Methods for increasing CAS9-mediated engineering efficiency |
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| 申请号 | US14836753 | 申请日 | 2015-08-26 | 公开(公告)号 | US09970030B2 | 公开(公告)日 | 2018-05-15 |
| 申请人 | Caribou Biosciences, Inc.; | 发明人 | Peter Sean Cameron; Rachel E. Haurwitz; Andrew P. May; Christopher H. Nye; Megan van Overbeek; | ||||
| 摘要 | Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease the number of off-target nucleic acid double-stranded breaks and/or to enhance homology-directed repair of a cleaved target nucleic acid. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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