| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | The compounds of the order to interact with the Gabaa receptor complex | JP50089295 | 1994-05-23 | JP4008024B2 | 2007-11-14 | ビー． ウパサニ，ラビンドラ; ダブリュ． ギー，ケルビン; タヒール、ハサン; パディ，ロバート; ジェイ． ホゲンガンプ，デーク; ビー． ボルガー，マイケル; ツサイ‐コン ラン，ナンシー |
| 122 | 17-deoxy-corticosteroid-21 [o] - carboxylic acid ester, a manufacturing method thereof and pharmaceutical containing it | JP23939895 | 1995-09-19 | JP3902255B2 | 2007-04-04 | ウルリツヒ・シユターヒエ; ハンス−ゲオルク・アルパーマン; マンフレート・ボーン |
| 123 | Corticosteroids 17 alkyl carbonate 21- [o] - carboxylic acid and carbonic esters, process for their preparation and pharmaceutical compositions containing these compounds | JP22396394 | 1994-08-26 | JP3780007B2 | 2006-05-31 | ヴアルター・デユルクハイマー; ウルリツヒ・シユターヘ; ハンス−ゲオルク・アルパーマン; マンフレート・ボーン |
| 124 | Method and composition for inducing sleep | JP2005006594 | 2005-01-13 | JP2005179370A | 2005-07-07 | GEE KELVIN W; LAN NANCY TSAI-YUN; UPASANI RAVINDRA B; HOGENKAMP DERK J; PURDY ROBERT; BOLGER MICHAEL B; TAHIR HASAN |
| <P>PROBLEM TO BE SOLVED: To provide a method and to obtain a composition for causing the interaction with a GABA<SB>A</SB>(γ-aminobutyric acid A) receptor complex to induce sleep in Homo sapiens. <P>SOLUTION: In the sleep induction method, a 3α-hydroxy-5-reduced steroid derivative is administered to an animal to be treated. <P>COPYRIGHT: (C)2005,JPO&NCIPI | ||||||
| 125 | Anti-inflammatory, 17α heterocyclic ester which is 17β- carbothioamide Art androstane derivative | JP2003503645 | 2002-06-11 | JP2005500290A | 2005-01-06 | ジョーンズ，ポール; ビッガダイク，キース |
| 式(I)［式中、R 1はC 1-6アルキルまたはC 1-6ハロアルキルを表し；R 2は、場合によっては１個以上のメチル基、エチル基またはハロゲン基により置換されていてもよい、O、NおよびSから選択される1〜3個のヘテロ原子を含む4〜7員の非芳香族環を表し；R 3は、水素、メチル(α配置もしくはβ配置のいずれであってもよい)、またはメチレンを表し；R 4およびR 5は、同一であるかまたは異なっており、かつ、それぞれが水素またはハロゲンを表し； -----は、単結合または二重結合を表す］で表される化合物ならびにその塩および溶媒和物、それらを調製する方法、ならびに治療におけるそれらの使用を提供する。 | ||||||
| 126 | Corticoid 17,21-dicarboxylic acid ester and a corticosteroid 17-carboxylic acid ester 21-carbonic esters, their preparation and medicine containing these compounds | JP26323494 | 1994-10-04 | JP3549125B2 | 2004-08-04 | ヴアルター・デユルクハイマー; ウルリツヒ・シユターヘ; ハンス−ゲオルク・アルパーマン; マンフレート・ボーン |
| 127 | Organic compound | JP2002505801 | 2001-06-26 | JP2004501930A | 2004-01-22 | ゲイナー・エリザベス・ピルグリム; サイモン・ジェイムズ・ワトソン; デイビッド・アンドリュー・サンダム; デイビッド・ビーティー; トーマス・ヒューゴ・ケラー; ベルナール・クエヌー |
| Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals | ||||||
| 128 | 14β-H-, 14- and 15-yen -11β--aryl-4-Esutoren | JP50140691 | 1991-12-21 | JP3048636B2 | 2000-06-05 | エックハルト オットフ，; クルツィツトーフ クヴァリツ，; アルヴェート クレーフェ，; ヴォルフガング シュヴェーデ，; ギュンター ネーフ，; ウルリケ フールマン，; ホルスト ミヒナ， |
| 129 | 13-alkyl -11β- Fuenirugonan | JP50718889 | 1989-07-03 | JP2956776B2 | 1999-10-04 | SHORUTSU SHUTEFUAN; OTSUTO ETSUKUHARUTO; NEEFU GYUNTAA; ERUGAA UARUTAA; BAIYAA JIBIRE; SHUBARITSU KURUTSUISUTOFU |
| 130 | Methods and compositions for inducing sleep | JP50089295 | 1994-05-23 | JPH08511771A | 1996-12-10 | ビー． ウパサニ，ラビンドラ; ダブリュ． ギー，ケルビン; タヒール、ハサン; パディ，ロバート; ジェイ． ホゲンガンプ，デーク; ビー． ボルガー，マイケル; ツサイ‐コン ラン，ナンシー |
| (57)【要約】 ある種の３α‐ヒドロキシ‐５‐還元ステロイド誘導体を用いてヒトで睡眠を誘導するためにＧＡＢＡ Aレセプター複合体と相互作用させるための方法および組成物。 | ||||||
| 131 | Intermediate for production of new steroid having spiro ring at 17-position | JP14116496 | 1996-05-13 | JPH08311094A | 1996-11-26 | NIIKU FURANSOWA; NUDEREKU RIYUSHIAN; FUIRIBEERU DANIERU; MOGIRUSUKI MARUTEIINU |
| PROBLEM TO BE SOLVED: To obtain the subject new compound having a spiro ring at the 17-position and useful as an intermediate for producing steroids used for the treatments of various diseases related to hormone irregularities, such as hypertension, arteriosclerosis, adiposity, hirsutism and dysmenorrhea, etc. SOLUTION: A new compound of formula I [R 1 is a (substituted) carbocyclic or heterocyclic aryl or aralkyl; R 2 at the α-position or at the β-position is a 1-18C hydrocarbon; the waved line in the spiro ether exhibits that 0 can exist at the α-position or the β-position; the dotted line expresses that the second bond can exist between the carbon atoms having the dotted line; K is a ketone- protecting group] has the spiro ring at the 17-position, and is useful as an intermediate for producing steroids used for treating various kinds of diseases related to hormone irregularities, such as hypertension, arteriosclerosis, adiposity, immunodeficiency, cancers dependent on estrogen and paramenia, etc. The compound is obtained by reducing a compound of formula II with tosyl chloride, etc., in the presence of pyridine. COPYRIGHT: (C)1996,JPO | ||||||
| 132 | Corticosteroid 17-alkyl carbonate 21-(o)-carboxylic acid carbonic ester, production thereof, and medicine composition containing the same | JP22396394 | 1994-08-26 | JPH0789982A | 1995-04-04 | URURITSUHI SHIYUTAAHE; HANSUUGEORUKU ARUPAAMAN; BUARUTAA DEYURUKUHAIMAA; MANFUREETO BOON |
| PURPOSE: To obtain a corticosteroid 17-alkyl carbonate 21-[0]-carboxylic acid carbonic ester which has a very strong local and topical anti-inflammatory action and is effctive in treating inflammatory dermatosis by reacting a specific alkyl carbonate with a specific activated carboxylic acid. CONSTITUTION: The objective compd. is represented by formula I [wherein A is CHOH, CHCl, CH 2, C=O, or a 9(11) double bond and is arbitrarily sterically arranged; Y is H, F, or Cl; Z is H, F, or methyl; R(1) is (substd.) aryl or hetaryl; n and m are each 0 or 1; R(2) is 1-8C alkyl or -(CH 2) 2-OCH 3; and R(3) is H or methyl]. An example is prednisolone 17-ethyl carbonate 21- benzoic ester. The compd. is prepd. by reacting a compd. of formula II [wherein R(5) is OH] with an activated carboxylic acid of formula III [wherein R(6) is Cl, Br, or the like] (pref. a halide, anhydride, or azolide thereof). COPYRIGHT: (C)1995,JPO | ||||||
| 133 | Novelcyclopentaneperhydrophenanthren-17beta-(hydroxy or alcoxy)-17alpha-(aryl or heterocyclic)-3beta-derivative active on cardiovascular system, its preparation, and pharmaceutical composition containing same | JP24336093 | 1993-09-29 | JPH06211893A | 1994-08-02 | MAURO GOBIINI; MARA FUERANDEI; MARUKO FURIGERIO; PIERO MEROONI; MARUKO TORI; ROREDANA BUARENTEINO |
| PURPOSE: To provide the novel derivative exhibiting low toxicity and useful for remedy for diseases such as hear failure, hypertension or the like containing the derivative active on cardiovascular system. CONSTITUTION: By condensing a 17α-(3-furyl)-5β-androstane-3β,17β-diol derivative of formula I [wherein R 1 represents a (substituted) monoheterocyclic ring containing an aryl or a hetero atom except for 4-hydroxy-2-butenoic lactone; R 2 represents O or S] with a compound of formula R-Y [wherein R represents a (substituted) 2-6C alkyl, a 3-6C alkenyl or the like; Y represents an electron withdrawing group such as a halogen, a mesyloxy, a tosyloxy or the like], the objective novel cyclopentaneperhydrophenanthlene derivative of formula II which is useful in the treatment of diseases of cardiovascular system such as heart failure, hypertension or the like is obtained. COPYRIGHT: (C)1994,JPO | ||||||
| 134 | JPH0443920B2 - | JP4602390 | 1990-02-28 | JPH0443920B2 | 1992-07-20 | DANIERU FUIRIBEERU; JAN JORUJU TOOCHI; JERUMAN KOSUTORUUSU; ROJE DORAE |
| 135 | JPS6411037B2 - | JP10875581 | 1981-07-10 | JPS6411037B2 | 1989-02-23 | NIKORASU SUTEFUAN BOODAA |
| 136 | JPS6360036B2 - | JP1319182 | 1982-01-29 | JPS6360036B2 | 1988-11-22 | |
| 137 | JPS631320B2 - | JP206578 | 1978-01-13 | JPS631320B2 | 1988-01-12 | JAN JORUJU TOICHI |
| 138 | Coupling agent and product | JP25395384 | 1984-11-30 | JPS60152481A | 1985-08-10 | SUCHIIBUN DEII AREN; MAIKERU TONPUSON |
| 139 | Novel 11betaasubstituted 1*3*5*10**trienesteroid process for preparing same and pharmaceutical composition | JP206778 | 1978-01-13 | JPS5390254A | 1978-08-08 | JIYAN JIYORUJIYU TOICHI; DANIERU FUIRIBEERU |
| 140 | Androstanes and pregnanes for allosteric modulation of GABA receptor | EP00200119.6 | 1995-02-14 | EP1038880B1 | 2007-10-17 | Upasani, Ravindra B.; Xia, Haiji; Hogenkamp, Derk |
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