SUPPRESSION OF ITCH |
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| 申请号 | US15964969 | 申请日 | 2018-04-27 | 公开(公告)号 | US20180298367A1 | 公开(公告)日 | 2018-10-18 |
| 申请人 | IPSEN BIOINNOVATION LIMITED; | 发明人 | KEITH FOSTER; | ||||
| 摘要 | The invention provides a polypeptide, for use in suppressing or treating itch, wherein the polypeptide comprises: a non-cytotoxic protease, which protease is capable of cleaving a SNARE protein in an itch-specific DRG neuron or a pruriceptor; a Targeting Moiety (TM) that is capable of binding to a Binding Site on the itch-specific DRG neuron or a pruriceptor, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the itch-specific DRG neuron or a pruriceptor, and wherein said itch-specific DRG neuron or a pruriceptor expresses said SNARE protein; and a translocation domain that is capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the itch-specific DRG neuron or a pruriceptor; with the proviso that the polypeptide is not a clostridial neurotoxin (holotoxin) molecule. | ||||||
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| 说明书全文 | |||||||
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