Steroid formulation
阅读：887发布：2023-09-02
专利汇可以提供Steroid formulation专利检索，专利查询，专利分析的服务。并且A steroid formulation having enhanced properties for topical application comprises 21-chloro-9 Alpha -fluoro- Delta 4pregnene-11 Beta ,16 Alpha ,17 Alpha -triol-3,20-dione 16,17acetonide in a vehicle containing as major ingredients propylene glycol and water.，下面是Steroid formulation专利的具体信息内容。
1. A CREAM COMPOSITION FOR TOPICAL APPLICATION COMPRISING FROM ABOUT 0.05 PART TO ABOUT 2,0 PARTS BY WEOGHT OF 21CHLORO-9A-FLUORO-$4PREGENE-11B, 16A, 17A-TRIOL-3,2-,DIONE U6,17-ACETONIDE, FROM ABOUT 300 TO ABOUT 700 PARTS BY WEIGHT OF PROPYLENE GLYCOL, FROM ABOUT 70 TO ABOUT 440 PARTS BY WEIGHT OF WATER, ABOUT 33 PARTS BY WEIGHT OF POLYOXYALKYLENE DERIVATIVE OF HEXITOL ANHYDRIDE PARTIAL LONG CHAIN FATTY ACID ESTER, AND FROM ABOUT 180 TO ABOUT 260 PARTS BY WEIGHT OF MONOGLYCERIDE OF FATTY ACID OF FROM 16 TO 18 CARBON ATOMS FATTY ALCOHOL OF FROM 12 TO 16 CARBON ATOMS, OR FATTY ACID ESTER OF ALCOHOL HAVING FROM 3 TO ABOUT 16 CARBON ATOMS, THE LOWER AMOUNTS OF THE STEROID BEING EMPLOYED WITH THE LOWER AMOUNTS OF PROPYLENE GLYCOL, AND THE HIGHER AMOUNTS OF THE STEROID BEING EMPLOYED WITH THE HIGHER AMOUNTS OF PROPYLENE GLYCOL, WHEREBY FROM ABOUT 30 TO ABOUT 75% BY WEIGHT OF THE STEROID IS IN SOLUTION IN THE PROPYLENE GLYCOL.
2. A composition according to claim 1 which contains from about 0.01% by weight to about 0.2% by weight of steroid, from about 30% by weight to about 70% by weight of propylene glycol, from about 7% by weight to about 45% by weight of water, about 3% polyoxyalkylene derivative of hexitol anhydride partial long chain fatty acid ester, and from about 15 to about 25% by weight of monoglyceride of fatty acid of from 16 to 18 carbon atoms, fatty alcohol of from 12 to 16 carbon atoms, or fatty acid ester of alcohols having from 3 to about 16 carbon atoms, the percentages of propylene glycol and water being such that from about 30 to about 75% by weight of the steroid is in solution in the propylene glycol.
3. A composition according to claim 1 which contains with respect to propylene glycol and water from about 40% by weight to about 90% by weight of propylene glycol and, correspondingly, from about 60% by weight to about 10% by weight of water, the propylene glycol and water together accounting for from about 73% by weight to about 82% by weight of the total composition, from about 0.1% by weight to about 0.2% by weight of steroid, about 3% polyoxyalkylene derivative of hexitol anhydride partial long chain fatty acid ester and from about 15 to about 25% monoglyceride of fatty acid of from 16 to 18 carbon atoms, fatty alcohol of from 12 to 16 carbon atoms, or fatty acid ester of alcohols having from 3 to about 16 carbon atoms.
4. A composition according to claim 1 which contains about 1 part by weight of steroid, about 94 parts by weight of glyceryl monostearate, about 22 parts by weight of cetyl alcohol, about 55 parts by weight of myristyl stearate, about 22 parts by weight of isopropyl palmitate, about 33 parts by weight of polyoxyethylene sorbitan monostearate, about 600 parts by weight of propylene glycol, and about 171 parts by weight of water.
5. A method of treating dermatitis which comprises administerming topically an effective amount of a composition of claim 1.
6. A method of treating dermatitis which comprises administering topically an effective amount of a composition of claim 2.
7. A method of treating dermatitis which comprises administering topically an effective amount of a composition of claim 3.
8. A method of treating dermatitis which comprises administering topically an effective amount of a composition of claim 4.
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