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Production of tetracycline and substituted tetracyclines

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1. IN A PROCESS FOR THE PRODUCTION OF AN ANTIBIOTIC COMPOUND SELECTED FROM THE GROUP CONSISTING OF TETRACYCLINE AND SUBSTITUTED TETRACYCLINES WHICH COMPRISES GROWING UNDER AEROBIC CONDITIONS A CULTURE OF A SPECIES OF STREPTOMYCES WHICH PRODUCES SAID ANTIBIOTIC COMPOUND IN AN AQUEOUS, NITROGENOUS NUTRIENT CONTAINING CARBOHYDRATE SOLUTION, THE STEP COMPRISING GROWING SAID ORGANISM IN SAID SOLUTION IN THE PRESENCE OF A MEMBER SELECTED FROM THE GROUP CONSISTING OF QUINIC ACID, SHIKIMIC ACID, 5-DEHYDROQUINIC ACID, 5-DEHYDROSHIKIMIC ACID, SALTS THEREOF AND METABOLICALLY CONVERTIBLE DERIVATIVES THEREOF UNTIL SUBSTANTIAL ANTIBACTERIAL ACTIVITY IS IMPARTED TO SAID SOLUTION.
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