| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 201 | Chain terpene compound | JP18171089 | 1989-07-14 | JPH0348633A | 1991-03-01 | TAKAYANAGI HISAO; KITANO YASUNORI; MORINAKA YASUHIRO |
| NEW MATERIAL:The compound of formula [R is CO 2R 1 (R 1 is 1-4C alkyl or phenyl), hydroxymethyl, formyl or C(CN)HOR 2 (R 2 is H, trimethylsilyl or 1- ethoxyethyl); X is halogen or OSO 2R 3 (R 3 is (substituted) 1-4C alkyl or phenyl); the double bonds 8, 12 among the double bonds 2, 4, 8, 12 take type-E steric configuration and the double bonds 2, 4 take type-(Z, E), (E, E), (Z, Z) or (E, Z) configuration]. EXAMPLE: 14-Chloro-2-(1-methylethyl)-5,9,13-trimethyl 2,4,1,12-tetradecatetraenoic acid ethyl ester. USE: An intermediate for the total synthesis of an antitumor agent sarcophytol A. PREPARATION: The compound of formula wherein R is CO 2R 1 can be produced e.g. by halogenating a 14-hydroxy-2-(1-methylethyl)-5,9,13-trimethyl 2,4,8,12- tetradecatetraenoic acid ester. COPYRIGHT: (C)1991,JPO&Japio | ||||||
| 202 | 스트랩토키나제와 스트렙토도르나제를 생산하는 미생물 및 이를 이용한 스트렙토키나제 및 스트렙토도르나제의 제조방법 | KR1019940020022 | 1994-08-13 | KR1019960007770A | 1996-03-22 | 최덕호; 배신규; 최미영; 이상훈; 조연덕 |
| 203 | STREPTOSPIROLE DERIVATIVES | PCT/EP2009/005155 | 2009-07-16 | WO2010012381A1 | 2010-02-04 | WINK, Joachim; GERLITZ, Martin; OLIVAN, Hélène; KURZ, Michael |
The invention relates to streptospirole derivatives of the general formula (I), wherein R1, R2, R3, X1, X2, Y1 and Y2 are as defined herein, a process for the preparation of said compounds by fermenting the microorganism Streptomyces sp. ST 108140 (DSM 19369) and optionally derivatizing the compounds produced by said microorganism, a pharmaceutical composition comprising at least one compound of the formula (I), and the use of a compound of the formula (I) for the preparation of a medicament for the treatment and/or prophylaxis of bacterial infections. |
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| 204 | Reduction of streptomycins | US33475953 | 1953-02-02 | US2790792A | 1957-04-30 | ARTHUR KAPLAN MURRAY |
| 205 | Streptomycin extraction | US63462245 | 1945-12-12 | US2701795A | 1955-02-08 | WICK ARNE N; VANDER BROOK MILTON J |
| 206 | Cloning vectors for use in Streptomyces | EP82305471.3 | 1982-10-14 | EP0077649A2 | 1983-04-27 | Fayerman, Jeffrey Tobin; Mabe, James Albert; Nakatsukasa, Walter Mitsuo; Richardson, Mark Alan |
The present invention discloses selectable recombinant DNA cloning vectors comprising:
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| 207 | Streptomycin and dihydrostreptomycin salts | US64796357 | 1957-03-25 | US2945784A | 1960-07-19 | WEITNAUER GUSTAVO A |
| 208 | Streptomycin purification | US70918658 | 1958-01-16 | US2921063A | 1960-01-12 | HEUSER LEON J |
| 209 | Crystallization of streptomycins | US18648750 | 1950-09-23 | US2633464A | 1953-03-31 | HEUSER LEON J |
| 210 | Streptomycin purification | US17393450 | 1950-07-14 | US2578840A | 1951-12-18 | RHODEHAMEL JR HARLEY W; FORTUNE WILLIAM B |
| 211 | Streptomycin preparation | US6491148 | 1948-12-11 | US2565402A | 1951-08-21 | SOLOMONS ISAIAH A |
| 212 | Production of streptomycin | US2313648 | 1948-04-24 | US2538943A | 1951-01-23 | EVERETT MCDANIEL LLOYD; DAVID HENDLIN |
| 213 | STREPTOSPIROLE DERIVATIVES | EP09777218.0 | 2009-07-16 | EP2321322B1 | 2012-12-19 | WINK, Joachim; GERLITZ, Martin; OLIVAN, Hélène; KURZ, Michael; DUFOUR-SCHROIF, Cosima |
| 214 | Preparation of straight-chain polybenzyl | JP2494178 | 1978-03-07 | JPS54118500A | 1979-09-13 | TOYOSHIMA ISAMU; ARATA KAZUSHI |
| PURPOSE: To obtain a straight-chain polybenzyl by polycondensation of a hagenated benzyl in the presence of an iron oxide prepared through thermal decomposition of ferrous sulfate as a catalyst. CONSTITUTION: An ferric oxide prepared by thermal decomposition of ferrous or ferric sulfide is used as a catalyst in polycondensation of a halogenated benzyl. In the preparation of the catalyst, ferrous sulfate is heated in an atmosphere of air or nitrogen under a reduced or an atmospheric pressure at 250W750°C for 30 minutesW4 hours; ferric sulfate, at 550W750°C, and thermally decomposed into ferric oxide which is used as the catalyst to give a straight-chain polybenzyl free from branches. The catalyst has specificity. Ferric oxide prepared by heating ferric hydroxide has no effect, ferric oxide from nickel or cobalt sulfate which is a homologue compound of iron is inert. COPYRIGHT: (C)1979,JPO&Japio | ||||||
| 215 | 지방산전이효소를 이용한 신규의 스트렙토마이신 생성균주의 생산 | KR1019970004094 | 1997-02-12 | KR1019980067794A | 1998-10-15 | 서주원; 김종우 |
| 본 발명은 지방산 전이효소 유전자를 이용하여 살균력이 개선된 신규한 구조의 스트렙토마이신 유사물질을 제공하며, 종래의 스트렙토마이신 등 아미노글리코사이드계 항생물질에 대하여 내성을 갖는 균주를 살균할 수 있는 재조합 플라스미드백터pKTC로 형질전환시킨 신규한 숙주세포 Streptomyces griseus DW 1011를 제공한다. | ||||||
| 216 | 二氫鏈黴素之製造 | TW001816 | 1956-11-09 | TW001266U | 1960-05-01 | HIROICHI YAMAMOTO 等12人; KAZUO TANABE; KOITI NAKAZAWA; MOTOO SHIBATA |
| 217 | Process for producing streptovaricin C | EP92309457.7 | 1992-10-16 | EP0538050A3 | 1994-05-04 | Inoue, Kaname; Murofushi, Kanji; Yamazaki, Motohide; Armentrout, Richard W. |
Disclosed is a method for selecting a mutant strain belonging to the genus Streptomyces which is a hyperproducer of Streptovaricin C by subjecting a natural strain of Streptomyces spectabilis to conditions so as to isolate streptovaricin resistant organism. Such organisms are subjected to mutagenesis and cultured. The strain producing the smallest pellet or having the deepest color is a streptovaricin hyperproducer. |
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| 218 | POLYMER-LINKED PSEUDOMONAS EXOTOXIN IMMUNOTOXIN | PCT/US2005045177 | 2005-12-14 | WO2006065867A3 | 2007-07-19 | FILPULA DAVID RAY; YANG KAREN; BASU AMARTYA; PASTAN IRA H |
| The present invention relates to polymer conjugates of SS 1 P, and methods of making and using the same. | ||||||
| 219 | POLYMER-LINKED PSEUDOMONAS EXOTOXIN IMMUNOTOXIN | PCT/US2005/045177 | 2005-12-14 | WO2006065867A2 | 2006-06-22 | FILPULA, David, Ray; YANG, Karen; BASU, Amartya; PASTAN, Ira, H. |
The present invention relates to polymer conjugates of SS 1 P, and methods of making and using the same. |
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| 220 | PRODUCTION OPEN-CHAINED SOPHOROLIPIDS | PCT/US2006/007399 | 2006-03-01 | WO2006094112A2 | 2006-09-08 | ASHBY, Richard, D.; SOLAIMAN, Daniel, K., Y.; FOGLIA, Thomas, A.; HAAS, Michael, J. |
Methods for the production of open-chained sophoro lipids, involving cultivating a yeast capable of producing open-chained sophoro lipids in a culture medium containing fatty acid alkyl esters, and glycerol or carbohydrates (e.g., glucose) or mixtures thereof; wherein at least about 60% of the sophorolipids produced are open-chained sophoro lipids. |
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