专利汇可以提供IMMUNOGLOBULIN A1 PROTEASES (IgA1 PROTEASES), METHOD OF GENE-TECHNOLOGICALLY PRODUCING THIS TYPE OF ENZYME AND VACCINES CONTAINING THE ENZYMES AND FRAGMENTS THEREOF FOR IMMUNIZING AGAINST BACTERIAL MENINGITIS AND OTHER DISEASES CAUSED BY IgA1 PROTEASE-PRODUCING BACTERIA专利检索,专利查询,专利分析的服务。并且Secretion of IgA1 proteases is a characteristic of Haemophilus influenzae and several other bacterial pathogens causing infectious diseases, including meningitis. Indirect evidence suggests that the proteases are important virulence factors. The iga gene encoding IgA1 protease, especially that from H. influenzae serotype b, has been cloned into Escherichia coli in which the recombinant iga gene was expressed and the resulting protease secreted. Sequencing a part of a 7.5 kb DNA fragment containing the iga gene revealed a large open reading frame (ORF) with a strongly biased codon usage and having the potential of encoding a protein of 1541 amino acids and a molecular mass of 169 kd. Putative promoter and terminator elements flanking the ORF have been identified. Comparing the deduced amino acid sequence of the produced H. influenzae IgA1 protease with that of a similar protease from Neisseria gonorrhoeae reveals several domains with a high degree of homology. Analogous to mechanisms known from the N. gonorrhoeae IgA protease secretion, there is proposed a scheme of post-translational modifications of the H. influenzae IgA1 protease precursor leading to a secreted protease with a molecular mass of 108 kd which is close to the Mr 100 kd estimated for the mature IgA1 protease.,下面是IMMUNOGLOBULIN A1 PROTEASES (IgA1 PROTEASES), METHOD OF GENE-TECHNOLOGICALLY PRODUCING THIS TYPE OF ENZYME AND VACCINES CONTAINING THE ENZYMES AND FRAGMENTS THEREOF FOR IMMUNIZING AGAINST BACTERIAL MENINGITIS AND OTHER DISEASES CAUSED BY IgA1 PROTEASE-PRODUCING BACTERIA专利的具体信息内容。
标题 | 发布/更新时间 | 阅读量 |
---|---|---|
重组减毒炭疽芽胞杆菌及其应用 | 2020-05-08 | 983 |
用于牲畜生产系统的疫苗 | 2020-05-11 | 830 |
人类肠道病原菌感染诊断用鼠伤寒沙门菌特异性基因探针 | 2020-05-12 | 74 |
一种油茶育苗方法 | 2020-05-11 | 703 |
扁刺蛾核型多角体病毒及其生产方法 | 2020-05-08 | 573 |
用于绵羊肺炎支原体毒力比较分析方法 | 2020-05-12 | 240 |
一种抗金黄色葡萄球菌毒力和生物被膜形成的抑制剂Lo-乙酸乙酯及其用途 | 2020-05-12 | 253 |
一种提高蛋鸡非特异性免疫的添加剂的制备方法 | 2020-05-12 | 368 |
朱槿木尔坦棉花曲叶病毒病防治方法 | 2020-05-12 | 924 |
一种抗紫外线和耐高温的高毒力爪哇棒束孢菌诱变株IJUV-6及其应用 | 2020-05-12 | 476 |
高效检索全球专利专利汇是专利免费检索,专利查询,专利分析-国家发明专利查询检索分析平台,是提供专利分析,专利查询,专利检索等数据服务功能的知识产权数据服务商。
我们的产品包含105个国家的1.26亿组数据,免费查、免费专利分析。
专利汇分析报告产品可以对行业情报数据进行梳理分析,涉及维度包括行业专利基本状况分析、地域分析、技术分析、发明人分析、申请人分析、专利权人分析、失效分析、核心专利分析、法律分析、研发重点分析、企业专利处境分析、技术处境分析、专利寿命分析、企业定位分析、引证分析等超过60个分析角度,系统通过AI智能系统对图表进行解读,只需1分钟,一键生成行业专利分析报告。