序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
161 Benzamide derivative JP13207678 1978-10-25 JPS5470275A 1979-06-05 ROJIYAA EDOWAADO FUOODO; FUIRITSUPU NOURUZU; EDOWAADO RUNTO; SUCHIYUAATO MARUKOMU MAASHIYAR; ANSONII JIYON HENRII SAMAAZU
162 Benzamide derivatives JP13299377 1977-11-04 JPS5359669A 1978-05-29 ROJIYAA EDOWAADO FUOODO; FUIRITSUPU NOURUZU; EDOWAADO RUNTO; SUCHIYUAATO MARUKOMU MAASHIYAR; ANSONII JIYON HENTEII SAMAAZU
163 Production of penicillin ester JP10216376 1976-08-25 JPS5253888A 1977-04-30 HARII FUERESU; JIYON PIITAA KUREITON
164 Preparation and use of novel 22hydroxynaphthalinee 11aldehyde JP8928476 1976-07-28 JPS5217454A 1977-02-09 TEODOORU PAAPENFUUSU; HAINRITSUHI FUORUKU
165 Hatsushokuseishikiryokagobutsu JP13674475 1975-11-13 JPS5174021A 1976-06-26 DERETSUKU JEE ORUSOPU
166 Shinkinahokozoku 00 hidorokishiarudehidokagobutsunoseiho JP8969875 1975-07-24 JPS5148642A 1976-04-26 TEODOORU PAAPENFUUSU; HERUMUUTO TOREESUTERU
167 COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN EP14768317 2014-03-10 EP2970308A4 2016-08-10 METCALF BRIAN W; LI ZHE; XU QING; GWALTNEY STEPHEN L II; HARRIS JASON R; YEE CALVIN W
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
168 IRE-1A INHIBITORS EP08770492.0 2008-06-09 EP2155643B1 2016-08-10 PATTERSON, John, Bruce; LONERGAN, David, Gregory; FLYNN, Gary A.; ZHENG, Qingping; PALLAI, Peter V.
Methods of treating disorders associated with unfolded protein response and methods of inhibiting IRE-1± activity are provided.
169 IRE-1A Inhibitors EP12171202.0 2008-06-09 EP2532643A1 2012-12-12 Patterson, John Bruce; Lonergan, David Gregory; Flynn, Gary A.; Zeng, Qingping; Pallai, Peter V.

Methods of treating disorders associated with unfolded protein response and methods of inhibiting IRE-1α activity are provided.

170 IRE-1A INHIBITORS EP08770492.0 2008-06-09 EP2155643A1 2010-02-24 PATTERSON, John, Bruce; LONERGAN, David, Gregory; FLYNN, Gary A.; ZHENG, Qingping; PALLAI, Peter V.
Methods of treating disorders associated with unfolded protein response and methods of inhibiting IRE-1± activity are provided.
171 BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS EP05799391.7 2005-10-26 EP1806332A1 2007-07-11 TAMAKI, Kazuhiko c/o Sanky Company Limited; YAMAGUCHI, Takahiro c/o Sankyo Company Limited; ODA, Kozo c/o Sankyo Company Limited; TERASAKA, Naoki c/o Sankyo Company Limited; NAKAI, Daisuke c/o Sankyo Company Limited; NAKADAI, Masakazu c/o Sankyo Company Limited

A superior LXR modulator is provided. A compound represented by the general formula (I): [wherein R1: -COR9 (wherein R9: alkyl, optionally substituted alkoxy or optionally substituted amino); R2: H, OH, alkoxy, optionally substituted amino, etc.; R3: H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno, etc.; R4 and R5: H, optionally substituted alkyl, halogeno, etc.; R6 and R7: H, alkyl; R8: -X2R10 [wherein R10: -COR11 (wherein R11 : OH, optionally substituted alkoxy, optionally substituted amino, etc.), -SO2R12 (wherein R12: optionally substituted alkyl, optionally substituted amino, etc.), tetrazol-5-yl, etc.; X2: single bond, optionally substituted alkylene, etc.]; X1: -NH-, -O-, -S-, etc.; Y1: optionally substituted phenyl, optionally substituted 5- to 6-membered aromatic heterocyclyl; Y2: optionally substituted aryl, optionally substituted heterocyclyl, etc.] and the like is provided.

172 LIGANDS OF ADENINE NUCLEOTIDE TRANSLOCASE (ANT) AND COMPOSITIONS AND METHODS RELATED THERETO EP03814376.4 2003-12-19 EP1581472A2 2005-10-05 GHOSH, Soumitra, S.; PEI, Yazhong; TANG, Xiao-Qing; LIRAS, Spiros, J.; AHLIJANIAN, Michael, K.
Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
173 METHOD OF MODIFYING COMPONENTS PRESENT IN CASHEW NUT SHELL LIQUID EP99963628.5 1999-11-25 EP1131277B1 2005-07-13 KHAN, Mohammed, Lokman; TOMKINSON, Jeremy; SALISBURY, Richard, James
The invention provides a process for modifying CNSL comprising subjecting the CNSL to ozonolysis to form ozonolysis reaction products followed by reduction of the ozonolysis reaction products to give a mixture of phenolic components and aldehydes. In a preferred embodiment, the invention provides a process for modifying CNSL which comprises the steps of first reacting CNSL with ozone to form a mixture containing ozonolysis reaction products, and secondly treating the mixture under reducing conditions to form a further mixture containing phenolic components with an eight carbon chain having a terminal CHO group and alkyl components of varying lengths with either one or two terminal CHO groups. The resulting CNSL aldehydes can be used to form adhesives for use in the manufacture of composites such as wood particle board.
174 NOVEL AMPHIPATHIC ALDEHYDES AND THEIR USE AS ADJUVANTS AND IMMUNOEFFECTORS EP01918784.8 2001-03-16 EP1265840A2 2002-12-18 JOHNSON, David
This invention relates to novel aldehyde containing compounds and their uses as adjuvants and immunoeffectors.
175 METHOD OF MODIFYING COMPONENTS PRESENT IN CASHEW NUT SHELL LIQUID EP99963628.5 1999-11-25 EP1131277A1 2001-09-12 KHAN, Mohammed, Lokman; TOMKINSON, Jeremy; SALISBURY, Richard, James
The invention provides a process for modifying CNSL comprising subjecting the CNSL to ozonolysis to form ozonolysis reaction products followed by reduction of the ozonolysis reaction products to give a mixture of phenolic components and aldehydes. In a preferred embodiment, the invention provides a process for modifying CNSL which comprises the steps of first reacting CNSL with ozone to form a mixture containing ozonolysis reaction products, and secondly treating the mixture under reducing conditions to form a further mixture containing phenolic components with an eight carbon chain having a terminal CHO group and alkyl components of varying lengths with either one or two terminal CHO groups. The resulting CNSL aldehydes can be used to form adhesives for use in the manufacture of composites such as wood particle board.
176 LTB4 Synthesis inhibitors EP90124571.2 1990-12-18 EP0435134B1 1995-06-21 Djuric, Stevan Wakefield; Miyashiro, Julie Marion; Haack, Richard Arthur
177 LTB4 Synthesis inhibitors EP90124571.2 1990-12-18 EP0435134A3 1992-05-13 Djuric, Stevan Wakefield; Miyashiro, Julie Marion; Haack, Richard Arthur

This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, -CH = CH-or -CH = N-; wherein R1 is alkyl, alkenyl or alkynyl of about 1 to 20 carbon atoms; wherein R is -C02R2, tetrazole, methylsulfonamide or benzenesulfonamide, wherein R2 is hydrogen, alkyl of 1 to 6 carbon atoms or a pharmaceutically acceptable cation and R3 is hydroxyl or halogen, having utility as LTB4 synthesis inhibitors.

178 Verfahren zur Herstellung von 4,4'-Stilbendialdehyden EP86810587.5 1986-12-15 EP0229593B1 1991-10-16 Reinehr, Dieter, Dr.; Steiner, Heinz
179 LTB4 Synthesis inhibitors EP90124571.2 1990-12-18 EP0435134A2 1991-07-03 Djuric, Stevan Wakefield; Miyashiro, Julie Marion; Haack, Richard Arthur

This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, -CH = CH-or -CH = N-; wherein R1 is alkyl, alkenyl or alkynyl of about 1 to 20 carbon atoms; wherein R is -C02R2, tetrazole, methylsulfonamide or benzenesulfonamide, wherein R2 is hydrogen, alkyl of 1 to 6 carbon atoms or a pharmaceutically acceptable cation and R3 is hydroxyl or halogen, having utility as LTB4 synthesis inhibitors.

180 Verfahren zur Herstellung von 4,4'-Stilbendialdehyden EP86810587.5 1986-12-15 EP0229593A1 1987-07-22 Reinehr, Dieter, Dr.; Steiner, Heinz

Herstellung von 4,4ʹ-Stilbendialdehyden aus den entsprechenden Säurechloriden in Gegenwart von Edelmetallkatalysatoren.

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