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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
121	Novel amphipathic aldehydes and their uses as adjuvants and immunoeffectors	US09810915	2001-03-16	US20010053363A1	2001-12-20	David A. Johnson
This invention relates to novel aldehyde containing compounds and their uses as adjuvants and immunoeffectors.
122	Processes for the preparation of 5,6-di-hydropyrrolo[2,3-d]pyrimidines	US156327	1993-11-23	US5382668A	1995-01-17	Charles J. Barnett; Thomas M. Wilson
This invention relates to intermediates and processes thereto, for the preparation of 5,6-dihydropyrro[2,3-d]pyrimidines which are useful for the treatment of susceptible neoplasms.
123	Intermediates, and processes thereto, for the preparation of 5,6-dihydropyrrolo[2,3-d]pyrimidines	US961595	1992-10-15	US5254716A	1993-10-19	Charles J. Barnett; Thomas M. Wilson
This invention relates to intermediates and processes thereto, for the preparation of 5,6-dihydropyrro[2,3-d]pyrimidines which are useful for the treatment of susceptible neoplasms
124	LTB4 synthesis inhibitors	US787273	1991-11-04	US5179123A	1993-01-12	Stevan W. Djuric; Richard A. Haack; Julie M. Miyashiro
This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxgen, sulfur, --CH.dbd.CH--or --CH.dbd.N--; wherein R.sub.1 is alkyl, alkenyl or alkynyl of about 1 to 20 carbon atoms; wherein R is --CO.sub.2 R.sup.2, tetrazole, methylsulfonamide or benzenesulfonamide, wherein R.sup.2 is hydrogen, alkyl of 1 to 6 carbon atoms or a pharmaceutically acceptable cation and R.sup.3 is hydroxyl or halogen, having utility as LTB.sub.4 synthesis inhibitors.
125	Compounds useful in treating sickle cell anemia	US44268	1987-04-30	US4751244A	1988-06-14	Donald J. Abraham; Otto W. Woltersdorf, Jr.; Edward J. Cragoe, Jr.
The present invention is directed to compounds of the general formula I and pharmaceutically acceptable salts thereof: ##STR1## wherein: R.sup.1 =HO or HOOC(CH.sub.2).sub.x CHR.sup.2 NH--;R.sup.2 =H, lower alkyl, benzyl or --CH.sub.2 OH;x=0 or 1;A=--(CH.sub.2).sub.n -- or ##STR2## n=1 to 5; and Y=H, Cl or OCH.sub.3Z=H or Clm=0 or 1R=lower alkyl;with the proviso that where R.sup.1 =OH, Y is H or Cl and m is 1, n is 4 or 5.The present invention is also directed to an antisickling pharmaceutical carrier and an antisickling agent of the general formula (I) (without the proviso) and pharmaceutically acceptable salts thereof.
126	Compounds useful in treating sickle cell anemia	US848080	1986-04-04	US4699926A	1987-10-13	Donald J. Abraham; Otto W. Woltersdorf, Jr.; Edward J. Cragoe, Jr.
The present invention is directed to compounds of the general formula I and pharmaceutically acceptable salts thereof: ##STR1## wherein R=H or lower alkyl;R'=H, lower alkyl, benzyl, CH.sub.2 OH;A=(CH.sub.2).sub.1 to 5, >C(CH.sub.3).sub.2, >C (CH.sub.2).sub.3 ; andX=0 or 1.The present invention is also directed to a method of treating a person for sickle cell anemia comprising administering to the person a therapeutically effective dosage of the above compounds.In addition the invention includes the novel compound: ##STR2## which is inaccessible by synthetic procedures previously described for this general class of compounds.
127	Pharmaceutical compounds, preparation, use and intermediates therefor and their preparation	US332246	1981-12-18	US4535183A	1985-08-13	Geoffrey Kneen
This invention is directed to novel ether compounds of formula (I) ##STR1## which are of value in medicine in the palliation of haemoglobinopathies, in particular sickle-cell anemia, and also in the palliation of pulmonary dyefunction, protection from the effects of hypoxia and the radio-sensitization of tumours. The invention is also directed to methods for the preparation of the ether compounds, to pharmaceutical formulations containing them, the preparation of such formulations and the use of the compounds in human medicine. Also provided by the invention are intermediates of value in the preparation of the ether compounds, by the methods described, and the preparation of the intermediates.
128	Pharmaceutical ethers	US271950	1981-06-09	US4410537A	1983-10-18	Geoffrey Kneen
This invention is directed to novel ether compounds of formula (I) ##STR1## which are of value in medicine in the palliation of haemoglobinopathies, in particular sickle-cell anaemia, and also in the palliation of pulmonary dysfunction, protection from the effects of hypoxia and the radio-sensitization of tumors. The invention is also directed to methods for the preparation of the ether compounds, to pharmaceutical formulations containing them, the preparation of such formulations and the use of the compounds in human medicine. Also provided by the invention are intermediates of value in the preparation of the ether compounds, by the methods described, and the preparation of the intermediates.
129	Pharmaceutical compositions and method of use	US747995	1976-12-06	US4113879A	1978-09-12	Geraint Jones; David Summers Thomson
Pharmaceutical compositions, containing a 4,4'-dihydroxy-3,3'-triphenylmethanedicarboxylic acid (or an oxidized derivative) as active ingredient, are described and are prepared conventionally in a form suitable for topical administration, e.g., ointment. The compositions are useful for the treatment of inflammatory diseases and inflammatory conditions of the skin. Many of the active ingredients are novel compounds. A representative novel active ingredient is 4"-cyano-4,4'-dihydroxy-5,5'-dimethyl-3,3'-triphenylmethanedicarboxylic acid.
130	Novel 2-hydroxynaphthalene-1-aldehydes, process for preparing them and their use	US835299	1977-09-21	US4110375A	1978-08-29	Theodor Papenfuhs; Heinrich Volk
Novel 2-hydroxynaphthalene-1-aldehydes have been found which have the general formula (I) ##STR1## wherein R is a carboxylic acid group, a carboxylic acid ester group, preferably of an alkanol or of an optionally substituted phenol, an optionally substituted carboxylic acid amide group, or an optionally substituted carboxylic acid hydrazide group, which are very valuable intermediate products for the preparation of coloring agents, optical brighteners, textile auxiliary agents and pharmaceutical products.
131	Substituted phenoxy-3-chloro-malealdehydic acids	US61017	1970-07-09	US3954853A	1976-05-04	Rene Jean Dennilauler; Maurice Edgar Pfaff; Pierre Amedee Roman
Tanning (hardening) agents in a colloid layer of gelatin or the like are inactive at ordinary temperatures but are activated at temperatures above 70.degree.C. to rapidly tan the colloid in which they are incorporated. Suggested uses are in thermography and photography. Specific examples describe various gelatin layers containing the heat-activated hardeners. The class of useful tanning agents is described by the formula ##SPC1##Wherein the substituents R and R' are selected from hydrogen and halogen atoms and alkyl, carboxyl, alkoxy, formyl, tertiary amino and sulfo radicals. Some specific new compounds of this class are described.
132	Trifluoromethyl-substituted aromatic acids	US27309072	1972-07-19	US3882180A	1975-05-06	ENGELHARDT EDWARD L
Disclosed is the preparation of trifluoromethyl dibenzocyclohepten-5-ones, compounds useful as intermediates for medicinals.
133	Method of producing 1,8-naphthaldehyde monocarboxylic	US3728384D	1970-07-24	US3728384A	1973-04-17	POSPELOV M; YAKOVLEVA A; MENYAILO A; POKROVSKAYA I
A method of producing 1,8-naphthaldehyde monocarboxylic acid, characterized in that acenaphthylene is ozonized in the medium of a lower aliphatic alcohol, or in a mixture of a lower aliphatic alcohol with water, or in a mixture of an aliphatic ketone with water, in the presence of an alkaline earth metal hydroxide. The resulting reaction mass is treated with hydrochloric acid, the formed 1,8-naphthaldehyde monocarboxylic acid is separated from the alkaline earth metal hydroxide and washed to remove the traces of hydrochloric acid.
134	Preparation of 2-phenethyl-5-trifluoro-methylbenzoic acid	US3714239D	1969-10-08	US3714239A	1973-01-30	ENGELHARDT E
3-(BENZYL),6-(F3C-)ISOBENZOFURAN-1-ONE WHICH COMPRISES HYDROGENATING IN THE PRESENCE OF A PALLADIUM CATALYST IN A BASIC MEDIUM THE COMPOUND OF STRUCTURAL FORMULA 2-(PHENYL-CH2-CH2-),5-(F3C-)BENZOIC ACID 1. A PROCESS FOR THE PREPARATION OF THE COMPOUND OF STRUCTURAL FORMULA
135	Catalytic process of no oxidation of dialkylnaphthalenes	US3637830D	1968-11-25	US3637830A	1972-01-25	VANDERWERFF WILLIAM D; PETERSON HENRY J
USEFUL PARTIAL OXIDATION PRODUCTS OF DIALKYLNAPHTHALENES, SUCH AS THE NAPHTHALENEDICARBOXALDEHYDE AND THE NAPHTHALENEDICARBOXYLIC ACID ARE PREPARED BY USING MOLECULAR OXYGEN AND A CATALYTIC AMOUNT OF NITRIC OXIDE OR NITROGEN DIOXIDE, THAT IS SUBSTANTIALLY LESS THAN THE STOICHIOMETRIC AMOUNT OF NITROGEN DIOXIDE NECESSARY TO OXIDIZE THE DIALKYLNAPHTHALENES. THE CATALYST IS A COMBINATION OF 0.01 MOLES TO 0.6 MOLE OF THE NITROGEN OXIDE PER MOLE OF DIALKYLNAPHTHALENE AND 0.1 TO 6 WEIGHT PERCENT OF SELENIUM. THE OXIDATIONS ARE CARRIED AT SUPERATMOSPHERIC PRESSURES IN A CLOSED SYSTEM AT TEMPERATURES OF ABOUT 160275* C. OXYGEN IS ADDED IN AT LEAST THE STOICHIOMETRIC AMOUNT NEEDED FOR THE OXIDATIONS. IN THE TEMPERATURE RANGE OF ABOUT 160-225* C. THE DIALDEHYDE IS THE PREDOMINANT PRODUCT; AT ABOUT 225 TO 275* C. THE DIACID PREDOMINATES.
136	Preparation of aromatic disubstituted carboxylic acids	US3519684D	1966-12-27	US3519684A	1970-07-07	WITT ENRIQUE ROBERTO; ZEE-CHENG KWANG YUEN; CAVE JAMES PATRICK

137	Preparation of trifluoromethyl substituted dibenzocycloheptenes	US3499037D	1966-05-31	US3499037A	1970-03-03	ENGELHARDT EDWARD L

138	2,3-epoxypropylidene derivative of 5h-dibenzo(a,d)-10,11-dihydrocycloheptenes	US3452009D	1965-05-03	US3452009A	1969-06-24	WENDLER NORMAN L

139	Naphthalene separation process	US75340358	1958-08-06	US3016401A	1962-01-09	STURROCK MURRAY G; CLINE EDWIN L; ROBINSON KENNETH R; LOVIN ROBERT J

140	Process for the production of aromatic hydroxy aldehydes	US58592656	1956-05-21	US2903483A	1959-09-08	CARL BERRES

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