| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | INFANT FORMULA WITH PROBIOTICS AND MILK FAT GLOBULE MEMBRANE COMPONENTS | US13514513 | 2010-12-07 | US20120321600A1 | 2012-12-20 | Jalil Benyacoub; Stephanie Blum-Sperisen; Mohamed Nabil Bosco; Lionel Jean Rene Bovetto; Isabelle Bureau-Franz; Anne Donnet-Hughes; Eduardo Schiffrin; Laurent Favre |
| A nutritional composition is proposed comprising a probiotic and milk fat globule membrane (MFGM) wherein the MFGM and the probiotics mutually potentiate their respective effects and promote complementary beneficial protective mechanisms that reflect physiological synergy. The nutritional composition can be an infant formula, infant cereals, baby food or health care nutritional product. The synergistic effect can include promoting immune maturation and/or immune education and/or reducing inflammation and/or treating or preventing disease or infections. | ||||||
| 42 | METHOD FOR INHIBITING ACCUMULATION OF VISCERAL FAT | US13053992 | 2011-03-22 | US20110171317A1 | 2011-07-14 | Hiroshi KAWAKAMI; Satoshi HIGURASHI; Hiroaki MATSUYAMA |
| Disclosed is: a visceral fat accumulation inhibitor or a food or drink for inhibiting the accumulation of a visceral fat, which composes a fat globule membrane component as an active ingredient; or a agent or food or drink for promoting the increase in the blood adiponection level and/or inhibiting the decrease in the blood adiponection level, which composes a fat globule membrane component as an active ingredient. A fat globule membrane component can inhibit the accumulation of a visceral fat, and/or can promote the increase in or inhibit the decrease in the blood adiponection level. | ||||||
| 43 | COMPOSITIONS COMPRISING PHOSPHOLIPIDS | US12673300 | 2008-08-15 | US20110098254A1 | 2011-04-28 | Andrew Brown; Michelle Rowney |
| The present invention provides compositions comprising phospholipids and particularly those comprising at least 40% phospholipid and at least 80% phospholipid as a percentage of total fat in the extract, comprising polyunsaturated and saturated phospholipids, in a ratio of saturated phospholipid to monounsaturated to polyunsaturated phospholipid of about 6:3:1 respectively, or comprising at least 40% phospholipid and less than 40% protein and methods for their production from dairy products. | ||||||
| 44 | VISCERAL FAT ACCUMULATION INHIBITOR, AND AGENT FOR PROMOTING THE INCREASE IN AND/OR INHIBITING THE DECREASE IN BLOOD ADIPONECTIN LEVEL | US12302973 | 2006-05-31 | US20090117198A1 | 2009-05-07 | Hiroshi Kawakami; Satoshi Higurashi; Hiroaki Matsuyama |
| Disclosed is: a visceral fat accumulation inhibitor or a beverage/food for inhibiting the accumulation of a visceral fat, which comprises a fat globule membrane component as an active ingredient; or a agent or beverage/food for promoting the increase in and/or inhibiting the decrease in the blood adiponectin level, which comprises a fat globule membrane component as an active ingredient. A fat globule membrane component can inhibit the accumulation of a visceral fat, and/or can promote the increase in or inhibit the decrease in the blood adiponectin level. | ||||||
| 45 | Bulk preparation of milk fat globule membranes | US09714423 | 2000-11-16 | US06391362B1 | 2002-05-21 | Ronald C. Gorewit |
| A bulk preparation method for isolating milk fat globule membranes from milk in which the separation method is the same whether the milk fat globule membranes are collected in bulk in the dairy industry or collected for an individual patient for diagnostic purposes. The method includes the steps of channeling the desired quantity of unhomogenized milk through a pasteurizer (high temperature, short time) and whipping the milk thus pasteurized into two phases. Phase 1 is the cream phase and phase 2 is the first aqueous phase. The cream phase is separated from the first aqueous phase and is washed with distilled or sterile water at about 37 degrees Celsius for approximately 24 hours to create a second aqueous phase, which is then filtered and dried (by spray drying or lyophilization, for example) to create a solid milk fat globule membrane product. | ||||||
| 46 | Method of detecting expression of and isolating the protein encoded by the BRCA1 gene | US703776 | 1996-08-27 | US5905026A | 1999-05-18 | Vitaly L. Spitsberg; Ronald C. Gorewit |
| The present disclosure teaches that the proteins encoded by the BRCA1 and BRCA2 genes are found in the milk fat globule membranes from humans and cows. Therefore, BRCA1 and BRCA2 proteins can be isolated from milk produced by lactating animals. The level of expression of BRCA1 or BRCA2 can be determined by sampling the levels of BCRA1 or BRCA2 proteins found in the MFGM of lactating animals. The present invention also includes a method of determining the likelihood that a woman will develop breast cancer by measuring the amount of the BRCA1 or JBRCA2 expression during lactation. The detection of expression of BRCA1 or BRCA2 can be accomplished with an antibody raised specifically against BRCA1 or BRCA2 proteins, by isolating BCRA1 or BRCA2 from the milk fat globule membranes or by detecting activity of BRCA1 or BRCA2. The level of BRCA1 or BRCA2 is compared to a reference scale of propensity for breast cancer development correlated to normally active BRCA1 or BRCA2 levels. BRCA1, BRCA2, fatty acid binding proteins and phosphorylated proteins are found in the MFGM and the MFGM can be isolated from milk and provided in a form suitable for oral consumption, i.e. a tablet or capsule of separated milk fat globule membranes, a food additive, or a fortified dairy commodity. | ||||||
| 47 | 극성 지질 강화 우유 성분 및 이의 사용 | KR1020097000987 | 2007-07-13 | KR101492647B1 | 2015-02-12 | 달레만스,다니엘; 블렉커,크리스토프; 보드슨,파스칼; 단틴,사바인; 데로안,클라우드; 파쿠오트,미첼 |
| 극성 지질, 특히 인지질 및 스핑고지질이 강화된 우유 성분으로서, 인지질의 백분율 함량은 상기 성분의 고체 중량에 대하여 10중량% 이상인 우유 성분, 및 파스퇴르화 크림으로부터 출발하여 상기 성분을 얻는 방법 및 식품 및/또는 약학적 생산물에의 이들의 사용이 개시된다. | ||||||
| 48 | SUPPLEMENTATION OF MILK FORMULAS WITH MICROVESICLES ISOLATED FROM MILK | EP16868155.9 | 2016-11-29 | EP3380617A1 | 2018-10-03 | REIF, Shimon; GOLAN, Regina |
| Provided are microvesicles isolated from milk, compositions thereof and uses for the preparation of milk formulas. Further provided are microvesicles, including exosomes and/or fat globules which encapsulate various miRNA molecules and uses thereof, as exemplified by supplementing milk formulas. | ||||||
| 49 | POWDER BEING RICH IN MILK-ORIGIN COMPLEX LIPIDS | EP12154529.7 | 2006-09-27 | EP2452567B8 | 2017-04-12 | Miura, Susumu; Kojima, Kenji; Nakano, Taku; Kato, Ken; Tomizawa, Akira; Yoshioka, Toshimitsu |
| 50 | PROCEDE DE FABRICATION D'UN PRODUIT LAITIER A TENEUR REDUITE EN GLUCIDES ET ENRICHI EN PHOSPOLIPIDES, NOTAMMENT EN CHOLINE, PROTEINES ET CALCIUM | EP10703188.2 | 2010-02-09 | EP2413705B1 | 2013-01-16 | EFSTATHIOU, Théo |
| 51 | Verfahren zum Behandeln von Milch, mit derartigen Verfahren erhaltene Milchprodukte und Verwendung von mit solchen Verfahren erhaltenen Milchprodukten | EP10001672.4 | 2010-02-18 | EP2227943A1 | 2010-09-15 | Besner, Hans |
Verfahren zum Behandeln von Milch, bei dem die Milch einem Trennvorgang in einer Zentrifugenanordnung unterzogen wird, wobei die Betriebsparameter der Zentrifugenanordnung so eingestellt werden, daß Fraktionen unterschiedlicher Fettkugelgrößenverteilung voneinander getrennt werden. |
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| 52 | VISCERAL FAT ACCUMULATION INHIBITOR, AND AGENT FOR PROMOTING THE INCREASE IN AND/OR INHIBITING THE DECREASE IN BLOOD ADIPONECTIN LEVEL | EP07737233 | 2007-05-30 | EP2039365A4 | 2010-08-11 | KAWAKAMI HIROSHI; HIGURASHI SATOSHI; MATSUYAMA HIROAKI |
| 53 | COMPOSITIONS COMPRISING PHOSPHOLIPIDS | EP08782939.6 | 2008-08-15 | EP2178539A1 | 2010-04-28 | BROWN, Andrew; ROWNEY, Michelle |
| The present invention provides compositions comprising phospholipids and particularly those comprising at least 40% phospholipid and at least 80% phospholipid as a percentage of total fat in the extract, comprising polyunsaturated and saturated phospholipids, in a ratio of saturated phospholipid to monounsaturated to polyunsaturated phospholipid of about 6:3:1 respectively, or comprising at least 40% phospholipid and less than 40% protein and methods for their production from dairy products. | ||||||
| 54 | POWDER BEING RICH IN MILK-ORIGIN COMPLEX LIPIDS | EP06810632 | 2006-09-27 | EP1938695A4 | 2009-08-19 | MIURA SUSUMU; KOJIMA KENJI; NAKANO TAKU; KATO KEN; TOMIZAWA AKIRA; YOSHIOKA TOSHIMITSU |
| A dry substance which can be obtained by adjusting the pH value of butter serum or a liquid comprising reconstituted butter serum powder to 4.0 to 5.0, adding calcium chloride thereto to promote protein aggregation, removing the precipitate thus formed, ultrafiltering or microfiltering the supernatant, and then drying the liquid concentrate thus obtained and contains from 15 to 35% by weight of proteins and from 45 to 60% by weight of lipids wherein the content of complex lipids originating in milk amounts to 20% by weight or more in the dry product. Thus, it is possible to produce a powder being rich in milk-origin complex lipids which contains milk-origin phospholipids and milk-origin ganglioside at high concentrations and is usable as a starting material for producing a functional food, a substitute for maternal milk or a drug. | ||||||
| 55 | 종양 형성 또는 성장을 억제하고, 암, 암 증상 또는 암 치료 증후를 치료 또는 예방하는 면역 또는 혈액학적 강화 방법 | KR1020097025876 | 2008-05-14 | KR1020100024930A | 2010-03-08 | 칸워자가트라케시; 크리산센제프리웨인; 선수에잉; 팔마노케이패트리시아; 맥기본알래스테어케네스휴 |
| The present invention relates to administration of milk fat or a milk fat analogue, optionally with at least one additional therapeutic factor, preferably lactoferrin or metal ion lactoferrin, preferably iron lactoferrin, preferably bovine lactoferrin, preferably iron bovine lactoferrin, or a metal ion functional variant or functional fragment thereof, to inhibit tumour formation or growth, maintain or improve one or more of the white blood cell count, the red blood cell count, or the myeloid cell count, reduce cachexia, mucositis, and anemia, stimulate the immune system and treat or prevent cancer and the symptoms of cancer and side-effects of cancer therapies. The methods and medicinal uses of the invention may be carried out by employing dietary (as foods or food supplements), nutraceutical or pharmaceutical compositions. Compositions useful in the methods of the invention are also provided. | ||||||
| 56 | 극성 지질 강화 우유 성분 및 이의 사용 | KR1020097000987 | 2007-07-13 | KR1020090046784A | 2009-05-11 | 달레만스,다니엘; 블렉커,크리스토프; 보드슨,파스칼; 단틴,사바인; 데로안,클라우드; 파쿠오트,미첼 |
| 극성 지질, 특히 인지질 및 스핑고지질이 강화된 우유 성분으로서, 인지질의 백분율 함량은 상기 성분의 고체 중량에 대하여 10중량% 이상인 우유 성분, 및 파스퇴르화 크림으로부터 출발하여 상기 성분을 얻는 방법 및 식품 및/또는 약학적 생산물에의 이들의 사용이 개시된다. | ||||||
| 57 | 젖 유래 복합지질 고함유 분말 | KR1020087010139 | 2006-09-27 | KR1020080066726A | 2008-07-16 | 미우라스스무; 고지마겐지; 나카노다쿠; 가토겐; 도미자와아키라; 요시오카도시미쯔 |
| A dry substance which can be obtained by adjusting the pH value of butter serum or a liquid comprising reconstituted butter serum powder to 4.0 to 5.0, adding calcium chloride thereto to promote protein aggregation, removing the precipitate thus formed, ultrafiltering or microfiltering the supernatant, and then drying the liquid concentrate thus obtained and contains from 15 to 35% by weight of proteins and from 45 to 60% by weight of lipids wherein the content of complex lipids originating in milk amounts to 20% by weight or more in the dry product. Thus, it is possible to produce a powder being rich in milk-origin complex lipids which contains milk-origin phospholipids and milk-origin ganglioside at high concentrations and is usable as a starting material for producing a functional food, a substitute for maternal milk or a drug. | ||||||
| 58 | 내장 지방 축적 억제제 및 혈중 아디포넥틴 농도 증가 촉진및/또는 감소 억제제 | KR1020087030960 | 2007-05-30 | KR101390044B1 | 2014-04-29 | 카와카미,히로시; 히구라시,사토시; 마츄야마,히로아키 |
| 본 발명은 지방구 피막 성분을 유효 성분으로 하는 내장 지방 축적 억제제 및 내장 지방 축적 억제용 음식품, 혹은 지방구 피막 성분을 유효 성분으로 하는 혈중 아디포넥틴 농도 증가 촉진 및/또는 감소 억제제, 및 혈중 아디포넥틴 농도 증가 촉진 및/또는 감소 억제용 음식품을 공개한다. 지방구 피막 성분에 의해 내장 지방 축적 억제 및/또는 혈중 아디포넥틴 농도의 증가를 촉진, 혹은 혈중 아디포넥틴 농도의 감소를 억제한다. | ||||||
| 59 | 젖 유래 복합지질 고함유 분말 | KR1020087010139 | 2006-09-27 | KR101317037B1 | 2013-10-11 | 미우라스스무; 고지마겐지; 나카노다쿠; 가토겐; 도미자와아키라; 요시오카도시미쯔 |
| 버터 세럼(butter serum) 또는 버터 세럼 파우더 환원액을 pH 4.0~5.0으로 조정하고, 염화칼슘을 첨가하여 단백질의 응집을 촉진시켜, 생성된 침전을 제거하고, 상청을 한외여과 또는 정밀여과함으로써 얻어진 농축액을 건조함으로써 얻을 수 있는, 건조물 중 단백질 15~35 중량%, 지질 45~60 중량%를 함유하고, 그 중 젖 유래 복합지질을 건조물 중 20 중량% 이상 함유함으로써, 기능성 식품, 모유 대체품 또는 의약품의 원료로서 이용 가능한, 젖 유래 인지질 및 젖 유래 강글리오시드를 고농도로 함유하는 젖 유래 복합지질 고함유 분말을 제조한다. | ||||||
| 60 | 내장 지방 축적 억제제 및 혈중 아디포넥틴 농도 증가 촉진및/또는 감소 억제제 | KR1020087030960 | 2007-05-30 | KR1020090024167A | 2009-03-06 | 카와카미,히로시; 히구라시,사토시; 마츄야마,히로아키 |
| a visceral fat accumulation inhibitor or a beverage/food for inhibiting the accumulation of a visceral fat, which comprises a fat globule membrane component as an active ingredient; or a agent or beverage/food for promoting the increase in and/or inhibiting the decrease in the blood adiponectin level, which comprises a fat globule membrane component as an active ingredient. A fat globule membrane component can inhibit the accumulation of a visceral fat, and/or can promote the increase in or inhibit the decrease in the blood adiponectin level. | ||||||
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