人类肝脏中表达的表达序列标签A组
阅读：178发布：2020-05-12
专利汇可以提供人类肝脏中表达的表达序列标签A组专利检索，专利查询，专利分析的服务。并且本 发明 公开了一类在人类肝脏中表达的表达序列标签的序列。利用本发明的在人类肝脏中表达的表达序列标签，可以方便的寻找出在人类肝脏中表达的相关基因，从而在研究肝脏 疾病 的致病机理以及开发 治疗 肝脏疾病的药物中发挥重要作用。，下面是人类肝脏中表达的表达序列标签A组专利的具体信息内容。
1.一类在人类肝脏中表达的表达序列标签的序列，其特征在于，它包括：
(a)SEQ ID No.1～SEQ ID No.55所示的序列；
(b)SEQ ID No.1～SEQ ID No.55所示的序列中每条序列的互补序列；
(c)与SEQ ID No.1～SEQ ID No.55所示的序列中每条序列有至少70％同源性的 序列；
(d)上述(a)～(c)中一条或数条的组合。
2.如权利要求1所述的表达序列标签的序列，其特征在于，所述序列包括具有SEQ ID No.1～SEQ ID No.55所示的序列。
3.一种探针分子，其特征在于，所述的探针分子含有权利要求1中所述的序列中约 8-100个连续的核苷酸。
技术领域
本发明涉及生物技术领域，尤其涉及一类在人类肝脏中表达的表达序列标签。
背景技术
肝脏是人体内最大的消化腺。也是体内新陈代谢的中心站。据估计，在肝脏中发 生的化学反应有500种以上，实验证明，动物在完全摘除肝脏后即使给予相应的治疗， 最多也只能生存50多个小时。这说明肝脏是维持生命活动的一个必不可少的重要器 官。肝脏的血流量极为丰富，约占心输出量的1/4。每分钟进入肝脏的血流量为 1000-1200ml。肝脏的主要功能是进行糖的分解、贮存糖原；参与蛋白质、脂肪、维 生素、激素的代谢；解毒；分泌胆汁；吞噬、防御机能；制造凝血因子；调节血容量 及水电解质平衡；产生热量等。在胚胎时期肝脏还有造血功能。
肝脏疫病分为肝炎、肝硬化、脂肪肝、肝癌等。现代医学实验证明，肝病病毒侵 入人体后，并不直接引起肝细胞的损害，只是在肝细胞内吸收营养赖以生存，并在肝 细胞内复制、繁殖。其复制病毒的“零部件”如表面抗原(HBsAg)、e抗原(HBeAg) 释放在肝细胞膜上，引起人体免疫系统对这些抗原物质产生免疫反应，这种反应造成 肝细胞的损伤、坏死。免疫反应的强弱决定于肝脏受损程度及临床症状轻重。这场由 病毒引发的、免疫系统对肝细胞的战争，使大约25％的患者的肝脏成为战火连绵的战 场，肝脏的损伤由此加重。肝病的危害绝不仅仅限于肝脏本身，它还可以引起其它多 种疾病。常见的有：(1)糖尿病；(2)胰腺炎；(3)胆道感染；(4)功能性肾衰竭； (5)胆汗性肾病；(6)肾小球肾炎；(7)肾小管酸中毒；(8)溶血性贫血；(9)再 生障碍性贫血；(10)心肌炎和心包炎；(11)结节性动脉炎；(12)消化性溃疡；(13) 自发性腹膜炎；(14)性激素代谢紊乱；(15)甲状腺功能改变；(16)肝性骨病，等 等。肝病不仅对患者的身体甚至生命造成危害，而且对患者心理上的打击也是十分沉 重的。无论是肝病患者还是病毒携带者，在生活、社交、求职、升学等方面都会受到 严重影响。
生物基因组中可转录表达的序列(即基因)仅占总序列的3-5％，对这部分序列 进行测定，将直接导致新基因的发现，并获取基因组中与产业化关系最为密切的信息。 20世纪80年代，高通量的自动测序的出现，使从质粒互补脱氧核糖核酸 (Complementary DNA，简称cDNA)文库随机选取许多cDNA克隆和决定来自非载体两 端的几百个碱基的DNA序列成为可能。这些短的DNA序列叫做“表达序列标签” (Expressed Sequence Tags，简称ESTs)。表达序列标签的概念最早是由Adams等在 1992年提出来的(Nature，355，642-644)。1992年Sikela和Matsubara(Sikela， et al.Nucleic Acids Res.19，1837-1843；Matsubara，et al.Nature Genetics， 2，173-179)针对获得大量信使核糖核酸(mRNA)序列的迫切需要，提出大规模互补 脱氧核糖核酸(cDNA)测序的研究战略。随后Venter创立了大规模表达序列标签技 术。其基本特征就是从以质粒为载体，构建完成的目的组织互补脱氧核糖核酸 (Complementary DNA，简称cDNA)文库中，随机选择许多cDNA克隆，利用质粒上携 带的通用引物对cDNA两端进行一轮脱氧核糖核酸序列测定，所获得的来自3’端或 5’端的几百个碱基的非载体短脱氧核糖核酸(DNA)序列。简而言之，表达序列标签 是来自表达基因片段3’端或5’端的短脱氧核糖核酸序列，代表一个表达基因的部 分转录片段。
表达序列标签可用于新基因克隆、人类基因组图谱绘制、基因组序列编码区的确 定等。如果一个表达序列标签在基因组中只出现一次，那么它可以作为序列标签位点 (STS)。由表达序列标签构建的物理图谱叫表达图或转录图(expression or transcript map)。利用表达序列标签进行基因图制作，可以加快序列标签位点的制 作和新基因的染色体定位。表达序列标签可以作为基因特异性探针，对组织特异性基 因表达的研究具有重要的作用。表达序列标签还可以进行新基因的遗传进化关系分 析。表达序列标签可以对所有动植物的基因作为一种数据库，通过不同的序列比较可 以获得保守序列片段，从而获得基因的遗传进化图谱。正因为表达序列标签具有如此 的优越性，因此表达序列标签测序已经成为许多基因组研究机构的工作重点。
表达序列标签(EST)是一种快速有效揭示基因组容量的方法。ESTs在新基因的 发现、基因作图和基因组序列编码区域的确定等方面起到重要作用。EST不仅为基因 组遗传图谱的构建提供了大量的分子标记，而且来自不同组织和器官的EST也为基因 的功能研究提供了有价值的信息。此外，EST计划还为基因的鉴定提供了候选基因 (candidantes)。
在本发明之前，还没有出现涉及本发明的一类在人类肝脏中表达的表达序列标签 的公开报道。
肝脏疫病分为肝炎、肝硬化、脂肪肝、肝癌等。现代医学实验证明，肝病病毒侵 入人体后，并不直接引起肝细胞的损害，只是在肝细胞内吸收营养赖以生存，并在肝 细胞内复制、繁殖。其复制病毒的“零部件”如表面抗原(HBsAg)、e抗原(HBeAg) 释放在肝细胞膜上，引起人体免疫系统对这些抗原物质产生免疫反应，这种反应造成 肝细胞的损伤、坏死。免疫反应的强弱决定于肝脏受损程度及临床症状轻重。这场由 病毒引发的、免疫系统对肝细胞的战争，使大约25％的患者的肝脏成为战火连绵的战 场，肝脏的损伤由此加重。肝病的危害绝不仅仅限于肝脏本身，它还可以引起其它多 种疾病。常见的有：(1)糖尿病；(2)胰腺炎；(3)胆道感染；(4)功能性肾衰竭； (5)胆汗性肾病；(6)肾小球肾炎；(7)肾小管酸中毒；(8)溶血性贫血；(9)再 生障碍性贫血；(10)心肌炎和心包炎；(11)结节性动脉炎；(12)消化性溃疡；(13) 自发性腹膜炎；(14)性激素代谢紊乱；(15)甲状腺功能改变；(16)肝性骨病，等 等。肝病不仅对患者的身体甚至生命造成危害，而且对患者心理上的打击也是十分沉 重的。无论是肝病患者还是病毒携带者，在生活、社交、求职、升学等方面都会受到 严重影响。
生物基因组中可转录表达的序列(即基因)仅占总序列的3-5％，对这部分序列 进行测定，将直接导致新基因的发现，并获取基因组中与产业化关系最为密切的信息。 20世纪80年代，高通量的自动测序的出现，使从质粒互补脱氧核糖核酸 (Complementary DNA，简称cDNA)文库随机选取许多cDNA克隆和决定来自非载体两 端的几百个碱基的DNA序列成为可能。这些短的DNA序列叫做“表达序列标签” (Expressed Sequence Tags，简称ESTs)。表达序列标签的概念最早是由Adams等在 1992年提出来的(Nature，355，642-644)。1992年Sikela和Matsubara(Sikela， et al.Nucleic Acids Res.19，1837-1843；Matsubara，et al.Nature Genetics， 2，173-179)针对获得大量信使核糖核酸(mRNA)序列的迫切需要，提出大规模互补 脱氧核糖核酸(cDNA)测序的研究战略。随后Venter创立了大规模表达序列标签技 术。其基本特征就是从以质粒为载体，构建完成的目的组织互补脱氧核糖核酸 (Complementary DNA，简称cDNA)文库中，随机选择许多cDNA克隆，利用质粒上携 带的通用引物对cDNA两端进行一轮脱氧核糖核酸序列测定，所获得的来自3’端或 5’端的几百个碱基的非载体短脱氧核糖核酸(DNA)序列。简而言之，表达序列标签 是来自表达基因片段3’端或5’端的短脱氧核糖核酸序列，代表一个表达基因的部 分转录片段。
表达序列标签可用于新基因克隆、人类基因组图谱绘制、基因组序列编码区的确 定等。如果一个表达序列标签在基因组中只出现一次，那么它可以作为序列标签位点 (STS)。由表达序列标签构建的物理图谱叫表达图或转录图(expression or transcript map)。利用表达序列标签进行基因图制作，可以加快序列标签位点的制 作和新基因的染色体定位。表达序列标签可以作为基因特异性探针，对组织特异性基 因表达的研究具有重要的作用。表达序列标签还可以进行新基因的遗传进化关系分 析。表达序列标签可以对所有动植物的基因作为一种数据库，通过不同的序列比较可 以获得保守序列片段，从而获得基因的遗传进化图谱。正因为表达序列标签具有如此 的优越性，因此表达序列标签测序已经成为许多基因组研究机构的工作重点。
表达序列标签(EST)是一种快速有效揭示基因组容量的方法。ESTs在新基因的 发现、基因作图和基因组序列编码区域的确定等方面起到重要作用。EST不仅为基因 组遗传图谱的构建提供了大量的分子标记，而且来自不同组织和器官的EST也为基因 的功能研究提供了有价值的信息。此外，EST计划还为基因的鉴定提供了候选基因 (candidantes)。
在本发明之前，还没有出现涉及本发明的一类在人类肝脏中表达的表达序列标签 的公开报道。
发明内容
本发明要解决的技术问题是提供一类在人类肝脏中表达的表达序列标签。
为了解决上述技术问题，本发明通过如下技术方案实现：
在本发明的一个方面，提供了一类在人类肝脏中表达的表达序列标签的序列，其 包括：
(a)SEQ ID No.1～SEQ ID No.55所示的序列；
(b)SEQ ID No.1～SEQ ID No.55所示的序列中每条序列的互补序列；
(c)与SEQ ID No.1～SEQ ID No.55所示的序列中每条序列有至少70％同源性的 序列；
(d)上述(a)～(c)中一条或数条的组合。
较佳地，所述序列包括具有SEQ ID No.1～SEQ ID No.55所示的序列。
本发明还提供了一种探针分子，所述的探针分子含有上述序列中约8-100个连续 的核苷酸。
由本发明的一类在人类肝脏中表达的表达序列标签，可以方便的寻找出在人类肝 脏中特异表达的相关基因，从而在研究肝脏疾病的致病机理以及开发治疗肝脏疾病的 药物中发挥重要作用。
为了解决上述技术问题，本发明通过如下技术方案实现：
在本发明的一个方面，提供了一类在人类肝脏中表达的表达序列标签的序列，其 包括：
(a)SEQ ID No.1～SEQ ID No.55所示的序列；
(b)SEQ ID No.1～SEQ ID No.55所示的序列中每条序列的互补序列；
(c)与SEQ ID No.1～SEQ ID No.55所示的序列中每条序列有至少70％同源性的 序列；
(d)上述(a)～(c)中一条或数条的组合。
较佳地，所述序列包括具有SEQ ID No.1～SEQ ID No.55所示的序列。
本发明还提供了一种探针分子，所述的探针分子含有上述序列中约8-100个连续 的核苷酸。
由本发明的一类在人类肝脏中表达的表达序列标签，可以方便的寻找出在人类肝 脏中特异表达的相关基因，从而在研究肝脏疾病的致病机理以及开发治疗肝脏疾病的 药物中发挥重要作用。
具体实施方式
下面结合具体实施例，进一步阐述本发明。应理解，这些实施例仅用于说明本发 明而不是限制本发明的范围。下列实施例中未注明具体条件的实验方法，通常按照常 规条件如Sambrook等人，分子克隆：实验室手册(New York：Cold Spring Harbor Laboratory Press，1989)中所述的条件，或按照制造厂商所建议的条件。
实施例1
人肝脏组织的mRNA的分离
组织分离(Tissue isolation)：肝脏来源于5个成年男性，在肝脏切除手术后， 将肝脏组织立即置于液氮中冷冻保存。
mRNA的分离(mRNA isolation)：取出肝脏组织，用研钵研碎，加入盛有裂解液 的50ml管，充分振荡后，再移入玻璃匀浆器内，匀浆后移至50ml新管，抽提总RNA (TRIzol Reagents，Gibco，NY，USA)。用甲醛变性胶电泳鉴定总RNA质量。用带Oligo d(T)的纤维素柱分离总RNA中的mRNA，定量。
实施例2
cDNA文库的构建(Constuction of cDNA library)
以mRNA为模板，合成双链cDNA。补平末端后，加含EcoRI切点的接头。磷酸化 EcoRI末端后，用XhoI限制性内切酶消化1.5小时，再进行片断分离。过柱筛选长 度＞500bp的片段，用酚-氯仿抽提，乙醇沉淀，无菌水溶解，连接至Uni-ZAP XR载体 (Strategene，CA9203，USA)，以ZAP-cDNA Gigapack III Gold Cloning Kit (Strategene，CA9203，USA)进行包装，宿主菌使用XL 1 Blue MRF’ (Strategene，CA9203，USA)细菌。涂板并测定滴度。
实施例3
测序及数据库建立(Seqencing and Database Constructing)
挑选文库中有外源片段插入的克隆，扩增后抽提质粒(Qiagen Germany)，用T3 和T7作为3’和5’端的通用引物，采用终止物荧光标记 (Big-Dye，Perkin-Elmer，USA)的方法，在ABI 377测序仪(Perkin-Elmer，USA)上 进行EST大规模测序。测序结果用FACTURA软件去除载体序列，传输到SUN Ultra 450
Server上进行下一步的处理。所有的序列信息再用GCG软件包(Wisconsin group，USA) 中的BLAST和FASTA软件搜索已有的数据库(Genebank+EMBL)，将无同源性或同源性 低于95％的序列视为新基因建立数据库。
实施例4
基因的全长克隆(Cloning of Full-length cDNA)
在得到的新基因片段序列信息基础上，进行cDNA全长克隆，分两阶段进行：
(1)“电子克隆”(Electronic Cloning)
以新基因片段序列作为探针搜寻dbEST数据库，将重叠序列＞50bp，同源性在98％ 以上的表达序列标签(Expressed Sequence Tag，简称“EST”)序列认为同一序列 (Consensus Sequence)，取出并用AUTOASSEMBLER软件进行连接，部分EST可以延 伸探针序列。再用STRIDER软件分析被延伸的序列是否具有完整的开放阅读框架(Open Reading Frame，ORF)，用BLAST搜寻Genbank或SwissProt以确定该序列的核苷酸 和氨基酸水平上是否与其他物种有同源性，以帮助判别所得到的基因全长完整性如 何。通过电子克隆的方法，通常可获取人肝脏相关基因的全长序列。
(2)cDNA末端快速扩增(Rapid Amplification of cDNA Ends，RACE)
如果通过“电子克隆”方法仍未得到完整的cDNA全长，则在已有序列5’或3’ 端设计引物，在人类肝脏Marathon-Ready cDNA文库(Clontech Lab，Inc，USA)中 进行长距离PCR反应。然后对PCR产物克隆、测序。用AUTOASSEMBLER及STRIDER软 件分析被延长的序列有无完整的ORF，如无，重复上述过程直至获得全长。
(3)RT-PCR
对于5’和3’端的已知的序列，如果中间有一段间隙(gap)无法从已有的公共 数据库或自身数据库获得，可考虑采用RT-PCR的方法。在序列5’端设计引物，3’ 端引物采用Oligo-dT，在肝脏总RNA库中进行扩增。然后对产物进行克隆、测序。最 后拼接便获得全长。
通过组合使用上述3种方法，可获得人肝脏相关蛋白的全长编码序列。
序列表
<110>上海人类基因组研究中心
<120>人类肝脏中表达的表达序列标签
<130>NP-10048
<160>55
<210>1
<211>550
<212>DNA
<213>Homo sapiens
<400>1
1 catcgttttt gtttttattt ttcccctttc aacctggttt tcggctctgg aagctgttcc
61 tgtgcacagt tctatttcct acagttctga gaaagcggtt ccatcgcaga tgaccaaagg
121 ctggacccct ctggctataa cgtagacctt ccagtgggtg gtgtcgacat agccgatatc
181 ccctggctct attggcatgg ccacagactg acaatgtctt cggcactgga agggagggat
241 gagctgcaac atggcctcac cgctgccaat gataaatagg tcanggcatc ttatgcatct
301 tactccccac aacaggttct gggtgaagaa aggagcactt gtttaaagag gcatcttttn
361 ggaaatgnca ggtgagtgaa aacaggaaaa agctcacgta acatttgtna tctgttcana
421 ggtctcctcc atggataagg naatgggaac caccgctcag gaaagcagcg ccaccacttg
481 tcgaaaaaac ctttcaggag aangccttct gtcgnctcag gggtactggc acanaaaaat
541 gctgaatctc
<210>2
<211>410
<212>DNA
<213>Homo sapiens
<400>2
1 atggggtttc accatgttgg ccaggctggt cttgaactcc agacctcaag tgatctgccc
61 gcctggcctc ccaaagtgct ggggttacag gcgtgacacn tgcgcccggt caggctttta
121 atttttttaa tttttaattt ttgctcaggg tggtttggct attctgggcc ttttgtggtt
181 ccatataaat tttagggtta ttgtttctat ttctgcgaag aatggcattg atattacagg
241 gagcccacgt agccctttac attgtaattg gcacctccac caggccataa gaccccaggt
301 cccagcccag aagcatgtcc cagaggaaag actcagagaa gctcctggaa tgtgtgtgca
361 cggctccttg gtattgcttn gggccttcac ccctttggtg gccactttcc
<210>3
<211>553
<212>DNA
<213>Homo sapiens
<400>3
1 tgccagcatt tccctttatt tctggatgga aacggggccc taaaagcaga aatcaatatt
61 tttgtttgaa agatgcagtc atgctaattt cacttttggc taaaaccgag acgataaaag
121 aacagttggg tgtttatagg atgccctcaa agtgagctgg ctaagtgagc tgggctctaa
181 cttcactcac aaatttatag tacagctaag aaggccagtc tgtccatgaa agggagccga
241 gacaagacga gggcggcctc ttccaggcct gtgccaagtg tccttggggt cccgccatgg
301 tccacacttc tgcagcatcc gcagaacatg tggccggggt cctgcccagc agcagggaca
361 gcccaagtgg ggaggcaggc atggtgcaca ccctggggag gcccctgggt gcagaagcag
421 ccccacagta gcagccccat ccagaggaag accactcccg aggggccaca gccttcttgc
481 agcccctngg aattgccgcc caacccctcc attttcagcg ggatgtttca agggtgagac
541 aaggaattna ggg
<210>4
<211>767
<212>DNA
<213>Homo sapiens
<400>4
1 gagaatcaat acaaaatatt tatttttttt caaaccacag aattcttaac cccagagcca
61 cacaataaag ttctcagaat tgtaagccat taacattttt ctaaacaatg cagtccagag
121 atgaagataa tttccaacca gcagggatgc aatatatagt aggttcccct atgaatgaag
181 ctcaaattag catttccttt aattctccca cagccactcc atcaacagaa gcagaaacag
241 tacacatatt catgccactc ggctctgaaa agaggttcaa ggtgggtcaa ggtgggtctt
301 ggccagtgga ggaaggaagg tgtccaggac tttagttaat caacagtggg gacagagagg
361 aatgatttcc cttggaaaac aacagggttc ctttctcata ttcttgtggc cagaaactgg
421 ggtgaacttc agtggggtaa tgaaagaaac aggagagcca tttctccagg aactcctatg
481 acctccattt taacttctga caaagttaac ttcattatac aatcgtattg aaaacagtaa
541 tcacaaccaa aaggtctata acctgtaata gtgtcaaggg atcncattcc ggactttaat
601 ttaaggnccc ttaaaagcct agcctggtta agtaccgaat attcccagct aagnggcctt
661 aaatccccaa catccaccat ggtnagctag tngtgttcnt tgtgnacctt cggtncgatg
721 ggggnttaaa agccggtttt tnggtgaaaa agttnctagg ggacttt
<210>5
<211>468
<212>DNA
<213>Homo sapiens
<400>5
1 tgcagtttga atttatattt tattattttg aaatacaaaa atttaaaaac atttcaaaat
61 acaccagtac atgtttgttg taaaaatttc acctaggagg atataaaata gaaaagccga
121 atattccttc taactctccc ctctacctca attcccttca gaggtaacac agcaaaaaaa
181 aactggggaa aagcaaacaa ctttccagac ctctactatt ctaaaacaca aagagcatta
241 cagcttgcta tgcatttttt tttnnttnng gggggggttg ttttttagag acggagntcc
301 cctctgtcac ccaggctgga atgcagttgt gtgatctcgg ctcactggaa cctccacctc
361 cccagttcaa gcgattctcc tgcctcagcc tgccgagtag ctggggatta cagggcangc
421 gccaccacgc ccagctaatt tttgtagttt tagtagagac agcgtttg
<210>6
<211>605
<212>DNA
<213>Homo sapiens
<400>6
1 tatgaaaaaa gcagcaactc tttagtgatc atggaattaa tctgacagca attaaatgtg
61 tttaagcatc tggcatatct cctcaattgc accaaaagaa tttggaagca cttggtttgg
121 tctcaaaggc aaaaggaaag gacgaggaag gggccaggct cccgccagcc cccgcccccc
181 tcacatttct gagtccgcat acatcccgtt gattaagtag tccacctggg tgtagtcctt
241 cttcttgtag ctctcatagg cctgcaggna aacaaaacca agactgtgat gaaaagggtc
301 accccgagta acagcaccac cagaaggaga gttttgtcta ccacggcctg gggtgagggg
361 ctcagtggtg accaccatgt actgggcctt gggtgctggg ctggcacgag tccgtggctg
421 gcatcttagt gcccctgagc tcctgggtgt tgggcccagt ggaatcagta cctggtgtgg
481 cttcagtctc tacctgctcn ggtgcctggg atgtgcctgg cccagcggcc ctctgggtat
541 atggcatggg gcttggntgt gtcgtggggg acatgncctc catctcaggg attgggctcg
601 tccga
<210>7
<211>660
<212>DNA
<213>Homo sapiens
<400>7
1 caaatntaan acccccntnn nanttncccc ccaannggta cttttgtttt acaaaaatta
61 caaaaaatga ctcttaaaaa tagaaatagc ttctcagact cttgggaact acttttaagc
121 aaccaaggag ttagaactca gatggttttc ttctttgtaa cagcaacaat gaccacggct
181 ctgtgccatg gcaatcactg ctgagtgtct tctcctacaa ttacacaggc ccgagctgtg
241 tctggtggaa aggtctccac tcaggtcaga gtctgaagga gcaagatctt ctcattaatg
301 cagaacctgt gcagaaccac catcagattc tctccacagc gggagacctg gcgctccatg
361 gccaggcgaa agtcctcctt cacgcctttg gtgatgcctc gagttacagt gtggtgcctg
421 aggtcagcaa tagggaaaca gacaaagacc aggggttagc accagcatcg ctgatcgctg
481 ctacttgggt aggaataaag cctgccccat atctaagtat aatttcagat attttaaaaa
541 gaaccaagaa tagctgcacc aaccaaacat tccagccatt tctcttcaga agctttaact
601 agacagacat cttctcactc tataaaggta cttcaaacat ttattgtcag taaatgcncc
<210>8
<211>611
<212>DNA
<213>Homo sapiens
<400>8
1 acatttaaga catatttttg tgtttcttaa tgaataaatt atgaaagaat gttaatttaa
61 aattcataat atgtaaaaga atatttagat ttcatttcct ataatcagac acgctgttgt
121 ttttactata taactgttag aagatataaa tctataacat atgcagcata tacataaaaa
181 taatcacaat atttttaaaa gtttctgtta atgtcatgta tcttcttttt ttatccaaaa
241 gaaaacttat tcaaaaaaat gtacccagaa gacacagcct aaggaataca agcaggaaac
301 tgagaaacct gccaacaaca gctaaaggga cacaaacagg tacatgcaaa gttgccagta
361 agcagcattt aaaatgctga ttttcagaaa gagagcagca ggtggagtta agggtttagg
421 ctctggcgtc gactacttag ggacgttggg aaagtttcta ccctctctgt accaagtttt
481 ctctttgtaa aatgggaacc aatccttctt gctttttttt tttttgagac ggatcttgct
541 cggttgccca gccttgagtg cagtggcgca atctcactcg ctgcaacctc cgcctcccgg
601 gttcaatgga t
<210>9
<211>596
<212>DNA
<213>Homo sapiens
<400>9
1 ttcttgtggc aaatttaata gaagaatatg agactcaccc ttacttccca cacataaaac
61 actgcaggca ctccaaatcc ttacagacat atgcacttcg gaatcaactc aggcatgcac
121 agcatccctg tgctggagtt tattttaaaa aacaacgccc cagttatcac agtttctttt
181 tttgtccacc attttccata acaaaagaag ctacacaaaa tttgggggga gatactctct
241 ttggagactg acacatttgc agaggggtca tgaataatga ttccaaagct cctatttaac
301 ttctgaatca ggcaaagaat aagtgacaat ataagaatga attttgttta cagcaatatc
361 ataatacagc attgaatcat tacagtggca gtggttgtaa ttaagtcccc ataaaatatt
421 cttaggcccg aaacaccaga ccaactaaaa tcaccaactg gctcacgaac caaatgatca
481 gtgcaagcag ttgnggtctc catagtgaaa accaaaatgg gtagggcntt tctgggcagt
541 gggtctctga catgaacggt ccctctctgc tcaagangac ttggcgnccc ccttgg
<210>10
<211>607
<212>DNA
<213>Homo sapiens
<400>10
1 ggagaagtct agagtgtttg ctttattcat gttgtttatg cgttaaaata taagcatatt
61 gcatacataa gcatatttac acccacatct aaaagataac atattatata tacttttcca
121 tacttctgaa caagcgtctc atatccataa ctaaaaatta gatgagaaag acaaagaact
181 cttgtcttcg aattgacttc attgcactat atagcatttc acactgcggt tccaggccac
241 agggtccctt gggtaggggg agacaaaggg tgtggctgac agggagactc taggactacc
301 attgccactt ccaccagagc agccacactt ctgttccaca tagttggcat ccaaatttga
361 tttgaaaaac agtttccact tacctaaaag aaaaatccta tgngaaaaat gaccacaagc
421 caattatcca ctcnaacctg ctgatnctgg gccctgggga gaagctgttt tgagaccnca
481 tatttcccta ttacctttac ccatgatggg attatcctac tgtctngggg gcatccccaa
541 cttgagctcc ccagaaaccc ccnggtggtg aggggaaaaa aaaaaccctt ctcccattca
601 cagtggn
<210>11
<211>665
<212>DNA
<213>Homo sapiens
<400>11
1 gtatttttaa aatttttatt gtattttttt tcagaatatt ttccatccac agttggttga
61 acagagtgcc atctgcacct agaatgctgt ctcagcccaa ggtaccttct tcacatcatt
121 catgaagtgc tttaaaccac tccccctcaa gaagcccttt agaacactca gaaaaagatc
181 ctcatctcat aattcttggt ccaaatacaa aactccagac tcctcaatta ctgcatcact
241 aaaattccca ccatttcagt gcatataatt agctttttaa gttatatatt tattattagc
301 ttggtgtttg tgtgtttcca tcagtggtaa caccataaac atgattcttc caattttact
361 acttctgtaa cacagttgca tgtggaaaac ggacattcga taaatttatc ctgacttcac
421 atggccaaat agtaccttac acagccctca gttaaagcca ccagtttata agtaactagt
481 ggaatagcct agaggtgaca aaggaagagt tgggcagcag cattcaacaa acatccgtga
541 atgaaacttg ctcctccatt ccgatatctg ggctgcactg atctaccact ctccggtttc
601 tgcntcgttc tncctgcttg cattagaatc agctcgtgtt aaagtgggcc gaaagacaat
661 tcccc
<210>12
<211>529
<212>DNA
<213>Homo sapiens
<400>12
1 cttgagacta gtggccagtt caaaaattaa tagccgctca ttaacaattt ttgggacggg
61 agacacccta aaagccatca caatgactgc taatagtggt tttgtcagag ctgcaaacaa
121 ccagggtgtt aaatttagtg tgtttatcca tcagcccaga gcacttactg agagtaaaga
181 ggctctagcc acccccttac caaaagacta cacaactgac agtgaacact aaagataccc
241 tttaaatatt tttgtggaag taagttattt ataccaaagg ctgggtcttc ccatctaaac
301 tggtgggaaa aaaggtctat agtaaaagta aaactgagaa ctcttaaacc agtagagttt
361 ctttgtctct catctaaagt atataacctc ccaaagtaga aaaagcacaa gagagaagct
421 tatctatcaa actgtctgca ttagtgcaat taagaaccga aatacgtcta tataaagctt
481 tcagctgtat tgtaatactt tgattcgata gggctacaac ttccctact
<210>13
<211>480
<212>DNA
<213>Homo sapiens
<400>13
1 tttcaaattt ttaatgtacc aatttattgc atatgtcagt acagaaaaat agaaagtata
61 ttttaaaaga aatttattgt aaaaaacaaa tgtaaatgtt tgcttgccat ggttagcaca
121 caatgtacta tgacattcaa atttgagtta taaaatttta tcacttcaaa taaaatatgg
181 caaataacaa aaatatgatt tacattatga aatgggatta acttatttta tactgaacat
241 acttgaatat gttaaaaaca acttgaattt tccatatacg ctgtactgac agaaataatt
301 ataaattatg ttaaacacac actcacctgt tacatatgta tatacggcac tttttgtaaa
361 aaagtgtctc atacatggtc ctatttttaa actacatttt aagatacaaa atataaatgg
421 aggtatattt gcgccatttg gcaaaaatgt atagactagt attaagatga ctgcatttat
<210>14
<211>551
<212>DNA
<213>Homo sapiens
<400>14
1 tttgatatca aaatgcatct tgtttatttg gtttttgaaa ctgttataac acaacttata
61 acattggaaa tacattattt tattaataca aagtagtttt catagtaaaa taccaaatta
121 attaaaaggc agaatgaaac gtaccatata catgtagacg acaaatgaaa actgtcaaag
181 tatccttctc tctaaaaagc cacaaattac attctttgaa gtaagtattg ggttttattt
241 cctaaactat acacatcaat atcacctcct gaagcttttt acccagtttc acggttggta
301 tttcggacat gcaatgttcc atgctgtcaa acttggaatg cctcgtttgg atacagggag
361 acaaagactt ggagacccag aagcctgaaa gtggttcttg accgactttg tccactcaaa
421 ttaaggcatc atgcagctgg tcatcactta cattgctggt tgcacgcagg cacacacaca
481 ccagtgctca cagccagcac ttgttaagaa tggttgagct ggaccaaatg gtatacgtgt
541 ctttcatcaa t
<210>15
<211>534
<212>DNA
<213>Homo sapiens
<400>15
1 gccgacagtc cctccttgtc tgtctccggg attcaggcct ccctccctga catggagagt
61 aacctgtctg gcctggtgcc tgctgccggg ctggtgcctg cgctgccacc tgctgtgacc
121 ctggggctga cagctgccta caccaccctg tatgccctgc tcttcttctc cgtctatgcc
181 cagctctggc tggtgcttct gtatgggcac aagcgtctca gctatcagac ggtgttcctg
241 gccctctgtc tgctctgggc cgccttgcgt accaccctct tctccttcta cttccgagat
301 actccccgcg ccaaccgcct ggggcccttg cccttctggc ttctctactg ctgccccgtc
361 tgcctgcagt tcttcacctt gacgcttatg aacctctact ttgcccaggt ggtgttcaag
421 gccaaggtga agcgtcggcc ggagatgagc cgaggcttgc tcgctgtcag aggggccttt
481 gtgggggcct cgctgctctt tctgctggtg aacgtgctgt gtgctgtgct ctcc
<210>16
<211>627
<212>DNA
<213>Homo sapiens
<400>16
1 ttttttttta aaaattattt tatttatgta tgcattttat aagcaactga ttaatttaaa
61 ctgaaaaatg atgaagtaaa ggcctacagc tctaagaatc atttctaggc tgggcgtggt
121 ggctcacacc tgcaatccca gcacttgggg aggctgaggc aggtggatca aactgaggtc
181 aggagttcga gaccagcata ttttcttcca aagccatcat atatatatat atatatatat
241 atatatagat acgaggaaac aganagagat acaaaagtgc atagatgtat atatagagtg
301 taaggtaatc agggatatat tgattcaggt gggacatgtt gcgaaagagc ggttgttgtg
361 aggtgagggt ggtggcgcgc gatggattcc tggagtgttt acttatccgt gcccgagacg
421 cccatgccgt gtttgtgtac ctggtccccg gggtcccaac cactttgccg tgggacgcca
481 ggagtaacgc ctgatgtcgg aagaatagat gtgtgttgtt gtggtagtgt tgtgttgggt
541 gacgtgagag aggtgctgag gcgcatacgt agtaatatag gctggaagag agtaccttgt
601 gagaagtgtg agcggagacg cctagta
<210>17
<211>537
<212>DNA
<213>Homo sapiens
<400>17
1 catgtttttc ttttaataag ggtttttact caaaagtgta gctttgaaaa tctctagctt
61 gttgtgaaaa ccaggaaagc caaggagctg cctcacactg cacaccacca cgtgaagctg
121 tgggccgctg tgtgtttgca aactctccat taccaaggct ggaatcaaat gcaccacttt
181 aaaatcagag ccaacattta aaattaggag gatgatgcat gtcctacttt gattcaagga
241 gaaaggacaa gttcttagta cagtaaaaca aaacacaaaa gtaaacaaat ctttagaaat
301 cactatatat atgtgtgttt atatatatat ttttatataa ttaggattat catcatttca
361 aactattaaa aataaggttg ccaccttacc ttttcttttg gtaatggggt gttatttttt
421 ttaagagaaa aaaccaaaca ttttgcccag actctagagt tcccaacttc aattctgttt
481 tctgctgtgc acttccccac cttcacgctg tatcccaagt ccgccaccat tctggct
<210>18
<211>485
<212>DNA
<213>Homo sapiens
<400>18
1 tatttcaact tttattaaac caaatccagt aacttttaca atgccttact agagggttgc
61 ctcataactg aaccttcatt tctggcaggg aagaaaccat ggcttcagga tcatgactga
121 agtttggcca tgttccatca ttaatgttcc aacatcacca gggacacaaa gctgcaaaaa
181 tgagaaggga aataaggtta gagaaaggat ctgggcaatc ttaaggactg aggaagacat
241 gttccccaac ccttgaactc acaaaccctg aagctcaagg attgcatcct tcctccaaat
301 ctcactcaac ataataagtg cagaacaaca tgccaaagca ctgtatgaag cactagggac
361 aaagacaagg tcaaaatcct tgtaaccaaa tttaatggta ttgtaatgca gtgttaacac
421 aggacagtaa cagaacaccc agaaccaaan cagagagggt agggataagc taaatgaact
481 cgtgg
<210>19
<211>611
<212>DNA
<213>Homo sapiens
<400>19
1 tttttttttt caacttaacc atactttatt tgactgcatc ttatttagac agcttgcaca
61 tttcaaatcc cattaaatct ctctccaaaa ggatatggga caatagaaga aaattatgca
121 gcaatatcca gtcaaacagc agtccaatat tttgagatac acgtgatatt ttatagatac
181 tcaactcata tctgacgtca atataattta tggttatgtt tttacaaacc tgaaagccct
241 gtaacattac agcactcatt ttagtgatgt catggtgcac tgaaaagtaa ctctgatgta
301 ctaccaattt gattttatct atactcctga aaagtgatga acttcatgat ttttagacac
361 cataataaat atacacatcc agtcttagac atgtcagcca gtaccataac acagggcaag
421 gtaaagttaa aacatgaaaa aacaaactgc tttacataga tttgtcgagc aagtgggaag
481 ggtaatttgg gaaagaggca gaaaatatta taatcgattn ttgtattttc cttaatttgg
541 ctggttcaac ttcataaact accggtctgg gttctgatct gtggacttgg ctaagtagtt
601 catcccaatg a
<210>20
<211>477
<212>DNA
<213>Homo sapiens
<400>20
1 cctcagaaac attttattga caacagttcc caacagagtc tttggggtct ttaagtggca
61 ggtgcagcgt ccacaggcag agtgagggct cctgaggaac ctcaccccaa attccctaac
121 cggccgagga cgcgacccca ggcccctctc aggtgggcat ggcagtcccg gcagcacccc
181 ctctgagcag cctgctgtgg ggaagaagcc gggccgggag cctccagtcg tggtgccagc
241 ccagctcatg ctccccgccc cgaggccccc agcctgtggg aagcccctgc ctgtaatgga
301 cagctcgtga agacacagga acagtggtgg gggtgagggt ctaggaatga ggcagagggt
361 ggctgagcac acacctgact ccctggaggg tcgcttcaaa gacatgggag gcgagggcac
421 tggggaggct gggatgaaca accgactcca tgcacctcaa cgctctcatc aaagagg
<210>21
<211>449
<212>DNA
<213>Homo sapiens
<400>21
1 tttaggatga atgactgaat ttaatgatga actttgagaa ggatagacta gtaaattctg
61 ttcttggacc tgagtacagt ctgggagaaa cataatgtag caggaggtct tatgaaagag
121 agttaggcat tccagttgac tgagttcact gtgggatgtg acaagccact tcccaaatca
181 gtgctgggaa catggcactg tgcttcacct gccaatcaga atgcccctgg agaattgtat
241 tctcctcagg gcattgcttt aagagcacta cgtgttcagg aaacaaccag agaaaaccac
301 cgtcaatgag cactgactgt aaagactgac gttaataaac cagaaaaaac tcaggaaagt
361 gggtgagggt gtgacattgc cttcaaattc ctgaggggct gtcacttgag gagacattat
421 tttggaaggc tccagtaagc ctatggaaa
<210>22
<211>516
<212>DNA
<213>Homo sapiens
<400>22
1 cctttttctc tttggatggg agaagggagg atctgggaaa atcttatggt tctaagattt
61 atctccatta acaacgttta gaagtaaagt acaggagtta aggatgtatg actgttctta
121 acttataact ctacttataa aattctatga aaagaactgt caaaatatat aatactacgc
181 agatataata ctatacagac atcatcaaat aaacataata ctatacagga ctattacaaa
241 aaggctaacc aaccaaatat tttacttctt ggtatcaaaa ccagaagaaa ggggcttaga
301 ttatggagag aataatgtaa gttgaacata tggacaggtt attcacataa aagacatatt
361 aaatgcctac tgtgaaacag agcactagat ttcgtgaatg caaagatgag taagacgttg
421 tccctgtcct caggaaactc ctgtgacaac gcagtaatac agcaaggtat aaggagcaca
481 cagccggctt gcctagtagc tgtgtggccc ctctaa
<210>23
<211>493
<212>DNA
<213>Homo sapiens
<400>23
1 aatattgaat aagtaatttt atttccatga tctatttaca ctgtacaaag actgttgaaa
61 agcaccctac aagttcacag tacattacaa tatatttact ttaaaaatat attcctttat
121 aaaaggttta taagaacatt ggcatgtcaa catgtgacaa aactctcaaa gcatgtcacc
181 aattctgtga gagcaagaat gcatccaagt gttatcaatt tcacaatcac aagtcaccag
241 ttgagtttta aatacataca tgttttaaat aaaaaagaat tctatagtgg aaagttcttg
301 aggcaatact tattagttca ttaacgtatg cattttcatg gagatgtggc ataataaccc
361 acaatatcaa cttaatctgt ccaaagaaac atttcaacaa gtttagcagt acagaaattc
421 tggtcatttg tttctacttt ttcttctttg ctggttctcc tggctctact ttgcgctttt
481 tagaagtatg ctc
<210>24
<211>494
<212>DNA
<213>Homo sapiens
<400>24
1 tttgcaaatc ttttatattt ccagctgttg agacagtatt tttgagggct gatgttacct
61 ctagcggcga aaccagagcc agctattaag cagccagaaa gctacagtaa ttgaatacat
121 gaccatttct cttttagcac gttctttgtt ctcctcttcc agaagttgta gacgtctatt
181 tagtttgatt atctgtcgtc ttagtgaagc tgcatctaca acagtcaggt catctgacgt
241 tccttcaatg gttgtatcta tatttgaaat gccatacaga gaatcatttc tgaccagctg
301 tccattttgg cgaacagcat tttcactcat agaccgctct ctttttagtc tgccaactgc
361 tcggatttct tcattttgag gggttgtagg aggtctttct aaatccagaa aatctagtgg
421 tctttcactc agtgtaagta cacgaggtgg tgttttcagt gccaggggtt taaagggagt
481 tgactgaata aggt
<210>25
<211>439
<212>DNA
<213>Homo sapiens
<400>25
1 tttttttttt atatctcttt gttaagttta ttaatgtata cgtttttcaa ataaacattt
61 tgaacagccc aaatcaatca aagccatgag atcacaaagt gttgcttctc gacacaacat
121 tagcttgttc agaaaatcca aaagccacat ccaaagatca atgatgctac cttaaagaca
181 tgagggaggc tccttaagac cctagagaca ccaaggaccc cacagggcca gtcatatgaa
241 caggctcaga agccggcttg atcctcagca cctctgcaaa gccatcacca aaccagcaag
301 tgacatgcgc tatgtctaca gtaaagtaga aaaggcggtc ctggcaaagc ttccggcggt
361 acacagaccg aggatccgct gacagcacag cctcaatggc acgctttgct tcctctgctg
421 actgaaaata tttaaatga
<210>26
<211>571
<212>DNA
<213>Homo sapiens
<400>26
1 gcatatacat acaggtttat ttaaatgatt ggatctacac ttttggaggc tatttgaagt
61 atcttatcaa aataaaacgc attttaagca agaagttaaa aaagcttttc agacccgaag
121 gccatttaat acagtaaatc ttacttgggt agtttagcaa acatttttta aaacccacat
181 ccaacagatt ggttagtatt agatacacag atttggtttc aaagctgaaa tacccctggt
241 ggaataaatc ttctcatgaa attcagttat attatgccac aaaacaggga cacttatcta
301 ttgacaactt aaatattaac tcagtgggct acctggtgat ataaatagga aaaaaacagt
361 ggtcatggat taggagtgag aagactatga caccagccta ccttggactg ggaccgcaaa
421 ggatgttaaa atctatccta gaatttaaaa caggagaaat gtcaaatatt ccagtctcca
481 ttcggctcaa gccatcgccc aaggaataca cccccacccc agccccacat gaggtttact
541 aaccagctgc tacagatgtt actatgtcac t
<210>27
<211>447
<212>DNA
<213>Homo sapiens
<400>27
1 taaattattt ggacattgat agctctgcaa aatacttctc ccatcccaaa ccctcaaact
61 ccttccacat gtcctccata aagaaacaaa atatttatac tttgtgccca ttcaagtcta
121 atttttaaaa acatttaaga ttcaaaatca aatattattt ttctttccca caacttgtta
181 gtaattttaa accacgatac aacacagtta atggcatttc tttttaaaaa ttagcttatc
241 agactatttt atgagaaaaa aatcaattca aggccttagt gagaatatta tattctctgt
301 ttctgaaagc aaaagacatt gaaaaacccc tttgctcctc tggagtttgt gatttccaca
361 taaccaacaa aaccagcaca cagattgact tcctacttaa cagtaggtat tgttttgtta
421 ctttgggaca gcagctgaaa cactatc
<210>28
<211>165
<212>DNA
<213>Homo sapiens
<400>28
1 tttttttttt tttttttatt ttgttctgtt ttatttggta gagcaagtga tcaaagtgaa
61 gcttgagtga ttggcgccgt tggcctggcc atgggtagat cccagcatgt cccgcctccc
121 actgcagctc cgtttctcgg tcacggatga gacaggtggc ctgag
<210>29
<211>529
<212>DNA
<213>Homo sapiens
<400>29
1 tttttgccaa taaagaatat tcttttcttt attattatag ttcccattaa gctagcaaat
61 gcttgttttg tagttcttcc tgtaaaaatt taccccaagt attaacaaag tatttgatag
121 atgaaaaaat ttattaaagt tgaatcttca aacctaaatc tctacacaaa aggaaaaact
181 tcactattaa ataacatgct cccaaggaga ttcttatata taaactgctc cacaaatgac
241 caagtatctc tttgagataa atgaagcagt aataacccaa aattctttgc aatgtttagc
301 agtatgagcc gatactacct gaagatcata tggattgtta aggggattag gacttttccg
361 aggaaggcaa taaacaaatt ctccatcatc ttccaaaggt ttctttaaag taatcttctg
421 aattgcaatt ttggagcttc cgtatttcaa actgtgctgc ggtaatatag tttgccaacc
481 aagcttttct cgtagcctaa taatatttct tatcacatca tcatctttt
<210>30
<211>811
<212>DNA
<213>Homo sapiens
<400>30
1 tttttttttt tttttttttt tttggggnca tatttttgtt cactgaaagg accaaccagt
61 ttcatcaaac aagctttaga gaaagagaaa ctgagtaatt catcttgtca gttacagttc
121 acatatatgc acacacatac aaactggctc agcatcagtg aaacataact attcaaatac
181 aaaagtataa aaaacctctt taaaaaacca atagcagcca aaacagaaca tttgtaaaca
241 aaaccacaac tatcagccct gtgcttaaac acagaatctg cattcttttg aaacattaag
301 tatatgcaat aaagagaata tagaccatct ttttccttaa tatacaatac ccaatatcta
361 aaacaatgtc accaataata gacacaaatc ggtgttatca taaggcatgt tgaacagtct
421 ttttcacagt actcaggggc atcatgttgc tgcagaggcc acactttcca gaagttttct
481 cctcgctgtg atcctcgcac accgggggca ctcggaggac tggaagcact gtttgtgaaa
541 gcaagccctg cacgctgaac atcttctaca tgttgctgtc tgaaatggga agatgacagt
601 cgtattctgg caaaattcac aaataaagcc ctttccttga cacagctcac agccagccac
661 atgtgcaagg gaagctttca gaatgtcctt gagtaaaggt gccagcagcc ctttcttgat
721 cctgaccagg tcctaaggga ggacaggtgg agtcatcagt caagtgtccc ggcacctgct
781 cgaactcctt taatgcactg gtagcaaacc t
<210>31
<211>488
<212>DNA
<213>Homo sapiens
<400>31
1 tttttcacta ttcaacatgt cttcgtatta tcttccttcc tctcgtatct gatagacaaa
61 gaatgatata aaattttggt tgaaaaaagc cagttgattg ggatgactag aaatgttaac
121 tttttcagta aaaagctttc accgaatcac tgggcagtta gtaatgcagc ttacaaataa
181 ataaagctga ggcgagaggt ttaaacagca agaaaagctg cagagcatat tgaggaaggg
241 aagcagtgaa atggtggttt taatacatcc caaactggaa gcaagaaccc taacacaaag
301 aggattggaa tactctacca tctgtaagga agtagctagc tacaagccac ctcacacaaa
361 acacccacta aggcctttca ccgagatcct cttgttatat tctcattatg aatccccagc
421 aggtgcacct caataaatag gtgtggagta tactgctgag gacctctagg tcacctaagc
481 agaaactg
<210>32
<211>576
<212>DNA
<213>Homo sapiens
<400>32
1 cttacatttc ttatacaaat aacagaatgc ttcattttat tcacttcaat aggacaaagt
61 ccttaaagaa agactgaaaa gagctgataa tcaaaatccc aaattttatg cttatttttg
121 ttttagtgct atcaattttc tgacatatta acataggcag gaaaacattc tcagtaaatt
181 gagcatttga gtctacaaat gtcttgaagc actctggcaa gttacatgta tcccatgttg
241 cttttggttt cccatctctt ctttgcttca aacccccatg caagtttctt cttttttcgg
301 gcagcctgtg aattttcaac ctcctttttg gcttttacaa agttgtggca ggcaactgct
361 ttggcaattt ttacaccaag ctctcgagta gctagctggt tgctgagttc ctcagccttc
421 tcaatattcc actcctccac agcctggtct atcctctttt caaggcctga ctagaaaaaa
481 aagaaaccta aaattaaggg ctggaaggaa agcaaacatt tgctagccaa gaccatgtca
541 cagaattata ctgaatgtgt tacacaagta gaccat
<210>33
<211>1005
<212>DNA
<213>Homo sapiens
<400>33
1 tctgcccgct gtgtcctggg catggagggt cagcaggtca tcctgcacct gcccctatcc
61 cagaaggggc ccttctggac atgggagcct agtgcccctc gaactctgct ccaggtccta
121 caggatccag ccctgaaaga cctcgtcctc acctgcccca ccctgccctg gcattccctg
181 atcctgcggc cccagtatga gatccaagcc atcatgcaca tcttctcaag tcttaggatt
241 gcagcaacac gctcggctgc ccaaacccaa ggcgaagacc ttgccagagt tcatcaagga
301 tggctccagt acgtacagca agattcctgc ccacaggaag ggccacaggc ccgctaagcc
361 ccaaaggcag gatctagatg atgatgaaca tgattatgaa gaaatacttg agcaatttca
421 gaaaaccatc taagtgctgg aggaaccacg cttcctaact gctgcttctc agggaatccg
481 acaccagcca accattttaa gcctctaaaa gacctcgggc aagtctcaca gaaactgagc
541 tgcagacggg gagtagcttt gtggaaactg atttgatgga cactgcacca gcttccttca
601 ggttctagat tcttgctact tagggcgggc tggtttggac ctaacatctc gcacgtgact
661 ccctcagcct cagagccttg ggatgcagag cagctggcag ggttcctctc aatcctgcaa
721 ccccagctgt cccaccggtg gatgcagagg ggaatccgag gccatcaacc ttggtgacag
781 cagcgcagtg ccaatgctga tcacactgca tgggagattt tgttaacgtc tgccaccccc
841 actctcaccc ccaagctcta agcccccggg aggcctggac tgtcttcctc atctctgtag
901 caccaagcct gatagatctg tatatggtaa acaggggttt aaccacatgt ggttaacatg
961 gattaatgtg ggaatttggc ttcaagaaca caaccttagg acctt
<210>34
<211>483
<212>DNA
<213>Homo sapiens
<400>34
1 ggcacgaggg gctcaaagag aagtataaga ctaggtcttt atatttgtaa gttacttaca
61 ctctagatat caaacgaaat gtaactcaca tgaagtgctt caatgttgaa tagtgaggaa
121 cgcacagcgg aaacatattc ttgcagccca tcagatcatc cacagttaca cggaaagcat
181 ggttcaaaag aaattaactg agggagagca agatgaggcc tcaaatgctg ccatgttact
241 tgagaaagaa actcaaaatg agaacaacag ctaagattgt gatttttttg caaaagaagc
301 tgtacgaatc atcataaata attccaatag tctgcacttc tcccaaggtg tgcactgctc
361 ataaacttgc cagtgtgtga ttcatgagaa aggagattta ttttccttaa acatccaata
421 atttaaaatg attttcaata ataataatca aatgaaaaaa aaaaaaaaaa aaaaaaaaaa
481 aaa
<210>35
<211>644
<212>DNA
<213>Homo sapiens
<400>35
1 gcgcgggcgg ctggggaatg gctgctgcca tggtgccggg gcgcagcgag agctgggagc
61 gcggggagcc tggccgcccg gccctgtact tctgcgggag cattcgcggc ggacgcgagg
121 acaggacgct gtacgagcgg atcgtgtctc ggctgcggcg attcgggaca gtgctcaccg
181 agcacgtggc ggccgccgag ctgggcgcgc gcggggaaga ggctgctggg ggtgacaggc
241 tcatccatga gcaggacctg gagtggctgc agcaggcgga cgtggtcgtg gcagaagtga
301 cacagccatc cttgggtgta ggctatgagc tgggccgggc cgtggccttt aacaagcgga
361 tcctgtgcct gttccgcccg cagtctggcc gcgtgctttc ggccatgatc cggggagcag
421 cagatggctc tcggttccag gtgtgggact atgaggaggg agaggtggag gccctgctgg
481 atcgatactt cgaggctgat cctccagggc aggtggctgc ctcccctgac ccaaccactt
541 gacttaatct cactttctta aattcttcta ttctcagaca ctgctctagt accattcctt
601 cctcttagcc ccaggagcaa attaaaaggt acagttaaaa tcct
<210>36
<211>1434
<212>DNA
<213>Homo sapiens
<400>36
1 cctcgtgcca tgagcattta gaaatggaga ccacttctgg tgaattgtca gatgtttcca
61 atgatcccac cacatctgtc tgtgtagcta gtgccccaac aaaagaagca attgacaata
121 ccctgcttga acacaaagaa agaagtgaga atataaatct taatgaaaag caaattcctt
181 ttcaggtgcc taatattgaa aggaacttta gacagtcaca gcctaaatcc tatctttgcc
241 attatgaact ggctgaggcc cttccacaag gaaagatgaa tgagacacca actgagtggc
301 tgcgttataa ttcaggaatc cttaacacac aaccaccatt accattcaaa gaagcacatg
361 tcagtggtca tacttttgta acagctgagc aaatcctggc tccattagct ttaccagagc
421 aagcattatt gatcccacta gaaaaccatg acaaattcaa aaatgtacca tgtgaggtct
481 accagcacat tctgcagcca aacatgctgg ccaacaaggt taaatttacc tttcctccag
541 ctgccctccc accccctagc acacctctgc agcctttgcc tttgcagcag tccttatgtt
601 ctacctctgt aaccactatc catcacactg ttttgcagca gcacgctgca gctgctgcag
661 ctgcagctgc agccgcagct gcaggaacct ttaaagtgct tcagccacac caacagtttc
721 tttcccaaat cccagctctc accagaacct cattacctca gctctcagta ggaccagtag
781 gaccgaggct ttgtcctggg aaccagccaa cttttgttgc tcctcctcag atgccaatca
841 ttccagcttc cgttcttcat cctagccatc tggctttccc atctttaccc catgcactct
901 ttccttcact gctttcccca caccctactg tcatcccttt gcaacctctc ttctagtcat
961 caccataatg ggaaaaaaat actcttgtga aaactattgc tatatgcgtt aagtgttcat
1021 ctatgtgggt acatggctat ttaactggtg gaaataaact ggccgataca tggcgtcatt
1081 ggtttgaaat catttactgt aagtgcaatg atgcaaataa atccctaagt ttctgatata
1141 taatattatt aaagcactga atagtttgaa aatcaataca atatatgcta tatattaaaa
1201 tgatgtctta agagtatgta taatgtacat aaaatatatt tatagtactc taatttatgt
1261 tgtaaagtat gctcccttgg tttttcttaa tctttgtgta tttgcaccta tttaatgttt
1321 agacaaagct gatggcacta tgttttgtat catgttcctt gaaactgtaa attcagtgaa
1401 aaatatctct tgcaataaat ttttgttaac tatttaaaaa aaaaaaaaaa aaaa
<210>37
<211>1640
<212>DNA
<213>Homo sapiens
<400>37
1 gggctgcgtg cggcgggaat catggctgct cgcagagctc tgcacttcgt attcaaagtg
61 ggaaaccgct tccagacggc gcgtttctat cgggacgtcc tggggatgaa ggttctgcgg
121 catgaggaat ttgaagaagg ctgcaaagct gcctgtaatg ggccttatga tgggaaatgg
181 agtaaaacaa tggtgggatt tgggcctgag gatgatcatt ttgtcgcaga actgacttac
241 aattatggcg tcggagacta caagcttggc aatgacttta tgggaatcac gctcgcttct
301 agccaggctg tcagcaacgc caggaagctg gagtggccac tgacggaagt tgcagaaggt
361 gtttttgaaa ccgaggcccc gggaggatat aagttctatt tgcagaatcg cagtctgcct
421 cagtcagatc ctgtattaaa agtaactcta gcagtgtctg atcttcaaaa gtccttgaac
481 tactggtgta atctactggg aatgaaaatt tatgaaaaag atgaagaaaa gcaaagggct
541 ttgctgggct atgctgataa ccagtgtaag ctggagctac agggcgtcaa gggtggggtg
601 gaccatgcag cagcttttgg aagaattgcc ttctcttgcc cccagaaaga gttgccagac
661 ttagaagact tgatgaaaag ggagaaccag aagattctga ctcccctggt gagcctggac
721 accccaggga aagcaacagt acaggtggtc attctggccg accctgacgg acatgaaatt
781 tgctttgtcg gggatgaagc atttcgagaa ctttctaaga tggatccaga gggaagcaaa
841 ttgttggatg atgcaatggc agcagataaa agtgacgagt ggtttgccaa acacaataaa
901 cccaaagctt caggttaacg gaagacatga tgcagagcaa gcctctgtga ttcctgccca
961 gcacctgtga ggcctgacgt gtcagttccc aataaatgct cttctgattt gtttcccgta
1021 caggcaagga ggcttgggta gtgcagattt gtgtatttca atctttgaaa gctctgatgt
1081 aatttagaaa tgaaatccaa tcatgagtcc aggtagagaa cgcctgctgt aatctacact
1141 gttgctggga ctgcgcattc tgtatataac tgtgttggat gagtgacaga tgattgtcca
1201 gactaggaca gcggcatgaa catgactttg gttgggattg cggatagtta gggttacctc
1261 tgaatcgtgt agcttttatg agagcagctg tgcaagtgaa tccacattaa tgccttgtcg
1321 tggtgccatt cccagcgcct gacgatacgc tcttctattg tcttattctg gcaggttttg
1401 acgttttaaa ttttttaaag aaattttatt ccttggacca aaaggtttgg ttaaccaccc
1441 ccctcttact tgctttcaca ttttgagtgt ccagaggaaa cagaaaggaa tgagtgtgtg
1501 acgttgctgc acgcctgact ctgtgcgagc ttctttctgt gtatatattt tgttttattt
1561 ttttccgtgt atatttttaa tcccgacaga acatcatgtg agatttcttt aaaatggatt
1621 aaacgatttc ttcagccg
<210>38
<211>1428
<212>DNA
<213>Homo sapiens
<400>38
1 agcggcctcc ggtgtgggat ggccgcggag ccgggcggag ctggcttgcg gctcccgggg
61 ccggctctcc ggccggagac atggcccggg ggcccggccc gctaggcagg cctcgccccg
121 atacggtcgc catgcccaag agaggaaagc gactcaagtt ccgggcccac gacgcctgct
181 ccggccgagt gaccgtggcg gattacgcca actcggatcc ggcggtcgtg aggtctggac
241 gagtcaagaa agccgtagcc aacgctgttc agcaggaagt aaaatctctt tgtggcttgg
301 aagcctctca ggttcctgca gaggaagctc tttctggggc tggtgagccc tgtgacatca
361 tcgacagcag tgatgagatg gatgcccagg aggaaagcat ccatgagaga actgtctcca
421 gaaaaaagaa aagcaagaga cacaaagaac tggacggggc tggaggagaa gagtatccca
481 tggatatttg gctattgctg gcctcctata tccgtcctga ggacattgtg aatttttccc
541 tgatttgtaa gaatgcctgg actgtcactt gcactgctgc cttttggacc aggttgtacc
601 gaaggcacta cacgctggat gcttccctgc ctttgcgtct gcgaccagag tcaatggaga
661 agctgcgctg tctccgggct tgtgtgatcc gatctctgta ccatatgtat gagccatttg
721 ctgctcgaat ctccaagaat ccagccattc cagaaagcac ccccagcaca ttaaagaatt
781 ccaaatgctt acttttctgg tgcagaaaga ttgttgggaa cagacaggaa ccaatgtggg
841 aattcaactt caagttcaaa aaacagtccc ctaggttaaa gagcaagtgt acaggaggat
901 tgcagcctcc cgttcagtac gaagatgttc ataccaatcc agaccaggac tgctgcctac
961 tgcaggtcac caccctcaat ttcatcttta ttccgattgt catgggaatg atatttactc
1021 tgtttactat caatgtgagc acggacatgc ggcatcatcg agtgagactg gtgttccaag
1081 attcccctgt ccatggtggt cggaaactgc gcagtgaaca gggtgtgcaa gtcatcctgg
1141 acccagtgca cagcgttcgg ctctttgact ggtggcatcc tcagtaccca ttctccctga
1201 gagcgtagtt actgcttccc atcccttggg ggcagcctcg agtgtagtcc attagtaatc
1261 agattccagt ttggacaggg tggctggatt gtatatctcg ttagtaatgt acatgctctt
1321 caggttctag ggctcctgtt aggggaggga gaaatgttga atcaagaggg aaaacaacta
1401 ctatgattta taaacatatt ttaatgtaaa aaaaaaaaaa aaaaaaaa
<210>39
<211>855
<212>DNA
<213>Homo sapiens
<400>39
1 ggcacgaggg ggaagctgaa gcagttcgat gcctacccca agactttgga ggacttccgg
61 gtcaagacct gcgggggcgc caccgtgacc attgtcagtg gccttctcat gctgctatgg
121 tgctgaggca gaagatatca agtgctgtaa cacctgtgaa gatgtgcggg aggcatatcg
181 ccgtagaggc tgggccttca agaacccaga tactattgag cagtgccggc gagagggctt
241 cagccagaag atgcaggagc agaagaatga aggctgccag gtgtatggct tcttggaagt
301 caataaggtg gccggaaact tccactttgc ccctgggaag agcttccagc agtcccatgt
361 gcacgtccat gacttgcaga gctttggcct tgacaacatc aacatgaccc actacatcca
421 gcacctgtca tttggggagg actatccagg cattgtgaac cccctggacc acaccaatgt
481 cactgcgccc caagcctcca tgatgttcca gtactttgtg aaggtggtgc ccactgtgta
541 catgaaggtg gacggagagg tactgaggac aaatcagttc tctgtgacca gacatgagaa
601 ggttgccaat gggctgttgg gcgaccaagg ccttcccgga gtcttcgctc atctaccact
661 cagcacgagc catccagaag aaaattgatc tagggaagac aacgtagtca ccctcggtgc
721 ttcctctgtc tcctctttct ccctggcctg tggttgtccc ccagcctctg ccaccctcca
781 cctcctcggt cagccccagc cccaggttga taaatctatt gattgattgt gatagtaaaa
841 aaaaaaaaaa aaaaa
<210>40
<211>587
<212>DNA
<213>Homo sapiens
<400>40
1 gggatgagtg gaggatggga tgagtggagg atgggatgag tggcgttggc tgcagatttg
61 tggtgcgttc tgagccgtct gtcctgcgcc aagatgcttc aaagtattat taaaaacata
121 tggatcccca tgaagcccta ctacaccaaa gtttaccagg agatttggat aggaatgggg
181 ctgatgggct tcatcgttta taaaatccgg gctgctgata aaagaagtaa ggctttgaaa
241 gcttcagcgc ctgctcctgg tcatcactaa ccagatttac ttggagtaca tgtgaaagaa
301 aacgtcagtc tgcctgtaaa tttcagcaag ccgtgttaga tggggagcgt ggaacgtcac
361 tgtacacttg tataagtacc gtttacttca tggcatgaat aaatggatct gtgagatgca
421 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
481 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
541 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
<210>41
<211>437
<212>DNA
<213>Homo sapiens
<400>41
1 ggattcactg ttacttcctc tttattcctg cagtgaaaac aatattttct tatgtcagat
61 ttctctcaat ctcttagtca atgaagacct gaactacaac aatatagagt cccattttaa
121 attcaaacaa agatatttag gtttgacaac agactcatgg taatgtcatt taaaaagatg
181 gatccaatga acacagacaa acatcaaagt tttcaccatg gcacaaacct ctgccacaat
241 cactcataat aattcaactg ccttcatatt tggcagtaac gtcatgcaag tgaatttgct
301 gatgattagc aaaatggcaa aatgaaagtc aaggtcactt aatcaagaat tacagcaaca
361 aagaaattct aggaatgcag gtcaaggcaa gaggctgcag ctggcctgat aatgatacca
421 cttgcctaat gttcatt
<210>42
<211>710
<212>DNA
<213>Homo sapiens
<400>42
1 tttttttttt tttttattct aaaatacaac gtttattaaa aaaacatgcg atcttgccaa
61 taggccaatt ccatgagaac aaaagatttt ttttcccacc tacaagtctt tttagagaaa
121 caaacggaac tatttccaga tgaggcgggg tgtctgggag gggctgtggg tggtctgggg
181 ctggtgactg gtgaggttgg gtggccctct gggggtccgg gaggcacttt ccgttttgct
241 tctgttggag atgttcccgt cggatgctga agaacaagcc tgccggctgg gccactccga
301 cctgggctgt ggcacccgtg tggccctcgg ccctcctggc ctgccgttcc ccagggccgt
361 caccgccgat agcggtagcg cttgaagtga aaccacagct ggaagatgcc gttggcaaac
421 tggcagcgga agccgtggcg gtgcgagtat tcccactcgc gggtgacgat cttgaaagcg
481 atgtcctcgt agggcggccc cgcgtggaag cgcacgatgg cgaaatcctt gttgtcggcg
541 caggccttca agaagtactc tggcgtggag cgcttgtcga taagtctggg gtaaagaagt
601 gaacttgtat ccatggacga acttgggcgg aggttggtaa aatcgaaatg cgtctggttg
661 accttggtcc actcgaaacc cgtgtgcacc ccgttgaaag agcgccgctt
<210>43
<211>388
<212>DNA
<213>Homo sapiens
<400>43
1 tttttttttt ttaaaaatga tggtttatta ttaaaatgat cttacaatgt caacatcaat
61 gttaataaaa atatataata ggctgaattc atcaatgata gaataagttg taattcactt
121 ggaggttcca tctttcaaag taagcctttc atagataaat gaaaatcctt tattttgtag
181 aattttaaag attgttaaag gctgggtcaa ggcaaagcca cctctattag aaggggaaag
241 aaaagcaaga tgaaacaaaa tatgttatca tacatatcgc gtgtgctatg agcatctttc
301 tactcctgcc agattgaaaa ttctaggttt caacattctt caggatttaa caagtcaaaa
361 taaaagcaga attcaaatct agacagat
<210>44
<211>433
<212>DNA
<213>Homo sapiens
<400>44
1 agaaagctgt agcaggagct ccagaaaatt tgcacgtgca gcccccagca gttcaacaga
61 ctgcacgtct ttggaaaagt ctttgaagat atttgtaaca gttctttgat atttggtgat
121 ctcttgaaaa aagttaagga tgaatatgaa ctctacatgg caacgctcct ggagtcccag
181 cctgcagcac agtacgaggc tcttctggct caactcaagg cgctggggca gaggccggtg
241 aagacggcgg acatggatct cgccagggaa gagctgagga tgctcgtgac agccacaaaa
301 gcagccctgg agcagaatga tagactcaga agtgaactgg agatggaggt ggcattgctg
361 cagtctgcan aggaacgatc agaatcatct gagacacata taattgatga aaaccgactt
421 actcttactg aga
<210>45
<211>811
<212>DNA
<213>Homo sapiens
<400>45
1 tttttttttt ttttttttcc aaagagtaaa tattttaatt ttttcttcaa gagtattctt
61 attttcatat tatttaaata gtcacattaa caaggtacat ttccacaaaa atatttgtac
121 agcatcagta ttcttattca catccataat tgccataatt aggaaaaatt aggaaactta
181 gcaaagacag tcaatacaca tgttctttta cttgtggtga gataaattca atgtctaaaa
241 taagtcagga tggatcaaca taaaagctga actagacacc cctaccaaat ttctcaatga
301 aaaagcaaat agccctgggt gaccagcaag ttatacaaac aatgcaagac aaatccaact
361 agaaatcgga agctgccatt tcgtatacac aaaatacaag tgaaacagcg aagtaaacat
421 atttttagag ggaggtgctg ctacccggac attagagata tactgggcca gctggaaata
481 acattcacaa tctcttgaaa tgcagcagat ggcactctgg ggcttcctat gaagcaacat
541 gcttgaaatc aagggccaac aattgttgta ggaaagcaaa atatacctct aacacctacg
601 tttaccaaaa aagctgacat ctcaaactct gagttgttga gactcacatt tctcatcccc
661 aaagaagcct attacgggag tgcgttggat gctttttgta tctctgatag gccggcccct
721 atagtggggg gaatacttct gaataaaaac ctgggctgac ttgcacctgg cctttaacgt
781 tattncaggg gggcgtgggc ctaactgaac c
<210>46
<211>400
<212>DNA
<213>Homo sapiens
<400>46
1 tttttttttt tttttttttt atttacccac gattcttctt tatttggctg ccaaatatag
61 gggcacgtta gtattgcggt cagcttaata ttaagtagaa ggcattaaag gctaaaacag
121 gggtgcaaaa agctgtaggt aaatctcttc tatgctggct gttagcaaag cactgggatg
181 ctatataatt gcagcaaact ttttttttgg ttctgctgca ctgcagctca taaagggagc
241 actcattctg gaaaaaaaaa aaaaagttaa atctagcaac tggttagcac cagcattcca
301 aaaaacttca gcagcctgtg ttttcagcct ctgctccaac ttcattgctc tttggaatca
361 agagcttcat gttcaggaat agccaccatt ggatgactca
<210>47
<211>590
<212>DNA
<213>Homo sapiens
<400>47
1 ttcataagta aaatcaattt tattagtaag gctctttcca catgtccaaa gcaaacaatt
61 aatgaattcc agggaaaacc acctatatac aatgaaatta gaagtatctc aggatgacaa
121 aaaatataca aatatgtaca cccataatca ccgccgcctc cgaaaacctt ttttcttccg
181 acctttctga ggtatcttct tccgcttctt aataggattc tgatcctcat caagatgaac
241 agttccccct gtcaaagcac tgatgtcact gaagtgtgta agggaatgaa gttgtgagct
301 catgacattt gctcgttttc gccgtccttt ctctcgctta ctgacgctca aacgcaccat
361 catgctctcc tcatagttaa tcctgtgttg gcctcctgac tctggcggga acatngggat
421 gccgagcatc acggatttcc tctggagcat ctgagtactg ctcctttaag tcacgaatga
481 cagagctgct caatgcccgt cntcttggct cgtctagacg cttcttctcc ccggtcaggt
541 tcttgttcat cataattgac ttgaacccag cgtggaggaa catatttctt
<210>48
<211>504
<212>DNA
<213>Homo sapiens
<400>48
1 gcggccgcac catgagcgac atccgccgcc caccccgccc tgcccacgca ccccggccac
61 accttcatct ccggcgtgac ctttcccttc aggcccatcc gctaggctgg cccgtgtgtg
121 ccttctgcgc tctcgctgga cgaagccttt cgagatggaa ggggtggccg gactcccaga
181 agagaacctc ggggaagggg tcgggcagcc cctccccgcc ggcagaaccg tcttggtgtc
241 acggagtcca ggtgcttccc acccggtcgc attctttgac atgcagattg gatggtggag
301 ggaagagtcc agcctctgcc gagagcctgc tgcgtgcatt tttaaaagat gccgatcctg
361 ggagcctctg ttctctgcgc atttcagaca cagcctgtgt ggcgaggagt gtgacggcag
421 gagccacggg tgcaagcccg tgtgtctggc ctctntcctc gtgaagacga tgtgtccccg
481 ccagaaaaag tgggctcctt ctgc
<210>49
<211>456
<212>DNA
<213>Homo sapiens
<400>49
1 gcctgggggg gaaaaaaccc acaaatgtct ttccccagtt tcctccagta acacagatgg
61 aaatagtagt ttatacttgg gatggtgctc ggggaaatag tgtctcagaa ccaattactg
121 aaatgaccag aatggatata aaatgtggct gcataatttc ctaagtccca tttctcaggg
181 taaaaatggt tcagaccatc caaatgcttc tccgaagaaa ttacacaagc gagatggaaa
241 aagaaagtat tggtttctca gcgctggtaa taattaggac ttgaatgagt ggtgataaac
301 ccatttacag acaggaagtg tgaaggcctg aatggccagg agatttgcta agtgatgaca
361 agatcaagat caggcctctg gcctctgagc ccagctccct aagcctagtg aactttgaat
421 gacacctgat tttttgcccc atccagcacc catttn
<210>50
<211>566
<212>DNA
<213>Homo sapiens
<400>50
1 tttgctctct acagaagcct ttactgggga ggggtcagag ttcatggatc accgggaggt
61 gcgagtagag tgttctgagg acactgctgg ggcgggggcg gtggcgggag gccatggctt
121 gggcagactg cccaaaagtc cagcttctta ggtcagagct ctgctgccca tcctgcggtg
181 gtcttgccag ggaatgccca ggcatcctgg cttcacagag cctccctctg ggggccccca
241 tgggcttgct gctgtccatc tgtctatgtg gaccccagag gccagcagag gggccagtcc
301 tccttggcag gtccctctgg cttggctgct tttcctggga ctccccaaaa agccagtcca
361 gggggtccac agtatcagcc atgggcagtg tgggctgctg gccactgaaa cgtgcggtga
421 tgtctcgcag ggacacagca aggcggccct tccggcaggc ctgggctggc ctgtggggtg
481 gcctgtgttg gccctgngcc gtggccttgt ccagcacaga ggtgggctgt gccagtcgag
541 atatagacct cacgtagtca tccagg
<210>51
<211>515
<212>DNA
<213>Homo sapiens
<400>51
1 acttttatta gtctttttat tcttctttta ttgatcacct ctgaagttca gtagcacact
61 gcataatttt ttgcattagc atgctgttgt ttctacctaa aatgaccggg gtccttgcct
121 tctgcttccc atagagattg tcccaactcc ataggtccat agtcacaaat gaggacagct
181 ttacatgtaa catgaatcta aaagaaaaaa acaccaccct taattaagag gcaaggaagc
241 tatgacagat ccctcccaaa tgcagtaata ggtcagctat tactatacca acctccagag
301 cttcacacgc atccttccct tagcctaaga ttatacttca ttttacaatt tcagagatcc
361 aaccatctct gaaacctgtc tgaaactagc ccacatgcca tataccagat tacaacattt
421 aggccagctt cactattact tttcctcctt ttacgaccac caagaccagt gttcagatcc
481 gatgggaaag ggatcaggag gattaagctg atcaa
<210>52
<211>469
<212>DNA
<213>Homo sapiens
<400>52
1 tttgacattt tatgttcaaa tatatttgct gcctcaccct acagggcccc tccctaagga
61 ggaccacact cctgcccagg atgtccggca cagccctgtg acttggttgg ccggtggaat
121 atgagtgggt aggatctgtg cccttccctt gtcagcagag gctcagaagc tccctgaggg
181 tccactgttt caccatttcc ctttgtccag aggccagggc atcctgacag agtcagcctt
241 ttgcgtaagg tcactggctt ggttgatgta ccggtcacgc tccttttcca gatgaaagat
301 gatctttctc tgcttctgag cctcatcctt gtagttctgg atttctccct ccaggttcct
361 cttggcttgt tcatggaacc ttaccaaagt ttgtctgctc ctggggcgca ttgaccgcct
421 taagcatgtt cttatttagt atgtcccttt ctcttagaag ctcgtccat
<210>53
<211>585
<212>DNA
<213>Homo sapiens
<400>53
1 gtataaaatt taaattttat gatcatgtct ggaccttttt acacttaaca caatggaaat
61 gttcatattc atttttttcc ccaaaggaaa aatttctgaa tcatcactat gttgcacagt
121 agaatagaaa tatgaattca ggtacttagt caagtttcta aagaatgcaa ataacagaca
181 tgatttaact tccaaaatct gaagtcatca acatgatttt gtagtactct atctcaggtt
241 ttacctaaaa attcgttatt attcagataa agatagctcc ctaatcacat gtttttaaaa
301 agcctctgcc ccacgacaac ttcctgagat ctgtgaagaa actgcagtct tgtgatcaga
361 ctccatatag gactggcagt tttgtaatcg tagggaaaaa acggtgactg attttacgtg
421 tcaatcagtt gtagtctgct gatctgatta gaagccttga caaatgcctg gtggcgattg
481 caaataactg ccaagcatat agggatgata cagtagccca ctgttttggg atcagctctt
541 gtacaagagt ataggaacaa aaacatctgt aagtaaggta ccaga
<210>54
<211>676
<212>DNA
<213>Homo sapiens
<400>54
1 agtgagacaa tttattttta ttgcctaaac tgcagagcat tctctacaca gcgtaaagga
61 gaagtggggc agctgcagga catgtagaga aaccaaaccg ggaaatctta caaggagttg
121 aaaagattaa tgtcccaacc tgatgagatt acggccttga gacaataagg tggagcaaca
181 gaacaatggg aaagaggact gggagaggaa tctaagaacc agatggcttc agctctctag
241 aggagctgag cctattcaca gtgcctaacc tggaagcctg tgaggaacag gcctcaggcc
301 cttgccatga cctacttagg ctacaatttc ctttaaggca gcccctagct ctgggaagga
361 atactggtag ccagtggccc agtgttcgcc gtgggatcac cttctggccc tccagcagca
421 tgatggcacg ctgtcgccca aagacagctt gcaccacagc gctggggaga gggatgaagg
481 ctcggcggcc cagggcagca ccgaaggtct gggcaaactc agcattagtg gcggaggatg
541 gagccactcc attcaggacc ccgtgcacgt ggtttgcttc aagggcatgg gtcaggattc
601 ctgccaggtc cccgatgtgt atccaggggg agaattgggg gcctgagccg atggggcccc
661 ccaggcccag gcgaaa
<210>55
<211>455
<212>DNA
<213>Homo sapiens
<400>55
1 ggtccgggtt agctttattg gagcctccta gcaggccagg tgtttcaggc accagtagtg
61 ctgcaggcac gggggcctgt ggtgtggcca gctgcaggtg atctcggtgg tggactccga
121 agtgtactcc agagaggtcc cggaatggca ggggaccagc tcgggcactg aggcgctgct
181 ggcaggctgt ttcgacgatt ccttctggcg ctgtccgctg gtcttggggg ctgcgtcctc
241 cggcttgcca gaggacttgc tggggggctg cgtggggatg ttgctgctgc tgggagactg
301 gaccatgggt gggaccgggc tggaggtgac gttgggtggc tgcaggggcc ccgaggacgg
361 gagggctgac tgggaggggc cggaggaagt accaggcggc tgggtgtgtt gccgagacca
421 gtgggagctg ccctgtgccc gacgctggcc ctgng
实施例1
人肝脏组织的mRNA的分离
组织分离(Tissue isolation)：肝脏来源于5个成年男性，在肝脏切除手术后， 将肝脏组织立即置于液氮中冷冻保存。
mRNA的分离(mRNA isolation)：取出肝脏组织，用研钵研碎，加入盛有裂解液 的50ml管，充分振荡后，再移入玻璃匀浆器内，匀浆后移至50ml新管，抽提总RNA (TRIzol Reagents，Gibco，NY，USA)。用甲醛变性胶电泳鉴定总RNA质量。用带Oligo d(T)的纤维素柱分离总RNA中的mRNA，定量。
实施例2
cDNA文库的构建(Constuction of cDNA library)
以mRNA为模板，合成双链cDNA。补平末端后，加含EcoRI切点的接头。磷酸化 EcoRI末端后，用XhoI限制性内切酶消化1.5小时，再进行片断分离。过柱筛选长 度＞500bp的片段，用酚-氯仿抽提，乙醇沉淀，无菌水溶解，连接至Uni-ZAP XR载体 (Strategene，CA9203，USA)，以ZAP-cDNA Gigapack III Gold Cloning Kit (Strategene，CA9203，USA)进行包装，宿主菌使用XL 1 Blue MRF’ (Strategene，CA9203，USA)细菌。涂板并测定滴度。
实施例3
测序及数据库建立(Seqencing and Database Constructing)
挑选文库中有外源片段插入的克隆，扩增后抽提质粒(Qiagen Germany)，用T3 和T7作为3’和5’端的通用引物，采用终止物荧光标记 (Big-Dye，Perkin-Elmer，USA)的方法，在ABI 377测序仪(Perkin-Elmer，USA)上 进行EST大规模测序。测序结果用FACTURA软件去除载体序列，传输到SUN Ultra 450
Server上进行下一步的处理。所有的序列信息再用GCG软件包(Wisconsin group，USA) 中的BLAST和FASTA软件搜索已有的数据库(Genebank+EMBL)，将无同源性或同源性 低于95％的序列视为新基因建立数据库。
实施例4
基因的全长克隆(Cloning of Full-length cDNA)
在得到的新基因片段序列信息基础上，进行cDNA全长克隆，分两阶段进行：
(1)“电子克隆”(Electronic Cloning)
以新基因片段序列作为探针搜寻dbEST数据库，将重叠序列＞50bp，同源性在98％ 以上的表达序列标签(Expressed Sequence Tag，简称“EST”)序列认为同一序列 (Consensus Sequence)，取出并用AUTOASSEMBLER软件进行连接，部分EST可以延 伸探针序列。再用STRIDER软件分析被延伸的序列是否具有完整的开放阅读框架(Open Reading Frame，ORF)，用BLAST搜寻Genbank或SwissProt以确定该序列的核苷酸 和氨基酸水平上是否与其他物种有同源性，以帮助判别所得到的基因全长完整性如 何。通过电子克隆的方法，通常可获取人肝脏相关基因的全长序列。
(2)cDNA末端快速扩增(Rapid Amplification of cDNA Ends，RACE)
如果通过“电子克隆”方法仍未得到完整的cDNA全长，则在已有序列5’或3’ 端设计引物，在人类肝脏Marathon-Ready cDNA文库(Clontech Lab，Inc，USA)中 进行长距离PCR反应。然后对PCR产物克隆、测序。用AUTOASSEMBLER及STRIDER软 件分析被延长的序列有无完整的ORF，如无，重复上述过程直至获得全长。
(3)RT-PCR
对于5’和3’端的已知的序列，如果中间有一段间隙(gap)无法从已有的公共 数据库或自身数据库获得，可考虑采用RT-PCR的方法。在序列5’端设计引物，3’ 端引物采用Oligo-dT，在肝脏总RNA库中进行扩增。然后对产物进行克隆、测序。最 后拼接便获得全长。
通过组合使用上述3种方法，可获得人肝脏相关蛋白的全长编码序列。
序列表
<110>上海人类基因组研究中心
<120>人类肝脏中表达的表达序列标签
<130>NP-10048
<160>55
<210>1
<211>550
<212>DNA
<213>Homo sapiens
<400>1
1 catcgttttt gtttttattt ttcccctttc aacctggttt tcggctctgg aagctgttcc
61 tgtgcacagt tctatttcct acagttctga gaaagcggtt ccatcgcaga tgaccaaagg
121 ctggacccct ctggctataa cgtagacctt ccagtgggtg gtgtcgacat agccgatatc
181 ccctggctct attggcatgg ccacagactg acaatgtctt cggcactgga agggagggat
241 gagctgcaac atggcctcac cgctgccaat gataaatagg tcanggcatc ttatgcatct
301 tactccccac aacaggttct gggtgaagaa aggagcactt gtttaaagag gcatcttttn
361 ggaaatgnca ggtgagtgaa aacaggaaaa agctcacgta acatttgtna tctgttcana
421 ggtctcctcc atggataagg naatgggaac caccgctcag gaaagcagcg ccaccacttg
481 tcgaaaaaac ctttcaggag aangccttct gtcgnctcag gggtactggc acanaaaaat
541 gctgaatctc
<210>2
<211>410
<212>DNA
<213>Homo sapiens
<400>2
1 atggggtttc accatgttgg ccaggctggt cttgaactcc agacctcaag tgatctgccc
61 gcctggcctc ccaaagtgct ggggttacag gcgtgacacn tgcgcccggt caggctttta
121 atttttttaa tttttaattt ttgctcaggg tggtttggct attctgggcc ttttgtggtt
181 ccatataaat tttagggtta ttgtttctat ttctgcgaag aatggcattg atattacagg
241 gagcccacgt agccctttac attgtaattg gcacctccac caggccataa gaccccaggt
301 cccagcccag aagcatgtcc cagaggaaag actcagagaa gctcctggaa tgtgtgtgca
361 cggctccttg gtattgcttn gggccttcac ccctttggtg gccactttcc
<210>3
<211>553
<212>DNA
<213>Homo sapiens
<400>3
1 tgccagcatt tccctttatt tctggatgga aacggggccc taaaagcaga aatcaatatt
61 tttgtttgaa agatgcagtc atgctaattt cacttttggc taaaaccgag acgataaaag
121 aacagttggg tgtttatagg atgccctcaa agtgagctgg ctaagtgagc tgggctctaa
181 cttcactcac aaatttatag tacagctaag aaggccagtc tgtccatgaa agggagccga
241 gacaagacga gggcggcctc ttccaggcct gtgccaagtg tccttggggt cccgccatgg
301 tccacacttc tgcagcatcc gcagaacatg tggccggggt cctgcccagc agcagggaca
361 gcccaagtgg ggaggcaggc atggtgcaca ccctggggag gcccctgggt gcagaagcag
421 ccccacagta gcagccccat ccagaggaag accactcccg aggggccaca gccttcttgc
481 agcccctngg aattgccgcc caacccctcc attttcagcg ggatgtttca agggtgagac
541 aaggaattna ggg
<210>4
<211>767
<212>DNA
<213>Homo sapiens
<400>4
1 gagaatcaat acaaaatatt tatttttttt caaaccacag aattcttaac cccagagcca
61 cacaataaag ttctcagaat tgtaagccat taacattttt ctaaacaatg cagtccagag
121 atgaagataa tttccaacca gcagggatgc aatatatagt aggttcccct atgaatgaag
181 ctcaaattag catttccttt aattctccca cagccactcc atcaacagaa gcagaaacag
241 tacacatatt catgccactc ggctctgaaa agaggttcaa ggtgggtcaa ggtgggtctt
301 ggccagtgga ggaaggaagg tgtccaggac tttagttaat caacagtggg gacagagagg
361 aatgatttcc cttggaaaac aacagggttc ctttctcata ttcttgtggc cagaaactgg
421 ggtgaacttc agtggggtaa tgaaagaaac aggagagcca tttctccagg aactcctatg
481 acctccattt taacttctga caaagttaac ttcattatac aatcgtattg aaaacagtaa
541 tcacaaccaa aaggtctata acctgtaata gtgtcaaggg atcncattcc ggactttaat
601 ttaaggnccc ttaaaagcct agcctggtta agtaccgaat attcccagct aagnggcctt
661 aaatccccaa catccaccat ggtnagctag tngtgttcnt tgtgnacctt cggtncgatg
721 ggggnttaaa agccggtttt tnggtgaaaa agttnctagg ggacttt
<210>5
<211>468
<212>DNA
<213>Homo sapiens
<400>5
1 tgcagtttga atttatattt tattattttg aaatacaaaa atttaaaaac atttcaaaat
61 acaccagtac atgtttgttg taaaaatttc acctaggagg atataaaata gaaaagccga
121 atattccttc taactctccc ctctacctca attcccttca gaggtaacac agcaaaaaaa
181 aactggggaa aagcaaacaa ctttccagac ctctactatt ctaaaacaca aagagcatta
241 cagcttgcta tgcatttttt tttnnttnng gggggggttg ttttttagag acggagntcc
301 cctctgtcac ccaggctgga atgcagttgt gtgatctcgg ctcactggaa cctccacctc
361 cccagttcaa gcgattctcc tgcctcagcc tgccgagtag ctggggatta cagggcangc
421 gccaccacgc ccagctaatt tttgtagttt tagtagagac agcgtttg
<210>6
<211>605
<212>DNA
<213>Homo sapiens
<400>6
1 tatgaaaaaa gcagcaactc tttagtgatc atggaattaa tctgacagca attaaatgtg
61 tttaagcatc tggcatatct cctcaattgc accaaaagaa tttggaagca cttggtttgg
121 tctcaaaggc aaaaggaaag gacgaggaag gggccaggct cccgccagcc cccgcccccc
181 tcacatttct gagtccgcat acatcccgtt gattaagtag tccacctggg tgtagtcctt
241 cttcttgtag ctctcatagg cctgcaggna aacaaaacca agactgtgat gaaaagggtc
301 accccgagta acagcaccac cagaaggaga gttttgtcta ccacggcctg gggtgagggg
361 ctcagtggtg accaccatgt actgggcctt gggtgctggg ctggcacgag tccgtggctg
421 gcatcttagt gcccctgagc tcctgggtgt tgggcccagt ggaatcagta cctggtgtgg
481 cttcagtctc tacctgctcn ggtgcctggg atgtgcctgg cccagcggcc ctctgggtat
541 atggcatggg gcttggntgt gtcgtggggg acatgncctc catctcaggg attgggctcg
601 tccga
<210>7
<211>660
<212>DNA
<213>Homo sapiens
<400>7
1 caaatntaan acccccntnn nanttncccc ccaannggta cttttgtttt acaaaaatta
61 caaaaaatga ctcttaaaaa tagaaatagc ttctcagact cttgggaact acttttaagc
121 aaccaaggag ttagaactca gatggttttc ttctttgtaa cagcaacaat gaccacggct
181 ctgtgccatg gcaatcactg ctgagtgtct tctcctacaa ttacacaggc ccgagctgtg
241 tctggtggaa aggtctccac tcaggtcaga gtctgaagga gcaagatctt ctcattaatg
301 cagaacctgt gcagaaccac catcagattc tctccacagc gggagacctg gcgctccatg
361 gccaggcgaa agtcctcctt cacgcctttg gtgatgcctc gagttacagt gtggtgcctg
421 aggtcagcaa tagggaaaca gacaaagacc aggggttagc accagcatcg ctgatcgctg
481 ctacttgggt aggaataaag cctgccccat atctaagtat aatttcagat attttaaaaa
541 gaaccaagaa tagctgcacc aaccaaacat tccagccatt tctcttcaga agctttaact
601 agacagacat cttctcactc tataaaggta cttcaaacat ttattgtcag taaatgcncc
<210>8
<211>611
<212>DNA
<213>Homo sapiens
<400>8
1 acatttaaga catatttttg tgtttcttaa tgaataaatt atgaaagaat gttaatttaa
61 aattcataat atgtaaaaga atatttagat ttcatttcct ataatcagac acgctgttgt
121 ttttactata taactgttag aagatataaa tctataacat atgcagcata tacataaaaa
181 taatcacaat atttttaaaa gtttctgtta atgtcatgta tcttcttttt ttatccaaaa
241 gaaaacttat tcaaaaaaat gtacccagaa gacacagcct aaggaataca agcaggaaac
301 tgagaaacct gccaacaaca gctaaaggga cacaaacagg tacatgcaaa gttgccagta
361 agcagcattt aaaatgctga ttttcagaaa gagagcagca ggtggagtta agggtttagg
421 ctctggcgtc gactacttag ggacgttggg aaagtttcta ccctctctgt accaagtttt
481 ctctttgtaa aatgggaacc aatccttctt gctttttttt tttttgagac ggatcttgct
541 cggttgccca gccttgagtg cagtggcgca atctcactcg ctgcaacctc cgcctcccgg
601 gttcaatgga t
<210>9
<211>596
<212>DNA
<213>Homo sapiens
<400>9
1 ttcttgtggc aaatttaata gaagaatatg agactcaccc ttacttccca cacataaaac
61 actgcaggca ctccaaatcc ttacagacat atgcacttcg gaatcaactc aggcatgcac
121 agcatccctg tgctggagtt tattttaaaa aacaacgccc cagttatcac agtttctttt
181 tttgtccacc attttccata acaaaagaag ctacacaaaa tttgggggga gatactctct
241 ttggagactg acacatttgc agaggggtca tgaataatga ttccaaagct cctatttaac
301 ttctgaatca ggcaaagaat aagtgacaat ataagaatga attttgttta cagcaatatc
361 ataatacagc attgaatcat tacagtggca gtggttgtaa ttaagtcccc ataaaatatt
421 cttaggcccg aaacaccaga ccaactaaaa tcaccaactg gctcacgaac caaatgatca
481 gtgcaagcag ttgnggtctc catagtgaaa accaaaatgg gtagggcntt tctgggcagt
541 gggtctctga catgaacggt ccctctctgc tcaagangac ttggcgnccc ccttgg
<210>10
<211>607
<212>DNA
<213>Homo sapiens
<400>10
1 ggagaagtct agagtgtttg ctttattcat gttgtttatg cgttaaaata taagcatatt
61 gcatacataa gcatatttac acccacatct aaaagataac atattatata tacttttcca
121 tacttctgaa caagcgtctc atatccataa ctaaaaatta gatgagaaag acaaagaact
181 cttgtcttcg aattgacttc attgcactat atagcatttc acactgcggt tccaggccac
241 agggtccctt gggtaggggg agacaaaggg tgtggctgac agggagactc taggactacc
301 attgccactt ccaccagagc agccacactt ctgttccaca tagttggcat ccaaatttga
361 tttgaaaaac agtttccact tacctaaaag aaaaatccta tgngaaaaat gaccacaagc
421 caattatcca ctcnaacctg ctgatnctgg gccctgggga gaagctgttt tgagaccnca
481 tatttcccta ttacctttac ccatgatggg attatcctac tgtctngggg gcatccccaa
541 cttgagctcc ccagaaaccc ccnggtggtg aggggaaaaa aaaaaccctt ctcccattca
601 cagtggn
<210>11
<211>665
<212>DNA
<213>Homo sapiens
<400>11
1 gtatttttaa aatttttatt gtattttttt tcagaatatt ttccatccac agttggttga
61 acagagtgcc atctgcacct agaatgctgt ctcagcccaa ggtaccttct tcacatcatt
121 catgaagtgc tttaaaccac tccccctcaa gaagcccttt agaacactca gaaaaagatc
181 ctcatctcat aattcttggt ccaaatacaa aactccagac tcctcaatta ctgcatcact
241 aaaattccca ccatttcagt gcatataatt agctttttaa gttatatatt tattattagc
301 ttggtgtttg tgtgtttcca tcagtggtaa caccataaac atgattcttc caattttact
361 acttctgtaa cacagttgca tgtggaaaac ggacattcga taaatttatc ctgacttcac
421 atggccaaat agtaccttac acagccctca gttaaagcca ccagtttata agtaactagt
481 ggaatagcct agaggtgaca aaggaagagt tgggcagcag cattcaacaa acatccgtga
541 atgaaacttg ctcctccatt ccgatatctg ggctgcactg atctaccact ctccggtttc
601 tgcntcgttc tncctgcttg cattagaatc agctcgtgtt aaagtgggcc gaaagacaat
661 tcccc
<210>12
<211>529
<212>DNA
<213>Homo sapiens
<400>12
1 cttgagacta gtggccagtt caaaaattaa tagccgctca ttaacaattt ttgggacggg
61 agacacccta aaagccatca caatgactgc taatagtggt tttgtcagag ctgcaaacaa
121 ccagggtgtt aaatttagtg tgtttatcca tcagcccaga gcacttactg agagtaaaga
181 ggctctagcc acccccttac caaaagacta cacaactgac agtgaacact aaagataccc
241 tttaaatatt tttgtggaag taagttattt ataccaaagg ctgggtcttc ccatctaaac
301 tggtgggaaa aaaggtctat agtaaaagta aaactgagaa ctcttaaacc agtagagttt
361 ctttgtctct catctaaagt atataacctc ccaaagtaga aaaagcacaa gagagaagct
421 tatctatcaa actgtctgca ttagtgcaat taagaaccga aatacgtcta tataaagctt
481 tcagctgtat tgtaatactt tgattcgata gggctacaac ttccctact
<210>13
<211>480
<212>DNA
<213>Homo sapiens
<400>13
1 tttcaaattt ttaatgtacc aatttattgc atatgtcagt acagaaaaat agaaagtata
61 ttttaaaaga aatttattgt aaaaaacaaa tgtaaatgtt tgcttgccat ggttagcaca
121 caatgtacta tgacattcaa atttgagtta taaaatttta tcacttcaaa taaaatatgg
181 caaataacaa aaatatgatt tacattatga aatgggatta acttatttta tactgaacat
241 acttgaatat gttaaaaaca acttgaattt tccatatacg ctgtactgac agaaataatt
301 ataaattatg ttaaacacac actcacctgt tacatatgta tatacggcac tttttgtaaa
361 aaagtgtctc atacatggtc ctatttttaa actacatttt aagatacaaa atataaatgg
421 aggtatattt gcgccatttg gcaaaaatgt atagactagt attaagatga ctgcatttat
<210>14
<211>551
<212>DNA
<213>Homo sapiens
<400>14
1 tttgatatca aaatgcatct tgtttatttg gtttttgaaa ctgttataac acaacttata
61 acattggaaa tacattattt tattaataca aagtagtttt catagtaaaa taccaaatta
121 attaaaaggc agaatgaaac gtaccatata catgtagacg acaaatgaaa actgtcaaag
181 tatccttctc tctaaaaagc cacaaattac attctttgaa gtaagtattg ggttttattt
241 cctaaactat acacatcaat atcacctcct gaagcttttt acccagtttc acggttggta
301 tttcggacat gcaatgttcc atgctgtcaa acttggaatg cctcgtttgg atacagggag
361 acaaagactt ggagacccag aagcctgaaa gtggttcttg accgactttg tccactcaaa
421 ttaaggcatc atgcagctgg tcatcactta cattgctggt tgcacgcagg cacacacaca
481 ccagtgctca cagccagcac ttgttaagaa tggttgagct ggaccaaatg gtatacgtgt
541 ctttcatcaa t
<210>15
<211>534
<212>DNA
<213>Homo sapiens
<400>15
1 gccgacagtc cctccttgtc tgtctccggg attcaggcct ccctccctga catggagagt
61 aacctgtctg gcctggtgcc tgctgccggg ctggtgcctg cgctgccacc tgctgtgacc
121 ctggggctga cagctgccta caccaccctg tatgccctgc tcttcttctc cgtctatgcc
181 cagctctggc tggtgcttct gtatgggcac aagcgtctca gctatcagac ggtgttcctg
241 gccctctgtc tgctctgggc cgccttgcgt accaccctct tctccttcta cttccgagat
301 actccccgcg ccaaccgcct ggggcccttg cccttctggc ttctctactg ctgccccgtc
361 tgcctgcagt tcttcacctt gacgcttatg aacctctact ttgcccaggt ggtgttcaag
421 gccaaggtga agcgtcggcc ggagatgagc cgaggcttgc tcgctgtcag aggggccttt
481 gtgggggcct cgctgctctt tctgctggtg aacgtgctgt gtgctgtgct ctcc
<210>16
<211>627
<212>DNA
<213>Homo sapiens
<400>16
1 ttttttttta aaaattattt tatttatgta tgcattttat aagcaactga ttaatttaaa
61 ctgaaaaatg atgaagtaaa ggcctacagc tctaagaatc atttctaggc tgggcgtggt
121 ggctcacacc tgcaatccca gcacttgggg aggctgaggc aggtggatca aactgaggtc
181 aggagttcga gaccagcata ttttcttcca aagccatcat atatatatat atatatatat
241 atatatagat acgaggaaac aganagagat acaaaagtgc atagatgtat atatagagtg
301 taaggtaatc agggatatat tgattcaggt gggacatgtt gcgaaagagc ggttgttgtg
361 aggtgagggt ggtggcgcgc gatggattcc tggagtgttt acttatccgt gcccgagacg
421 cccatgccgt gtttgtgtac ctggtccccg gggtcccaac cactttgccg tgggacgcca
481 ggagtaacgc ctgatgtcgg aagaatagat gtgtgttgtt gtggtagtgt tgtgttgggt
541 gacgtgagag aggtgctgag gcgcatacgt agtaatatag gctggaagag agtaccttgt
601 gagaagtgtg agcggagacg cctagta
<210>17
<211>537
<212>DNA
<213>Homo sapiens
<400>17
1 catgtttttc ttttaataag ggtttttact caaaagtgta gctttgaaaa tctctagctt
61 gttgtgaaaa ccaggaaagc caaggagctg cctcacactg cacaccacca cgtgaagctg
121 tgggccgctg tgtgtttgca aactctccat taccaaggct ggaatcaaat gcaccacttt
181 aaaatcagag ccaacattta aaattaggag gatgatgcat gtcctacttt gattcaagga
241 gaaaggacaa gttcttagta cagtaaaaca aaacacaaaa gtaaacaaat ctttagaaat
301 cactatatat atgtgtgttt atatatatat ttttatataa ttaggattat catcatttca
361 aactattaaa aataaggttg ccaccttacc ttttcttttg gtaatggggt gttatttttt
421 ttaagagaaa aaaccaaaca ttttgcccag actctagagt tcccaacttc aattctgttt
481 tctgctgtgc acttccccac cttcacgctg tatcccaagt ccgccaccat tctggct
<210>18
<211>485
<212>DNA
<213>Homo sapiens
<400>18
1 tatttcaact tttattaaac caaatccagt aacttttaca atgccttact agagggttgc
61 ctcataactg aaccttcatt tctggcaggg aagaaaccat ggcttcagga tcatgactga
121 agtttggcca tgttccatca ttaatgttcc aacatcacca gggacacaaa gctgcaaaaa
181 tgagaaggga aataaggtta gagaaaggat ctgggcaatc ttaaggactg aggaagacat
241 gttccccaac ccttgaactc acaaaccctg aagctcaagg attgcatcct tcctccaaat
301 ctcactcaac ataataagtg cagaacaaca tgccaaagca ctgtatgaag cactagggac
361 aaagacaagg tcaaaatcct tgtaaccaaa tttaatggta ttgtaatgca gtgttaacac
421 aggacagtaa cagaacaccc agaaccaaan cagagagggt agggataagc taaatgaact
481 cgtgg
<210>19
<211>611
<212>DNA
<213>Homo sapiens
<400>19
1 tttttttttt caacttaacc atactttatt tgactgcatc ttatttagac agcttgcaca
61 tttcaaatcc cattaaatct ctctccaaaa ggatatggga caatagaaga aaattatgca
121 gcaatatcca gtcaaacagc agtccaatat tttgagatac acgtgatatt ttatagatac
181 tcaactcata tctgacgtca atataattta tggttatgtt tttacaaacc tgaaagccct
241 gtaacattac agcactcatt ttagtgatgt catggtgcac tgaaaagtaa ctctgatgta
301 ctaccaattt gattttatct atactcctga aaagtgatga acttcatgat ttttagacac
361 cataataaat atacacatcc agtcttagac atgtcagcca gtaccataac acagggcaag
421 gtaaagttaa aacatgaaaa aacaaactgc tttacataga tttgtcgagc aagtgggaag
481 ggtaatttgg gaaagaggca gaaaatatta taatcgattn ttgtattttc cttaatttgg
541 ctggttcaac ttcataaact accggtctgg gttctgatct gtggacttgg ctaagtagtt
601 catcccaatg a
<210>20
<211>477
<212>DNA
<213>Homo sapiens
<400>20
1 cctcagaaac attttattga caacagttcc caacagagtc tttggggtct ttaagtggca
61 ggtgcagcgt ccacaggcag agtgagggct cctgaggaac ctcaccccaa attccctaac
121 cggccgagga cgcgacccca ggcccctctc aggtgggcat ggcagtcccg gcagcacccc
181 ctctgagcag cctgctgtgg ggaagaagcc gggccgggag cctccagtcg tggtgccagc
241 ccagctcatg ctccccgccc cgaggccccc agcctgtggg aagcccctgc ctgtaatgga
301 cagctcgtga agacacagga acagtggtgg gggtgagggt ctaggaatga ggcagagggt
361 ggctgagcac acacctgact ccctggaggg tcgcttcaaa gacatgggag gcgagggcac
421 tggggaggct gggatgaaca accgactcca tgcacctcaa cgctctcatc aaagagg
<210>21
<211>449
<212>DNA
<213>Homo sapiens
<400>21
1 tttaggatga atgactgaat ttaatgatga actttgagaa ggatagacta gtaaattctg
61 ttcttggacc tgagtacagt ctgggagaaa cataatgtag caggaggtct tatgaaagag
121 agttaggcat tccagttgac tgagttcact gtgggatgtg acaagccact tcccaaatca
181 gtgctgggaa catggcactg tgcttcacct gccaatcaga atgcccctgg agaattgtat
241 tctcctcagg gcattgcttt aagagcacta cgtgttcagg aaacaaccag agaaaaccac
301 cgtcaatgag cactgactgt aaagactgac gttaataaac cagaaaaaac tcaggaaagt
361 gggtgagggt gtgacattgc cttcaaattc ctgaggggct gtcacttgag gagacattat
421 tttggaaggc tccagtaagc ctatggaaa
<210>22
<211>516
<212>DNA
<213>Homo sapiens
<400>22
1 cctttttctc tttggatggg agaagggagg atctgggaaa atcttatggt tctaagattt
61 atctccatta acaacgttta gaagtaaagt acaggagtta aggatgtatg actgttctta
121 acttataact ctacttataa aattctatga aaagaactgt caaaatatat aatactacgc
181 agatataata ctatacagac atcatcaaat aaacataata ctatacagga ctattacaaa
241 aaggctaacc aaccaaatat tttacttctt ggtatcaaaa ccagaagaaa ggggcttaga
301 ttatggagag aataatgtaa gttgaacata tggacaggtt attcacataa aagacatatt
361 aaatgcctac tgtgaaacag agcactagat ttcgtgaatg caaagatgag taagacgttg
421 tccctgtcct caggaaactc ctgtgacaac gcagtaatac agcaaggtat aaggagcaca
481 cagccggctt gcctagtagc tgtgtggccc ctctaa
<210>23
<211>493
<212>DNA
<213>Homo sapiens
<400>23
1 aatattgaat aagtaatttt atttccatga tctatttaca ctgtacaaag actgttgaaa
61 agcaccctac aagttcacag tacattacaa tatatttact ttaaaaatat attcctttat
121 aaaaggttta taagaacatt ggcatgtcaa catgtgacaa aactctcaaa gcatgtcacc
181 aattctgtga gagcaagaat gcatccaagt gttatcaatt tcacaatcac aagtcaccag
241 ttgagtttta aatacataca tgttttaaat aaaaaagaat tctatagtgg aaagttcttg
301 aggcaatact tattagttca ttaacgtatg cattttcatg gagatgtggc ataataaccc
361 acaatatcaa cttaatctgt ccaaagaaac atttcaacaa gtttagcagt acagaaattc
421 tggtcatttg tttctacttt ttcttctttg ctggttctcc tggctctact ttgcgctttt
481 tagaagtatg ctc
<210>24
<211>494
<212>DNA
<213>Homo sapiens
<400>24
1 tttgcaaatc ttttatattt ccagctgttg agacagtatt tttgagggct gatgttacct
61 ctagcggcga aaccagagcc agctattaag cagccagaaa gctacagtaa ttgaatacat
121 gaccatttct cttttagcac gttctttgtt ctcctcttcc agaagttgta gacgtctatt
181 tagtttgatt atctgtcgtc ttagtgaagc tgcatctaca acagtcaggt catctgacgt
241 tccttcaatg gttgtatcta tatttgaaat gccatacaga gaatcatttc tgaccagctg
301 tccattttgg cgaacagcat tttcactcat agaccgctct ctttttagtc tgccaactgc
361 tcggatttct tcattttgag gggttgtagg aggtctttct aaatccagaa aatctagtgg
421 tctttcactc agtgtaagta cacgaggtgg tgttttcagt gccaggggtt taaagggagt
481 tgactgaata aggt
<210>25
<211>439
<212>DNA
<213>Homo sapiens
<400>25
1 tttttttttt atatctcttt gttaagttta ttaatgtata cgtttttcaa ataaacattt
61 tgaacagccc aaatcaatca aagccatgag atcacaaagt gttgcttctc gacacaacat
121 tagcttgttc agaaaatcca aaagccacat ccaaagatca atgatgctac cttaaagaca
181 tgagggaggc tccttaagac cctagagaca ccaaggaccc cacagggcca gtcatatgaa
241 caggctcaga agccggcttg atcctcagca cctctgcaaa gccatcacca aaccagcaag
301 tgacatgcgc tatgtctaca gtaaagtaga aaaggcggtc ctggcaaagc ttccggcggt
361 acacagaccg aggatccgct gacagcacag cctcaatggc acgctttgct tcctctgctg
421 actgaaaata tttaaatga
<210>26
<211>571
<212>DNA
<213>Homo sapiens
<400>26
1 gcatatacat acaggtttat ttaaatgatt ggatctacac ttttggaggc tatttgaagt
61 atcttatcaa aataaaacgc attttaagca agaagttaaa aaagcttttc agacccgaag
121 gccatttaat acagtaaatc ttacttgggt agtttagcaa acatttttta aaacccacat
181 ccaacagatt ggttagtatt agatacacag atttggtttc aaagctgaaa tacccctggt
241 ggaataaatc ttctcatgaa attcagttat attatgccac aaaacaggga cacttatcta
301 ttgacaactt aaatattaac tcagtgggct acctggtgat ataaatagga aaaaaacagt
361 ggtcatggat taggagtgag aagactatga caccagccta ccttggactg ggaccgcaaa
421 ggatgttaaa atctatccta gaatttaaaa caggagaaat gtcaaatatt ccagtctcca
481 ttcggctcaa gccatcgccc aaggaataca cccccacccc agccccacat gaggtttact
541 aaccagctgc tacagatgtt actatgtcac t
<210>27
<211>447
<212>DNA
<213>Homo sapiens
<400>27
1 taaattattt ggacattgat agctctgcaa aatacttctc ccatcccaaa ccctcaaact
61 ccttccacat gtcctccata aagaaacaaa atatttatac tttgtgccca ttcaagtcta
121 atttttaaaa acatttaaga ttcaaaatca aatattattt ttctttccca caacttgtta
181 gtaattttaa accacgatac aacacagtta atggcatttc tttttaaaaa ttagcttatc
241 agactatttt atgagaaaaa aatcaattca aggccttagt gagaatatta tattctctgt
301 ttctgaaagc aaaagacatt gaaaaacccc tttgctcctc tggagtttgt gatttccaca
361 taaccaacaa aaccagcaca cagattgact tcctacttaa cagtaggtat tgttttgtta
421 ctttgggaca gcagctgaaa cactatc
<210>28
<211>165
<212>DNA
<213>Homo sapiens
<400>28
1 tttttttttt tttttttatt ttgttctgtt ttatttggta gagcaagtga tcaaagtgaa
61 gcttgagtga ttggcgccgt tggcctggcc atgggtagat cccagcatgt cccgcctccc
121 actgcagctc cgtttctcgg tcacggatga gacaggtggc ctgag
<210>29
<211>529
<212>DNA
<213>Homo sapiens
<400>29
1 tttttgccaa taaagaatat tcttttcttt attattatag ttcccattaa gctagcaaat
61 gcttgttttg tagttcttcc tgtaaaaatt taccccaagt attaacaaag tatttgatag
121 atgaaaaaat ttattaaagt tgaatcttca aacctaaatc tctacacaaa aggaaaaact
181 tcactattaa ataacatgct cccaaggaga ttcttatata taaactgctc cacaaatgac
241 caagtatctc tttgagataa atgaagcagt aataacccaa aattctttgc aatgtttagc
301 agtatgagcc gatactacct gaagatcata tggattgtta aggggattag gacttttccg
361 aggaaggcaa taaacaaatt ctccatcatc ttccaaaggt ttctttaaag taatcttctg
421 aattgcaatt ttggagcttc cgtatttcaa actgtgctgc ggtaatatag tttgccaacc
481 aagcttttct cgtagcctaa taatatttct tatcacatca tcatctttt
<210>30
<211>811
<212>DNA
<213>Homo sapiens
<400>30
1 tttttttttt tttttttttt tttggggnca tatttttgtt cactgaaagg accaaccagt
61 ttcatcaaac aagctttaga gaaagagaaa ctgagtaatt catcttgtca gttacagttc
121 acatatatgc acacacatac aaactggctc agcatcagtg aaacataact attcaaatac
181 aaaagtataa aaaacctctt taaaaaacca atagcagcca aaacagaaca tttgtaaaca
241 aaaccacaac tatcagccct gtgcttaaac acagaatctg cattcttttg aaacattaag
301 tatatgcaat aaagagaata tagaccatct ttttccttaa tatacaatac ccaatatcta
361 aaacaatgtc accaataata gacacaaatc ggtgttatca taaggcatgt tgaacagtct
421 ttttcacagt actcaggggc atcatgttgc tgcagaggcc acactttcca gaagttttct
481 cctcgctgtg atcctcgcac accgggggca ctcggaggac tggaagcact gtttgtgaaa
541 gcaagccctg cacgctgaac atcttctaca tgttgctgtc tgaaatggga agatgacagt
601 cgtattctgg caaaattcac aaataaagcc ctttccttga cacagctcac agccagccac
661 atgtgcaagg gaagctttca gaatgtcctt gagtaaaggt gccagcagcc ctttcttgat
721 cctgaccagg tcctaaggga ggacaggtgg agtcatcagt caagtgtccc ggcacctgct
781 cgaactcctt taatgcactg gtagcaaacc t
<210>31
<211>488
<212>DNA
<213>Homo sapiens
<400>31
1 tttttcacta ttcaacatgt cttcgtatta tcttccttcc tctcgtatct gatagacaaa
61 gaatgatata aaattttggt tgaaaaaagc cagttgattg ggatgactag aaatgttaac
121 tttttcagta aaaagctttc accgaatcac tgggcagtta gtaatgcagc ttacaaataa
181 ataaagctga ggcgagaggt ttaaacagca agaaaagctg cagagcatat tgaggaaggg
241 aagcagtgaa atggtggttt taatacatcc caaactggaa gcaagaaccc taacacaaag
301 aggattggaa tactctacca tctgtaagga agtagctagc tacaagccac ctcacacaaa
361 acacccacta aggcctttca ccgagatcct cttgttatat tctcattatg aatccccagc
421 aggtgcacct caataaatag gtgtggagta tactgctgag gacctctagg tcacctaagc
481 agaaactg
<210>32
<211>576
<212>DNA
<213>Homo sapiens
<400>32
1 cttacatttc ttatacaaat aacagaatgc ttcattttat tcacttcaat aggacaaagt
61 ccttaaagaa agactgaaaa gagctgataa tcaaaatccc aaattttatg cttatttttg
121 ttttagtgct atcaattttc tgacatatta acataggcag gaaaacattc tcagtaaatt
181 gagcatttga gtctacaaat gtcttgaagc actctggcaa gttacatgta tcccatgttg
241 cttttggttt cccatctctt ctttgcttca aacccccatg caagtttctt cttttttcgg
301 gcagcctgtg aattttcaac ctcctttttg gcttttacaa agttgtggca ggcaactgct
361 ttggcaattt ttacaccaag ctctcgagta gctagctggt tgctgagttc ctcagccttc
421 tcaatattcc actcctccac agcctggtct atcctctttt caaggcctga ctagaaaaaa
481 aagaaaccta aaattaaggg ctggaaggaa agcaaacatt tgctagccaa gaccatgtca
541 cagaattata ctgaatgtgt tacacaagta gaccat
<210>33
<211>1005
<212>DNA
<213>Homo sapiens
<400>33
1 tctgcccgct gtgtcctggg catggagggt cagcaggtca tcctgcacct gcccctatcc
61 cagaaggggc ccttctggac atgggagcct agtgcccctc gaactctgct ccaggtccta
121 caggatccag ccctgaaaga cctcgtcctc acctgcccca ccctgccctg gcattccctg
181 atcctgcggc cccagtatga gatccaagcc atcatgcaca tcttctcaag tcttaggatt
241 gcagcaacac gctcggctgc ccaaacccaa ggcgaagacc ttgccagagt tcatcaagga
301 tggctccagt acgtacagca agattcctgc ccacaggaag ggccacaggc ccgctaagcc
361 ccaaaggcag gatctagatg atgatgaaca tgattatgaa gaaatacttg agcaatttca
421 gaaaaccatc taagtgctgg aggaaccacg cttcctaact gctgcttctc agggaatccg
481 acaccagcca accattttaa gcctctaaaa gacctcgggc aagtctcaca gaaactgagc
541 tgcagacggg gagtagcttt gtggaaactg atttgatgga cactgcacca gcttccttca
601 ggttctagat tcttgctact tagggcgggc tggtttggac ctaacatctc gcacgtgact
661 ccctcagcct cagagccttg ggatgcagag cagctggcag ggttcctctc aatcctgcaa
721 ccccagctgt cccaccggtg gatgcagagg ggaatccgag gccatcaacc ttggtgacag
781 cagcgcagtg ccaatgctga tcacactgca tgggagattt tgttaacgtc tgccaccccc
841 actctcaccc ccaagctcta agcccccggg aggcctggac tgtcttcctc atctctgtag
901 caccaagcct gatagatctg tatatggtaa acaggggttt aaccacatgt ggttaacatg
961 gattaatgtg ggaatttggc ttcaagaaca caaccttagg acctt
<210>34
<211>483
<212>DNA
<213>Homo sapiens
<400>34
1 ggcacgaggg gctcaaagag aagtataaga ctaggtcttt atatttgtaa gttacttaca
61 ctctagatat caaacgaaat gtaactcaca tgaagtgctt caatgttgaa tagtgaggaa
121 cgcacagcgg aaacatattc ttgcagccca tcagatcatc cacagttaca cggaaagcat
181 ggttcaaaag aaattaactg agggagagca agatgaggcc tcaaatgctg ccatgttact
241 tgagaaagaa actcaaaatg agaacaacag ctaagattgt gatttttttg caaaagaagc
301 tgtacgaatc atcataaata attccaatag tctgcacttc tcccaaggtg tgcactgctc
361 ataaacttgc cagtgtgtga ttcatgagaa aggagattta ttttccttaa acatccaata
421 atttaaaatg attttcaata ataataatca aatgaaaaaa aaaaaaaaaa aaaaaaaaaa
481 aaa
<210>35
<211>644
<212>DNA
<213>Homo sapiens
<400>35
1 gcgcgggcgg ctggggaatg gctgctgcca tggtgccggg gcgcagcgag agctgggagc
61 gcggggagcc tggccgcccg gccctgtact tctgcgggag cattcgcggc ggacgcgagg
121 acaggacgct gtacgagcgg atcgtgtctc ggctgcggcg attcgggaca gtgctcaccg
181 agcacgtggc ggccgccgag ctgggcgcgc gcggggaaga ggctgctggg ggtgacaggc
241 tcatccatga gcaggacctg gagtggctgc agcaggcgga cgtggtcgtg gcagaagtga
301 cacagccatc cttgggtgta ggctatgagc tgggccgggc cgtggccttt aacaagcgga
361 tcctgtgcct gttccgcccg cagtctggcc gcgtgctttc ggccatgatc cggggagcag
421 cagatggctc tcggttccag gtgtgggact atgaggaggg agaggtggag gccctgctgg
481 atcgatactt cgaggctgat cctccagggc aggtggctgc ctcccctgac ccaaccactt
541 gacttaatct cactttctta aattcttcta ttctcagaca ctgctctagt accattcctt
601 cctcttagcc ccaggagcaa attaaaaggt acagttaaaa tcct
<210>36
<211>1434
<212>DNA
<213>Homo sapiens
<400>36
1 cctcgtgcca tgagcattta gaaatggaga ccacttctgg tgaattgtca gatgtttcca
61 atgatcccac cacatctgtc tgtgtagcta gtgccccaac aaaagaagca attgacaata
121 ccctgcttga acacaaagaa agaagtgaga atataaatct taatgaaaag caaattcctt
181 ttcaggtgcc taatattgaa aggaacttta gacagtcaca gcctaaatcc tatctttgcc
241 attatgaact ggctgaggcc cttccacaag gaaagatgaa tgagacacca actgagtggc
301 tgcgttataa ttcaggaatc cttaacacac aaccaccatt accattcaaa gaagcacatg
361 tcagtggtca tacttttgta acagctgagc aaatcctggc tccattagct ttaccagagc
421 aagcattatt gatcccacta gaaaaccatg acaaattcaa aaatgtacca tgtgaggtct
481 accagcacat tctgcagcca aacatgctgg ccaacaaggt taaatttacc tttcctccag
541 ctgccctccc accccctagc acacctctgc agcctttgcc tttgcagcag tccttatgtt
601 ctacctctgt aaccactatc catcacactg ttttgcagca gcacgctgca gctgctgcag
661 ctgcagctgc agccgcagct gcaggaacct ttaaagtgct tcagccacac caacagtttc
721 tttcccaaat cccagctctc accagaacct cattacctca gctctcagta ggaccagtag
781 gaccgaggct ttgtcctggg aaccagccaa cttttgttgc tcctcctcag atgccaatca
841 ttccagcttc cgttcttcat cctagccatc tggctttccc atctttaccc catgcactct
901 ttccttcact gctttcccca caccctactg tcatcccttt gcaacctctc ttctagtcat
961 caccataatg ggaaaaaaat actcttgtga aaactattgc tatatgcgtt aagtgttcat
1021 ctatgtgggt acatggctat ttaactggtg gaaataaact ggccgataca tggcgtcatt
1081 ggtttgaaat catttactgt aagtgcaatg atgcaaataa atccctaagt ttctgatata
1141 taatattatt aaagcactga atagtttgaa aatcaataca atatatgcta tatattaaaa
1201 tgatgtctta agagtatgta taatgtacat aaaatatatt tatagtactc taatttatgt
1261 tgtaaagtat gctcccttgg tttttcttaa tctttgtgta tttgcaccta tttaatgttt
1321 agacaaagct gatggcacta tgttttgtat catgttcctt gaaactgtaa attcagtgaa
1401 aaatatctct tgcaataaat ttttgttaac tatttaaaaa aaaaaaaaaa aaaa
<210>37
<211>1640
<212>DNA
<213>Homo sapiens
<400>37
1 gggctgcgtg cggcgggaat catggctgct cgcagagctc tgcacttcgt attcaaagtg
61 ggaaaccgct tccagacggc gcgtttctat cgggacgtcc tggggatgaa ggttctgcgg
121 catgaggaat ttgaagaagg ctgcaaagct gcctgtaatg ggccttatga tgggaaatgg
181 agtaaaacaa tggtgggatt tgggcctgag gatgatcatt ttgtcgcaga actgacttac
241 aattatggcg tcggagacta caagcttggc aatgacttta tgggaatcac gctcgcttct
301 agccaggctg tcagcaacgc caggaagctg gagtggccac tgacggaagt tgcagaaggt
361 gtttttgaaa ccgaggcccc gggaggatat aagttctatt tgcagaatcg cagtctgcct
421 cagtcagatc ctgtattaaa agtaactcta gcagtgtctg atcttcaaaa gtccttgaac
481 tactggtgta atctactggg aatgaaaatt tatgaaaaag atgaagaaaa gcaaagggct
541 ttgctgggct atgctgataa ccagtgtaag ctggagctac agggcgtcaa gggtggggtg
601 gaccatgcag cagcttttgg aagaattgcc ttctcttgcc cccagaaaga gttgccagac
661 ttagaagact tgatgaaaag ggagaaccag aagattctga ctcccctggt gagcctggac
721 accccaggga aagcaacagt acaggtggtc attctggccg accctgacgg acatgaaatt
781 tgctttgtcg gggatgaagc atttcgagaa ctttctaaga tggatccaga gggaagcaaa
841 ttgttggatg atgcaatggc agcagataaa agtgacgagt ggtttgccaa acacaataaa
901 cccaaagctt caggttaacg gaagacatga tgcagagcaa gcctctgtga ttcctgccca
961 gcacctgtga ggcctgacgt gtcagttccc aataaatgct cttctgattt gtttcccgta
1021 caggcaagga ggcttgggta gtgcagattt gtgtatttca atctttgaaa gctctgatgt
1081 aatttagaaa tgaaatccaa tcatgagtcc aggtagagaa cgcctgctgt aatctacact
1141 gttgctggga ctgcgcattc tgtatataac tgtgttggat gagtgacaga tgattgtcca
1201 gactaggaca gcggcatgaa catgactttg gttgggattg cggatagtta gggttacctc
1261 tgaatcgtgt agcttttatg agagcagctg tgcaagtgaa tccacattaa tgccttgtcg
1321 tggtgccatt cccagcgcct gacgatacgc tcttctattg tcttattctg gcaggttttg
1401 acgttttaaa ttttttaaag aaattttatt ccttggacca aaaggtttgg ttaaccaccc
1441 ccctcttact tgctttcaca ttttgagtgt ccagaggaaa cagaaaggaa tgagtgtgtg
1501 acgttgctgc acgcctgact ctgtgcgagc ttctttctgt gtatatattt tgttttattt
1561 ttttccgtgt atatttttaa tcccgacaga acatcatgtg agatttcttt aaaatggatt
1621 aaacgatttc ttcagccg
<210>38
<211>1428
<212>DNA
<213>Homo sapiens
<400>38
1 agcggcctcc ggtgtgggat ggccgcggag ccgggcggag ctggcttgcg gctcccgggg
61 ccggctctcc ggccggagac atggcccggg ggcccggccc gctaggcagg cctcgccccg
121 atacggtcgc catgcccaag agaggaaagc gactcaagtt ccgggcccac gacgcctgct
181 ccggccgagt gaccgtggcg gattacgcca actcggatcc ggcggtcgtg aggtctggac
241 gagtcaagaa agccgtagcc aacgctgttc agcaggaagt aaaatctctt tgtggcttgg
301 aagcctctca ggttcctgca gaggaagctc tttctggggc tggtgagccc tgtgacatca
361 tcgacagcag tgatgagatg gatgcccagg aggaaagcat ccatgagaga actgtctcca
421 gaaaaaagaa aagcaagaga cacaaagaac tggacggggc tggaggagaa gagtatccca
481 tggatatttg gctattgctg gcctcctata tccgtcctga ggacattgtg aatttttccc
541 tgatttgtaa gaatgcctgg actgtcactt gcactgctgc cttttggacc aggttgtacc
601 gaaggcacta cacgctggat gcttccctgc ctttgcgtct gcgaccagag tcaatggaga
661 agctgcgctg tctccgggct tgtgtgatcc gatctctgta ccatatgtat gagccatttg
721 ctgctcgaat ctccaagaat ccagccattc cagaaagcac ccccagcaca ttaaagaatt
781 ccaaatgctt acttttctgg tgcagaaaga ttgttgggaa cagacaggaa ccaatgtggg
841 aattcaactt caagttcaaa aaacagtccc ctaggttaaa gagcaagtgt acaggaggat
901 tgcagcctcc cgttcagtac gaagatgttc ataccaatcc agaccaggac tgctgcctac
961 tgcaggtcac caccctcaat ttcatcttta ttccgattgt catgggaatg atatttactc
1021 tgtttactat caatgtgagc acggacatgc ggcatcatcg agtgagactg gtgttccaag
1081 attcccctgt ccatggtggt cggaaactgc gcagtgaaca gggtgtgcaa gtcatcctgg
1141 acccagtgca cagcgttcgg ctctttgact ggtggcatcc tcagtaccca ttctccctga
1201 gagcgtagtt actgcttccc atcccttggg ggcagcctcg agtgtagtcc attagtaatc
1261 agattccagt ttggacaggg tggctggatt gtatatctcg ttagtaatgt acatgctctt
1321 caggttctag ggctcctgtt aggggaggga gaaatgttga atcaagaggg aaaacaacta
1401 ctatgattta taaacatatt ttaatgtaaa aaaaaaaaaa aaaaaaaa
<210>39
<211>855
<212>DNA
<213>Homo sapiens
<400>39
1 ggcacgaggg ggaagctgaa gcagttcgat gcctacccca agactttgga ggacttccgg
61 gtcaagacct gcgggggcgc caccgtgacc attgtcagtg gccttctcat gctgctatgg
121 tgctgaggca gaagatatca agtgctgtaa cacctgtgaa gatgtgcggg aggcatatcg
181 ccgtagaggc tgggccttca agaacccaga tactattgag cagtgccggc gagagggctt
241 cagccagaag atgcaggagc agaagaatga aggctgccag gtgtatggct tcttggaagt
301 caataaggtg gccggaaact tccactttgc ccctgggaag agcttccagc agtcccatgt
361 gcacgtccat gacttgcaga gctttggcct tgacaacatc aacatgaccc actacatcca
421 gcacctgtca tttggggagg actatccagg cattgtgaac cccctggacc acaccaatgt
481 cactgcgccc caagcctcca tgatgttcca gtactttgtg aaggtggtgc ccactgtgta
541 catgaaggtg gacggagagg tactgaggac aaatcagttc tctgtgacca gacatgagaa
601 ggttgccaat gggctgttgg gcgaccaagg ccttcccgga gtcttcgctc atctaccact
661 cagcacgagc catccagaag aaaattgatc tagggaagac aacgtagtca ccctcggtgc
721 ttcctctgtc tcctctttct ccctggcctg tggttgtccc ccagcctctg ccaccctcca
781 cctcctcggt cagccccagc cccaggttga taaatctatt gattgattgt gatagtaaaa
841 aaaaaaaaaa aaaaa
<210>40
<211>587
<212>DNA
<213>Homo sapiens
<400>40
1 gggatgagtg gaggatggga tgagtggagg atgggatgag tggcgttggc tgcagatttg
61 tggtgcgttc tgagccgtct gtcctgcgcc aagatgcttc aaagtattat taaaaacata
121 tggatcccca tgaagcccta ctacaccaaa gtttaccagg agatttggat aggaatgggg
181 ctgatgggct tcatcgttta taaaatccgg gctgctgata aaagaagtaa ggctttgaaa
241 gcttcagcgc ctgctcctgg tcatcactaa ccagatttac ttggagtaca tgtgaaagaa
301 aacgtcagtc tgcctgtaaa tttcagcaag ccgtgttaga tggggagcgt ggaacgtcac
361 tgtacacttg tataagtacc gtttacttca tggcatgaat aaatggatct gtgagatgca
421 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
481 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
541 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
<210>41
<211>437
<212>DNA
<213>Homo sapiens
<400>41
1 ggattcactg ttacttcctc tttattcctg cagtgaaaac aatattttct tatgtcagat
61 ttctctcaat ctcttagtca atgaagacct gaactacaac aatatagagt cccattttaa
121 attcaaacaa agatatttag gtttgacaac agactcatgg taatgtcatt taaaaagatg
181 gatccaatga acacagacaa acatcaaagt tttcaccatg gcacaaacct ctgccacaat
241 cactcataat aattcaactg ccttcatatt tggcagtaac gtcatgcaag tgaatttgct
301 gatgattagc aaaatggcaa aatgaaagtc aaggtcactt aatcaagaat tacagcaaca
361 aagaaattct aggaatgcag gtcaaggcaa gaggctgcag ctggcctgat aatgatacca
421 cttgcctaat gttcatt
<210>42
<211>710
<212>DNA
<213>Homo sapiens
<400>42
1 tttttttttt tttttattct aaaatacaac gtttattaaa aaaacatgcg atcttgccaa
61 taggccaatt ccatgagaac aaaagatttt ttttcccacc tacaagtctt tttagagaaa
121 caaacggaac tatttccaga tgaggcgggg tgtctgggag gggctgtggg tggtctgggg
181 ctggtgactg gtgaggttgg gtggccctct gggggtccgg gaggcacttt ccgttttgct
241 tctgttggag atgttcccgt cggatgctga agaacaagcc tgccggctgg gccactccga
301 cctgggctgt ggcacccgtg tggccctcgg ccctcctggc ctgccgttcc ccagggccgt
361 caccgccgat agcggtagcg cttgaagtga aaccacagct ggaagatgcc gttggcaaac
421 tggcagcgga agccgtggcg gtgcgagtat tcccactcgc gggtgacgat cttgaaagcg
481 atgtcctcgt agggcggccc cgcgtggaag cgcacgatgg cgaaatcctt gttgtcggcg
541 caggccttca agaagtactc tggcgtggag cgcttgtcga taagtctggg gtaaagaagt
601 gaacttgtat ccatggacga acttgggcgg aggttggtaa aatcgaaatg cgtctggttg
661 accttggtcc actcgaaacc cgtgtgcacc ccgttgaaag agcgccgctt
<210>43
<211>388
<212>DNA
<213>Homo sapiens
<400>43
1 tttttttttt ttaaaaatga tggtttatta ttaaaatgat cttacaatgt caacatcaat
61 gttaataaaa atatataata ggctgaattc atcaatgata gaataagttg taattcactt
121 ggaggttcca tctttcaaag taagcctttc atagataaat gaaaatcctt tattttgtag
181 aattttaaag attgttaaag gctgggtcaa ggcaaagcca cctctattag aaggggaaag
241 aaaagcaaga tgaaacaaaa tatgttatca tacatatcgc gtgtgctatg agcatctttc
301 tactcctgcc agattgaaaa ttctaggttt caacattctt caggatttaa caagtcaaaa
361 taaaagcaga attcaaatct agacagat
<210>44
<211>433
<212>DNA
<213>Homo sapiens
<400>44
1 agaaagctgt agcaggagct ccagaaaatt tgcacgtgca gcccccagca gttcaacaga
61 ctgcacgtct ttggaaaagt ctttgaagat atttgtaaca gttctttgat atttggtgat
121 ctcttgaaaa aagttaagga tgaatatgaa ctctacatgg caacgctcct ggagtcccag
181 cctgcagcac agtacgaggc tcttctggct caactcaagg cgctggggca gaggccggtg
241 aagacggcgg acatggatct cgccagggaa gagctgagga tgctcgtgac agccacaaaa
301 gcagccctgg agcagaatga tagactcaga agtgaactgg agatggaggt ggcattgctg
361 cagtctgcan aggaacgatc agaatcatct gagacacata taattgatga aaaccgactt
421 actcttactg aga
<210>45
<211>811
<212>DNA
<213>Homo sapiens
<400>45
1 tttttttttt ttttttttcc aaagagtaaa tattttaatt ttttcttcaa gagtattctt
61 attttcatat tatttaaata gtcacattaa caaggtacat ttccacaaaa atatttgtac
121 agcatcagta ttcttattca catccataat tgccataatt aggaaaaatt aggaaactta
181 gcaaagacag tcaatacaca tgttctttta cttgtggtga gataaattca atgtctaaaa
241 taagtcagga tggatcaaca taaaagctga actagacacc cctaccaaat ttctcaatga
301 aaaagcaaat agccctgggt gaccagcaag ttatacaaac aatgcaagac aaatccaact
361 agaaatcgga agctgccatt tcgtatacac aaaatacaag tgaaacagcg aagtaaacat
421 atttttagag ggaggtgctg ctacccggac attagagata tactgggcca gctggaaata
481 acattcacaa tctcttgaaa tgcagcagat ggcactctgg ggcttcctat gaagcaacat
541 gcttgaaatc aagggccaac aattgttgta ggaaagcaaa atatacctct aacacctacg
601 tttaccaaaa aagctgacat ctcaaactct gagttgttga gactcacatt tctcatcccc
661 aaagaagcct attacgggag tgcgttggat gctttttgta tctctgatag gccggcccct
721 atagtggggg gaatacttct gaataaaaac ctgggctgac ttgcacctgg cctttaacgt
781 tattncaggg gggcgtgggc ctaactgaac c
<210>46
<211>400
<212>DNA
<213>Homo sapiens
<400>46
1 tttttttttt tttttttttt atttacccac gattcttctt tatttggctg ccaaatatag
61 gggcacgtta gtattgcggt cagcttaata ttaagtagaa ggcattaaag gctaaaacag
121 gggtgcaaaa agctgtaggt aaatctcttc tatgctggct gttagcaaag cactgggatg
181 ctatataatt gcagcaaact ttttttttgg ttctgctgca ctgcagctca taaagggagc
241 actcattctg gaaaaaaaaa aaaaagttaa atctagcaac tggttagcac cagcattcca
301 aaaaacttca gcagcctgtg ttttcagcct ctgctccaac ttcattgctc tttggaatca
361 agagcttcat gttcaggaat agccaccatt ggatgactca
<210>47
<211>590
<212>DNA
<213>Homo sapiens
<400>47
1 ttcataagta aaatcaattt tattagtaag gctctttcca catgtccaaa gcaaacaatt
61 aatgaattcc agggaaaacc acctatatac aatgaaatta gaagtatctc aggatgacaa
121 aaaatataca aatatgtaca cccataatca ccgccgcctc cgaaaacctt ttttcttccg
181 acctttctga ggtatcttct tccgcttctt aataggattc tgatcctcat caagatgaac
241 agttccccct gtcaaagcac tgatgtcact gaagtgtgta agggaatgaa gttgtgagct
301 catgacattt gctcgttttc gccgtccttt ctctcgctta ctgacgctca aacgcaccat
361 catgctctcc tcatagttaa tcctgtgttg gcctcctgac tctggcggga acatngggat
421 gccgagcatc acggatttcc tctggagcat ctgagtactg ctcctttaag tcacgaatga
481 cagagctgct caatgcccgt cntcttggct cgtctagacg cttcttctcc ccggtcaggt
541 tcttgttcat cataattgac ttgaacccag cgtggaggaa catatttctt
<210>48
<211>504
<212>DNA
<213>Homo sapiens
<400>48
1 gcggccgcac catgagcgac atccgccgcc caccccgccc tgcccacgca ccccggccac
61 accttcatct ccggcgtgac ctttcccttc aggcccatcc gctaggctgg cccgtgtgtg
121 ccttctgcgc tctcgctgga cgaagccttt cgagatggaa ggggtggccg gactcccaga
181 agagaacctc ggggaagggg tcgggcagcc cctccccgcc ggcagaaccg tcttggtgtc
241 acggagtcca ggtgcttccc acccggtcgc attctttgac atgcagattg gatggtggag
301 ggaagagtcc agcctctgcc gagagcctgc tgcgtgcatt tttaaaagat gccgatcctg
361 ggagcctctg ttctctgcgc atttcagaca cagcctgtgt ggcgaggagt gtgacggcag
421 gagccacggg tgcaagcccg tgtgtctggc ctctntcctc gtgaagacga tgtgtccccg
481 ccagaaaaag tgggctcctt ctgc
<210>49
<211>456
<212>DNA
<213>Homo sapiens
<400>49
1 gcctgggggg gaaaaaaccc acaaatgtct ttccccagtt tcctccagta acacagatgg
61 aaatagtagt ttatacttgg gatggtgctc ggggaaatag tgtctcagaa ccaattactg
121 aaatgaccag aatggatata aaatgtggct gcataatttc ctaagtccca tttctcaggg
181 taaaaatggt tcagaccatc caaatgcttc tccgaagaaa ttacacaagc gagatggaaa
241 aagaaagtat tggtttctca gcgctggtaa taattaggac ttgaatgagt ggtgataaac
301 ccatttacag acaggaagtg tgaaggcctg aatggccagg agatttgcta agtgatgaca
361 agatcaagat caggcctctg gcctctgagc ccagctccct aagcctagtg aactttgaat
421 gacacctgat tttttgcccc atccagcacc catttn
<210>50
<211>566
<212>DNA
<213>Homo sapiens
<400>50
1 tttgctctct acagaagcct ttactgggga ggggtcagag ttcatggatc accgggaggt
61 gcgagtagag tgttctgagg acactgctgg ggcgggggcg gtggcgggag gccatggctt
121 gggcagactg cccaaaagtc cagcttctta ggtcagagct ctgctgccca tcctgcggtg
181 gtcttgccag ggaatgccca ggcatcctgg cttcacagag cctccctctg ggggccccca
241 tgggcttgct gctgtccatc tgtctatgtg gaccccagag gccagcagag gggccagtcc
301 tccttggcag gtccctctgg cttggctgct tttcctggga ctccccaaaa agccagtcca
361 gggggtccac agtatcagcc atgggcagtg tgggctgctg gccactgaaa cgtgcggtga
421 tgtctcgcag ggacacagca aggcggccct tccggcaggc ctgggctggc ctgtggggtg
481 gcctgtgttg gccctgngcc gtggccttgt ccagcacaga ggtgggctgt gccagtcgag
541 atatagacct cacgtagtca tccagg
<210>51
<211>515
<212>DNA
<213>Homo sapiens
<400>51
1 acttttatta gtctttttat tcttctttta ttgatcacct ctgaagttca gtagcacact
61 gcataatttt ttgcattagc atgctgttgt ttctacctaa aatgaccggg gtccttgcct
121 tctgcttccc atagagattg tcccaactcc ataggtccat agtcacaaat gaggacagct
181 ttacatgtaa catgaatcta aaagaaaaaa acaccaccct taattaagag gcaaggaagc
241 tatgacagat ccctcccaaa tgcagtaata ggtcagctat tactatacca acctccagag
301 cttcacacgc atccttccct tagcctaaga ttatacttca ttttacaatt tcagagatcc
361 aaccatctct gaaacctgtc tgaaactagc ccacatgcca tataccagat tacaacattt
421 aggccagctt cactattact tttcctcctt ttacgaccac caagaccagt gttcagatcc
481 gatgggaaag ggatcaggag gattaagctg atcaa
<210>52
<211>469
<212>DNA
<213>Homo sapiens
<400>52
1 tttgacattt tatgttcaaa tatatttgct gcctcaccct acagggcccc tccctaagga
61 ggaccacact cctgcccagg atgtccggca cagccctgtg acttggttgg ccggtggaat
121 atgagtgggt aggatctgtg cccttccctt gtcagcagag gctcagaagc tccctgaggg
181 tccactgttt caccatttcc ctttgtccag aggccagggc atcctgacag agtcagcctt
241 ttgcgtaagg tcactggctt ggttgatgta ccggtcacgc tccttttcca gatgaaagat
301 gatctttctc tgcttctgag cctcatcctt gtagttctgg atttctccct ccaggttcct
361 cttggcttgt tcatggaacc ttaccaaagt ttgtctgctc ctggggcgca ttgaccgcct
421 taagcatgtt cttatttagt atgtcccttt ctcttagaag ctcgtccat
<210>53
<211>585
<212>DNA
<213>Homo sapiens
<400>53
1 gtataaaatt taaattttat gatcatgtct ggaccttttt acacttaaca caatggaaat
61 gttcatattc atttttttcc ccaaaggaaa aatttctgaa tcatcactat gttgcacagt
121 agaatagaaa tatgaattca ggtacttagt caagtttcta aagaatgcaa ataacagaca
181 tgatttaact tccaaaatct gaagtcatca acatgatttt gtagtactct atctcaggtt
241 ttacctaaaa attcgttatt attcagataa agatagctcc ctaatcacat gtttttaaaa
301 agcctctgcc ccacgacaac ttcctgagat ctgtgaagaa actgcagtct tgtgatcaga
361 ctccatatag gactggcagt tttgtaatcg tagggaaaaa acggtgactg attttacgtg
421 tcaatcagtt gtagtctgct gatctgatta gaagccttga caaatgcctg gtggcgattg
481 caaataactg ccaagcatat agggatgata cagtagccca ctgttttggg atcagctctt
541 gtacaagagt ataggaacaa aaacatctgt aagtaaggta ccaga
<210>54
<211>676
<212>DNA
<213>Homo sapiens
<400>54
1 agtgagacaa tttattttta ttgcctaaac tgcagagcat tctctacaca gcgtaaagga
61 gaagtggggc agctgcagga catgtagaga aaccaaaccg ggaaatctta caaggagttg
121 aaaagattaa tgtcccaacc tgatgagatt acggccttga gacaataagg tggagcaaca
181 gaacaatggg aaagaggact gggagaggaa tctaagaacc agatggcttc agctctctag
241 aggagctgag cctattcaca gtgcctaacc tggaagcctg tgaggaacag gcctcaggcc
301 cttgccatga cctacttagg ctacaatttc ctttaaggca gcccctagct ctgggaagga
361 atactggtag ccagtggccc agtgttcgcc gtgggatcac cttctggccc tccagcagca
421 tgatggcacg ctgtcgccca aagacagctt gcaccacagc gctggggaga gggatgaagg
481 ctcggcggcc cagggcagca ccgaaggtct gggcaaactc agcattagtg gcggaggatg
541 gagccactcc attcaggacc ccgtgcacgt ggtttgcttc aagggcatgg gtcaggattc
601 ctgccaggtc cccgatgtgt atccaggggg agaattgggg gcctgagccg atggggcccc
661 ccaggcccag gcgaaa
<210>55
<211>455
<212>DNA
<213>Homo sapiens
<400>55
1 ggtccgggtt agctttattg gagcctccta gcaggccagg tgtttcaggc accagtagtg
61 ctgcaggcac gggggcctgt ggtgtggcca gctgcaggtg atctcggtgg tggactccga
121 agtgtactcc agagaggtcc cggaatggca ggggaccagc tcgggcactg aggcgctgct
181 ggcaggctgt ttcgacgatt ccttctggcg ctgtccgctg gtcttggggg ctgcgtcctc
241 cggcttgcca gaggacttgc tggggggctg cgtggggatg ttgctgctgc tgggagactg
301 gaccatgggt gggaccgggc tggaggtgac gttgggtggc tgcaggggcc ccgaggacgg
361 gagggctgac tgggaggggc cggaggaagt accaggcggc tgggtgtgtt gccgagacca
421 gtgggagctg ccctgtgccc gacgctggcc ctgng
| 标题 | 发布/更新时间 | 阅读量 |
|---|---|---|
| 用于植物基因表达的终止子序列 | 2020-05-12 | 695 |
| 干扰PRKCE基因表达的siRNA序列及其用途 | 2020-05-12 | 348 |
| 用于提高表达的细菌前导序列 | 2020-05-13 | 773 |
| 在人类肝脏中表达的表达序列标签 | 2020-05-11 | 188 |
| 表达调控序列 | 2020-05-11 | 340 |
| 增强表达的内含子序列 | 2020-05-11 | 59 |
| 人类肝脏中表达的表达序列标签G组 | 2020-05-12 | 896 |
| 表达序列 | 2020-05-11 | 388 |
| 增强表达的内含子序列及其用途 | 2020-05-12 | 905 |
| 表达序列 | 2020-05-11 | 277 |
高效检索全球专利专利汇是专利免费检索,专利查询,专利分析-国家发明专利查询检索分析平台，是提供专利分析，专利查询，专利检索等数据服务功能的知识产权数据服务商。
我们的产品包含105个国家的1.26亿组数据，免费查、免费专利分析。
分析报告
专利汇分析报告产品可以对行业情报数据进行梳理分析，涉及维度包括行业专利基本状况分析、地域分析、技术分析、发明人分析、申请人分析、专利权人分析、失效分析、核心专利分析、法律分析、研发重点分析、企业专利处境分析、技术处境分析、专利寿命分析、企业定位分析、引证分析等超过60个分析角度，系统通过AI智能系统对图表进行解读，只需1分钟，一键生成行业专利分析报告。
QQ群二维码
意见反馈
意见反馈