序号 | 专利名 | 申请号 | 申请日 | 公开(公告)号 | 公开(公告)日 | 发明人 |
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161 | Benzamide derivative | JP13207678 | 1978-10-25 | JPS5470275A | 1979-06-05 | ROJIYAA EDOWAADO FUOODO; FUIRITSUPU NOURUZU; EDOWAADO RUNTO; SUCHIYUAATO MARUKOMU MAASHIYAR; ANSONII JIYON HENRII SAMAAZU |
162 | Benzamide derivatives | JP13299377 | 1977-11-04 | JPS5359669A | 1978-05-29 | ROJIYAA EDOWAADO FUOODO; FUIRITSUPU NOURUZU; EDOWAADO RUNTO; SUCHIYUAATO MARUKOMU MAASHIYAR; ANSONII JIYON HENTEII SAMAAZU |
163 | Production of penicillin ester | JP10216376 | 1976-08-25 | JPS5253888A | 1977-04-30 | HARII FUERESU; JIYON PIITAA KUREITON |
164 | Preparation and use of novel 22hydroxynaphthalinee 11aldehyde | JP8928476 | 1976-07-28 | JPS5217454A | 1977-02-09 | TEODOORU PAAPENFUUSU; HAINRITSUHI FUORUKU |
165 | Hatsushokuseishikiryokagobutsu | JP13674475 | 1975-11-13 | JPS5174021A | 1976-06-26 | DERETSUKU JEE ORUSOPU |
166 | Shinkinahokozoku 00 hidorokishiarudehidokagobutsunoseiho | JP8969875 | 1975-07-24 | JPS5148642A | 1976-04-26 | TEODOORU PAAPENFUUSU; HERUMUUTO TOREESUTERU |
167 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | EP14768317 | 2014-03-10 | EP2970308A4 | 2016-08-10 | METCALF BRIAN W; LI ZHE; XU QING; GWALTNEY STEPHEN L II; HARRIS JASON R; YEE CALVIN W |
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation. | ||||||
168 | IRE-1A INHIBITORS | EP08770492.0 | 2008-06-09 | EP2155643B1 | 2016-08-10 | PATTERSON, John, Bruce; LONERGAN, David, Gregory; FLYNN, Gary A.; ZHENG, Qingping; PALLAI, Peter V. |
Methods of treating disorders associated with unfolded protein response and methods of inhibiting IRE-1± activity are provided. | ||||||
169 | IRE-1A Inhibitors | EP12171202.0 | 2008-06-09 | EP2532643A1 | 2012-12-12 | Patterson, John Bruce; Lonergan, David Gregory; Flynn, Gary A.; Zeng, Qingping; Pallai, Peter V. |
Methods of treating disorders associated with unfolded protein response and methods of inhibiting IRE-1α activity are provided. |
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170 | IRE-1A INHIBITORS | EP08770492.0 | 2008-06-09 | EP2155643A1 | 2010-02-24 | PATTERSON, John, Bruce; LONERGAN, David, Gregory; FLYNN, Gary A.; ZHENG, Qingping; PALLAI, Peter V. |
Methods of treating disorders associated with unfolded protein response and methods of inhibiting IRE-1± activity are provided. | ||||||
171 | BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS | EP05799391.7 | 2005-10-26 | EP1806332A1 | 2007-07-11 | TAMAKI, Kazuhiko c/o Sanky Company Limited; YAMAGUCHI, Takahiro c/o Sankyo Company Limited; ODA, Kozo c/o Sankyo Company Limited; TERASAKA, Naoki c/o Sankyo Company Limited; NAKAI, Daisuke c/o Sankyo Company Limited; NAKADAI, Masakazu c/o Sankyo Company Limited |
A superior LXR modulator is provided. A compound represented by the general formula (I):
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172 | LIGANDS OF ADENINE NUCLEOTIDE TRANSLOCASE (ANT) AND COMPOSITIONS AND METHODS RELATED THERETO | EP03814376.4 | 2003-12-19 | EP1581472A2 | 2005-10-05 | GHOSH, Soumitra, S.; PEI, Yazhong; TANG, Xiao-Qing; LIRAS, Spiros, J.; AHLIJANIAN, Michael, K. |
Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed. | ||||||
173 | METHOD OF MODIFYING COMPONENTS PRESENT IN CASHEW NUT SHELL LIQUID | EP99963628.5 | 1999-11-25 | EP1131277B1 | 2005-07-13 | KHAN, Mohammed, Lokman; TOMKINSON, Jeremy; SALISBURY, Richard, James |
The invention provides a process for modifying CNSL comprising subjecting the CNSL to ozonolysis to form ozonolysis reaction products followed by reduction of the ozonolysis reaction products to give a mixture of phenolic components and aldehydes. In a preferred embodiment, the invention provides a process for modifying CNSL which comprises the steps of first reacting CNSL with ozone to form a mixture containing ozonolysis reaction products, and secondly treating the mixture under reducing conditions to form a further mixture containing phenolic components with an eight carbon chain having a terminal CHO group and alkyl components of varying lengths with either one or two terminal CHO groups. The resulting CNSL aldehydes can be used to form adhesives for use in the manufacture of composites such as wood particle board. | ||||||
174 | NOVEL AMPHIPATHIC ALDEHYDES AND THEIR USE AS ADJUVANTS AND IMMUNOEFFECTORS | EP01918784.8 | 2001-03-16 | EP1265840A2 | 2002-12-18 | JOHNSON, David |
This invention relates to novel aldehyde containing compounds and their uses as adjuvants and immunoeffectors. | ||||||
175 | METHOD OF MODIFYING COMPONENTS PRESENT IN CASHEW NUT SHELL LIQUID | EP99963628.5 | 1999-11-25 | EP1131277A1 | 2001-09-12 | KHAN, Mohammed, Lokman; TOMKINSON, Jeremy; SALISBURY, Richard, James |
The invention provides a process for modifying CNSL comprising subjecting the CNSL to ozonolysis to form ozonolysis reaction products followed by reduction of the ozonolysis reaction products to give a mixture of phenolic components and aldehydes. In a preferred embodiment, the invention provides a process for modifying CNSL which comprises the steps of first reacting CNSL with ozone to form a mixture containing ozonolysis reaction products, and secondly treating the mixture under reducing conditions to form a further mixture containing phenolic components with an eight carbon chain having a terminal CHO group and alkyl components of varying lengths with either one or two terminal CHO groups. The resulting CNSL aldehydes can be used to form adhesives for use in the manufacture of composites such as wood particle board. | ||||||
176 | LTB4 Synthesis inhibitors | EP90124571.2 | 1990-12-18 | EP0435134B1 | 1995-06-21 | Djuric, Stevan Wakefield; Miyashiro, Julie Marion; Haack, Richard Arthur |
177 | LTB4 Synthesis inhibitors | EP90124571.2 | 1990-12-18 | EP0435134A3 | 1992-05-13 | Djuric, Stevan Wakefield; Miyashiro, Julie Marion; Haack, Richard Arthur |
This invention relates to a compound of the formula:
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178 | Verfahren zur Herstellung von 4,4'-Stilbendialdehyden | EP86810587.5 | 1986-12-15 | EP0229593B1 | 1991-10-16 | Reinehr, Dieter, Dr.; Steiner, Heinz |
179 | LTB4 Synthesis inhibitors | EP90124571.2 | 1990-12-18 | EP0435134A2 | 1991-07-03 | Djuric, Stevan Wakefield; Miyashiro, Julie Marion; Haack, Richard Arthur |
This invention relates to a compound of the formula:
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180 | Verfahren zur Herstellung von 4,4'-Stilbendialdehyden | EP86810587.5 | 1986-12-15 | EP0229593A1 | 1987-07-22 | Reinehr, Dieter, Dr.; Steiner, Heinz |
Herstellung von 4,4ʹ-Stilbendialdehyden aus den entsprechenden Säurechloriden in Gegenwart von Edelmetallkatalysatoren. |