81 |
VISUAL DETECTION OF FLUORIDE IONS |
US13528981 |
2012-06-21 |
US20130344608A1 |
2013-12-26 |
Prasad EDAMANA; Rajamalli PACHAIYAPPAN |
Dendrimer-hydrazides are coupled to polycyclic aromatic hydrocarbons for use in the visual detection of the presence of low levels of fluoride in a sample The dendrimers can have a phenyl core, a first generation of aralkyl ethers, and an optional second generation of aralkyl ethers. The compounds form gels with solvents. In the presence of fluoride ion, the gels undergo color changes and/or gel to liquid phase change. |
82 |
NOVEL CATALYSTS |
US13885415 |
2011-11-17 |
US20130253185A1 |
2013-09-26 |
Rylan J. Lundgren; Mark Stradiotto |
The present invention provides novel compounds and ligands that are useful in transition metal catalyzed cross-coupling reactions. For example, the compounds and ligands of the present invention are useful in palladium or gold catalyzed cross-coupling reactions. |
83 |
PROCESS FOR THE PREPARATION OF CHIRAL HYDRAZIDES |
US13697800 |
2011-05-18 |
US20130203993A1 |
2013-08-08 |
Martin Albert; Dominic De Souza; Joerg Salchenegger; Michael Oberhuber |
The present invention relates to a process for the preparation of a chiral compound according to formula (V) wherein R1 is preferably an alkyl residue preferably having from 1 to 6 carbon atoms, in particular to a process for the preparation of a chiral compound the crystalline chiral compounds as such, and their use for the preparation of an antifungal agent, in particular posaconazole. |
84 |
Ligands for estrogen related receptors and methods for synthesis of said ligands |
US12475323 |
2009-05-29 |
US08044241B2 |
2011-10-25 |
Barry Forman; Donna Yu |
Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described. |
85 |
Method of forming a carbon-heteroatom bond |
US10556849 |
2004-05-12 |
US07557248B2 |
2009-07-07 |
Christelle Mauger; Gérard Mignani |
The present invention relates to a method of creating a carbon-heteroatom bond, and preferably a carbon-nitrogen bond, by reacting a leaving group-bearing unsaturated compound and a nucleophilic compound. In particular, the invention relates to the creation of a carbon-nitrogen bond, using a method involving the arylation of nitrogenous organic derivatives; the inventive method consists in creating a carbon-heteroatom bond by reacting a leaving group-bearing unsaturated compound and a nucleophilic compound introducing a heteroatom which can be substituted for the leaving group, thereby creating a carbon-heteroatom bond, in the presence of a palladium-based catalyst, optionally a ligand. The invention is characterized in that the reaction takes place in the presence of an effective quantity of a metal hydroxide or ammonium hydroxide which is associated with an alcohol-type solvent. |
86 |
Ligands for estrogen related receptors and methods for synthesis of said ligands |
US11336515 |
2006-01-20 |
US07544838B2 |
2009-06-09 |
Barry Forman; Donna Yu |
Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described. |
87 |
Process for the preparation of aryl hydrazone and aryl hydrazine |
US10493503 |
2002-10-02 |
US07138548B2 |
2006-11-21 |
Andrew John Blacker; David Dodman; David Anthony Jackson; Jan Michael Fielden; John Heathcote Atherton |
A process for the preparation of a compound of formula (I): wherein Ar represents an optionally substituted aromatic carbocycle or heterocycle, and R1 and R2 independently represent hydrogen, C1-10 alkyl, C(O)C1-10 alkyl or optionally substituted aryl provided that R1 and R2 are not both hydrogen which process comprises reacting together a compound of formula (II): Ar—X (II) wherein Ar is as defined in relation to formula (I) and X represents a leaving group with a a compound of formula (III) wherein R1 and R2 are as defined in relation to formula (I) under aqueous conditions in the presence of a Pd (II) salt, a ligand and a Group I or Group II metal hydroxide base at a pH greater than 7. Compounds of formula (I) may be hydrolysed to the corresponding hydrazine. |
88 |
Method for the organometallic production of organic intermediate products comprising carbon-heteroatom bonds achieved by the deprotonation of heteroatoms |
US10526327 |
2003-08-21 |
US20050258553A1 |
2005-11-24 |
Andreas Meudt; Bernd Lehnemann; Michael Erbes; Klaus Forstinger |
The invention relates to a method for binding heteroatom-carbon bonds. According to said method, a lithium compound (II) is first generated by reacting aliphatic or aromatic halogen compounds (I) with lithium metal, said compound is then used for the deprotonation of the compounds (III) or (V). The lithium salts of formulas (IV) or (VI) obtained by said deprotonation are subsequently reacted with suitable carbon electrophiles (equation I), said process binding the heteroatom-carbon bond and forming the products (VIII) or (VIII), (equation I). |
89 |
Ligands for metals and improved metal-catalyzed processes based thereon |
US10420950 |
2003-04-22 |
US06946560B2 |
2005-09-20 |
Stephen L. Buchwald; David W. Old; John P. Wolfe; Michael Palucki; Ken Kamikawa |
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency. |
90 |
Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds |
US10128981 |
2002-04-24 |
US06759554B2 |
2004-07-06 |
Stephen L. Buchwald; Artis Klapars; Jon C. Antilla; Gabriel E. Job; Martina Wolter; Fuk Y. Kwong; Gero Nordmann; Edward J. Hennessy |
The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-oxygen bond between the oxygen atom of an alcohol and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. The present invention also relates to copper-catalyzed methods of forming a carbon-carbon bond between a reactant comprising a nucleophilic carbon atom, e.g., an enolate or malonate anion, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. Importantly, all the methods of the present invention are relatively inexpensive to practice due to the low cost of the copper comprised by the catalysts. |
91 |
Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds |
US10435719 |
2003-05-08 |
US20040019216A1 |
2004-01-29 |
Stephen
L.
Buchwald; Artis
Klapars; Jon
C.
Antilla; Gabriel
E.
Job; Martina
Wolter; Fuk
Y.
Kwong; Gero
Nordmann; Edward
J.
Hennessy |
The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-oxygen bond between the oxygen atom of an alcohol and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. The present invention also relates to copper-catalyzed methods of forming a carbon-carbon bond between a reactant comprising a nucleophilic carbon atom, e.g., an enolate or malonate anion, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. Importantly, all the methods of the present invention are relatively inexpensive to practice due to the low cost of the copper comprised by the catalysts. |
92 |
Ligands for metals and improved metal-catalyzed processes based thereon |
US10420950 |
2003-04-22 |
US20040010149A1 |
2004-01-15 |
Stephen
L.
Buchwald; David
W.
Old; John
P.
Wolfe; Michael
Palucki; Ken
Kamikawa |
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency. |
93 |
Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds |
US10128981 |
2002-04-24 |
US20030065187A1 |
2003-04-03 |
Stephen
L.
Buchwald; Artis
Klapars; Jon
C.
Antilla; Gabriel
E.
Job; Martina
Wolter; Fuk
Y.
Kwong; Gero
Nordmann; Edward
J.
Hennessy |
The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-oxygen bond between the oxygen atom of an alcohol and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. The present invention also relates to copper-catalyzed methods of forming a carbon-carbon bond between a reactant comprising a nucleophilic carbon atom, e.g., an enolate or malonate anion, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. Importantly, all the methods of the present invention are relatively inexpensive to practice due to the low cost of the copper comprised by the catalysts. |
94 |
Ligands for metals and improved metal-catalyzed processes based thereon |
US09113478 |
1998-07-10 |
US06395916B1 |
2002-05-28 |
Stephen L. Buchwald; John P. Wolfe; David W. Old; Ken Kamikawa; Michael Palucki |
One aspect of the present invention relates to novel, electron-rich bidentate ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency. |
95 |
Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates |
US09030936 |
1998-02-26 |
US06235936B1 |
2001-05-22 |
Stephen L. Buchwald; Seble Wagaw; Oliver Fabian Geis |
A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols. |
96 |
Catalytic synthesis of azines from H.sub.2 O.sub.2 /NH.sub.3 /carbonyl
compounds |
US797356 |
1991-11-25 |
US5239119A |
1993-08-24 |
Jean-Pierre Schirmann; Pierre Tellier |
Azines are synthesized from aqueous hydrogen peroxide, ammonia and a carbonyl compound, e.g., acetone, methyl ethyl ketone or methyl isobutyl ketone, in the presence of a catalytically effective amount of immixture of an amide of a weak acid and an ammonium salt corresponding to such weak acid. A more general high output such process comprises (a) interreacting aqueous hydrogen peroxide, ammonia and a carbonyl compound in the presence of a catalytically effective amount of immixture comprising an amide of a weak acid, (b) separating the azine thus produced from the medium of reaction, (c) reconstituting the amount of the amide in the medium of reaction to the initial amount thereof present at the onset of step (a), and (d) recycling such reconstituted medium of reaction to step (a). |
97 |
Purification of 1,1-dimethyl hydrazine (UDMH) containing formaldehyde
dimethyl hydrazone |
US921926 |
1978-07-03 |
US4154658A |
1979-05-15 |
George W. Nauflett |
The formaldehyde hydrazone of UDMH can be removed from an aqueous solutionf UDMH by codistillation with a hydrocarbon or other solvent which is inert to both acidic or basis mediums. The solvent can then be recovered from the hydrazone solution by washing with an acid solution and the solvent can be reused. |
98 |
Process for the preparation of hydrazones |
US406467 |
1973-10-15 |
US3943132A |
1976-03-09 |
Jean-Pierre Schirmann; Henri Mathais; Pierre Tellier; Francis Weiss |
This invention relates to a method of preparing hydrazones of the formula ##EQU1## in which R.sub.1 and R.sub.2, which may be identical or different, represent a linear alkyl radical of from 1 to 12 carbon atoms, a branched alkyl or cycloalkyl radical of from 3 to 12 carbon atoms, an aromatic radical of from 6 to 12 carbon atoms having a benzene or naphthalene nucleus, or a radical of from 5 to 12 carbon atoms having a pyridine nucleus, or R.sub.1 and R.sub.2 together form a linear or branched alkylene radical of from 3 to 12 carbon atoms in which one of the carbon atoms of the chain may be replaced by an oxygen atom, all of the above radicals being unsubstituted or substituted by one or more atoms or groups such as chlorine, bromine, fluorine, or iodine atoms or hydroxy, ether, carboxylic acid, carboxylic amide or ester, nitrile, nitro, or sulphonic acid or amide groups, or one of the two radicals R.sub.1 and R.sub.2 may be a hydrogen atom, and in which R.sub.3 and R.sub.4, which may be identical or different, represent a hydrogen atom, a linear alkyl or cycloalkyl radical of from 3 to 12 carbon atoms, in which one of the carbon atoms of the cycloalkyl radical may be replaced by an oxygen atom, or an aromatic hydrocarbon radical of from 6 to 12 carbon atoms or R.sub.3 and R.sub.4 together represent a linear or branched alkylene radical of from 3 to 11 carbon atoms, the above radicals being unsubstituted or substituted by atoms or groups such as chlorine, bromine, fluorine, ethylenic groups, nitro, hydroxy, alkoxy, or carboxylic acid or ester radicals , which comprises reacting a primary or secondary amine of the formulaWherein R.sub.1 and R.sub.2 are as defined above, ammonia, and a carbonyl compound of the formulaWherein R.sub.3 and R.sub.4 are as defined above, with a peroxide compound. |
99 |
Carboalkoxylation of olefins |
US3527794D |
1965-08-13 |
US3527794A |
1970-09-08 |
HECK RICHARD F |
|
100 |
Process |
US61064356 |
1956-09-18 |
US2872485A |
1959-02-03 |
GRUNDMAUN CHRISTOPH J; ALFRED KREUTZBERGER |
|