| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 用于预防和/或治疗龋齿的手段和方法 | CN200580038100.2 | 2005-09-09 | CN101056972B | 2012-07-04 | B·卡斯勒; R·克内尔; M·博特内尔; E·布德; C·朗; M·里瑟尔; M·维恩 |
| 本发明涉及属于乳酸细菌组的特征在于能够特异性结合至变形链球菌的微生物，其中所述特异性结合(i)抗热处理；和/或(ii)抗蛋白酶处理；和/或(iii)是钙依赖性的；和/或(iv)在pH 4.5和8.5范围间形成；和/或(v)在唾液存在时形成。优选地，该特异性结合可以如下分析：(a)生长所述微生物至稳定期(b)将所述微生物与已经生长至稳定期的变形链球菌混合；(c)在允许所述微生物与变形链球菌形成聚集体的条件下温育步骤(b)得到的混合物，和(d)通过沉淀的出现检测聚集体。本发明的另一个方面是所述微生物的经热灭活或冻干的类似物或碎片，其中所述类似物或碎片保留特异性结合至变形链球菌的能力。此外，本发明包括用于食品、饲料或饮料的组合物和添加物，其包含特异性结合至变形链球菌的属于乳酸细菌组的微生物或类似物或其碎片。此外，本发明提供了所述微生物或所述类似物或其碎片用于制备防龋的组合物或药物组合物或防龋的食品或饲料的用途以及用于产生所述组合物或者食品或饲料的方法。 | ||||||
| 2 | 用于预防和/或治疗龋齿的手段和方法 | CN201010265371.4 | 2005-09-09 | CN101948773A | 2011-01-19 | B·卡斯勒; R·克内尔; M·博特内尔; E·布德; C·朗; M·里瑟尔; M·维恩 |
| 本发明涉及属于乳酸细菌组的特征在于能够特异性结合至变形链球菌的微生物，其中所述特异性结合(i)抗热处理；和/或(ii)抗蛋白酶处理；和/或(iii)是钙依赖性的；和/或(iv)在pH 4.5和8.5范围间形成；和/或(v)在唾液存在时形成。优选地，该特异性结合可以如下分析：(a)生长所述微生物至稳定期(b)将所述微生物与已经生长至稳定期的变形链球菌混合；(c)在允许所述微生物与变形链球菌形成聚集体的条件下温育步骤(b)得到的混合物，和(d)通过沉淀的出现检测聚集体。本发明的另一个方面是所述微生物的经热灭活或冻干的类似物或碎片，其中所述类似物或碎片保留特异性结合至变形链球菌的能力。此外，本发明包括用于食品、饲料或饮料的组合物和添加物，其包含特异性结合至变形链球菌的属于乳酸细菌组的微生物或类似物或其碎片。此外，本发明提供了所述微生物或所述类似物或其碎片用于制备防龋的组合物或药物组合物或防龋的食品或饲料的用途以及用于产生所述组合物或者食品或饲料的方法。 | ||||||
| 3 | 用于预防和/或治疗龋齿的手段和方法 | CN200580038100.2 | 2005-09-09 | CN101056972A | 2007-10-17 | B·卡斯勒; R·克内尔; M·博特内尔; E·布德; C·朗; M·里瑟尔; M·维恩 |
| 本发明涉及属于乳酸细菌组的特征在于能够特异性结合至变形链球菌的微生物，其中所述特异性结合(i)抗热处理；和/或(ii)抗蛋白酶处理；和/或(iii)是钙依赖性的；和/或(iv)在pH 4.5和8.5范围间形成；和/或(v)在唾液存在时形成。优选地，该特异性结合可以如下分析：(a)生长所述微生物至稳定期(b)将所述微生物与已经生长至稳定期的变形链球菌混合；(c)在允许所述微生物与变形链球菌形成聚集体的条件下温育步骤(b)得到的混合物，和(d)通过沉淀的出现检测聚集体。本发明的另一个方面是所述微生物的经热灭活或冻干的类似物或碎片，其中所述类似物或碎片保留特异性结合至变形链球菌的能力。此外，本发明包括用于食品、饲料或饮料的组合物和添加物，其包含特异性结合至变形链球菌的属于乳酸细菌组的微生物或类似物或其碎片。此外，本发明提供了所述微生物或所述类似物或其碎片用于制备防龋的组合物或药物组合物或防龋的食品或饲料的用途以及用于产生所述组合物或者食品或饲料的方法。 | ||||||
| 4 | MEANS AND METHODS FOR PREVENTING AND/OR TREATING CARIES | US15602475 | 2017-05-23 | US20170258708A1 | 2017-09-14 | Bruno KAESLER; Rolf Knöll; Mewes Boettner; Eckhard Budde; Christine Lang; Martin Ryser; Markus Veen |
| The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention. | ||||||
| 5 | Means and Methods for Preventing and/or Treating Caries | US13462171 | 2012-05-02 | US20120237454A1 | 2012-09-20 | Bruno Kaesler; Rolf Knöll; Mewes Boettner; Eckhard Budde; Christine Lang; Martin Ryser; Markus Veen |
| The present invention relates to a microorganism belonging to the group of lactic acid bacteria capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; (ii) resistant to protease treatment; (iii) calcium-dependent; (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. The present invention is also relates to an analog or fragment of the microorganism which is thermally inactivated or lyophilized, wherein the analog or fragment retains the capability of specifically binding to Streptococcus mutans. The invention further encompasses compositions and additives for food, feed or drinks comprising the microorganism or an analog or fragment thereof. Also provided is uses of the microorganism or an analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing the compositions or food or feedstuff. | ||||||
| 6 | Microorganism of the genus Lactobacillus capable of binding to S. mutans and compositions comprising the same | US11662347 | 2005-09-09 | US08192978B2 | 2012-06-05 | Bruno Kaesler; Rolf Knöll; Mewes Boettner; Eckhard Budde; Christine Lang; Martin Ryser; Markus Veen |
| The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention. | ||||||
| 7 | Means and Methods for Preventing and/or Treating Caries | US11662347 | 2005-09-09 | US20080193427A1 | 2008-08-14 | Bruno Kaesler; Rolf Knoll; Mewes Boettner; Eckhard Budde; Christine Lang; Martin Ryser; Markus Veen |
| The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention. | ||||||
| 8 | Means and methods for preventing and / or treating dental caries | JP2007530658 | 2005-09-09 | JP5143559B2 | 2013-02-13 | カエスラー，ブルーノ; クノル，ロルフ; ボエトナー，メヴェス; ブッデ，エクハルド; ラング，クリスティーネ; リゼル，マルティン; ヴェーン，マルクス |
| The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention. | ||||||
| 9 | Means and methods for preventing and / or treating dental caries | JP2007530658 | 2005-09-09 | JP2008512104A | 2008-04-24 | ヴェーン，マルクス; カエスラー，ブルーノ; クノル，ロルフ; ブッデ，エクハルド; ボエトナー，メヴェス; ラング，クリスティーネ; リゼル，マルティン |
| 本発明は、ストレプトコッカス・ミュータンス（Streptococcus mutans）と特異的に結合できることを特徴とする乳酸菌のグループに属する微生物に関し、前記特異的結合は、(i) 加熱処理に抵抗する、および/または(ii) プロテアーゼ処理に抵抗する、および/または(iii) カルシウム依存性である、および/または(iv) 4.5〜8.5のpH範囲で形成される、および/または(v) 唾液の存在下で形成される。 好ましくは、特異的結合は次のようにアッセイすることができる：(a) 前記微生物を静止期になるまで増殖させ、(b) 前記微生物を、静止期へと増殖させたストレプトコッカス・ミュータンスと混合し、(c) ステップ(b)で得られた混合物を、前記微生物とストレプトコッカス・ミュータンスとの凝集物の形成を可能にする条件下でインキュベートし、(d) ペレットの出現により凝集物を検出する。 本発明のもう一つの形態は、熱的に不活性化されているかまたは凍結乾燥されている前記微生物の類似体または断片であり、前記類似体または断片はストレプトコッカス・ミュータンスと特異的に結合する能力を保持している。 加えて、本発明は、ストレプトコッカス・ミュータンスと特異的に結合する乳酸菌のグループに属する微生物またはその類似体もしくは断片を含んでなる、食品、飼料または飲料用の組成物および添加物を包含する。 さらに、抗う蝕原性組成物もしくは医薬組成物、または抗う蝕原性食品もしくは飼料を製造するための前記微生物またはその類似体もしくは断片の使用、ならびに前記組成物または食品もしくは飼料を製造するための方法が本発明により提供される。 | ||||||
| 10 | Means and methods for preventing and/or treating caries | EP10184944.6 | 2005-09-09 | EP2267112B1 | 2016-05-11 | Kaesler, Bruno; Knöll, Rolf; Böttner, Mewes; Budde, Eckhard; Lang, Christine; Ryser, Martin; Veen, Markus |
| The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention. | ||||||
| 11 | Means and methods for preventing and/or treating caries | EP04021591.5 | 2004-09-10 | EP1634948A1 | 2006-03-15 | Kaesler, Bruno; Knöll, Rolf; Boettner, Mewes; Budde, Eckhard; Lang, Christine; Ryser, Martin; Veen, Markus |
The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows:
Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention. |
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| 12 | Means and methods for preventing and/or treating caries | EP10160493.2 | 2005-09-09 | EP2218774A2 | 2010-08-18 | Kaesler, Bruno; Knöll, Rolf; Boettner, Mewes; Budde, Eckhard; Lang, Christine; Ryser, Martin; Veen, Markus |
The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention. |
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| 13 | MEANS AND METHODS FOR PREVENTING AND/OR TREATING CARIES | EP05790013.6 | 2005-09-09 | EP1797170B1 | 2010-04-21 | KAESLER, Bruno; KNÖLL, Rolf; BOETTNER, Mewes; BUDDE, Eckhard; LANG, Christine; RYSER, Martin; VEEN, Markus |
| The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention. | ||||||
| 14 | う蝕を予防および／または治療するための手段ならびに方法 | JP2014138510 | 2014-07-04 | JP2015006185A | 2015-01-15 | KAESLER BRUNO; KNOELL ROLF; BOETTNER MEWES; BUDDE ECKHARD; LANG CHRISTINE; RYSER MARTIN; VEEN MARKUS |
| 【課題】う蝕の予防及び/又は治療に有用な作用物質の提供。【解決手段】ストレプトコッカス・ミュータンスと特異的に結合し、前記特異的結合が加熱処理に抵抗する、及び/又は、プロテアーゼ処理に抵抗する、及び/又は、カルシウム依存性である、及び/又は、pH4.5〜8.5の範囲で形成される、及び/又は、唾液の存在下で形成される、乳酸菌のグループに属する微生物、又は前記微生物の変異体、誘導体、類似体若しくは断片を含んでなる組成物。【選択図】なし | ||||||
| 15 | う蝕を予防および／または治療するための手段ならびに方法 | JP2012089420 | 2012-04-10 | JP5632874B2 | 2014-11-26 | カエスラー，ブルーノ; クノル，ロルフ; ボエトナー，メヴェス; ブッデ，エクハルド; ラング，クリスティーネ; リゼル，マルティン; ヴェーン，マルクス |
| 16 | Means and method for preventing and/or treating caries | JP2012089420 | 2012-04-10 | JP2012161327A | 2012-08-30 | KAESLER BRUNO; KNOELL ROLF; BOETTNER MEWES; BUDDE ECKHARD; LANG CHRISTINE; RYSER MARTIN; VEEN MARKUS |
| PROBLEM TO BE SOLVED: To provide an agent which is not harmful for a subject in need of caries prophylaxis and/or treatment, which can be effectively and easily used for treating caries and which can be cheaply produced in large amounts.SOLUTION: The invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it can specifically bind to Streptococcus mutans. Alternatively, the invention relates to an analog or fragment of the microorganism which retains the capacity of specifically binding to Streptococcus mutans and is thermally inactivated or lyophilized. In addition, the invention encompasses compositions and additives for food, feedstuff or drinks comprising the microorganism belonging to the group of lactic acid bacteria or an analog or fragment thereof. Moreover, uses of the microorganism or the analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing the compositions or food or feedstuff are provided. | ||||||
| 17 | Means and methods for preventing and/or treating caries | EP10184944.6 | 2005-09-09 | EP2267112A1 | 2010-12-29 | Kaesler, Bruno; Knöll, Rolf; Böttner, Mewes; Budde, Eckhard; Lang, Christine; Ryser, Martin; Veen, Markus |
The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.
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| 18 | Means and methods for preventing and/or treating caries | EP10160493.2 | 2005-09-09 | EP2218774A3 | 2010-09-22 | Kaesler, Bruno; Knöll, Rolf; Boettner, Mewes; Budde, Eckhard; Lang, Christine; Ryser, Martin; Veen, Markus |
The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention. |
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| 19 | MEANS AND METHODS FOR PREVENTING AND/OR TREATING CARIES | EP05790013.6 | 2005-09-09 | EP1797170A1 | 2007-06-20 | KAESLER, Bruno; KNÖLL, Rolf; BOETTNER, Mewes; BUDDE, Eckhard; LANG, Christine; RYSER, Martin; VEEN, Markus |
| The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention. | ||||||
