| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | METHODS OF IMMUNE OR HEMATOLOGICAL ENHANCEMENT, INHIBITING TUMOUR FORMATION OR GROWTH, AND TREATING OR PREVENTING CANCER, CANCER SYMPTOMS, OR THE SYMPTOMS OF CANCER TREATMENTS | US12600208 | 2008-05-14 | US20110182943A1 | 2011-07-28 | Jagat Rakesh Kanwar; Geoffrey Wayne Krissansen; Xueying Sun; Kay Patricia Palmano; Alastair Kenneth Hugh MacGibbon |
| The present invention relates to administration of milk fat or a milk fat analogue, optionally with at least one additional therapeutic factor, preferably lactoferrin or metal ion lactoferrin, preferably iron lactoferrin, preferably bovine lactoferrin, preferably iron bovine lactoferrin, or a metal ion functional variant or functional fragment thereof, to inhibit tumour formation or growth, maintain or improve one or more of the white blood cell count, the red blood cell count, or the myeloid cell count, reduce cachexia, mucositis, and anemia, stimulate the immune system and treat or prevent cancer and the symptoms of cancer and side-effects of cancer therapies. The methods and medicinal uses of the invention may be carried out by employing dietary (as foods or food supplements), nutraceutical or pharmaceutical compositions. Compositions useful in the methods of the invention are also provided. | ||||||
| 22 | POWDER BEING RICH IN MILK-ORIGIN COMPLEX LIPIDS | US12088224 | 2006-09-27 | US20090269458A1 | 2009-10-29 | Susumu Miura; Kenji Kojima; Taku Nakano; Ken Kato; Akira Tomizawa; Toshimitsu Yoshioka |
| Manufacture a powder with high milk-derived complex lipid content that contains milk-derived phospholipids and milk-derived ganglioside at high concentrations, which contains protein by 15 to 35 percent by dry weight and fat by 45 to 60 percent by dry weight, wherein the content of milk-derived complex lipids is 20 percent by dry weight or more, and which can be utilized as a material for functional food, mother's milk substitute or drug, by means of adjusting the pH value of a butter serum or butter serum powder reconstituted liquid to a range of 4.0 to 5.0, adding calcium chloride to promote coagulation of protein, removing the produced sediments, filtering the supernatant by means of ultrafiltration or microfiltration, and then drying the obtained concentrate. | ||||||
| 23 | Beta-Serum Dairy Products, Neutral Lipid-Depleted and/or Polar Lipid-Enriched Dairy Products, and Processes for Their Production | US11577190 | 2005-10-12 | US20080139499A1 | 2008-06-12 | Katrina Fletcher; Owen Catchpole; John Bertram Grey; Mark Pritchard |
| Processes for producing dairy products having lower levels of neutral lipids, and/or higher levels of polar lipids, by extraction using near critical carbon dioxide or dimethyl ether. These products may be used as ingredients in infant formulas. Infant formulas containing beta-serum are also claimed. “Beta-serum” means an aqueous dairy ingredient separated from dairy streams containing greater than 60% fat which have been through phase inversion from an oil-in- water to a water-in-oil emulsion, such as the serum produced during the production of butter oil. | ||||||
| 24 | Preparation of milk fat globule membranes in tablet or capsule form | US09236906 | 1999-01-25 | US06444247B1 | 2002-09-03 | Ronald C. Gorewit |
| The present disclosure teaches that the proteins encoded by the BRCA1 and BRCA2 genes are found in the milk fat globule membranes from humans and cows. Therefore, BRCA1 and BRCA2 proteins can be isolated from milk produced by lactating animals. The level of expression of BRCA1 or BRCA2 can be determined by sampling the levels of BRCA1 or BRCA2 proteins found in the MFGM of lactating animals. The present invention also includes a method of determining the likelihood that a woman will develop breast cancer by measuring the amount of the BRCA1 or BRCA2 expression during lactation. The detection of expression of BRCA1 or BRCA2 can be accomplished with an antibody raised specifically against BRCA1 or BRCA2 proteins, by isolating BRCA1 or BRCA2 from the milk fat globule membranes or by detecting activity of BRCA1 or BRCA2. The level of BRCA1 or BRCA2 is compared to a reference scale of propensity for breast cancer development correlated to normally active BRCA1 or BRCA2 levels. BRCA1, BRCA2, fatty acid binding proteins and phosphorylated proteins are found in the MFGM and the MFGM can be isolated from milk and provided in a form suitable for oral consumption, i.e. a tablet or capsule of separated milk fat globule membranes, a food additive, or a fortified dairy commodity. | ||||||
| 25 | Polar lipid fortified milk components and its application | JP2009519951 | 2007-07-13 | JP5079805B2 | 2012-11-21 | ダニエル・デールマン; クリストフ・ブレッカー; パスカル・ボドソン; サビーネ・ダンティーヌ; クロード・デロアンヌ; ミシェル・パコ |
| 26 | Immune or hematological enhancement, inhibition of tumor formation or growth, and, cancer, methods of treatment or prevention of the symptoms of cancer symptoms or cancer treatment | JP2010508327 | 2008-05-14 | JP2010526873A | 2010-08-05 | ラケシュ カンワル，ジャガート; ウェイン クリッサンセン，ジョフリー; スン，シュエイン; パトリシア パルマノ，ケイ; ケネス ヒュー マクギボン，アラステア |
| The present invention relates to administration of milk fat or a milk fat analogue, optionally with at least one additional therapeutic factor, preferably lactoferrin or metal ion lactoferrin, preferably iron lactoferrin, preferably bovine lactoferrin, preferably iron bovine lactoferrin, or a metal ion functional variant or functional fragment thereof, to treat mucositis. | ||||||
| 27 | Agent for inhibiting visceral fat accumulation and agent for promoting increase in and/or inhibiting decrease in blood adiponectin concentration | JP2006152553 | 2006-05-31 | JP2007320901A | 2007-12-13 | KAWAKAMI HIROSHI; HIGURE SATOSHI; MATSUYAMA HIROAKI |
| <P>PROBLEM TO BE SOLVED: To provide an agent and food or drink for inhibiting visceral fat accumulation, or an agent and food or drink for promoting increase in and/or inhibiting decrease in blood adiponectin concentration. <P>SOLUTION: The agent and the food or drink for inhibiting visceral fat accumulation each contains a fat globule membrane component as an active ingredient. The agent and the food or drink for promoting increase in and/or inhibiting decrease in blood adiponectin concentration each contains a fat globule membrane component as an active ingredient. The fat globule membrane component inhibits visceral fat accumulation and/or promotes increase in blood adiponectin concentration or inhibits decrease in blood adiponectin concentration. <P>COPYRIGHT: (C)2008,JPO&INPIT | ||||||
| 28 | SUPPLEMENTATION OF MILK FORMULAS WITH MICROVESICLES ISOLATED FROM MILK | US15778993 | 2016-11-29 | US20180343882A1 | 2018-12-06 | Shimon REIF; Regina GOLAN |
| Provided are microvesicles isolated from milk, compositions thereof and uses for the preparation of milk formulas. Further provided are microvesicles, including exosomes and/or fat globules which encapsulate various miRNA molecules and uses thereof, as exemplified by supplementing milk formulas. | ||||||
| 29 | LIPID COMPOSITION FOR IMPROVING BEHAVIOUR | US15503930 | 2015-08-17 | US20170273343A1 | 2017-09-28 | Annemiek Lidewij SCHIPPER; Eline Marleen VAN DER BEEK; Nana BARTKE |
| The present invention relates to a method for improving behaviour in a human subject, comprising administering a nutritional composition comprising 5-50 wt % vegetable lipids based on dry weight of the composition to the subject, the nutritional composition comprising lipid globules having (i) a volume-weighted mode diameter above 1.0 micrometer and/or (ii) a diameter of 2 to 12 micrometer in an amount of at least 45 volume % based on total lipid, wherein improving behaviour is selected from (a) increasing novel object recognition; (b) increasing the preference for novelty; (c) increasing the attention for surroundings; and (d) increasing exploratory behaviour and/or exploratory activity. | ||||||
| 30 | Milk ingredient enriched in polar lipids and uses thereof | US12306621 | 2007-07-13 | US09700061B2 | 2017-07-11 | Daniel Dalemans; Christophe Blecker; Pascal Bodson; Sabine Danthine; Claude Deroanne; Michel Paquot |
| A milk ingredient is enriched in polar lipids, in particular in phospholipids and in sphingolipids, in which the percentage of phospholipids is greater than 10% by weight, relative to the weight of solids of the ingredient, and a method obtains the same starting from pasteurized cream and is used in food and/or pharmaceutical products. | ||||||
| 31 | Infant formula with probiotics and milk fat globule membrane components | US13514513 | 2010-12-07 | US09226521B2 | 2016-01-05 | Jalil Benyacoub; Stephanie Blum-Sperisen; Mohamed Nabil Bosco; Lionel Jean Rene Bovetto; Isabelle Bureau-Franz; Anne Donnet-Hughes; Eduardo Schiffrin; Laurent Favre |
| A nutritional composition is proposed comprising a probiotic and milk fat globule membrane (MFGM) wherein the MFGM and the probiotics mutually potentiate their respective effects and promote complementary beneficial protective mechanisms that reflect physiological synergy. The nutritional composition can be an infant formula, infant cereals, baby food or health care nutritional product. The synergistic effect can include promoting immune maturation and/or immune education and/or reducing inflammation and/or treating or preventing disease or infections. | ||||||
| 32 | POWER BEING RICH IN MILK-ORIGIN COMPLEX LIPIDS | US14552012 | 2014-11-24 | US20150086698A1 | 2015-03-26 | Susumu Miura; Kenji Kojima; Taku Nakano; Ken Kato; Akira Tomizawa; Toshimitsu Yoshioka |
| Manufacture a powder with high milk-derived complex lipid content that contains milk-derived phospholipids and milk-derived ganglioside at high concentrations, which contains protein by 15 to 35 percent by dry weight and fat by 45 to 60 percent by dry weight, wherein the content of milk-derived complex lipids is 20 percent by dry weight or more, and which can be utilized as a material for functional food, mother's milk substitute or drug, by means of adjusting the pH value of a butter serum or butter serum powder reconstituted liquid to a range of 4.0 to 5.0, adding calcium chloride to promote coagulation of protein, removing the produced sediments, filtering the supernatant by means of ultrafiltration or microfiltration, and then drying the obtained concentrate. | ||||||
| 33 | METHOD TO SEPARATE LIPIDS FROM CHEESE WHEY AND FAT-FREE WHEY PROTEIN PRODUCT FORMED THEREBY | US13739501 | 2013-01-11 | US20130129889A1 | 2013-05-23 | Srinivasan Damodaran |
| Disclosed is a method of selectively separating milk fat globule membrane fragments and milk fat globules from whey. The method includes the steps of adding to whey an amount of a whey-soluble zinc salt and adjusting the pH of the whey to be less than 6.0. The amount of zinc salt added to the whey is sufficient to cause milk fat globule membrane fragments and milk fat globules contained in the whey to precipitate selectively from the whey. | ||||||
| 34 | Method to separate lipids from cheese whey | US12247324 | 2008-10-08 | US08431174B2 | 2013-04-30 | Srinivasan Damodaran |
| Shown is a method of selectively separating milk fat globule membrane fragments and milk fat globules from whey. The method includes the steps of adding to whey an amount of a whey-soluble zinc salt and adjusting the pH of the whey to be less than 6.0. The amount of zinc salt added to the whey is sufficient to cause milk fat globule membrane fragments and milk fat globules contained in the whey to precipitate selectively from the whey. | ||||||
| 35 | METHOD TO SEPARATE LIPIDS FROM CHEESE WHEY AND FAT-FREE WHEY PROTEIN PRODUCT FORMED THEREBY | US12247324 | 2008-10-08 | US20100086657A1 | 2010-04-08 | Srinivasan Damodaran |
| Disclosed is a method of selectively separating milk fat globule membrane fragments and milk fat globules from whey. The method includes the steps of adding to whey an amount of a whey-soluble zinc salt and adjusting the pH of the whey to be less than 6.0. The amount of zinc salt added to the whey is sufficient to cause milk fat globule membrane fragments and milk fat globules contained in the whey to precipitate selectively from the whey. | ||||||
| 36 | MILK INGREDIENT ENRICHED IN POLAR LIPIDS AND USES THEREOF | US12306621 | 2007-07-13 | US20100068293A1 | 2010-03-18 | Daniel Dalemans; Christophe Blecker; Pascal Bodson; Sabine Danthine; Claude Deroanne; Michel Paquot |
| A milk ingredient is enriched in polar lipids, in particular in phospholipids and in sphingolipids, in which the percentage of phospholipids is greater than 10% by weight, relative to the weight of solids of the ingredient, and a method obtains the same starting from pasteurized cream and is used in food and/or pharmaceutical products. | ||||||
| 37 | DAIRY SPREAD COMPOSITION AND METHOD FOR ITS PRODUCTION | US15947348 | 2018-04-06 | US20180332867A1 | 2018-11-22 | Uwe Wärner; Peter Stampe |
| A dairy spread composition is suggested, obtained or obtainable by: (a) providing a cream fraction having a content of at least 40% by weight fat and at least 6% by weight fat-free dry matter; (b) subjecting the cream fraction to a temperature ripening step; (c) churning the ripened cream fraction, and separating the buttermilk; (d) adding salt and an acidification permeate to the butter such obtained; (e) mixing the acidified at 12 to 16° C. with a vegetable fat that is liquid at this temperature; (f) adding an aqueous phase to the blend in small doses, and (g) packaging the blend after homogenisation and cooling. | ||||||
| 38 | Nutritional Compositions Containing an Enriched Lipid Fraction and Uses Thereof | US13794151 | 2013-03-11 | US20140255537A1 | 2014-09-11 | DATTATREYA BANAVARA; ZEINA JOUNI; JOHN ALVEY; JUAN GONZALEZ |
| The present disclosure relates to a nutritional composition comprising a fat source that includes an enriched lipid fraction derived from milk. The enriched lipid fraction may contain saturated fatty acids, trans-fatty acids, monounsaturated fatty acids, CLAs, BCFAs, cholesterol, milk fat globule membrane proteins, gangliosides, and mixtures thereof. The enriched lipid fraction may exhibit additive or synergistic beneficial health effects when consumed. The disclosure further relates to methods of providing a nutritional composition comprising an enriched lipid fraction to targeted subjects. | ||||||
| 39 | Method to separate lipids from cheese whey | US13956761 | 2013-08-01 | US08771772B2 | 2014-07-08 | Srinivasan Damodaran |
| Shown is a method of selectively separating milk fat globule membrane fragments and milk fat globules from whey. The method includes the steps of adding to whey an amount of a whey-soluble zinc salt and adjusting the pH of the whey to be less than 6.0. The amount of zinc salt added to the whey is sufficient to cause milk fat globule membrane fragments and milk fat globules contained in the whey to precipitate selectively from the whey. | ||||||
| 40 | Method to separate lipids from cheese whey | US13739501 | 2013-01-11 | US08734878B2 | 2014-05-27 | Srinivasan Damodaran |
| Shown is a method of selectively separating milk fat globule membrane fragments and milk fat globules from whey. The method includes the steps of adding to whey an amount of a whey-soluble zinc salt and adjusting the pH of the whey to be less than 6.0. The amount of zinc salt added to the whey is sufficient to cause milk fat globule membrane fragments and milk fat globules contained in the whey to precipitate selectively from the whey. | ||||||
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