| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | 바이아릴 설폰아미드 유도체 | KR1020107009047 | 2008-09-18 | KR1020100065195A | 2010-06-15 | 데흠로우헨리에타; 옵스트산데르율리케; 슐츠-가스흐탄자; 롸이트매튜 |
| The invention is concerned with novel biaryl sulfonamide derivatives of formula wherein Rto Rand Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments. | ||||||
| 42 | BIARYL SULFONAMIDE DERIVATIVES | PCT/EP2008062414 | 2008-09-18 | WO2009040289A2 | 2009-04-02 | DEHMLOW HENRIETTA; OBST SANDER ULRIKE; SCHULZ-GASCH TANJA; WRIGHT MATTHEW |
| The invention is concerned with novel biaryl sulfonamide derivatives of formula (I) wherein R1 to R3 and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments. | ||||||
| 43 | FLUORESCENTLY TAGGED LIGANDS | PCT/GB2004001418 | 2004-03-31 | WO2004088312A3 | 2005-03-24 | GEORGE MICHAEL; HILL STEPHEN JOHN; KELLAM BARRIE; MIDDLETON RICHARD JOHN |
| Library comprising a plurality of tagged non-peptide ligands of formula (I): (Lig JL)m L(JT Tag) m (JTL(JLLig)m)p including and salts thereof comprising one or a plurality of same or different ligand moieties Lig each linked to a one or a plurality of same or different tag moieties Tag via same or different linker moieties L and same or different linking site or linking functionality JT and JL wherein Lig comprises a GPCR ligand, an inhibitor of an intracellular enzyme or a substrate or inhibitor of a drug transporter; L is a single bond or is any linking moiety selected from a heteroatom such as N, O, S, P, branched or straight chain saturated or unsaturated, optionally heteroatom containing, CI-600 hydrocarbyl and combinations thereof, which may be monomeric, oligomeric having oligomeric repeat of 2 to 30 or polymeric having polymeric repeat in excess of 30 up to 300; Tag is any known or novel tagging substrate; m are each independently selected from a whole number integer from 1 to 3; p is 0 to 3 characterised in that linking is at same or different linking sites in compounds comprising different Lig, JL, L JT and/or - Tag and is at different linking sites in compounds comprising same Lig, JL, L JT and/or - Tag; process for the preparation thereof; process for the preparation of a library compound of formula (I) or a precursor of formula (IV); method for selecting a compound of formula (I) from a library thereof; compound of formula (I) associated with information relating to its pharmacological properties; a novel compound of formula (I) or precursor of formula (IV); uses thereof; methods for binding or inhibition therewith; use of a fluorescent target therewith; a modified cell surface GPCR and cells expressing the same; and a kit comprising a compound of formula (I) and a target therefor. | ||||||
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