O)-O-A701,-C(O)-C(S)-O-A702,-C(S)-C(S)-O-A703,-C(S)-C(O)-NH2,-C(S)-C(O)-NHA704,-C(S)-C(O)-NA705A706,-C(S)-C(S)-NH2,-C(S)-C(S)-NHA707,-C(S)-C(S)-NA708A709,-C(O)-C(S)-NH2,-C(O)-C(S)-NHA710,-C(O)-C(S)-NA711A712”;
其中A601,A602,A603,A604,A605,A606,A607,A608,A609,A610,A611,A612,A613,A614,A615,A616,A617,A618,A619,A620,A621,A622,A623,A624,A625,A626,A627,A628,A629,A630,A631,A632,A633,A634,A635,A636,A637,A638,A639,A640,A641,A642,A643,A644,A645,A646,A647,A648,A649,A650,A651,A652,A653,A654,A655,A656,A657,A658,A659,A660,A661,A662,A663,A664,A665,A666,A667,A668,A669,A670,A671,A672,A673,A674,A675,A676,A677,A678,A679,A680,A681,A682,A683,A684,A685,A686,A687,A688,A689,A690,A691,A692,A693,A694,A695,A696,A697,A698,A699,A700,A701,A702,A703,A704,A705,A706,A707,A708,A709,A710,A711,A712彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,A607,A608和/或A616,A617和/或A629,A630和/或A636,A637和/
或A645,A646和/或A655,A656和/或A660,A661和/或A677,A678和/或A686,A687
和/或A689,A690和/或A692,A693和/或A695,A696和/或A699,A700和/或A705,
A706和/或A708,A709和/或A711,A712和/或分别一起还可形成“杂环基”;
并且基团R1,R2,R5彼此独立地选自:
(3)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHB1,-NB2B3,-NO2,-OH,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-B4,-C(O)O-B5,-C(O)NH-B6,-C(O)NB7B8,-O-B9,-O(-B10-O)a-H(a=1,2,3,4,5),-O(-B11-O)b-B12(b= 1,2,3,4,5),-OC(O)-B13,-OC(O)-O-B14,-OC(O)-NHB15,-O-C(O)-NB16B17,-OP(O)(OB18)(OB19),-OSi(B20)(B21)(B22),-OS(O2)-B23,-NHC(O)-NH2,-NHC(O)-B24,-NB25C(O)-B26,-NH-C(O)-O-B27,-NH-C(O)-NH-B28,-NH-C(O)-NB29B30,-NB31-C(O)-O-B32,-NB33-C(O)-NH-B34,-NB35-C(O)-NB36B37,-NHS(O2)-B38,-NB39S(O2)-B40,-S-B41,-S(O)-B42,-S(O2)-B43,-S(O2)NH-B44,-S(O2)NB45B46,-S(O2)O-B47,-P(O)(OB48)(OB49),-Si(B50)(B51)(B5
2),-C(NH)-NH2,-C(NB53)-NH2,-C(NH)-NHB54,-C(NH)-NB55B56,-C(NB57)-NHB58,-C(NB59)-NB60B61,-NH-C(O)-NH-O-B62,-NH-C(O)-NB63-O-B64,-NB65-C(O)-NB66-O-B67,-N(-C(O)-NH-O-B68)2,-N(-C(O)-NB69-O-B70)2,-N(-C(O)-NH-O-B71)(-C(O)-NB72-O-B73),-C(S)-B74,-C(S)-O-B75,-C(S)-NH-B76,-C(S)-NB77B78,-C(O)-NH-O-B79,-C(O)-NB80-O-B81,-C(S)-NH-O-B82,-C(S)-NB83-O-B84,-C(O)-NH-NH-B85,-C(O)-NH-NB86B87,-C(O)-NB88-NB89B90,-C(S)-NH-NH-B91,-C(S)-NH-NB92B93,-C(S)-NB94-NB95B96,-C(O)-C(O)-O-B97,-C(O)-C(O)-NH2,-C(O)-C(O)-NHB98,-C(O)-C(O)-NB99B100,-C(S)-C(O)-O-B101,-C(O)-C(S)-O-B102,-C(S)-C(S)-O-B103,-C(S)-C(O)-NH2,-C(S)-C(O)-NHB104,-C(S)-C(O)-NB105B106,-C(S)-C(S)-NH2,-C(S)-C(S)-NHB107,-C(S)-C(S)-NB108B109,-C(O)-C(S)-NH2,-C(O)-C(S)-NHB110,-C(O)-C(S)-NB111B112”;
其中B1,B2,B 3,B4,B5,B6,B7,B8,B9,B10,B11,B12,B13,B14,B15,B16,B17,B18,B19,B20,B21,B22,B23,B24,B25,B26,B27,B28,B29,B30,B31,B32,B33,B34,B35,B36,B37,B38,B39,B40,B41,B42,B43,B44,B45,B46,B47,B48,B49,B50,B51,B52,B53,B54,B55,B56,B57,B58,B59,B60,B61,B62,B63,B64,B65,B66,B67,B68,B69,B70,B71,B72,B73,B74,B75,B76,B77,B78,B79,B80,B81,B82,B83,B84,B85,B86,B87,B88,B89,B90,B91,B92,B93,B94,B95,B96,B97,B98,B99,B100,B101,B102,B103,B104,B105,B106,B107,B108,B109,B110,B111,B112彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,B2,B3和/或B7,B8和/或B16,B17和/或B29,B30和/或B36,B37和/或B45,B46和/或B55,
B56和/或B60,B61和/或B77,B78和/或B86,B87和/或B89,B90和/或B92,B93和/
或B95,B96和/或B99,B100和/或B105,B106和/或B108,B109和/或B111,B112和/
或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(3)的取代基,如果不是氢,又可彼此独立地被至少一个相
同或不同的选自以下的取代基取代:
(i)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHB201,-NB202B203,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-B204,-C(O)O-B205,-C(O)NH-B206,-C(O)NB207B208,-O-B209,-O(-B210-O)c-H(c=1,2,3,4,5),-O(-B211-O)d-B212(d=1,2,3,4,5),-OC(O)-B213,-OC(O)-O-B214,-OC(O)-NHB215,-O-C(O)-NB216B217,-OP(O)(OB218)(OB219),-OSi(B220)(B221)(B222),-OS(O2)-B223,-NHC(O)-NH2,-NHC(O)-B224,-NB225C(O)-B226,-NH-C(O)-O-B227,-NH-C(O)-NH-B228,-NH-C(O)-NB229B230,-NB231-C(O)-O-B232,-NB233-C(O)-NH-B234,-NB235-C(O)-NB236B237,-NHS(O2)-B238,-NB239S(O2)-B240,-S-B241,-S(O)-B242,-S(O2)-B243,-S(O2)NH-B244,-S(O2)NB245B246,-S(O2)O-B247,-P(O)(OB248)(OB249),-Si(B250)(B251)(B252),-C(NH)-NH2,-C(NB253)-NH2,-C(NH)-NHB254,-C(NH)-NB255B256,-C(NB257)-NHB258,-C(NB259)-NB260B261,-NH-C(O)-NH-O-B262,-NH-C(O)-NB263-O-B264,-NB265-C(O)-NB266-O-B267,-N(-C(O)-NH-O-B268)2,-N(-C(O)-NB269-O-B270)2,-N(-C(O)-NH-O-B271)(-C(O)-NB272-O-B273),-C(S)-B274,-C(S)-O-B275,-C(S)-NH-B276,-C(S)-NB277B278,-C(O)-NH-O-B279,-C(O)-NB280-O-B281,-C(S)-NH-O-B282,-C(S)-NB283-O-B284,-C(O)-NH-NH-B285,-C(O)-NH-NB286B287,-C(O)-NB288-NB289B290,-C(S)-NH-NH-B291,-C(S)-NH-NB292B293,-C(S)-NB294-NB295B296,-C(O)-C(O)-O-B297,-C(O)-C(O)-NH2,-C(O)-C(O)-NHB298,-C(O)-C(O)-NB299B300,-C(S)-C(O)-O-B301,-C(O)-C(S)-O-B302,-C(S)-C(S)-O-B303,-C(S)-C(O)-NH2,-C(S)-C(O)-NHB304,-C(S)-C(O)-NB305B306,-C(S)-C(S)-NH2,-C(S)-C(S)-NHB307,-C(S)-C(S)-NB 308B 309,-C(O)-C(S)-NH2,-C(O)-C(S)-NHB310,-C(O)-C(S)-NB311B312”;
其中B201,B202,B203,B204,B205,B206,B207,B208,B209,B210,B211,B212,B213,B214,B215,B216,B217,B218,B219,B220,B221,B222,B223,B224,B225,B226,B227,B228,B229,B230,B231,B232,B233,B234,B235,B236,B237,B238,B239,B240,B241,B242,B243,B244,B245,B246,B247,B248,B249,B250,B251,B252,B253,B254,B255,B256,B257,B258,B259,B260,B261,B262,B263,B264,B265,B266,B267,B268,B269,B270,B271,B272,B273,B274,B275,B276,B277,B278,B279,B280,B281,B282,B283,B284,B285,B286,B287,B288,B289,B290,B291,B292,B293,B294,B295,B296,B297,B298,B299,B300,B301,B302,B303,B304,B305,B306,B307,B308,B309,B310,B311,B312彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,B207,B208和/或B216,B217和/或B229,B230和/或B236,B237和/
或B245,B246和/或B255,B256和/或B260,B261和/或B277,B278和/或B286,B287
和/或B289,B290和/或B292,B293和/或B295,B296和/或B299,B300和/或B305,
B306和/或B308,B309和/或B311,B312和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(i)的取代基又可彼此独立地被至少一个相同或不同的选
自以下的取代基取代:
(ii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHB401,-NB402B403,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-B404,-C(O)O-B405,-C(O)NH-B406,-C(O)NB407B408,-O-B409,-O(-B410-O)e-H(e=1,2,3,4,5),-O(-B411-O)f-B412(f=1,2,3,4,5),-OC(O)-B413,-OC(O)-O-B414,-OC(O)-NHB415,-O-C(O)-NB416B417,-OP(O)(OB418)(OB419),-OSi(B420)(B421)(B422),-OS(O2)-B
423,-NHC(O)-NH2,-NHC(O)-B424,-NB425C(O)-B426,-NH-C(O)-O-B427,-NH-C(O)-NH-B428,-NH-C(O)-NB429B430,-NB431-C(O)-O-B432,-NB433-C(O)-NH-B434,-NB435-C(O)-NB436B437,-NHS(O2)-B438,-NB439S(O2)-B440,-S-B441,-S(O)-B442,-S(O2)-B443,-S(O2)NH-B444,-S(O2)NB445B446,-S(O2)O-B447,-P(O)(OB448)(OB449),-Si(B450)(B451)(B452),-C(NH)-NH2,-C(NB453)-NH2,-C(NH)-NHB454,-C(NH)-NB455B456,-C(NB457)-NHB458,-C(NB459)-NB460B461,-NH-C(O)-NH-O-B462,-NH-C(O)-NB463-O-B464,-NB465-C(O)-NB466-O-B467,-N(-C(O)-NH-O-B468)2,-N(-C(O)-NB469-O-B470)2,-N(-C(O)-NH-O-B471)(-C(O)-NB472-O-B473),-C(S)-B474,-C(S)-O-B475,-C(S)-NH-B476,-C(S)-NB477B478,-C(O)-NH-O-B479,-C(O)-NB480-O-B481,-C(S)-NH-O-B482,-C(S)-NB483-O-B484,-C(O)-NH-NH-B485,-C(O)-NH-NB486B487,-C(O)-NB488-NB489B490,-C(S)-NH-NH-B491,-C(S)-NH-NB492B493,-C(S)-NB494-NB495B496,-C(O)-C(O)-O-B497,-C(O)-C(O)-NH2,-C(O)-C(O)-NHB498,-C(O)-C(O)-NB499B500,-C(S)-C(O)-O-B501,-C(O)-C(S)-O-B502,-C(S)-C(S)-O-B503,-C(S)-C(O)-NH2,-C(S)-C(O)-NHB504,-C(S)-C(O)-NB505B506,-C(S)-C(S)-NH2,-C(S)-C(S)-NHB507,-C(S)-C(S)-NB508B509,-C(O)-C(S)-NH2,-C(O)-C(S)-NHB510,-C(O)-C(S)-NB511B512”;
其中B401,B402,B403,B404,B405,B406,B407,B408,B409,B410,B411,B412,B413,B414,B415,B416,B417,B418,B419,B420,B421,B422,B423,B424,B425,B426,B427,B428,B429,B430,B431,B432,B433,B434,B435,B436,B437,B438,B439,B440,B441,B442,B443,B444,B445,B446,B447,B448,B449,B450,B451,B452,B453,B454,B455,B456,B457,B458,B459,B460,B461,B462,B463,B464,B465,B466,B467,B468,B469,B470,B471,B472,B473,B474,B475,B476,B477,B478,B479,B480,B481,B482,B483,B484,B485,B486,B487,B488,B489,B490,B491,B492,B493,B494,B495,B496,B497,B498,B499,B500,B501,B502,B503,B504,B505,B506,B507,B508,B509,B510,B511,B512彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,B407,B408和/或B416,B417和/或B429,B430和/或B436,B437和/
或B445,B446和/或B455,B456和/或B460,B461和/或B477,B478和/或B486,B487
和/或B489,B490和/或B492,B493和/或B495,B496和/或B499,B500和/或B505,
B506和/或B508,B509和/或B511,B512和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(ii)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(iii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHB601,-NB602B603,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-B604,-C(O)O-B605,-C(O)NH-B606,-C(O)NB607B608,-O-B609,-O(-B610-O)e-H(e=1,2,3,4,5),-O(-B611-O)f-B612(f=1,2,3,4,5),-OC(O)-B613,-OC(O)-O-B614,-OC(O)-NHB615,-O-C(O)-NB616B617,-OP(O)(OB618)(OB619),-OSi(B620)(B621)(B622),-OS(O2)-B62
3,-NHC(O)-NH2,-NHC(O)-B624,-NB625C(O)-B626,-NH-C(O)-O-B627,-NH-C(O)-NH-B628,-NH-C(O)-NB629B630,-NB631-C(O)-O-B632,-NB633-C(O)-NH-B634,-NB635-C(O)-NB636B637,-NHS(O2)-B638,-NB639S(O2)-B640,-S-B641,-S(O)-B642,-S(O2)-B643,-S(O2)NH-B644,-S(O2)NB645B646,-S(O2)O-B647,-P(O)(OB648)(OB649),-Si(B650)(B651)(B652),-C(NH)-NH2,-C(NB653)-NH2,-C(NH)-NHB654,-C(NH)-NB655B656,-C(NB657)-NHB658,-C(NB659)-NB660B661,-NH-C(O)-NH-O-B662,-NH-C(O)-NB663-O-B664,-NB665-C(O)-NB666-O-B667,-N(-C(O)-NH-O-B668)2,-N(-C(O)-NB669-O-B670)2,-N(-C(O)-NH-O-B671)(-C(O)-NB672-O-B673),-C(S)-B674,-C(S)-O-B675,-C(S)-NH-B676,-C(S)-NB677B678,-C(O)-NH-O-B679,-C(O)-NB680-O-B681,-C(S)-NH-O-B682,-C(S)-NB683-O-B684,-C(O)-NH-NH-B685,-C(O)-NH-NB686B687,-C(O)-NB688-NB689B690,-C(S)-NH-NH-B691,-C(S)-NH-NB692B693,-C(S)-NB694-NB695B696,-C(O)-C(O)-O-B697,-C(O)-C(O)-NH2,-C(O)-C(O)-NHB698,-C(O)-C(O)-NB699B700,-C(S)-C(O)-O-B701,-C(O)-C(S)-O-B702,-C(S)-C(S)-O-B703,-C(S)-C(O)-NH2,-C(S)-C(O)-NHB704,-C(S)-C(O)-NB705B706,-C(S)-C(S)-NH2,-C(S)-C(S)-NHB707,-C(S)-C(S)-NB708B709,-C(O)-C(S)-NH2,-C(O)-C(S)-NHB710,-C(O)-C(S)-NB711B712”;
其中B601,B602,B603,B604,B605,B606,B607,B608,B609,B610,B611,B612,B613,B614,B615,B616,B617,B618,B619,B620,B621,B622,B623,B624,B625,B626,B627,B628,B629,B630,B631,B632,B633,B634,B635,B636,B637,B638,B639,B640,B641,B642,B643,B644,B645,B646,B647,B648,B649,B650,B651,B652,B653,B654,B655,B656,B657,B658,B659,B660,B661,B662,B663,B664,B665,B666,B667,B668,B669,B670,B671,B672,B673,B674,B675,B676,B677,B678,B679,B680,B681,B682,B683,B684,B685,B686,B687,B688,B689,B690,B691,B692,B693,B694,B695,B696,B697,B698,B699,B700,B701,B702,B703,B704,B705,B706,B707,B708,B709,B710,B711,B712彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,B607,B608和/或B616,B617和/或B629,B630和/或B636,B637和/
或B645,B646和/或B655,B656和/或B660,B661和/或B677,B678和/或B686,B687
和/或B689,B690和/或B692,B693和/或B695,B696和/或B699,B700和/或B705,
B706和/或B708,B709和/或B711,B712和/或分别一起还可形成“杂环基”。
2.通式(Ib)所示的吡啶并[2,3-b]吡嗪衍生物,
其中
基团R3,R4之一独立地选自、或者基团R3,R4二者彼此独立地选自:
(1)“-NR6R7”;
其中基团R6,R7彼此独立地选自:
(e)“氢”;
第一个前提条件是,基团R6,R7不同时都是氢;
第二个前提条件是,如果基团R6,R7之一独立地是“氢”,则基团R5不选自:“-NH-环
烷基,-NH-杂环基,-NH-芳基,-NH-杂芳基,卤素,-F,-Cl,-Br,-I,-NRaRb”,其中Ra,Rb独立地选自:“H,烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-NRcRd”,其中Rc,Rd又独立地选自:“H,烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”;
(f)“-C(Y1)NR8R9,-C(=NR10)-R11,-C(Y2)NR12-Y3-R13”;
其中Y1,Y2彼此独立地选自:“=O,=S,=NH,=NR14”;
其中Y 3独立地选自:“O,S”;
其中基团R8,R9,R10,R11,R12,R13,R14彼此独立地选自:
(I)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHX1,-NX2X3,-NO2,-OH,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-X4,-C(O)O-X5,-C(O)NH-X6,-C(O)NX7X8,-O-X9,-O(-X10-O)a-H(a=1,2,3,4,5),-O(-X11-O)b-X12(b= 1,2,3,4,5),-OC(O)-X13,-OC(O)-O-X14,-OC(O)-NHX15,-O-C(O)-NX16X17,-OP(O)(OX18)(OX19),-OSi(X20)(X21)(X22),-OS(O2)-X23,-NHC(O)-NH2,-NHC(O)-X24,-NX25C(O)-X26,-NH-C(O)-O-X27,-NH-C(O)-NH-X28,-NH-C(O)-NX29X30,-NX31-C(O)-O-X32,-NX33-C(O)-NH-X34,-NX35-C(O)-NX36X37,-NHS(O2)-X38,-NX39S(O2)-X40,-S-X41,-S(O)-X42,-S(O2)-X43,-S(O2)NH-X44,-S(O2)NX45X46,-S(O2)O-X47,-P(O)(OX48)(OX49),-Si(X50)(X51)(X5
2),-C(NH)-NH2,-C(NX53)-NH2,-C(NH)-NHX54,-C(NH)-NX55X56,-C(NX57)-NHX58,-C(NX59)-NX60X61,-NH-C(O)-NH-O-X62,-NH-C(O)-NX63-O-X64,-NX65-C(O)-NX66-O-X67,-N(-C(O)-NH-O-X68)2,-N(-C(O)-NX69-O-X70)2,-N(-C(O)-NH-O-X71)(-C(O)-NX72-O-X73),-C(S)-X74,-C(S)-O-X75,-C(S)-NH-X76,-C(S)-NX77X78,-C(O)-NH-O-X79,-C(O)-NX80-O-X81,-C(S)-NH-O-X82,-C(S)-NX83-O-X84,-C(O)-NH-NH-X85,-C(O)-NH-NX86X87,-C(O)-NX88-NX89X90,-C(S)-NH-NH-X91,-C(S)-NH-NX92X93,-C(S)-NX94-NX95X96,-C(O)-C(O)-O-X97,-C(O)-C(O)-NH2,-C(O)-C(O)-NHX98,-C(O)-C(O)-NX99X100,-C(S)-C(O)-O-X101,-C(O)-C(S)-O-X102,-C(S)-C(S)-O-X103,-C(S)-C(O)-NH2,-C(S)-C(O)-NHX104,-C(S)-C(O)-NX105X106,-C(S)-C(S)-NH2,-C(S)-C(S)-NHX107,-C(S)-C(S)-NX108X109,-C(O)-C(S)-NH2,-C(O)-C(S)-NHX110,-C(O)-C(S)-NX111X112”;
其中X1,X2,X 3,X4,X5,X6,X7,X8,X9,X10,X11,X12,X13,X14,X15,X16,X 17,X18,X19,X20,X21,X22,X23,X24,X25,X26,X27,X28,X29,X30,X31,X32,X33,X34,X35,X36,X37,X38,X39,X40,X41,X42,X43,X44,X45,X46,X47,X48,X49,X50,X51,X52,X53,X54,X55,X56,X57,X58,X59,X60,X61,X62,X63,X64,X65,X66,X67,X68,X69,X70,X71,X72,X73,X74,X75,X76,X77,X78,X79,X80,X81,X82,X83,X84,X85,X86,X87,X88,X89,X90,X91,X92,X93,X94,X95,X96,X97,X98,X99,X100,X101,X102,X103,X104,X105,X106,X107,X108,X109,X110,X111,X112彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,X7,X8和/或X16,X17和/或X29,X30和/或X36,X37和/或X45,X46和/或X55,X56和/或
X60,X61和/或X77,X78和/或X86,X87和/或X89,X90和/或X92,X93和/或X95,X96
和/或X99,X100和/或X105,X106和/或X108,X109和/或X111,X112和/或分别一起
还可形成“杂环基”;
其中任选地,上述取代基组(I)的取代基,如果不是氢,又可彼此独立地被至少一个相
同或不同的选自以下的取代基取代:
(i)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-B r,-I,-CN,-CF3,-N3,-NH2,-NHX201,-NX202X203,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-X204,-C(O)O-X205,-C(O)NH-X206,-C(O)NX207X208,-O-X209,-O(-X210-O)c-H(c=1,2,3,4,5),-O(-X211-O)d-X212(d=1,2,3,4,5),-OC(O)-X213,-OC(O)-O-X214,-OC(O)-NHX215,-O-C(O)-NX216X217,-OP(O)(OX218)(OX219),-OSi(X220)(X221)(X222),-OS(O2)-X
223,-NHC(O)-NH2,-NHC(O)-X224,-NX225C(O)-X226,-NH-C(O)-O-X227,-NH-C(O)-NH-X228,-NH-C(O)-NX229X230,-NX231-C(O)-O-X232,-NX233-C(O)-NH-X234,-NX235-C(O)-NX236X237,-NHS(O2)-X238,-NX239S(O2)-X240,-S-X241,-S(O)-X242,-S(O2)-X243,-S(O2)NH-X244,-S(O2)NX245X246,-S(O2)O-X247,-P(O)(OX248)(OX249),-Si(X250)(X251)(X252),-C(NH)-NH2,-C(NX253)-NH2,-C(NH)-NHX254,-C(NH)-NX255X256,-C(NX257)-NHX258,-C(NX259)-NX260X261,-NH-C(O)-NH-O-X262,-NH-C(O)-NX263-O-X264,-NX265-C(O)-NX266-O-X267,-N(-C(O)-NH-O-X268)2,-N(-C(O)-NX269-O-X270)2,-N(-C(O)-NH-O-X271)(-C(O)-NX272-O-X273),-C(S)-X274,-C(S)-O-X275,-C(S)-NH-X276,-C(S)-NX277X278,-C(O)-NH-O-X279,-C(O)-NX280-O-X281,-C(S)-NH-O-X282,-C(S)-NX283-O-X284,-C(O)-NH-NH-X285,-C(O)-NH-NX286X287,-C(O)-NX288-NX289X290,-C(S)-NH-NH-X291,-C(S)-NH-NX292X293,-C(S)-NX294-NX295X296,-C(O)-C(O)-O-X297,-C(O)-C(O)-NH2,-C(O)-C(O)-NHX298,-C(O)-C(O)-NX299X300,-C(S)-C(O)-O-X301,-C(O)-C(S)-O-X302,-C(S)-C(S)-O-X303,-C(S)-C(O)-NH2,-C(S)-C(O)-NHX304,-C(S)-C(O)-NX305X306,-C(S)-C(S)-NH2,-C(S)-C(S)-NHX307,-C(S)-C(S)-NX308X309,-C(O)-C(S)-NH2,-C(O)-C(S)-NHX310,-C(O)-C(S)-NX311X312”;
其中X201,X202,X203,X204,X205,X206,X207,X208,X209,X210,X211,X212,X213,X214,X215,X216,X217,X218,X219,X220,X221,X222,X223,X224,X225,X226,X227,X228,X229,X230,X231,X232,X233,X234,X235,X236,X237,X238,X239,X240,X241,X242,X243,X244,X245,X246,X247,X248,X249,X250,X251,X252,X253,X254,X255,X256,X257,X258,X259,X260,X261,X262,X263,X264,X265,X266,X267,X268,X269,X270,X271,X272,X273,X274,X275,X276,X277,X278,X279,X280,X281,X282,X283,X284,X285,X286,X287,X288,X289,X290,X291,X292,X293,X294,X295,X296,X297,X298,X299,X300,X301,X302,X303,X304,X305,X306,X307,X308,X309,X310,X311,X312彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,X207,X208和/或X216,X217和/或X229,X230和/或X236,X237和/
或X245,X246和/或X255,X256和/或X260,X261和/或X277,X278和/或X286,X287
和/或X289,X290和/或X292,X293和/或X295,X296和/或X299,X300和/或X305,
X306和/或X308,X309和/或X311,X312和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(i)的取代基又可彼此独立地被至少一个相同或不同的选
自以下的取代基取代:
(ii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHX401,-NX402X403,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-X404,-C(O)O-X405,-C(O)NH-X406,-C(O)NX407X408,-O-X409,-O(-X410-O)e-H(e=1,2,3,4,5),-O(-X411-O)f-X412(f=1,2,3,4,5),-OC(O)-X413,-OC(O)-O-X414,-OC(O)-NHX415,-O-C(O)-NX416X417,-OP(O)(OX418)(OX419),-OSi(X420)(X421)(X422),-OS(O2)-X
423,-NHC(O)-NH2,-NHC(O)-X424,-NX425C(O)-X426,-NH-C(O)-O-X427,-NH-C(O)-NH-X428,-NH-C(O)-NX429X430,-NX431-C(O)-O-X432,-NX433-C(O)-NH-X434,-NX435-C(O)-NX436X437,-NHS(O2)-X438,-NX439S(O2)-X440,-S-X441,-S(O)-X442,-S(O2)-X443,-S(O2)NH-X444,-S(O2)NX445X446,-S(O2)O-X447,-P(O)(OX448)(OX449),-Si(X450)(X451)(X452),-C(NH)-NH2,-C(NX453)-NH2,-C(NH)-NHX454,-C(NH)-NX455X456,-C(NX457)-NHX458,-C(NX459)-NX460X461,-NH-C(O)-NH-O-X462,-NH-C(O)-NX463-O-X464,-NX465-C(O)-NX466-O-X467,-N(-C(O)-NH-O-X468)2,-N(-C(O)-NX469-O-X470)2,-N(-C(O)-NH-O-X471)(-C(O)-NX472-O-X473),-C(S)-X474,-C(S)-O-X475,-C(S)-NH-X476,-C(S)-NX477X478,-C(O)-NH-O-X479,-C(O)-NX480-O-X481,-C(S)-NH-O-X482,-C(S)-NX483-O-X484,-C(O)-NH-NH-X485,-C(O)-NH-NX486X487,-C(O)-NX488-NX489X490,-C(S)-NH-NH-X491,-C(S)-NH-NX492X493,-C(S)-NX494-NX495X496,-C(O)-C(O)-O-X497,-C(O)-C(O)-NH2,-C(O)-C(O)-NHX498,-C(O)-C(O)-NX499X500,-C(S)-C(O)-O-X501,-C(O)-C(S)-O-X502,-C(S)-C(S)-O-X503,-C(S)-C(O)-NH2,-C(S)-C(O)-NHX504,-C(S)-C(O)-NX505X506,-C(S)-C(S)-NH2,-C(S)-C(S)-NHX507,-C(S)-C(S)-NX508X509,-C(O)-C(S)-NH2,-C(O)-C(S)-NHX510,-C(O)-C(S)-NX511X512”;
其中X401,X402,X403,X404,X405,X406,X407,X408,X409,X410,X411,X412,X413,X414,X415,X416,X417,X418,X419,X420,X421,X422,X423,X424,X425,X426,X427,X428,X429,X430,X431,X432,X433,X434,X435,X436,X437,X438,X439,X440,X441,X442,X443,X444,X445,X446,X447,X448,X449,X450,X451,X452,X453,X454,X455,X456,X457,X458,X459,X460,X461,X462,X463,X464,X465,X466,X467,X468,X469,X470,X471,X472,X473,X474,X475,X476,X477,X478,X479,X480,X481,X482,X483,X484,X485,X486,X487,X488,X489,X490,X491,X492,X493,X494,X495,X496,X497,X498,X499,X500,X501,X502,X503,X504,X505,X506,X507,X508,X509,X510,X511,X512彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,X407,X408和/或X416,X417和/或X429,X430和/或X436,X437和/
或X445,X446和/或X455,X456和/或X460,X461和/或X477,X478和/或X486,X487
和/或X489,X490和/或X492,X493和/或X495,X496和/或X499,X500和/或X505,
X506和/或X508,X509和/或X511,X512和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(ii)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(iii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHX601,-NX602X603,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-X604,-C(O)O-X605,-C(O)NH-X606,-C(O)NX607X608,-O-X609,-O(-X610-O)e-H(e=1,2,3,4,5),-O(-X611-O)f-X612(f=1,2,3,4,5),-OC(O)-X613,-OC(O)-O-X614,-OC(O)-NHX615,-O-C(O)-NX616X617,-OP(O)(OX618)(OX619),-OSi(X620)(X621)(X622),-OS(O2)-X
623,-NHC(O)-NH2,-NHC(O)-X624,-NX625C(O)-X626,-NH-C(O)-O-X627,-NH-C(O)-NH-X628,-NH-C(O)-NX629X630,-NX631-C(O)-O-X632,-NX633-C(O)-NH-X634,-NX635-C(O)-NX636X637,-NHS(O2)-X638,-NX639S(O2)-X640,-S-X641,-S(O)-X642,-S(O2)-X643,-S(O2)NH-X644,-S(O2)NX645X646,-S(O2)O-X647,-P(O)(OX648)(OX649),-Si(X650)(X651)(X652),-C(NH)-NH2,-C(NX653)-NH2,-C(NH)-NHX654,-C(NH)-NX655X656,-C(NX657)-NHX658,-C(NX659)-NX660X661,-NH-C(O)-NH-O-X662,-NH-C(O)-NX663-O-X664,-NX665-C(O)-NX666-O-X667,-N(-C(O)-NH-O-X668)2,-N(-C(O)-NX669-O-X670)2,-N(-C(O)-NH-O-X671)(-C(O)-NX672-O-X673),-C(S)-X674,-C(S)-O-X675,-C(S)-NH-X676,-C(S)-NX677X678,-C(O)-NH-O-X679,-C(O)-NX680-O-X681,-C(S)-NH-O-X682,-C(S)-NX683-O-X684,-C(O)-NH-NH-X685,-C(O)-NH-NX686X687,-C(O)-NX688-NX689X690,-C(S)-NH-NH-X691,-C(S)-NH-NX692X693,-C(S)-NX694-NX695X696,-C(O)-C(O)-O-X697,-C(O)-C(O)-NH2,-C(O)-C(O)-NHX698,-C(O)-C(O)-NX699X700,-C(S)-C(O)-O-X701,-C(O)-C(S)-O-X702,-C(S)-C(S)-O-X703,-C(S)-C(O)-NH2,-C(S)-C(O)-NHX704,-C(S)-C(O)-NX705X706,-C(S)-C(S)-NH2,-C(S)-C(S)-NHX707,-C(S)-C(S)-NX708X709,-C(O)-C(S)-NH2,-C(O)-C(S)-NHX710,-C(O)-C(S)-NX711X712”;
其中X601,X602,X603,X604,X605,X606,X607,X608,X609,X610,X611,X612,X613,X614,X615,X616,X617,X618,X619,X620,X621,X622,X623,X624,X625,X626,X627,X628,X629,X630,X631,X632,X633,X634,X635,X636,X637,X638,X639,X640,X641,X642,X643,X644,X645,X646,X647,X648,X649,X650,X651,X652,X653,X654,X655,X656,X657,X658,X659,X660,X661,X662,X663,X664,X665,X666,X667,X668,X669,X670,X671,X672,X673,X674,X675,X676,X677,X678,X679,X680,X681,X682,X683,X684,X685,X686,X687,X688,X689,X690,X691,X692,X693,X694,X695,X696,X697,X698,X699,X700,X701,X702,X703,X704,X705,X706,X707,X708,X709,X710,X711,X712彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,X607,X608和/或X616,X617和/或X629,X630和/或X636,X637和/
或X645,X646和/或X655,X656和/或X660,X661和/或X677,X678和/或X686,X687
和/或X689,X690和/或X692,X693和/或X695,X696和/或X699,X700和/或X705,
X706和/或X708,X709和/或X711,X712和/或分别一起还可形成“杂环基”;
第一个前提条件是,“-C(Y1)-NR8R9”不选自:“-C(O)-NRaRb”,其中Ra,Rb彼此独立地选自:“氢,烷基,(C9-C30)烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,环烷基,环烷基烷基,杂环基,杂环基烷基”;
第二个前提条件是,如果“-C(Y1)-NR8R9”独立地选自:“-C(O)-N[C(O)-O-烷
基 ]2,-C(O)-N[C(O)- 烷 基 ]2,-C(O)-N[S(O2)- 烷 基 ]2,-C(O)-N[S(O2)- 环 烷
基]2,-C(O)-N[S(O2)-环烷基烷基]2,-C(O)-N[S(O2)-芳基]2,-C(O)-N[S(O2)-杂环基]2”,则基团R1,R2彼此独立地不是“苯基”;
第三个前提条件是,如果“-C(Y2)-NR12-Y3-R13”独立地选自:“-C(O)-N[O-烷基]2”,则基团R1,R2彼此独立地不是“苯基”;
(g)“-C(O)-C(O)-R16”;
其中基团R16独立地选自:
(II)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N2,-NH2,-NHZ1,-NZ2Z3,-NO2,-OH,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-Z4,-C(O)O-Z5,-C(O)NH-Z6,-C(O)NZ7Z8,-O-Z9,-O(-Z10-O)a-H(a=1,2,3,4,5),-O(-Z11-O)b-Z12(b= 1,2,3,4,5),-OC(O)-Z13,-OC(O)-O-Z14,-OC(O)-NHZ15,-O-C(O)-NZ16Z17,-OP(O)(OZ18)(OZ19),-OSi(Z20)(Z21)(Z22),-OS(O2)-Z23,-NHC(O)-NH2,-NHC(O)-Z24,-NZ25C(O)-Z26,-NH-C(O)-O-Z27,-NH-C(O)-NH-Z28,-NH-C(O)-NZ29Z30,-NZ31-C(O)-O-Z32,-NZ33-C(O)-NH-Z34,-NZ35-C(O)-NZ36Z37,-NHS(O2)-Z38,-NZ39S(O2)-Z40,-S-Z41,-S(O)-Z42,-S(O2)-Z43,-S(O2)NH-Z44,-S(O2)NZ45Z46,-S(O2)O-Z47,-P(O)(OZ48)(OZ49),-Si(Z50)(Z51)(Z5
2),-C(NH)-NH2,-C(NZ53)-NH2,-C(NH)-NHZ54,-C(NH)-NZ55Z56,-C(NZ57)-NHZ58,-C(NZ59)-NZ60Z61,-NH-C(O)-NH-O-Z62,-NH-C(O)-NZ63-O-Z64,-NZ65-C(O)-NZ66-O-Z67,-N(-C(O)-NH-O-Z68)2,-N(-C(O)-NZ69-O-Z70)2,-N(-C(O)-NH-O-Z71)(-C(O)-NZ72-O-Z73),-C(S)-Z74,-C(S)-O-Z75,-C(S)-NH-Z76,-C(S)-NZ77Z78,-C(O)-NH-O-Z79,-C(O)-NZ80-O-Z81,-C(S)-NH-O-Z82,-C(S)-NZ83-O-Z84,-C(O)-NH-NH-Z85,-C(O)-NH-NZ86Z87,-C(O)-NZ88-NZ89Z90,-C(S)-NH-NH-Z91,-C(S)-NH-NZ92Z93,-C(S)-NZ94-NZ95Z96,-C(O)-C(O)-O-Z97,-C(O)-C(O)-NH2,-C(O)-C(O)-NHZ98,-C(O)-C(O)-NZ99Z100,-C(S)-C(O)-O-Z101,-C(O)-C(S)-O-Z102,-C(S)-C(S)-O-Z103,-C(S)-C(O)-NH2,-C(S)-C(O)-NHZ104,-C(S)-C(O)-NZ105Z106,-C(S)-C(S)-NH2,-C(S)-C(S)-NHZ107,-C(S)-C(S)-NZ108Z109,-C(O)-C(S)-NH2,-C(O)-C(S)-NHZ110,-C(O)-C(S)-NZ111Z112”;
其中Z1,Z2,Z3,Z4,Z5,Z6,Z7,Z8,Z9,Z10,Z11,Z12,Z13,Z14,Z15,Z16,Z17,Z18,Z19,Z20,Z21,Z22,Z23,Z24,Z25,Z26,Z27,Z28,Z29,Z30,Z31,Z32,Z33,Z34,Z35,Z36,Z37,Z38,Z39,Z40,Z41,Z42,Z43,Z44,Z45,Z46,Z47,Z48,Z49,Z50,Z51,Z52,Z53,Z54,Z55,Z56,Z57,Z58,Z59,Z60,Z61,Z62,Z63,Z64,Z65,Z66,Z 67,Z68,Z69,Z70,Z71,Z72,Z73,Z74,Z75,Z76,Z77,Z78,Z79,Z80,Z81,Z82,Z83,Z84,Z85,Z86,Z87,Z 88,Z89,Z90,Z91,Z92,Z93,Z94,Z95,Z96,Z97,Z98,Z99,Z100,Z 101,Z102,Z103,Z104,Z105,Z106,Z107,Z108,Z109,Z110,Z111,Z112彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,Z7,Z8和/或Z16,Z17和/或Z29,Z30和/或Z36,Z37和/或Z45,Z46和/或Z55,Z56和/或
Z60,Z61和/或Z77,Z78和/或Z86,Z87和/或Z89,Z90和/或Z92,Z93和/或Z95,Z96
和/或Z99,Z100和/或Z105,Z106和/或Z108,Z109和/或Z111,Z112和/或分别一起
还可形成“杂环基”;
其中任选地,上述取代基组(II)的取代基,如果不是氢,又可彼此独立地被至少一个
相同或不同的选自以下的取代基取代:
(i)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHZ201,-NZ202Z203,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-Z204,-C(O)O-Z205,-C(O)NH-Z206,-C(O)NZ207Z208,-O-Z209,-O(-Z210-O)c-H(c=1,2,3,4,5),-O(-Z211-O)d-Z212(d=1,2,3,4,5),-OC(O)-Z213,-OC(O)-O-Z214,-OC(O)-NHZ215,-O-C(O)-NZ216Z217,-OP(O)(OZ218)(OZ219),-OSi(Z220)(Z221)(Z222),-OS(O2)-Z
223,-NHC(O)-NH2,-NHC(O)-Z224,-NZ225C(O)-Z226,-NH-C(O)-O-Z227,-NH-C(O)-NH-Z228,-NH-C(O)-NZ229Z230,-NZ231-C(O)-O-Z232,-NZ233-C(O)-NH-Z234,-NZ235-C(O)-NZ236Z237,-NHS(O2)-Z238,-NZ239S(O2)-Z240,-S-Z241,-S(O)-Z242,-S(O2)-Z243,-S(O2)NH-Z244,-S(O2)NZ245Z246,-S(O2)O-Z247,-P(O)(OZ248)(OZ249),-Si(Z250)(Z251)(Z252),-C(NH)-NH2,-C(NZ253)-NH2,-C(NH)-NHZ254,-C(NH)-NZ255Z256,-C(NZ257)-NHZ258,-C(NZ259)-NZ260Z261,-NH-C(O)-NH-O-Z262,-NH-C(O)-NZ263-O-Z264,-NZ265-C(O)-NZ266-O-Z267,-N(-C(O)-NH-O-Z268)2,-N(-C(O)-NZ269-O-Z270)2,-N(-C(O)-NH-O-Z271)(-C(O)-NZ272-O-Z273),-C(S)-Z274,-C(S)-O-Z275,-C(S)-NH-Z276,-C(S)-NZ277Z278,-C(O)-NH-O-Z279,-C(O)-NZ280-O-Z281,-C(S)-NH-O-Z282,-C(S)-NZ283-O-Z284,-C(O)-NH-NH-Z285,-C(O)-NH-NZ286Z287,-C(O)-NZ288-NZ289Z290,-C(S)-NH-NH-Z291,-C(S)-NH-NZ292Z293,-C(S)-NZ294-NZ295Z296,-C(O)-C(O)-O-Z297,-C(O)-C(O)-NH2,-C(O)-C(O)-NHZ298,-C(O)-C(O)-NZ299Z300,-C(S)-C(O)-O-Z301,-C(O)-C(S)-O-Z302,-C(S)-C(S)-O-Z303,-C(S)-C(O)-NH2,-C(S)-C(O)-NHZ304,-C(S)-C(O)-NZ305Z306,-C(S)-C(S)-NH2,-C(S)-C(S)-NHZ307,-C(S)-C(S)-NZ308Z309,-C(O)-C(S)-NH2,-C(O)-C(S)-NHZ310,-C(O)-C(S)-NZ311Z312”;
其中Z201,Z202,Z203,Z204,Z205,Z206,Z207,Z208,Z209,Z210,Z211,Z212,Z213,Z214,Z215,Z216,Z217,Z218,Z219,Z220,Z221,Z222,Z223,Z224,Z225,Z226,Z227,Z228,Z229,Z230,Z231,Z232,Z233,Z234,Z235,Z236,Z237,Z238,Z239,Z240,Z241,Z242,Z243,Z244,Z245,Z246,Z247,Z248,Z249,Z250,Z251,Z252,Z253,Z254,Z255,Z256,Z257,Z258,Z259,Z260,Z261,Z262,Z263,Z264,Z265,Z266,Z267,Z268,Z269,Z270,Z271,Z272,Z273,Z274,Z275,Z276,Z277,Z278,Z279,Z280,Z281,Z282,Z283,Z284,Z285,Z286,Z287,Z288,Z289,Z290,Z291,Z292,Z293,Z294,Z295,Z296,Z297,Z298,Z299,Z300,Z301,Z302,Z303,Z304,Z305,Z306,Z307,Z308,Z309,Z310,Z311,Z312彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,Z207,Z208和/或Z216,Z217和/或Z229,Z230和/或Z236,Z237和/
或Z245,Z246和/或Z255,Z256和/或Z260,Z261和/或Z277,Z278和/或Z286,Z287
和/或Z289,Z290和/或Z292,Z293和/或Z295,Z296和/或Z299,Z300和/或Z305,
Z306和/或Z308,Z309和/或Z311,Z312和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(i)的取代基又可彼此独立地被至少一个相同或不同的选
自以下的取代基取代:
(ii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHZ401,-NZ402Z403,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-Z404,-C(O)O-Z405,-C(O)NH-Z406,-C(O)NZ407Z408,-O-Z409,-O(-Z410-O)e-H(e=1,2,3,4,5),-O(-Z411-O)f-Z412(f=1,2,3,4,5),-OC(O)-Z413,-OC(O)-O-Z414,-OC(O)-NHZ415,-O-C(O)-NZ416Z417,-OP(O)(OZ418)(OZ419),-OSi(Z420)(Z421)(Z422),-OS(O2)-Z
423,-NHC(O)-NH2,-NHC(O)-Z424,-NZ425C(O)-Z426,-NH-C(O)-O-Z427,-NH-C(O)-NH-Z428,-NH-C(O)-NZ429Z430,-NZ431-C(O)-O-Z432,-NZ433-C(O)-NH-Z434,-NZ435-C(O)-NZ436Z437,-NHS(O2)-Z438,-NZ439S(O2)-Z440,-S-Z441,-S(O)-Z442,-S(O2)-Z443,-S(O2)NH-Z444,-S(O2)NZ445Z446,-S(O2)O-Z447,-P(O)(OZ448)(OZ449),-Si(Z450)(Z451)(Z452),-C(NH)-NH2,-C(NZ453)-NH2,-C(NH)-NHZ454,-C(NH)-NZ455Z456,-C(NZ457)-NHZ458,-C(NZ459)-NZ460Z461,-NH-C(O)-NH-O-Z462,-NH-C(O)-NZ463-O-Z464,-NZ465-C(O)-NZ466-O-Z467,-N(-C(O)-NH-O-Z468)2,-N(-C(O)-NZ469-O-Z470)2,-N(-C(O)-NH-O-Z471)(-C(O)-NZ472-O-Z473),-C(S)-Z474,-C(S)-O-Z475,-C(S)-NH-Z476,-C(S)-NZ477Z478,-C(O)-NH-O-Z479,-C(O)-NZ480-O-Z481,-C(S)-NH-O-Z482,-C(S)-NZ483-O-Z484,-C(O)-NH-NH-Z485,-C(O)-NH-NZ486Z487,-C(O)-NZ488-NZ489Z490,-C(S)-NH-NH-Z491,-C(S)-NH-NZ492Z493,-C(S)-NZ494-NZ495Z496,-C(O)-C(O)-O-Z497,-C(O)-C(O)-NH2,-C(O)-C(O)-NHZ498,-C(O)-C(O)-NZ499Z500,-C(S)-C(O)-O-Z501,-C(O)-C(S)-O-Z502,-C(S)-C(S)-O-Z503,-C(S)-C(O)-NH2,-C(S)-C(O)-NHZ504,-C(S)-C(O)-NZ505Z506,-C(S)-C(S)-NH2,-C(S)-C(S)-NHZ507,-C(S)-C(S)-NZ508Z509,-C(O)-C(S)-NH2,-C(O)-C(S)-NHZ510,-C(O)-C(S)-NZ511Z512”;
其中Z401,Z402,Z403,Z404,Z405,Z406,Z407,Z408,Z409,Z410,Z411,Z412,Z413,Z414,Z415,Z416,Z417,Z418,Z419,Z420,Z421,Z422,Z423,Z424,Z425,Z426,Z427,Z428,Z429,Z430,Z431,Z432,Z433,Z434,Z435,Z436,Z437,Z438,Z439,Z440,Z441,Z442,Z443,Z444,Z445,Z446,Z447,Z448,Z449,Z450,Z451,Z452,Z453,Z454,Z455,Z456,Z457,Z458,Z459,Z460,Z461,Z462,Z463,Z464,Z465,Z466,Z467,Z468,Z469,Z470,Z471,Z472,Z473,Z474,Z475,Z476,Z477,Z478,Z479,Z480,Z481,Z482,Z483,Z484,Z485,Z486,Z487,Z488,Z489,Z490,Z491,Z492,Z493,Z494,Z495,Z496,Z497,Z498,Z499,Z500,Z501,Z502,Z503,Z504,Z505,Z506,Z507,Z508,Z509,Z510,Z511,Z512彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,Z407,Z408和/或Z416,Z417和/或Z429,Z430和/或Z436,Z437和/
或Z445,Z446和/或Z455,Z456和/或Z460,Z461和/或Z477,Z478和/或Z486,Z487
和/或Z489,Z490和/或Z492,Z493和/或Z495,Z496和/或Z499,Z500和/或Z505,
Z506和/或Z508,Z509和/或Z511,Z512和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(ii)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(iii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHZ601,-NZ602Z603,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-Z604,-C(O)O-Z605,-C(O)NH-Z606,-C(O)NZ607Z608,-O-Z609,-O(-Z610-O)e-H(e=1,2,3,4,5),-O(-Z611-O)f-Z612(f=1,2,3,4,5),-OC(O)-Z613,-OC(O)-O-Z614,-OC(O)-NHZ615,-O-C(O)-NZ616Z617,-OP(O)(OZ618)(OZ619),-OSi(Z620)(Z621)(Z622),-OS(O2)-Z
623,-NHC(O)-NH2,-NHC(O)-Z624,-NZ625C(O)-Z626,-NH-C(O)-O-Z627,-NH-C(O)-NH-Z628,-NH-C(O)-NZ629Z630,-NZ631-C(O)-O-Z632,-NZ633-C(O)-NH-Z634,-NZ635-C(O)-NZ636Z637,-NHS(O2)-Z638,-NZ639S(O2)-Z640,-S-Z641,-S(O)-Z642,-S(O2)-Z643,-S(O2)NH-Z644,-S(O2)NZ645Z646,-S(O2)O-Z647,-P(O)(OZ648)(OZ649),-Si(Z650)(Z651)(Z652),-C(NH)-NH2,-C(NZ653)-NH2,-C(NH)-NHZ654,-C(NH)-NZ655Z656,-C(NZ657)-NHZ658,-C(NZ659)-NZ660Z661,-NH-C(O)-NH-O-Z662,-NH-C(O)-NZ663-O-Z664,-NZ665-C(O)-NZ666-O-Z667,-N(-C(O)-NH-O-Z668)2,-N(-C(O)-NZ669-O-Z670)2,-N(-C(O)-NH-O-Z671)(-C(O)-NZ672-O-Z673),-C(S)-Z674,-C(S)-O-Z675,-C(S)-NH-Z676,-C(S)-NZ677Z678,-C(O)-NH-O-Z679,-C(O)-NZ680-O-Z681,-C(S)-NH-O-Z682,-C(S)-NZ683-O-Z684,-C(O)-NH-NH-Z685,-C(O)-NH-NZ686Z687,-C(O)-NZ688-NZ689Z690,-C(S)-NH-NH-Z691,-C(S)-NH-NZ692Z693,-C(S)-NZ694-NZ695Z696,-C(O)-C(O)-O-Z697,-C(O)-C(O)-NH2,-C(O)-C(O)-NHZ698,-C(O)-C(O)-NZ699Z700,-C(S)-C(O)-O-Z701,-C(O)-C(S)-O-Z702,-C(S)-C(S)-O-Z703,-C(S)-C(O)-NH2,-C(S)-C(O)-NHZ704,-C(S)-C(O)-NZ705Z706,-C(S)-C(S)-NH2,-C(S)-C(S)-NHZ707,-C(S)-C(S)-NZ708Z709,-C(O)-C(S)-NH2,-C(O)-C(S)-NHZ710,-C(O)-C(S)-NZ711Z712”;
其中Z601,Z602,Z603,Z604,Z605,Z606,Z607,Z608,Z609,Z610,Z611,Z612,Z613,Z614,Z615,Z616,Z617,Z618,Z619,Z620,Z621,Z622,Z623,Z624,Z625,Z626,Z627,Z628,Z629,Z630,Z631,Z632,Z633,Z634,Z635,Z636,Z637,Z638,Z639,Z640,Z641,Z642,Z643,Z644,Z645,Z646,Z647,Z648,Z649,Z650,Z651,Z652,Z653,Z654,Z655,Z656,Z657,Z658,Z659,Z660,Z661,Z662,Z663,Z664,Z665,Z666,Z667,Z668,Z669,Z670,Z671,Z672,Z673,Z674,Z675,Z676,Z677,Z678,Z679,Z680,Z681,Z682,Z683,Z684,Z685,Z686,Z687,Z688,Z689,Z690,Z691,Z692,Z693,Z694,Z695,Z696,Z697,Z698,Z699,Z700,Z701,Z702,Z703,Z704,Z705,Z706,Z707,Z 708,Z709,Z710,Z711,Z712彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,Z607,Z608和/或Z616,Z617和/或Z629,Z630和/或Z636,Z637和/
或Z645,Z646和/或Z655,Z656和/或Z660,Z661和/或Z677,Z678和/或Z686,Z687
和/或Z689,Z690和/或Z692,Z693和/或Z695,Z696和/或Z699,Z700和/或Z705,
Z706和/或Z708,Z709和/或Z711,Z712和/或分别一起还可形成“杂环基”;
前提条件是基团R16不是“吲哚基”;
(h)“-S(O2)-R18”;
其中基团R18独立地选自:
(III)“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHW1,-NW2W3,-NO2,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-W4,-C(O)O-W5,-C(O)NH-W6,-C(O)NW7W8,-O-W9,-O(-W10-O)a-H(a = 1,2,3,4,5),-O(-W11-O)b-W12(b = 1,
2,3,4,5),-OC(O)-W13,-OC(O)-O-W14,-OC(O)-NHW15,-O-C(O)-NW16W17,-OP(O)(OW18)(OW19),-OSi(W20)(W21)(W22),-OS(O2)-W23,-NHC(O)-NH2,-NHC(O)-W24,-NW25C(O)-W26,-NH-C(O)-O-W27,-NH-C(O)-NH-W28,-NH-C(O)-NW29W30,-NW31-C(O)-O-W32,-NW33-C(O)-NH-W
34,-NW35-C(O)-NW36W37,-NHS(O2)-W38,-NW39S(O2)-W40,-S-W41,-S(O)-W42,-S(O2)-W43,-S(O2)NH-W44,-S(O2)NW45W46,-S(O2)O-W47,-P(O)(OW48)(OW49),-Si(W50)(W51)(W52),-C(NH)-NH2,-C(NW53)-NH2,-C(NH)-NHW54,-C(NH)-NW55W56,-C(NW57)-NHW58,-C(NW59)-NW60W61,-NH-C(O)-NH-O-W62,-NH-C(O)-NW63-O-W64,-NW65-C(O)-NW66-O-W67,-N(-C(O)-NH-O-W68)2,-N(-C(O)-NW69-O-W70)2,-N(-C(O)-NH-O-W71)(-C(O)-NW72-O-W73),-C(S)-W74,-C(S)-O-W
75,-C(S)-NH-W76,-C(S)-NW77W78,-C(O)-NH-O-W79,-C(O)-NW80-O-W81,-C(S)-NH-O-W82,-C(S)-NW83-O-W84,-C(O)-NH-NH-W85,-C(O)-NH-NW86W87,-C(O)-NW88-NW89W90,-C(S)-NH-NH-W91,-C(S)-NH-NW92W93,-C(S)-NW94-NW95W96,-C(O)-C(O)-O-W97,-C(O)-C(O)-NH2,-C(O)-C(O)-NHW98,-C(O)-C(O)-NW99W100,-C(S)-C(O)-O-W101,-C(O)-C(S)-O-W102,-C(S)-C(S)-O-W103,-C(S)-C(O)-NH2,-C(S)-C(O)-NHW104,-C(S)-C(O)-NW105W106,-C(S)-C(S)-NH2,-C(S)-C(S)-NHW107,-C(S)-C(S)-NW108W109,-C(O)-C(S)-NH2,-C(O)-C(S)-NHW110,-C(O)-C(S)-NW111W112”;
其中W1,W2,W3,W4,W5,W6,W7,W8,W9,W10,W11,W12,W13,W14,W15,W16,W17,W18,W19,W20,W21,W22,W23,W24,W25,W26,W27,W28,W29,W30,W31,W32,W33,W34,W35,W36,W37,W38,W39,W40,W41,W42,W43,W44,W45,W46,W47,W48,W49,W50,W51,W52,W53,W54,W55,W56,W57,W58,W59,W60,W61,W62,W63,W64,W65,W66,W67,W68,W69,W70,W71,W72,W73,W74,W75,W76,W77,W78,W79,W80,W81,W82,W83,W84,W85,W86,W87,W88,W89,W90,W91,W92,W93,W94,W95,W96,W97,W98,W99,W100,W101,W102,W103,W104,W105,W106,W107,W108,W109,W110,W111,W112彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,W7,W8和/或W16,W17和/或W29,W30和/或W36,W37和/或W45,W46和/或W55,W56和/或
W60,W61和/或W77,W78和/或W86,W87和/或W89,W90和/或W92,W93和/或W95,W96
和/或W99,W100和/或W105,W106和/或W108,W109和/或W111,W112和/或分别一起
还可形成“杂环基”;
其中任选地,上述取代基组(III)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(i)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHW201,-NW202W203,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-W204,-C(O)O-W205,-C(O)NH-W206,-C(O)NW207W208,-O-W209,-O(-W210-O)c-H(c=1,2,3,4,5),-O(-W211-O)d-W212(d=1,2,3,4,5),-OC(O)-W213,-OC(O)-O-W214,-OC(O)-NHW215,-O-C(O)-NW216W217,-OP(O)(OW218)(OW219),-OSi(W220)(W221)(W222),-OS(O2)-W
223,-NHC(O)-NH2,-NHC(O)-W224,-NW225C(O)-W226,-NH-C(O)-O-W227,-NH-C(O)-NH-W228,-NH-C(O)-NW229W230,-NW231-C(O)-O-W232,-NW233-C(O)-NH-W234,-NW235-C(O)-NW236W237,-NHS(O2)-W238,-NW239S(O2)-W240,-S-W241,-S(O)-W242,-S(O2)-W243,-S(O2)NH-W244,-S(O2)NW245W246,-S(O2)O-W247,-P(O)(OW248)(OW249),-Si(W250)(W251)(W252),-C(NH)-NH2,-C(NW253)-NH2,-C(NH)-NHW254,-C(NH)-NW255W256,-C(NW257)-NHW258,-C(NW259)-NW260W261,-NH-C(O)-NH-O-W262,-NH-C(O)-NW263-O-W264,-NW265-C(O)-NW266-O-W267,-N(-C(O)-NH-O-W268)2,-N(-C(O)-NW269-O-W270)2,-N(-C(O)-NH-O-W271)(-C(O)-NW272-O-W273),-C(S)-W274,-C(S)-O-W275,-C(S)-NH-W276,-C(S)-NW277W278,-C(O)-NH-O-W279,-C(O)-NW280-O-W281,-C(S)-NH-O-W282,-C(S)-NW283-O-W284,-C(O)-NH-NH-W285,-C(O)-NH-NW286W287,-C(O)-NW288-NW289W290,-C(S)-NH-NH-W291,-C(S)-NH-NW292W293,-C(S)-NW294-NW295W296,-C(O)-C(O)-O-W297,-C(O)-C(O)-NH2,-C(O)-C(O)-NHW298,-C(O)-C(O)-NW299W300,-C(S)-C(O)-O-W301,-C(O)-C(S)-O-W302,-C(S)-C(S)-O-W303,-C(S)-C(O)-NH2,-C(S)-C(O)-NHW304,-C(S)-C(O)-NW305W306,-C(S)-C(S)-NH2,-C(S)-C(S)-NHW307,-C(S)-C(S)-NW308W309,-C(O)-C(S)-NH2,-C(O)-C(S)-NHW310,-C(O)-C(S)-NW311W312”;
其中W201,W202,W203,W204,W205,W206,W207,W208,W209,W210,W211,W212,W213,W214,W215,W216,W217,W218,W219,W220,W221,W222,W223,W224,W225,W226,W227,W228,W229,W230,W231,W232,W233,W234,W235,W236,W237,W238,W239,W240,W241,W242,W243,W244,W245,W246,W247,W248,W249,W250,W251,W252,W253,W254,W255,W256,W257,W258,W259,W260,W261,W262,W263,W264,W265,W266,W267,W268,W269,W270,W271,W272,W273,W274,W275,W276,W277,W278,W279,W280,W281,W282,W283,W284,W285,W286,W287,W288,W289,W290,W291,W292,W293,W294,W295,W296,W297,W298,W299,W300,W301,W302,W303,W304,W305,W306,W307,W 308,W309,W310,W311,W312彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,W207,W208和/或W216,W217和/或W229,W230和/或W236,W237和/
或W245,W246和/或W255,W256和/或W260,W261和/或W277,W278和/或W286,W287
和/或W289,W290和/或W292,W293和/或W295,W296和/或W299,W300和/或W305,
W306和/或W308,W309和/或W311,W312和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(i)的取代基又可彼此独立地被至少一个相同或不同的选
自以下的取代基取代:
(ii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHW401,-NW402W403,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-W404,-C(O)O-W405,-C(O)NH-W406,-C(O)NW407W408,-O-W409,-O(-W410-O)e-H(e=1,2,3,4,5),-O(-W411-O)f-W412(f=1,2,3,4,5),-OC(O)-W413,-OC(O)-O-W414,-OC(O)-NHW415,-O-C(O)-NW416W417,-OP(O)(OW418)(OW419),-OSi(W420)(W421)(W422),-OS(O2)-W
423,-NHC(O)-NH2,-NHC(O)-W424,-NW425C(O)-W426,-NH-C(O)-O-W427,-NH-C(O)-NH-W428,-NH-C(O)-NW429W430,-NW431-C(O)-O-W432,-NW433-C(O)-NH-W434,-NW435-C(O)-NW436W437,-NHS(O2)-W438,-NW439S(O2)-W440,-S-W441,-S(O)-W442,-S(O2)-W443,-S(O2)NH-W444,-S(O2)NW445W446,-S(O2)O-W447,-P(O)(OW448)(OW449),-Si(W450)(W451)(W452),-C(NH)-NH2,-C(NW453)-NH2,-C(NH)-NHW454,-C(NH)-NW455W456,-C(NW457)-NHW458,-C(NW459)-NW460W461,-NH-C(O)-NH-O-W462,-NH-C(O)-NW463-O-W464,-NW465-C(O)-NW466-O-W467,-N(-C(O)-NH-O-W468)2,-N(-C(O)-NW469-O-W470)2,-N(-C(O)-NH-O-W471)(-C(O)-NW472-O-W473),-C(S)-W474,-C(S)-O-W475,-C(S)-NH-W476,-C(S)-NW477W478,-C(O)-NH-O-W479,-C(O)-NW480-O-W481,-C(S)-NH-O-W482,-C(S)-NW483-O-W484,-C(O)-NH-NH-W485,-C(O)-NH-NW486W487,-C(O)-NW488-NW489W490,-C(S)-NH-NH-W491,-C(S)-NH-NW492W493,-C(S)-NW494-NW495W496,-C(O)-C(O)-O-W497,-C(O)-C(O)-NH2,-C(O)-C(O)-NHW498,-C(O)-C(O)-NW499W500,-C(S)-C(O)-O-W501,-C(O)-C(S)-O-W502,-C(S)-C(S)-O-W503,-C(S)-C(O)-NH2,-C(S)-C(O)-NHW504,-C(S)-C(O)-NW505W506,-C(S)-C(S)-NH2,-C(S)-C(S)-NHW507,-C(S)-C(S)-NW508W509,-C(O)-C(S)-NH2,-C(O)-C(S)-NHW510,-C(O)-C(S)-NW511W512”;
其中W401,W402,W403,W404,W405,W406,W407,W408,W409,W410,W411,W412,W413,W414,W415,W416,W417,W418,W419,W420,W421,W422,W423,W424,W425,W426,W427,W428,W429,W430,W431,W432,W433,W434,W435,W436,W437,W438,W439,W440,W441,W442,W443,W444,W445,W446,W447,W448,W449,W450,W451,W452,W453,W454,W455,W456,W457,W458,W459,W460,W461,W462,W463,W464,W465,W466,W467,W468,W469,W470,W471,W472,W473,W474,W475,W476,W477,W478,W479,W480,W481,W482,W483,W484,W485,W486,W487,W488,W489,W490,W491,W492,W493,W494,W495,W496,W497,W498,W499,W500,W501,W502,W503,W504,W505,W506,W507,W508,W509,W510,W511,W512彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,W407,W408和/或W416,W417和/或W429,W430和/或W436,W437和/
或W445,W446和/或W455,W456和/或W460,W461和/或W477,W478和/或W486,W487
和/或W489,W490和/或W492,W493和/或W495,W496和/或W499,W500和/或W505,
W506和/或W508,W509和/或W511,W512和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(ii)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(iii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHW601,-NW602W603,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-W604,-C(O)O-W605,-C(O)NH-W606,-C(O)NW607W608,-O-W609,-O(-W610-O)e-H(e=1,2,3,4,5),-O(-W611-O)f-W612(f=1,2,3,4,5),-OC(O)-W613,-OC(O)-O-W614,-OC(O)-NHW615,-O-C(O)-NW616W617,-OP(O)(OW618)(OW619),-OSi(W620)(W621)(W622),-OS(O2)-W
623,-NHC(O)-NH2,-NHC(O)-W624,-NW625C(O)-W626,-NH-C(O)-O-W627,-NH-C(O)-NH-W628,-NH-C(O)-NW629W630,-NW631-C(O)-O-W632,-NW633-C(O)-NH-W634,-NW635-C(O)-NW636W637,-NHS(O2)-W638,-NW639S(O2)-W640,-S-W641,-S(O)-W642,-S(O2)-W643,-S(O2)NH-W644,-S(O2)NW645W646,-S(O2)O-W647,-P(O)(OW648)(OW649),-Si(W650)(W651)(W652),-C(NH)-NH2,-C(NW653)-NH2,-C(NH)-NHW654,-C(NH)-NW655W656,-C(NW657)-NHW658,-C(NW659)-NW660W661,-NH-C(O)-NH-O-W662,-NH-C(O)-NW663-O-W664,-NW665-C(O)-NW666-O-W667,-N(-C(O)-NH-O-W668)2,-N(-C(O)-NW669-O-W670)2,-N(-C(O)-NH-O-W671)(-C(O)-NW672-O-W673),-C(S)-W674,-C(S)-O-W675,-C(S)-NH-W676,-C(S)-NW677W678,-C(O)-NH-O-W679,-C(O)-NW680-O-W681,-C(S)-NH-O-W682,-C(S)-NW683-O-W684,-C(O)-NH-NH-W685,-C(O)-NH-NW686W687,-C(O)-NW688-NW689W690,-C(S)-NH-NH-W691,-C(S)-NH-NW692W693,-C(S)-NW694-NW695W696,-C(O)-C(O)-O-W697,-C(O)-C(O)-NH2,-C(O)-C(O)-NHW698,-C(O)-C(O)-NW699W700,-C(S)-C(O)-O-W701,-C(O)-C(S)-O-W702,-C(S)-C(S)-O-W703,-C(S)-C(O)-NH2,-C(S)-C(O)-NHW704,-C(S)-C(O)-NW705W706,-C(S)-C(S)-NH2,-C(S)-C(S)-NHW707,-C(S)-C(S)-NW708W709,-C(O)-C(S)-NH2,-C(O)-C(S)-NHW710,-C(O)-C(S)-NW711W712”;
其中W601,W602,W603,W604,W605,W606,W607,W608,W609,W610,W611,W612,W613,W614,W615,W616,W617,W618,W619,W620,W621,W622,W623,W624,W625,W626,W627,W628,W629,W630,W631,W632,W633,W634,W635,W636,W637,W638,W639,W640,W641,W642,W643,W644,W645,W646,W647,W648,W649,W650,W651,W652,W653,W654,W655,W656,W657,W658,W659,W660,W661,W662,W663,W664,W665,W666,W667,W668,W669,W670,W671,W672,W673,W674,W675,W676,W677,W678,W679,W680,W681,W682,W683,W684,W685,W686,W687,W688,W689,W690,W691,W692,W693,W694,W695,W696,W697,W698,W699,W700,W701,W702,W703,W704,W705,W706,W707,W708,W709,W710,W711,W712彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,W607,W608和/或W616,W617和/或W629,W630和/或W636,W637和/
或W645,W646和/或W655,W656和/或W660,W661和/或W677,W678和/或W686,W687
和/或W689,W690和/或W692,W693和/或W695,W696和/或W699,W700和/或W705,
W706和/或W708,W709和/或W711,W712和/或分别一起还可形成“杂环基”;
第一个前提条件是,基团R18不选自:“-O-烷基,-O-(C9-C30)烷基,-O-芳基,-O-芳基烷基,-O-杂芳基,-O-杂芳基烷基,-O-环烷基,-O-环烷基烷基,-O-杂环基,-O-杂环基烷基”;
第二个前提条件是,如果基团R18独立地选自:“-NRaRb”,其中Ra,Rb彼此独立地选自:
“氢,烷基,(C9-C30)烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,环烷基,环烷基烷基,杂环基,杂环基烷基”,则基团R1不选自:“被=O取代的杂环基烷基,其中杂环基是5元杂环基;
被杂环基取代的烷基,其中杂环基是5元杂环基并且被=O取代”;
并且基团R3,R4之一独立地选自或者基团R3,R4二者独立地均不选自:
(2)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHA1,-NA2A3,-NO2,-OH,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-A4,-C(O)O-A5,-C(O)NH-A6,-C(O)NA7A8,-O-A9,-O(-A10-O)a-H(a=1,2,3,4,5),-O(-A11-O)b-A12(b= 1,2,3,4,5),-OC(O)-A13,-OC(O)-O-A14,-OC(O)-NHA15,-O-C(O)-NA16A17,-OP(O)(OA18)(OA19),-OSi(A20)(A21)(A22),-OS(O2)-A23,-NHC(O)-NH2,-NHC(O)-A24,-NA25C(O)-A26,-NH-C(O)-O-A27,-NH-C(O)-NH-A28,-NH-C(O)-NA29A30,-NA31-C(O)-O-A32,-NA33-C(O)-NH-A34,-NA35-C(O)-NA36A37,-NHS(O2)-A38,-NA39S(O2)-A40,-S-A41,-S(O)-A42,-S(O2)-A43,-S(O2)NH-A44,-S(O2)NA45A46,-S(O2)O-A47,-P(O)(OA48)(OA49),-Si(A50)(A51)(A5
2),-C(NH)-NH2,-C(NA53)-NH2,-C(NH)-NHA54,-C(NH)-NA55A56,-C(NA57)-NHA58,-C(NA59)-NA60A61,-NH-C(O)-NH-O-A62,-NH-C(O)-NA63-O-A64,-NA65-C(O)-NA66-O-A67,-N(-C(O)-NH-O-A68)2,-N(-C(O)-NA69-O-A70)2,-N(-C(O)-NH-O-A71)(-C(O)-NA72-O-A73),-C(S)-A74,-C(S)-O-A75,-C(S)-NH-A76,-C(S)-NA77A78,-C(O)-NH-O-A79,-C(O)-NA80-O-A81,-C(S)-NH-O-A82,-C(S)-NA83-O-A84,-C(O)-NH-NH-A85,-C(O)-NH-NA86A87,-C(O)-NA88-NA89A90,-C(S)-NH-NH-A91,-C(S)-NH-NA92A93,-C(S)-NA94-NA95A96,-C(O)-C(O)-O-A97,-C(O)-C(O)-NH2,-C(O)-C(O)-NHA98,-C(O)-C(O)-NA99A100,-C(S)-C(O)-O-A101,-C(O)-C(S)-O-A102,-C(S)-C(S)-O-A103,-C(S)-C(O)-NH2,-C(S)-C(O)-NHA104,-C(S)-C(O)-NA105A106,-C(S)-C(S)-NH2,-C(S)-C(S)-NHA107,-C(S)-C(S)-NA108A109,-C(O)-C(S)-NH2,-C(O)-C(S)-NHA110,-C(O)-C(S)-NA111A112”;
其中A1,A2,A3,A4,A5,A6,A7,A8,A9,A10,A11,A12,A13,A14,A15,A16,A17,A18,A19,A20,A21,A22,A23,A24,A25,A26,A27,A28,A29,A30,A31,A32,A33,A34,A35,A36,A37,A38,A39,A40,A41,A42,A43,A44,A45,A46,A47,A48,A49,A50,A51,A52,A53,A54,A55,A56,A57,A58,A59,A60,A61,A62,A63,A64,A65,A66,A67,A68,A69,A70,A71,A72,A73,A74,A75,A76,A77,A78,A79,A80,A81,A82,A83,A84,A85,A86,A87,A88,A89,A90,A91,A92,A93,A94,A95,A96,A97,A98,A99,A100,A101,A102,A103,A104,A105,A106,A107,A108,A109,A110,A111,A112彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,A7,A8和/或A16,A17和/或A29,A30和/或A36,A37和/或A45,A46和/或A55,A56和/或
A60,A61和/或A77,A78和/或A86,A87和/或A89,A90和/或A92,A93和/或A95,A96
和/或A99,A100和/或A105,A106和/或A108,A109和/或A111,A112和/或分别一起
还可形成“杂环基”;
其中任选地,上述取代基组(2)的取代基,如果不是氢,又可彼此独立地被至少一个相
同或不同的选自以下的取代基取代:
(i)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHA201,-NA202A203,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-A204,-C(O)O-A205,-C(O)NH-A206,-C(O)NA207A208,-O-A209,-O(-A210-O)c-H(c=1,2,3,4,5),-O(-A211-O)d-A212(d=1,2,3,4,5),-OC(O)-A213,-OC(O)-O-A214,-OC(O)-NHA215,-O-C(O)-NA216A217,-OP(O)(OA218)(OA219),-OSi(A220)(A221)(A222),-OS(O2)-A223,-NHC(O)-NH2,-NHC(O)-A224,-NA225C(O)-A226,-NH-C(O)-O-A227,-NH-C(O)-NH-A228,-NH-C(O)-NA229A230,-NA231-C(O)-O-A232,-NA233-C(O)-NH-A234,-NA235-C(O)-NA236A237,-NHS(O2)-A238,-NA239S(O2)-A240,-S-A241,-S(O)-A242,-S(O2)-A243,-S(O2)NH-A244,-S(O2)NA245A246,-S(O2)O-A247,-P(O)(OA248)(OA249),-Si(A250)(A251)(A252),-C(NH)-NH2,-C(NA253)-NH2,-C(NH)-NHA254,-C(NH)-NA255A256,-C(NA257)-NHA258,-C(NA
259)-NA260A261,-NH-C(O)-NH-O-A262,-NH-C(O)-NA263-O-A264,-NA265-C(O)-NA266-O-A2
67,-N(-C(O)-NH-O-A268)2,-N(-C(O)-NA269-O-A270)2,-N(-C(O)-NH-O-A271)(-C(O)-NA27
2-O-A273),-C(S)-A274,-C(S)-O-A275,-C(S)-NH-A276,-C(S)-NA277A278,-C(O)-NH-O-A279,-C(O)-NA280-O-A281,-C(S)-NH-O-A282,-C(S)-NA283-O-A284,-C(O)-NH-NH-A285,-C(O)-NH-NA286A287,-C(O)-NA288-NA289A290,-C(S)-NH-NH-A291,-C(S)-NH-NA292A293,-C(S)-NA
294-NA295A296,-C(O)-C(O)-O-A297,-C(O)-C(O)-NH2,-C(O)-C(O)-NHA298,-C(O)-C(O)-NA
299A300,-C(S)-C(O)-O-A301,-C(O)-C(S)-O-A302,-C(S)-C(S)-O-A303,-C(S)-C(O)-NH2,-C(S)-C(O)-NHA304,-C(S)-C(O)-NA305A306,-C(S)-C(S)-NH2,-C(S)-C(S)-NHA307,-C(S)-C(S)-NA308A309,-C(O)-C(S)-NH2,-C(O)-C(S)-NHA310,-C(O)-C(S)-NA311A312”;
其中A201,A202,A203,A204,A205,A206,A207,A208,A209,A210,A211,A212,A213,A214,A215,A216,A217,A218,A219,A220,A221,A222,A223,A224,A225,A226,A227,A228,A229,A230,A231,A232,A233,A234,A235,A236,A237,A238,A239,A240,A241,A242,A243,A244,A245,A246,A247,A248,A249,A250,A251,A252,A253,A254,A255,A256,A257,A258,A259,A260,A261,A262,A263,A264,A265,A266,A267,A268,A269,A270,A271,A272,A273,A274,A275,A276,A277,A278,A279,A280,A281,A282,A283,A284,A285,A286,A287,A288,A289,A290,A291,A292,A293,A294,A295,A296,A297,A298,A299,A300,A301,A302,A303,A304,A305,A306,A307,A308,A309,A310,A311,A312彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,A207,A208和/或A216,A217和/或A229,A230和/或A236,A237和/
或A245,A246和/或A255,A256和/或A260,A261和/或A277,A278和/或A286,A287
和/或A289,A290和/或A292,A293和/或A295,A296和/或A299,A300和/或A305,
A306和/或A308,A309和/或A311,A312和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(i)的取代基又可彼此独立地被至少一个相同或不同的选
自以下的取代基取代:
(ii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHA401,-NA402A403,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-A404,-C(O)O-A405,-C(O)NH-A406,-C(O)NA407A408,-O-A409,-O(-A410-O)e-H(e=1,2,3,4,5),-O(-A411-O)f-A412(f=1,2,3,4,5),-OC(O)-A413,-OC(O)-O-A414,-OC(O)-NHA415,-O-C(O)-NA416A417,-OP(O)(OA418)(OA419),-OSi(A420)(A421)(A422),-OS(O2)-A423,-NHC(O)-NH2,-NHC(O)-A424,-NA425C(O)-A426,-NH-C(O)-O-A427,-NH-C(O)-NH-A428,-NH-C(O)-NA429A430,-NA431-C(O)-O-A432,-NA433-C(O)-NH-A434,-NA435-C(O)-NA436A437,-NHS(O2)-A438,-NA439S(O2)-A440,-S-A441,-S(O)-A442,-S(O2)-A443,-S(O2)NH-A444,-S(O2)NA445A446,-S(O2)O-A447,-P(O)(OA448)(OA449),-Si(A450)(A451)(A452),-C(NH)-NH2,-C(NA453)-NH2,-C(NH)-NHA454,-C(NH)-NA455A456,-C(NA457)-NHA458,-C(NA
459)-NA460A461,-NH-C(O)-NH-O-A462,-NH-C(O)-NA463-O-A464,-NA465-C(O)-NA466-O-A4
67,-N(-C(O)-NH-O-A468)2,-N(-C(O)-NA469-O-A470)2,-N(-C(O)-NH-O-A471)(-C(O)-NA47
2-O-A473),-C(S)-A474,-C(S)-O-A475,-C(S)-NH-A476,-C(S)-NA477A478,-C(O)-NH-O-A479,-C(O)-NA480-O-A481,-C(S)-NH-O-A482,-C(S)-NA483-O-A484,-C(O)-NH-NH-A485,-C(O)-NH-NA486A487,-C(O)-NA488-NA489A490,-C(S)-NH-NH-A491,-C(S)-NH-NA492A493,-C(S)-NA
494-NA495A496,-C(O)-C(O)-O-A497,-C(O)-C(O)-NH2,-C(O)-C(O)-NHA498,-C(O)-C(O)-NA
499A500,-C(S)-C(O)-O-A501,-C(O)-C(S)-O-A502,-C(S)-C(S)-O-A503,-C(S)-C(O)-NH2,-C(S)-C(O)-NHA504,-C(S)-C(O)-NA505A506,-C(S)-C(S)-NH2,-C(S)-C(S)-NHA507,-C(S)-C(S)-NA508A509,-C(O)-C(S)-NH2,-C(O)-C(S)-NHA510,-C(O)-C(S)-NA511A512”;
其中A401,A402,A403,A404,A405,A406,A407,A408,A409,A410,A411,A412,A413,A414,A415,A416,A417,A418,A419,A420,A421,A422,A423,A424,A425,A426,A427,A428,A429,A430,A431,A432,A433,A434,A435,A436,A437,A438,A439,A440,A441,A442,A443,A444,A445,A446,A447,A448,A449,A450,A451,A452,A453,A454,A455,A456,A457,A458,A459,A460,A461,A462,A463,A464,A465,A466,A467,A468,A469,A470,A471,A472,A473,A474,A475,A476,A477,A478,A479,A480,A481,A482,A483,A484,A485,A486,A487,A488,A489,A490,A491,A492,A493,A494,A495,A496,A497,A498,A499,A500,A501,A502,A503,A504,A505,A506,A507,A508,A509,A510,A511,A512彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,A407,A408和/或A416,A417和/或A429,A430和/或A436,A437和/
或A445,A446和/或A455,A456和/或A460,A461和/或A477,A478和/或A486,A487
和/或A489,A490和/或A492,A493和/或A495,A496和/或A499,A500和/或A505,
A506和/或A508,A509和/或A511,A512和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(ii)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(iii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHA601,-NA602A603,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-A604,-C(O)O-A605,-C(O)NH-A606,-C(O)NA607A608,-O-A609,-O(-A610-O)e-H(e=1,2,3,4,5),-O(-A611-O)f-A612(f=1,2,3,4,5),-OC(O)-A613,-OC(O)-O-A614,-OC(O)-NHA615,-O-C(O)-NA616A617,-OP(O)(OA618)(OA619),-OSi(A620)(A621)(A622),-OS(O2)-A623,-NHC(O)-NH2,-NHC(O)-A624,-NA625C(O)-A626,-NH-C(O)-O-A627,-NH-C(O)-NH-A628,-NH-C(O)-NA629A630,-NA631-C(O)-O-A632,-NA633-C(O)-NH-A634,-NA635-C(O)-NA636A637,-NHS(O2)-A638,-NA639S(O2)-A640,-S-A641,-S(O)-A642,-S(O2)-A643,-S(O2)NH-A644,-S(O2)NA645A646,-S(O2)O-A647,-P(O)(OA648)(OA649),-Si(A650)(A651)(A652),-C(NH)-NH2,-C(NA653)-NH2,-C(NH)-NHA654,-C(NH)-NA655A656,-C(NA657)-NHA658,-C(NA
659)-NA660A661,-NH-C(O)-NH-O-A662,-NH-C(O)-NA663-O-A664,-NA665-C(O)-NA666-O-A6
67,-N(-C(O)-NH-O-A668)2,-N(-C(O)-NA669-O-A670)2,-N(-C(O)-NH-O-A671)(-C(O)-NA67
2-O-A673),-C(S)-A674,-C(S)-O-A675,-C(S)-NH-A676,-C(S)-NA677A678,-C(O)-NH-O-A679,-C(O)-NA680-O-A681,-C(S)-NH-O-A682,-C(S)-NA683-O-A684,-C(O)-NH-NH-A685,-C(O)-NH-NA686A687,-C(O)-NA688-NA689A690,-C(S)-NH-NH-A691,-C(S)-NH-NA692A693,-C(S)-NA
694-NA695A696,-C(O)-C(O)-O-A697,-C(O)-C(O)-NH2,-C(O)-C(O)-NHA698,-C(O)-C(O)-NA
699A700,-C(S)-C(O)-O-A701,-C(O)-C(S)-O-A702,-C(S)-C(S)-O-A703,-C(S)-C(O)-NH2,-C(S)-C(O)-NHA704,-C(S)-C(O)-NA705A706,-C(S)-C(S)-NH2,-C(S)-C(S)-NHA707,-C(S)-C(S)-NA708A709,-C(O)-C(S)-NH2,-C(O)-C(S)-NHA710,-C(O)-C(S)-NA711A712”;
其中A601,A602,A603,A604,A605,A606,A607,A608,A609,A610,A611,A612,A613,A614,A615,A616,A617,A618,A619,A620,A621,A622,A623,A624,A625,A626,A627,A628,A629,A630,A631,A632,A633,A634,A635,A636,A637,A638,A639,A640,A641,A642,A643,A644,A645,A646,A647,A648,A649,A650,A651,A652,A653,A654,A655,A656,A657,A658,A659,A660,A661,A662,A663,A664,A665,A666,A667,A668,A669,A670,A671,A672,A673,A674,A675,A676,A677,A678,A679,A680,A681,A682,A683,A684,A685,A686,A687,A688,A689,A690,A691,A692,A693,A694,A695,A696,A697,A698,A699,A700,A701,A702,A703,A704,A705,A706,A707,A708,A709,A710,A711,A712彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,A607,A608和/或A616,A617和/或A629,A630和/或A636,A637和/
或A645,A646和/或A655,A656和/或A660,A661和/或A677,A678和/或A686,A687
和/或A689,A690和/或A692,A693和/或A695,A696和/或A699,A700和/或A705,
A706和/或A708,A709和/或A711,A712和/或分别一起还可形成“杂环基”;
并且基团R1,R2,R5彼此独立地选自:
(3)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHB1,-NB2B3,-NO2,-OH,-OCF
3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-B4,-C(O)O-B5,-C(O)NH-B6,-C(O)NB7B8,-O-B9,-O(-B10-O)a-H(a = 1,2,3,4,5),-O(-B11-O)b-B12(b=1,2,3,4,5),-OC(O)-B13,-OC(O)-O-B14,-OC(O)-NHB15,-O-C(O)-NB16B17,-OP(O)(OB18)(OB19),-OSi(B20)(B21)(B22),-OS(O2)-B23,-NHC(O)-NH2,-NHC(O)-B24,-NB25C(O)-B26,-NH-C(O)-O-B27,-NH-C(O)-NH-B28,-NH-C(O)-NB29B30,-NB31-C(O)-O-B32,-NB33-C(O)-NH-B34,-NB35-C(O)-NB36B37,-NHS(O2)-B38,-NB39S(O2)-B40,-S-B41,-S(O)-B42,-S(O2)-B43,-S(O2)NH-B44,-S(O2)NB45B46,-S(O2)O-B47,-P(O)(OB48)(OB49),-Si(B50)(B51)(B52),-C(NH)-NH2,-C(NB53)-NH2,-C(NH)-NHB54,-C(NH)-NB55B56,-C(NB57)-NHB58,-C(NB
59)-NB60B61,-NH-C(O)-NH-O-B62,-NH-C(O)-NB63-O-B64,-NB65-C(O)-NB66-O-B67,-N(-C(O)-NH-O-B68)2,-N(-C(O)-NB69-O-B70)2,-N(-C(O)-NH-O-B71)(-C(O)-NB72-O-B73),-C(S)-B74,-C(S)-O-B75,-C(S)-NH-B76,-C(S)-NB77B78,-C(O)-NH-O-B79,-C(O)-NB80-O-B81,-C(S)-NH-O-B82,-C(S)-NB83-O-B84,-C(O)-NH-NH-B85,-C(O)-NH-NB86B87,-C(O)-NB88-NB89B
90,-C(S)-NH-NH-B91,-C(S)-NH-NB92B93,-C(S)-NB94-NB95B96,-C(O)-C(O)-O-B97,-C(O)-C(O)-NH2,-C(O)-C(O)-NHB98,-C(O)-C(O)-NB99B100,-C(S)-C(O)-O-B101,-C(O)-C(S)-O-B1
02,-C(S)-C(S)-O-B103,-C(S)-C(O)-NH2,-C(S)-C(O)-NHB104,-C(S)-C(O)-NB105B106,-C(S)-C(S)-NH2,-C(S)-C(S)-NHB107,-C(S)-C(S)-NB108B109,-C(O)-C(S)-NH2,-C(O)-C(S)-NHB110,-C(O)-C(S)-NB111B112”;
其中B1,B2,B3,B4,B5,B6,B7,B8,B9,B10,B11,B12,B13,B14,B15,B16,B17,B18,B19,B20,B21,B22,B23,B24,B25,B26,B27,B28,B29,B30,B31,B32,B33,B34,B35,B36,B37,B38,B39,B40,B41,B42,B43,B44,B45,B46,B47,B48,B49,B50,B51,B52,B53,B54,B55,B56,B57,B58,B59,B60,B61,B62,B63,B64,B65,B66,B67,B68,B69,B70,B71,B72,B73,B74,B75,B76,B77,B78,B79,B80,B81,B82,B83,B84,B85,B86,B87,B88,B89,B90,B91,B92,B93,B94,B95,B96,B97,B98,B99,B100,B101,B102,B103,B104,B105,B106,B107,B108,B109,B110,B111,B112彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,B2,B3和/或B7,B8和/或B16,B17和/或B29,B30和/或B36,B37和/或B45,B46和/或B55,
B56和/或B60,B61和/或B77,B78和/或B86,B87和/或B89,B90和/或B92,B93和/
或B95,B96和/或B99,B100和/或B105,B106和/或B108,B109和/或B111,B112和/
或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(3)的取代基,如果不是氢,又可彼此独立地被至少一个相
同或不同的选自以下的取代基取代:
(i)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHB201,-NB202B203,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-B204,-C(O)O-B205,-C(O)NH-B206,-C(O)NB207B208,-O-B209,-O(-B210-O)c-H(c=1,2,3,4,5),-O(-B211-O)d-B212(d=1,2,3,4,5),-OC(O)-B213,-OC(O)-O-B214,-OC(O)-NHB215,-O-C(O)-NB216B217,-OP(O)(OB218)(OB219),-OSi(B220)(B221)(B222),-OS(O2)-B223,-NHC(O)-NH2,-NHC(O)-B224,-NB225C(O)-B226,-NH-C(O)-O-B227,-NH-C(O)-NH-B228,-NH-C(O)-NB229B230,-NB231-C(O)-O-B232,-NB233-C(O)-NH-B234,-NB235-C(O)-NB236B237,-NHS(O2)-B238,-NB239S(O2)-B240,-S-B241,-S(O)-B242,-S(O2)-B243,-S(O2)NH-B244,-S(O2)NB245B246,-S(O2)O-B247,-P(O)(OB248)(OB249),-Si(B250)(B251)(B252),-C(NH)-NH2,-C(NB253)-NH2,-C(NH)-NHB254,-C(NH)-NB255B256,-C(NB257)-NHB258,-C(NB
259)-NB260B261,-NH-C(O)-NH-O-B262,-NH-C(O)-NB263-O-B264,-NB265-C(O)-NB266-O-B2
67,-N(-C(O)-NH-O-B268)2,-N(-C(O)-NB269-O-B270)2,-N(-C(O)-NH-O-B271)(-C(O)-NB27
2-O-B273),-C(S)-B274,-C(S)-O-B275,-C(S)-NH-B276,-C(S)-NB277B278,-C(O)-NH-O-B279,-C(O)-NB280-O-B281,-C(S)-NH-O-B282,-C(S)-NB283-O-B284,-C(O)-NH-NH-B285,-C(O)-NH-NB286B287,-C(O)-NB288-NB289B290,-C(S)-NH-NH-B291,-C(S)-NH-NB292B293,-C(S)-NB
294-NB295B296,-C(O)-C(O)-O-B297,-C(O)-C(O)-NH2,-C(O)-C(O)-NHB298,-C(O)-C(O)-NB
299B300,-C(S)-C(O)-O-B301,-C(O)-C(S)-O-B302,-C(S)-C(S)-O-B303,-C(S)-C(O)-NH2,-C(S)-C(O)-NHB304,-C(S)-C(O)-NB305B306,-C(S)-C(S)-NH2,-C(S)-C(S)-NHB307,-C(S)-C(S)-NB 308B 309,-C(O)-C(S)-NH2,-C(O)-C(S)-NHB310,-C(O)-C(S)-NB311B312”;
其中B201,B202,B203,B204,B205,B206,B207,B208,B209,B210,B211,B212,B213,B214,B215,B216,B217,B218,B219,B220,B221,B222,B223,B224,B225,B226,B227,B228,B229,B230,B231,B232,B233,B234,B235,B236,B237,B238,B239,B240,B241,B242,B243,B244,B245,B246,B247,B248,B249,B250,B251,B252,B253,B254,B255,B256,B257,B258,B259,B260,B261,B262,B263,B264,B265,B266,B267,B268,B269,B270,B271,B272,B273,B274,B275,B276,B277,B278,B279,B280,B281,B282,B283,B284,B285,B286,B287,B288,B289,B290,B291,B292,B293,B294,B295,B296,B297,B298,B299,B300,B301,B302,B303,B304,B305,B306,B307,B308,B309,B310,B311,B312彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,B207,B208和/或B216,B217和/或B229,B230和/或B236,B237和/
或B245,B246和/或B255,B256和/或B260,B261和/或B277,B278和/或B286,B287
和/或B289,B290和/或B292,B293和/或B295,B296和/或B299,B300和/或B305,
B306和/或B308,B309和/或B311,B312和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(i)的取代基又可彼此独立地被至少一个相同或不同的选
自以下的取代基取代:
(ii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHB401,-NB402B403,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-B404,-C(O)O-B405,-C(O)NH-B406,-C(O)NB407B408,-O-B409,-O(-B410-O)e-H(e=1,2,3,4,5),-O(-B411-O)f-B412(f=1,2,3,4,5),-OC(O)-B413,-OC(O)-O-B414,-OC(O)-NHB415,-O-C(O)-NB416B417,-OP(O)(OB418)(OB419),-OSi(B420)(B421)(B422),-OS(O2)-B423,-NHC(O)-NH2,-NHC(O)-B424,-NB425C(O)-B426,-NH-C(O)-O-B427,-NH-C(O)-NH-B428,-NH-C(O)-NB429B430,-NB431-C(O)-O-B432,-NB433-C(O)-NH-B434,-NB435-C(O)-NB436B437,-NHS(O2)-B438,-NB439S(O2)-B440,-S-B441,-S(O)-B442,-S(O2)-B443,-S(O2)NH-B444,-S(O2)NB445B446,-S(O2)O-B447,-P(O)(OB448)(OB449),-Si(B450)(B451)(B452),-C(NH)-NH2,-C(NB453)-NH2,-C(NH)-NHB454,-C(NH)-NB455B456,-C(NB457)-NHB458,-C(NB
459)-NB460B461,-NH-C(O)-NH-O-B462,-NH-C(O)-NB463-O-B464,-NB465-C(O)-NB466-O-B4
67,-N(-C(O)-NH-O-B468)2,-N(-C(O)-NB469-O-B470)2,-N(-C(O)-NH-O-B471)(-C(O)-NB47
2-O-B473),-C(S)-B474,-C(S)-O-B475,-C(S)-NH-B476,-C(S)-NB477B478,-C(O)-NH-O-B479,-C(O)-NB480-O-B481,-C(S)-NH-O-B482,-C(S)-NB483-O-B484,-C(O)-NH-NH-B485,-C(O)-NH-NB486B487,-C(O)-NB488-NB489B490,-C(S)-NH-NH-B491,-C(S)-NH-NB492B493,-C(S)-NB
494-NB495B496,-C(O)-C(O)-O-B497,-C(O)-C(O)-NH2,-C(O)-C(O)-NHB498,-C(O)-C(O)-NB
499B500,-C(S)-C(O)-O-B501,-C(O)-C(S)-O-B502,-C(S)-C(S)-O-B503,-C(S)-C(O)-NH2,-C(S)-C(O)-NHB504,-C(S)-C(O)-NB505B506,-C(S)-C(S)-NH2,-C(S)-C(S)-NHB507,-C(S)-C(S)-NB508B509,-C(O)-C(S)-NH2,-C(O)-C(S)-NHB510,-C(O)-C(S)-NB511B512”;
其中B401,B402,B403,B404,B405,B406,B407,B408,B409,B410,B411,B412,B413,B414,B415,B416,B417,B418,B419,B420,B421,B422,B423,B424,B425,B426,B427,B428,B429,B430,B431,B432,B433,B434,B435,B436,B437,B438,B439,B440,B441,B442,B443,B444,B445,B446,B447,B448,B449,B450,B451,B452,B453,B454,B455,B456,B457,B458,B459,B460,B461,B462,B463,B464,B465,B466,B467,B468,B469,B470,B471,B472,B473,B474,B475,B476,B477,B478,B479,B480,B481,B482,B483,B484,B485,B486,B487,B488,B489,B490,B491,B492,B493,B494,B495,B496,B497,B498,B499,B500,B501,B502,B503,B504,B505,B506,B507,B508,B509,B510,B511,B512彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,B407,B408和/或B416,B417和/或B429,B430和/或B436,B437和/
或B445,B446和/或B455,B456和/或B460,B461和/或B477,B478和/或B486,B487
和/或B489,B490和/或B492,B493和/或B495,B496和/或B499,B500和/或B505,
B506和/或B508,B509和/或B511,B512和/或分别一起还可形成“杂环基”;
其中任选地,上述取代基组(ii)的取代基又可彼此独立地被至少一个相同或不同的
选自以下的取代基取代:
(iii)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NHB601,-NB602B603,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-C(O)-B604,-C(O)O-B605,-C(O)NH-B606,-C(O)NB607B608,-O-B609,-O(-B610-O)e-H(e=1,2,3,4,5),-O(-B611-O)f-B612(f=1,2,3,4,5),-OC(O)-B613,-OC(O)-O-B614,-OC(O)-NHB615,-O-C(O)-NB616B617,-OP(O)(OB618)(OB619),-OSi(B62O)(B621)(B622),-OS(O2)-B623,-NHC(O)-NH2,-NHC(O)-B624,-NB625C(O)-B626,-NH-C(O)-O-B627,-NH-C(O)-NH-B628,-NH-C(O)-NB629B630,-NB631-C(O)-O-B632,-NB633-C(O)-NH-B634,-NB635-C(O)-NB636B637,-NHS(O2)-B638,-NB639S(O2)-B640,-S-B641,-S(O)-B642,-S(O2)-B643,-S(O2)NH-B644,-S(O2)NB645B646,-S(O2)O-B647,-P(O)(OB648)(OB649),-Si(B650)(B651)(B652),-C(NH)-NH2,-C(NB653)-NH2,-C(NH)-NHB654,-C(NH)-NB655B656,-C(NB657)-NHB658,-C(NB
659)-NB660B661,-NH-C(O)-NH-O-B662,-NH-C(O)-NB663-O-B664,-NB665-C(O)-NB666-O-B6
67,-N(-C(O)-NH-O-B668)2,-N(-C(O)-NB669-O-B670)2,-N(-C(O)-NH-O-B671)(-C(O)-NB67
2-O-B673),-C(S)-B674,-C(S)-O-B675,-C(S)-NH-B676,-C(S)-NB677B678,-C(O)-NH-O-B679,-C(O)-NB680-O-B681,-C(S)-NH-O-B682,-C(S)-NB683-O-B684,-C(O)-NH-NH-B685,-C(O)-NH-NB686B687,-C(O)-NB688-NB689B690,-C(S)-NH-NH-B691,-C(S)-NH-NB692B693,-C(S)-NB
694-NB695B696,-C(O)-C(O)-O-B697,-C(O)-C(O)-NH2,-C(O)-C(O)-NHB698,-C(O)-C(O)-NB
699B700,-C(S)-C(O)-O-B701,-C(O)-C(S)-O-B702,-C(S)-C(S)-O-B703,-C(S)-C(O)-NH2,-C(S)-C(O)-NHB704,-C(S)-C(O)-NB705B706,-C(S)-C(S)-NH2,-C(S)-C(S)-NHB707,-C(S)-C(S)-NB708B709,-C(O)-C(S)-NH2,-C(O)-C(S)-NHB710,-C(O)-C(S)-NB711B712”;
其中B601,B602,B603,B604,B605,B606,B607,B608,B609,B610,B611,B612,B613,B614,B615,B616,B617,B618,B619,B620,B621,B622,B623,B624,B625,B626,B627,B628,B629,B630,B631,B632,B633,B634,B635,B636,B637,B638,B639,B640,B641,B642,B643,B644,B645,B646,B647,B648,B649,B650,B651,B652,B653,B654,B655,B656,B657,B658,B659,B660,B661,B662,B663,B664,B665,B666,B667,B668,B669,B670,B671,B672,B673,B674,B675,B676,B677,B678,B679,B680,B681,B682,B683,B684,B685,B686,B687,B688,B689,B690,B691,B692,B693,B694,B695,B696,B697,B698,B699,B700,B701,B702,B703,B704,B705,B706,B707,B708,B709,B710,B711,B712彼此独立地选自:“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基”,并且其中,作为替代,B607,B608和/或B616,B617和/或B629,B630和/或B636,B637和/
或B645,B646和/或B655,B656和/或B660,B661和/或B677,B678和/或B686,B687
和/或B689,B690和/或B692,B693和/或B695,B696和/或B699,B700和/或B705,
B706和/或B708,B709和/或B711,B712和/或分别一起还可形成“杂环基”。
3.权利要求1或2任一项的通式(Ia)或(Ib)所示的吡啶并[2,3-b]吡嗪衍生物,其
中
基团R1独立地选自:
(i)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,杂环基,杂环基烷基,-NH-烷基,-NH-(C9-C30)烷基,-NH-环烷基,-NH-环烷基烷基,-NH-芳基,-NH-芳基烷基,-NH-杂芳基,-NH-杂芳基烷基,-NH-杂环基,-NH-杂环基烷基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R2独立地是“氢”;
基团R3独立地选自:
(i)“-NH-C(O)-NH-C(O)-O- 烷 基,-NH-C(O)-NH-C(O)-O-(C9-C30) 烷
基,-NH-C(O)-NH-C(O)-O- 环 烷 基,-NH-C(O)-NH-C(O)-O- 环 烷 基 烷
基,-NH-C(O)-NH-C(O)-O-芳基,-NH-C(O)-NH-C(O)-O-芳基烷基,-NH-C(O)-NH-C(O)-O-杂芳 基,-NH-C(O)-NH-C(O)-O- 杂 芳 基 烷 基,-NH-C(O)-NH-C(O)-O- 杂 环
基,-NH-C(O)-NH-C(O)-O-杂环基烷基,-NH-C(S)-NH-烷基,-NH-C(S)-NH-(C9-C30)烷
基,-NH-C(S)-NH-环烷基,-NH-C(S)-NH-环烷基烷基,-NH-C(S)-NH-芳基,-NH-C(S)-NH-芳基 烷 基,-NH-C(S)-NH- 杂 芳 基,-NH-C(S)-NH- 杂 芳 基 烷 基,-NH-C(S)-NH- 杂 环基,-NH-C(S)-NH-杂环基烷基,-NH-C(=NH)-烷基,-NH-C(=NH)-(C9-C30)烷基,-NH-C(=NH)-环烷基,-NH-C(=NH)-环烷基烷基,-NH-C(=NH)-芳基,-NH-C(=NH)-芳基烷
基,-NH-C(=NH)-杂芳基,-NH-C(=NH)-杂芳基烷基,-NH-C(=NH)-杂环基,-NH-C(=
NH)-杂环基烷基,-NH-C(O)-C(O)-烷基,-NH-C(O)-C(O)-(C9-C30)烷基,-NH-C(O)-C(O)-环烷基,-NH-C(O)-C(O)-环烷基烷基,-NH-C(O)-C(O)-芳基,-NH-C(O)-C(O)-芳基烷
基,-NH-C(O)-C(O)-杂 芳 基,-NH-C(O)-C(O)-杂 芳 基 烷 基,-NH-C(O)-C(O)- 杂 环基,-NH-C(O)-C(O)-杂环基烷基”
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R4独立地选自:
(i)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,杂环基,杂环基烷基,-NH-烷基,-NH-(C9-C30)烷基,-NH-环烷基,-NH-环烷基烷基,-NH-芳基,-NH-芳基烷基,-NH-杂芳基,-NH-杂芳基烷基,-NH-杂环基,-NH-杂环基烷基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R5独立地是“氢”。
4.权利要求1-3中任一项的通式(Ia)或(Ib)所示的吡啶并[2,3-b]吡嗪衍生物,其
中
基团R1独立地选自:
(i)“氢,甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,
2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,
4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,
1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基,-NH-Rx1”,其中Rx1选自:“甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,
4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R2独立地是“氢”;
基团R3独立地选自:
(i)“-NH-C(O)-NH-C(O)-O-Rx2,-NH-C(S)-NH-Rx3,-NH-C( =
NH)-Rx4,-NH-C(O)-C(O)-Rx5”,其中Rx2,Rx3,Rx4,Rx5彼此独立地选自:“甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R4独立地选自:
(i)“氢,甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,
2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,
4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,
1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基,-NH-Rx6”,其中Rx6选自:“甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,
4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R5独立地是“氢”。
5.权利要求1-2中任一项的通式(Ia)或(Ib)所示的吡啶并[2,3-b]吡嗪衍生物,其
中基团R1独立地选自:
(i)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,杂环基,杂环基烷基,-NH-烷基,-NH-(C9-C30)烷基,-NH-环烷基,-NH-环烷基烷基,-NH-芳基,-NH-芳基烷基,-NH-杂芳基,-NH-杂芳基烷基,-NH-杂环基,-NH-杂环基烷基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R2独立地是“氢”;
基团R3独立地选自:
(i)“-NH-C(O)-NH2,-NH-C(O)-NH-烷基,-NH-C(O)-NH-(C9-C30)烷基,-NH-C(O)-NH-环烷 基,-NH-C(O)-NH- 环 烷 基 烷 基,-NH-C(O)-NH- 芳 基,-NH-C(O)-NH- 芳 基 烷基,-NH-C(O)-NH- 杂 芳 基,-NH-C(O)-NH- 杂 芳 基 烷 基,-NH-C(O)-NH- 杂 环
基,-NH-C(O)-NH- 杂 环 基 烷 基,-NH-C(O)-O- 烷 基,-NH-C(O)-O-(C9-C30) 烷
基,-NH-C(O)-O-环烷基,-NH-C(O)-O-环烷基烷基,-NH-C(O)-O-芳基,-NH-C(O)-O-芳基烷基,-NH-C(O)-O-杂芳基,-NH-C(O)-O-杂芳基烷基,-NH-C(O)-O-杂环基,-NH-C(O)-O-杂环基烷基,-NH-C(O)-烷基,-NH-C(O)-(C9-C30)烷基,-NH-C(O)-环烷基,-NH-C(O)-环烷基烷基,-NH-C(O)-芳基,-NH-C(O)-芳基烷基,-NH-C(O)-杂芳基,-NH-C(O)-杂芳基烷
基,-NH-C(O)-杂环基,-NH-C(O)-杂环基烷基,-NH-S(O2)-烷基,-NH-S(O2)-(C9-C30)烷基,-NH-S(O2)-环烷基,-NH-S(O2)-环烷基烷基,-NH-S(O2)-芳基,-NH-S(O2)-芳基烷
基,-NH-S(O2)-杂芳基,-NH-S(O2)-杂芳基烷基,-NH-S(O2)-杂环基,-NH-S(O2)-杂环基烷基;
其中上述取代基组(i)的取代基,如果不是氢、氮或硫,可任选地另外被至少一个选
自以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R4独立地选自:
(i)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,杂环基,杂环基烷基,-NH-烷基,-NH-(C9-C30)烷基,-NH-环烷基,-NH-环烷基烷基,-NH-芳基,-NH-芳基烷基,-NH-杂芳基,-NH-杂芳基烷基,-NH-杂环基,-NH-杂环基烷基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R5独立地选自:
(i)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,杂环基,杂环基烷基”;
其中上述取代基组(i)的取代基,如果不是氢,可任选地另外被至少一个选自以下
的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”。
6.权利要求1、2、5中任一项的通式(Ia)或(Ib)所示的吡啶并[2,3-b]吡嗪衍生物,
其中
基团R1独立地选自:
(i)“氢,甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,
2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,
4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,
1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基,-NH-Ry1”,其中Ry1选自:“甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,
4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R2独立地是“氢”;
基团R3独立地选自:
(i)“-NH-C(O)-NH2,-NH-C(O)-NH-Ry2,-NH-C(O)-O-Ry3,-NH-C(O)-Ry4,-NH-S(O2)-Ry5”;
其中,Ry2,Ry3,Ry4,Ry5彼此独立地选自:“甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,
4-四氢-异喹啉基甲基,1,2,3,4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,
2,3,4-四氢-异喹啉基丁基,1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,
4]噁嗪基丁基,苯并[1,4]噁嗪-6-基”;
其中上述取代基组(i)的取代基,如果不是氢、氮或硫,可任选地另外被至少一个选
自以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R4独立地选自:
(i)“氢,甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,
2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,
4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,
1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基,-NH-Ry6”,其中Ry6选自:“甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,
4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R5独立地选自:
(i)“氢,甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,1,2,3,
4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,4]噁嗪基甲基,苯并[1,
4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”。
7.权利要求1-2中任一项的通式(Ia)或(Ib)所示的吡啶并[2,3-b]吡嗪衍生物,其
中
基团R1独立地选自:
(i)“-NH-C(O)-NH2,-NH-C(S)-NH2,-NH-C(O)-NH- 烷 基,-NH-C(O)-NH-(C9-C30) 烷
基,-NH-C(O)-NH-环烷基,-NH-C(O)-NH-环烷基烷基,-NH-C(O)-NH-芳基,-NH-C(O)-NH-芳基 烷 基,-NH-C(O)-NH- 杂 芳 基,-NH-C(O)-NH- 杂 芳 基 烷 基,-NH-C(O)-NH- 杂 环基,-NH-C(O)-NH- 杂 环 基 烷 基,-NH-C(S)-NH- 烷 基,-NH-C(S)-NH-(C9-C30) 烷
基,-NH-C(S)-NH-环烷基,-NH-C(S)-NH-环烷基烷基,-NH-C(S)-NH-芳基,-NH-C(S)-NH-芳基 烷 基,-NH-C(S)-NH- 杂 芳 基,-NH-C(S)-NH- 杂 芳 基 烷 基,-NH-C(S)-NH- 杂 环基,-NH-C(S)-NH-杂环基烷基,-NH-C(O)-烷基,-NH-C(O)-(C9-C30)烷基,-NH-C(O)-环烷基,-NH-C(O)-环烷基烷基,-NH-C(O)-芳基,-NH-C(O)-芳基烷基,-NH-C(O)-杂芳
基,-NH-C(O)-杂芳基烷基,-NH-C(O)-杂环基,-NH-C(O)-杂环基烷基,-NH-C(S)-烷
基,-NH-C(S)-(C9-C30)烷基,-NH-C(S)-环烷基,-NH-C(S)-环烷基烷基,-NH-C(S)-芳
基,-NH-C(S)-芳基烷基,-NH-C(S)-杂芳基,-NH-C(S)-杂芳基烷基,-NH-C(S)-杂环
基,-NH-C(S)-杂环基烷基”;
其中上述取代基组(i)的取代基,如果不是氢、氮或硫,可任选地另外被至少一个选
自以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R2独立地是“氢”;
基团R3独立地选自:
(i)“烷基,(C9-C30)烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,杂环基,杂环基烷基,-NH-烷基,-NH-(C9-C30)烷基,-NH-环烷基,-NH-环烷基烷基,-NH-芳基,-NH-芳基烷基,-NH-杂芳基,-NH-杂芳基烷基,-NH-杂环基,-NH-杂环基烷基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R4独立地选自:
(i)“氢,烷基,(C9-C30)烷基,环烷基,环烷基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,杂环基,杂环基烷基,-NH-烷基,-NH-(C9-C30)烷基,-NH-环烷基,-NH-环烷基烷基,-NH-芳基,-NH-芳基烷基,-NH-杂芳基,-NH-杂芳基烷基,-NH-杂环基,-NH-杂环基烷基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R5独立地是“氢”。
8.权利要求1、2、7中任一项的通式(Ia)或(Ib)所示的吡啶并[2,3-b]吡嗪衍生物,
其中
基团R1独立地选自:
(i)“-NH-C(O)-NH2,-NH-C(S)-NH2,-NH-C(O)-NH-Rz1,-NH-C(S)-NH-Rz2,-NH-C(O)-Rz3,-NH-C(S)-NH-Rz4”,其中Rz1,Rz2,Rz3,Rz4彼此独立地选自:“甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,
4-四氢-异喹啉基甲基,1,2,3,4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,
2,3,4-四氢-异喹啉基丁基,1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,
4]噁嗪基丁基,苯并[1,4]噁嗪-6-基”;
其中上述取代基组(i)的取代基,如果不是氢、氮或硫,可任选地另外被至少一个选
自以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R2独立地是“氢”;
基团R3独立地选自:
(i)“甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,
2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,
4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,
1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基,-NH-Rz5”,其中Rz5选自:“甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,1,2,3,4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,
4]噁嗪基甲基,苯并[1,4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R4独立地选自:
(i)“氢,甲基,乙基,丙基,异丙基,叔丁基,己基,烯丙基,丙烯基,丙-2-烯-1-基,环丙基,环丙基甲基,环丙基乙基,环丙基丙基,环丙基丁基,环戊基,环戊基甲基,环戊基乙基,环戊基丙基,环戊基丁基,环己基,环己基甲基,环己基乙基,环己基丙基,环己基丁基,苯基,萘基,萘-1-基,萘-2-基,苄基,苯基-乙基,异噁唑,吡啶基,吡啶-2-基,吡啶-3-基,吡啶-4-基,吡唑基,吡唑-3-基,吡唑-4-基,喹啉基,喹啉-2-基,喹啉-3-基,喹啉-4-基,喹啉-8-基,噻吩基,噻吩-2-基,噻吩-3-基,呋喃基,呋喃-2-基,呋喃-3-基,嘧啶基,嘧啶-5-基,咪唑基,咪唑-4-基,咪唑-3-基,吡咯并[2,3-b]吡啶基,吡咯并[2,3-b]吡啶-5-基,吲哚基,1H-吲哚-2-基,二苯并呋喃基,二苯并呋喃-4-基,哌啶基,哌啶基甲基,哌啶基乙基,哌啶基丙基,哌啶基丁基,哌啶-1-基,哌啶-3-基,哌啶-4-基,哌嗪基,哌嗪基甲基,哌嗪基乙基,哌嗪基丙基,哌嗪基丁基,哌嗪-1-基,二氮杂环庚烷基,二氮杂环庚烷基甲基,二氮杂环庚烷基乙基,二氮杂环庚烷基丙基,二氮杂环庚烷基丁基,二氮杂环庚烷-1-基,吗啉基,吗啉基甲基,吗啉基乙基,吗啉基丙基,吗啉基丁基,吗啉-4-基,2-吗啉-4-基-乙基,1,2,3,4-四氢-异喹啉基,1,2,3,4-四氢-异喹啉基甲基,1,2,3,4-四氢-异喹啉基乙基,1,2,3,4-四氢-异喹啉基丙基,1,2,3,4-四氢-异喹啉基丁基,1,2,3,
4-四氢-异喹啉-7-基,苯并[1,3]二氧杂环戊烯基,苯并[1,3]二氧杂环戊烯基甲基,苯并[1,3]二氧杂环戊烯基乙基,苯并[1,3]二氧杂环戊烯基丙基,苯并[1,3]二氧杂环戊烯基丁基,苯并[1,3]二氧杂环戊烯-5-基,苯并[1,4]噁嗪基,苯并[1,4]噁嗪基甲基,苯并[1,
4]噁嗪基乙基,苯并[1,4]噁嗪基丙基,苯并[1,4]噁嗪基丁基,苯并[1,4]噁嗪-6-基”;
其中上述取代基组(i)的取代基,如果不是氢或氮,可任选地另外被至少一个选自
以下的取代基取代:“-F,-Cl,-Br,-I,-CN,-CF3,-N3,-NH2,-NO2,-OH,=O,-OCF3,-OCHF2,-SH,-O-SO3H,-OP(O)(OH)2,-CHO,-COOH,-C(O)NH2,-SO3H,-P(O)(OH)2,-NHC(O)-NH2,-C(NH)-NH2,-C(O)-C(O)-NH2,-C(O)-CF3,烷基,(C9-C30)烷基,环烷基,环烷基烷基,杂环基,杂环基烷基,芳基,芳基烷基,杂芳基,杂芳基烷基,烷基-OH,烷基-CN,烷基-COOH,烷基-P(O)(O-烷基)2,环烷基-CN,芳基-OH,芳基(-OH)(-烷基),-C(O)-烷基,-C(O)-杂
环基,-C(O)-O-烷基,-C(O)-O-杂环基,-P(O)(O-烷基-O-C(O)-烷基)2,-OP(O)(O-烷
基)2,-OS(O2)-烷基,-S-烷基,-O-烷基,-O-芳基,-O-芳基烷基,-O-杂环基,-O-杂环基烷基,-O-芳基烷基-(O-烷基)2,-O-烷基-O-烷基,-O-烷基-N(烷基)2,-O-烷基-卤
素,-O-烷基-Cl,-O-烷基-F,-O-烷基-Br,-O-烷基-I,-OC(O)-烷基,-OC(O)-N(烷
基 )2,-OC(O)-NH- 烷 基,-OC(O)-(C9-C30) 烷 基,-OC(O)-O- 烷 基,-OC(O)-O- 烷基-O-烷基,-OC(O)-O-芳基,-N(烷基)2,-N(芳基)2,-NHC(O)-烷基,-NHC(O)-烷
基-NH-烷基,-NHC(O)-烷基-C(O)-O-烷基,-NHC(O)-O-烷基,-NHC(O)-O-烷基-O-烷
基,-NHC(O)-O-烷基-O-烷基-O-烷基-O-烷基,-NHC(O)-NH-烷基,-NHC(O)-NH-芳
基,-NHC(O)-NH-杂芳基,-NHC(O)-NH-杂环基,-NHC(O)-NH-杂环基烷基,-NHC(O)-NH-烷基-卤素,-NHC(O)-NH-烷基-Cl,-NHC(O)-N(烷基)2,-NHS(O2)-烷基”;
基团R5独立地是“氢”。
9.吡啶并[2,3-b]吡嗪衍生物,其选自以下的化合物:
。
10.权利要求1-9中任一项的吡啶并[2,3-b]吡嗪衍生物的制备方法。
11.药物组合物,包含药学有效量的如权利要求1-9中任一项所述的至少一种化合物。
12.权利要求11的药物组合物,其中所述至少一种化合物以0.001mg~100mg/kg患者
体重的单位剂量存在。
13.权利要求11-12中任一项的药物组合物,其中该组合物还包含至少一种药学可接
受的载体和/或助剂。
14.权利要求11-13中任一项的药物组合物,其中该组合物还包含至少一种另外的药
理学活性物质。
15.权利要求14的药物组合物,其中另外的药理学活性物质选自:“DNA拓泊异构酶I
和/或II抑制剂,DNA嵌入剂,烷化剂,微管去稳定剂,激素和/或生长因子受体激动剂和/或拮抗剂,对抗生长因子及其受体的抗体,激酶抑制剂,抗代谢药”。
16.权利要求15的药物组合物,其中另外的药理学活性物质选自:“天冬酰胺酶,博来
霉素,卡铂,卡莫司汀,苯丁酸氮芥,顺铂,左旋天冬酰胺酶,环磷酰胺,阿糖胞苷,达卡巴嗪,更生霉素,柔红霉素,多柔比星(阿霉素),表柔比星,依托泊苷,5-氟尿嘧啶,六甲三聚氰胺,羟基脲,异环磷酰胺,伊立替康,亚叶酸,洛莫司汀,氮芥,6-巯基嘌呤,美司钠,甲氨蝶呤,丝裂霉素C,米托蒽醌,泼尼松龙,泼尼松,丙卡巴肼,雷洛昔芬,链佐星,他莫昔芬,硫鸟嘌呤,拓泊替康,长春碱,长春新碱,长春地辛,氨鲁米特,L-门冬酰胺酶,硫唑嘌呤,5-氮杂胞苷,克拉屈滨,白消安,己烯雌酚,2′,2′-二氟脱氧胞苷,多西他赛,赤藓羟基壬基腺嘌呤,乙炔雌二醇,5-氟脱氧尿苷,5-氟脱氧尿苷一磷酸,磷酸氟达拉滨,氟甲睾酮,氟他胺,己酸羟孕酮,伊达比星,干扰素,醋酸甲羟孕酮,醋酸甲地孕酮,美法仑,米托坦,紫杉醇,奥沙利铂,喷司他丁,N-膦酰乙酰基-L-天冬氨酸(PALA),普卡霉素,司莫司汀,替尼泊苷,丙酸睾酮,塞替派,三甲基三聚氰胺,尿苷,长春瑞滨,埃坡霉素,吉西他滨,泰素帝,BCNU,CCNU,DTIC,5-氟尿嘧啶,赫赛汀,阿瓦斯丁,爱必妥,索拉非尼,格列卫,易瑞沙,特罗凯,雷帕霉素,放线菌素D,舒尼替尼(索坦)”。
17.权利要求1-9中任一项的吡啶并[2,3-b]吡嗪衍生物或权利要求11-16中任一项
的药物组合物,用作药物。
18.权利要求1-9中任一项的吡啶并[2,3-b]吡嗪衍生物或权利要求11-16中任一项
的药物组合物用于制备药物的用途,所述药物用于调节方向错误的细胞信号转导过程、特别是用于影响活性和非活性的受体酪氨酸激酶以及胞质酪氨酸、丝氨酸-苏氨酸和脂类激酶诸如c-Raf,B-Raf,Mek,MAPK,PDGFRβ,Flt-3,IGF1R,PI3K,PKB/Akt1,c-Kit,c-Abl,FGFR1和KDR的功能。
19.权利要求1-9中任一项的吡啶并[2,3-b]吡嗪衍生物或权利要求11-16中任一
项的药物组合物用于制备用于治疗或预防哺乳动物的由一种或多种选自以下的信号通
道所介导的生理学病症和/或病理学病症的药物的用途:“ras-Raf-Mek-Erk信号通道,
PI3K-Akt信号通道和/或SAPK信号通道”。
20.权利要求19的用途,其中治疗或预防通过调节一种或多种选自以下的信号通道来
实现:“ras-Raf-Mek-Erk信号通道,PI3K-Akt信号通道和/或SAPK信号通道”。
21.权利要求19的用途,其中生理学病症和/或病理生理学病症由一种或多种选自以
下的酶所介导:“ATM,ATR,mTOR,DNA-PK,hSMG-1”。
22.权利要求21的用途,其中治疗或预防通过调节一种或多种选自以下的酶来实现:
“ATM,ATR,mTOR,DNA-PK,hSMG-1”。
23.权利要求19-20中任一项的用途,其中介导信号通道和/或经过调节的信号通道是
ras-Raf-Mek-Erk信号通道和PI3K-Akt信号通道。
24.权利要求19-20中任一项的用途,其中介导信号通道和/或经过调节的信号通道是
ras-Raf-Mek-Erk信号通道。
25.权利要求19-20中任一项的用途,其中介导信号通道和/或经过调节的信号通道是
PI3K-Akt信号通道。
26.权利要求19-20中任一项的用途,其中介导信号通道和/或经过调节的信号通道是
SAPK信号通道和PI3K-Akt信号通道。
27.权利要求19-20中任一项的用途,其中介导信号通道和/或经过调节的信号通道是
SAPK信号通道。
28.权利要求19-20和23-24中任一项的用途,其中调节ras-Raf-Mek-Erk信号通道通
过调节一种或多种选自以下的酶来实现:“酪氨酸激酶,丝氨酸-苏氨酸激酶,受体酪氨酸激酶,胞质酪氨酸激酶,胞质丝氨酸-苏氨酸激酶”。
29.权利要求28的用途,其中一种或多种酶选自:“Erk,Erk1,Erk2”。
30.权利要求19-20、23、25-26中任一项的用途,其中调节PI3K-Akt信号通道通过调
节一种或多种选自以下的酶来实现:“PI3K,PI3Kα,PI3Kβ,PI3Kγ,PI3Kδ,PI3K-C2α,PI3K-C2β,PI3K-Vps34p”。
31.权利要求19-20、26-27中任一项的用途,其中调节SAPK信号通道通过调节一种或
多种选自以下的酶来实现:“酪氨酸激酶,丝氨酸-苏氨酸激酶,受体酪氨酸激酶,胞质酪氨酸激酶,胞质丝氨酸-苏氨酸激酶”。
32.权利要求31的用途,其中一种或多种酶选自:“Jnk,Jnk1,Jnk2,Jnk3,p38,p38α,p38β,p38γ,p38δ”。
33.权利要求18-32中任一项的用途,其中两种或更多种酶经过了调节。
34.权利要求33的用途,其中至少一种酶选自:“Erk,Erk1,Erk2”,和至少一种酶选自:
“PI3K,PI3Kα,PI3Kβ,PI3Kγ,PI3Kδ,PI3K-C2α,PI3K-C2β,PI3K-Vps34p”。
35.权利要求32的用途,其中至少一种酶选自:“Jnk,Jnk1,Jnk2,Jnk3,p38,p38α,p38β,p38γ,p38δ”,和至少一种酶选自:“PI3K,PI3Kα,PI3Kβ,PI3Kγ,PI3Kδ,PI3K-C2α,PI3K-C2β,PI3K-Vps34p”。
36.权利要求33的用途,其中至少一种酶选自:“Erk,Erk1,Erk2”,和至少一种酶选自:
“ATM,ATR,mTOR,DNA-PK,hSMG-1”。
37.权利要求33的用途,其中至少一种酶选自:“Jnk,Jnk1,Jnk2,Jnk3,p38,p38α,p38β,p38γ,p38δ”,和至少一种酶选自:“ATM,ATR,mTOR,DNA-PK,hSMG-1”。
38.权利要求33的用途,其中至少一种酶选自:“PI3K,PI3Kα,PI3Kβ,PI3Kγ,
PI3Kδ,PI3K-C2α,PI3K-C2β,PI3K-Vps34p”,和至少一种酶选自:“ATM,ATR,mTOR,DNA-PK,hSMG-1”。
39.权利要求18-38中任一项的用途,其中调节是抑制。
40.权利要求19-39中任一项的用途,其中生理学病症和/或病理学病症选自:“恶性
肿瘤,良性肿瘤,炎性病症,炎症,疼痛,风湿病,关节炎病症,HI V感染,神经学或神经变性病症,风湿症,关节炎,AIDS,ARC(AIDS相关综合征),卡波西肉瘤,来源于脑和/或神经系统和/或脑膜的肿瘤,痴呆,阿尔茨海默病,过增生病,银屑病,子宫内膜异位症,瘢痕形成,良性前列腺增生(BPH),免疫系统病症,自身免疫病症,免疫缺陷病症,结肠肿瘤,胃肿瘤,肠肿瘤,肺肿瘤,胰腺肿瘤,卵巢肿瘤,前列腺肿瘤,白血病,黑素瘤,肝肿瘤,肾肿瘤,头肿瘤,咽喉肿瘤,神经胶质瘤,乳腺肿瘤,子宫癌,子宫内膜癌,宫颈癌,脑肿瘤,腺棘癌,膀胱癌,结肠直肠肿瘤,食道癌,妇科肿瘤,卵巢肿瘤,甲状腺癌,淋巴瘤,慢性白血病,急性白血病,再狭窄,糖尿病,糖尿病肾病,纤维变性疾病,囊性纤维化,恶性肾硬化,血栓性微血管病综合征,器官移植排斥,肾小球病,代谢障碍,实体瘤,风湿性关节炎,糖尿病性视网膜病,哮喘,变态反应,变应性紊乱,慢性阻塞性肺病,炎性肠病,纤维症,动脉粥样硬化,心脏疾病,心血管病,心肌病,血管病,血管生成病症,肾病,鼻炎,格雷夫斯病,局部缺血,心力衰竭,缺血,心脏肥大,肾衰竭,心肌细胞功能障碍,高血压,血管缩窄,中风,过敏性休克,血小板凝集,骨骼肌萎缩,肥胖症,超重,糖稳态异常,充血性心力衰竭,绞痛,心脏病发作,心肌梗塞,高血糖症,低血糖症,高血压”。
41.权利要求18-40中任一项的用途,其中药物包含至少一种另外的药理学活性物质。
42.权利要求18-40中任一项的用途,其中所述药物在用至少一种另外的药理学活性
物质进行治疗之前和/或治疗期间和/或治疗之后被给予。
43.权利要求18-42中任一项的用途,其中所述药物在用放疗和/或手术进行治疗之前
和/或治疗期间和/或治疗之后被给予。
44.权利要求41-43中任一项的用途,其中另外的药理学活性物质选自:“DNA拓泊异
构酶I和/或II抑制剂,DNA嵌入剂,烷化剂,微管去稳定剂,激素和/或生长因子受体激
动剂和/或拮抗剂,对抗生长因子及其受体的抗体,激酶抑制剂,抗代谢药”。
45.权利要求44的用途,其中另外的药理学活性物质选自:“天冬酰胺酶,博来霉素,
卡铂,卡莫司汀,苯丁酸氮芥,顺铂,左旋天冬酰胺酶,环磷酰胺,阿糖胞苷,达卡巴嗪,更生霉素,柔红霉素,多柔比星(阿霉素),表柔比星,依托泊苷,5-氟尿嘧啶,六甲三聚氰胺,羟基脲,异环磷酰胺,伊立替康,亚叶酸,洛莫司汀,氮芥,6-巯基嘌呤,美司钠,甲氨蝶呤,丝裂霉素C,米托蒽醌,泼尼松龙,泼尼松,丙卡巴肼,雷洛昔芬,链佐星,他莫昔芬,硫鸟嘌呤,拓泊替康,长春碱,长春新碱,长春地辛,氨鲁米特,L-门冬酰胺酶,硫唑嘌呤,5-氮杂胞苷,克拉屈滨,白消安,己烯雌酚,2′,2′-二氟脱氧胞苷,多西他赛,赤藓羟基壬基腺嘌呤,乙炔雌二醇,5-氟脱氧尿苷,5-氟脱氧尿苷一磷酸,磷酸氟达拉滨,氟甲睾酮,氟他胺,己酸羟孕酮,伊达比星,干扰素,醋酸甲羟孕酮,醋酸甲地孕酮,美法仑,米托坦,紫杉醇,奥沙利铂,喷司他丁,N-膦酰乙酰基-L-天冬氨酸(PALA),普卡霉素,司莫司汀,替尼泊苷,丙酸睾酮,塞替派,三甲基三聚氰胺,尿苷,长春瑞滨,埃坡霉素,吉西他滨,泰素帝,BCNU,CCNU,DTIC,
5-氟尿嘧啶,赫赛汀,阿瓦斯丁,爱必妥,索拉非尼,格列卫,易瑞沙,特罗凯,雷帕霉素,放线菌素D,舒尼替尼(索坦)”。
46.试剂盒,其包含药理学有效量的权利要求1-9中任一项的至少一种化合物和/或权
利要求11-16中任一项的至少一种药物组合物以及药理学有效量的权利要求44-45中任一
项的至少一种另外的药理学活性物质。
47.权利要求1-2中任一项的通式(Ia)或(Ib)所示的吡啶并[2,3-b]吡嗪衍生物,其
为以下形式:立体异构体,作为“纯”的E或Z异构体的双键异构体或双键异构体的混合物,互变异构体,以酯、碳酸酯、氨基甲酸酯、脲、酰胺、N-氧化物或磷酸酯形式存在的前体药物,或代谢物。
标题 | 发布/更新时间 | 阅读量 |
---|---|---|
防治再狭窄的药物及其使用方法 | 2020-05-13 | 10 |
防治血管再狭窄的药物 | 2020-05-11 | 346 |
抗再狭窄消化道内支架 | 2020-05-11 | 982 |
通过局部给药预防和治疗再狭窄 | 2020-05-12 | 323 |
一种具有防治再狭窄功能的声敏支架 | 2020-05-12 | 838 |
治疗再狭窄和动脉硬化的药物 | 2020-05-13 | 796 |
用于治疗支架内再狭窄的设备及方法 | 2020-05-13 | 781 |
预防再狭窄的制剂 | 2020-05-11 | 610 |
预防再狭窄的制剂 | 2020-05-11 | 895 |
预防再狭窄的制剂 | 2020-05-11 | 136 |
高效检索全球专利专利汇是专利免费检索,专利查询,专利分析-国家发明专利查询检索分析平台,是提供专利分析,专利查询,专利检索等数据服务功能的知识产权数据服务商。
我们的产品包含105个国家的1.26亿组数据,免费查、免费专利分析。
专利汇分析报告产品可以对行业情报数据进行梳理分析,涉及维度包括行业专利基本状况分析、地域分析、技术分析、发明人分析、申请人分析、专利权人分析、失效分析、核心专利分析、法律分析、研发重点分析、企业专利处境分析、技术处境分析、专利寿命分析、企业定位分析、引证分析等超过60个分析角度,系统通过AI智能系统对图表进行解读,只需1分钟,一键生成行业专利分析报告。