| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 521 | Test swab and method of using same | US325149 | 1994-10-20 | US5550061A | 1996-08-27 | Marcia J. Stone |
| A swab is impregnated with a test reagent such that a test for a specific substance can be effected by rubbing the impregnated swab over the surface to be tested and then viewing the swab for a reagent reaction. The swab may have a hollow stem, and within the hollow stem is a cartridge within another cartridge. An activator solution is in one of the cartridges and a reagent is in another of the cartridges. A method for testing for a substance includes impregnating a swab, and rubbing the swab over a surface suspected of containing the substance. If the substance is present in the surface, a reaction with the substance produces an easily detectable color on the swab tip. | ||||||
| 522 | Method for diagnosing myofibrogranuloma (MFG) in walleye | US532091 | 1995-09-22 | US5543330A | 1996-08-06 | Harry L. Holloway, Jr.; Craig A. Shoemaker |
| An improved method for diagnosing myofibrogranuloma (MFG) in walleye without harming the fish is described. Blood samples are drawn from walleye and creatinine and calcium levels are then determined along with the sex and length of the fish. These data are then analyzed and compared to data from healthy walleye using discriminant analysis. The process is effective for identifying approximately 88% of MFG-positive walleye. | ||||||
| 523 | Fluorescent polymers useful in conjunction with optical PH sensors | US453633 | 1995-05-30 | US5536783A | 1996-07-16 | Alan Olstein; William Fowler; Jo Pritchard |
| An optical sensor is provided for measuring the pH of a fluid sample. The sensor is formulated using a fluorescent polymer composition comprising a copolymer of a water-dispersable, polyether-containing urethane olefin precursor and a fluorescent monomer species, wherein the ratio of precursor and fluorescent monomer species is such that a predetermined apparent pKa is provided. The sensor is prepared by coating the distal end of an optical waveguide with the fluorescent polymer composition, and curing the copolymer contained in the composition, e.g., by exposure to radiation of a suitable wavelength. | ||||||
| 524 | Fluorescent ion-selective diaryldiaza crown ether conjugates | US375360 | 1995-01-19 | US5516864A | 1996-05-14 | Michael A. Kuhn; Richard P. Haugland |
| This invention describes novel sensors for ions that are based on the combination of xanthylium-based dyes with metal-binding N,N'-diaryldiaza crown ethers. These sensors are primarily useful for detection and quantitation of alkali-metal ions in aqueous solution. Binding of the ion results in a change in the fluorescence properties of the indicating dye that can be correlated with the ion concentration. Methods are provided for attaching reactive groups on these sensors for conjugation to dyes, lipids and polymers and for enhancing entry of the indicators into living cells. | ||||||
| 525 | Biosensor for detecting iron | US512950 | 1995-08-09 | US5516697A | 1996-05-14 | Marian L. Kruzel |
| A simple, cost effective assay of iron is accomplished by using lactoferrin as part of a biosensor to detect iron in a sample. The lactoferrin releases protons when the iron is sequestered by the lactoferrin and the change in potential caused by the release of protons is measured by a potentiometer or pH sensing device. The sensing devices include the ion-selective or ion sensitive field effect transistors (ISFET), a potentiometric device or the pH indicator papers. | ||||||
| 526 | Monoclonal antibodies specific for small moieties and method for their use | US990543 | 1992-12-14 | US5503987A | 1996-04-02 | Fred W. Wagner; Dwane E. Wylie; Sheldon M. Schuster |
| The invention is directed to monoclonal antibodies which immunoreact with bare small moieties such as metallic cations and small organic molecules, the hybridomas for production of the monoclonal antibodies, immunogen compounds for developing the hybridomas, and methods for use of the monoclonal antibodies. | ||||||
| 527 | Determination of potassium ions in fluids | US308823 | 1994-09-19 | US5501958A | 1996-03-26 | Michael N. Berry; Michael-Harold Town; Georg-Burkhard Kresse; Uwe Herrmann |
| A process and a reagent for the determination of ions in fluids, wherein the influence of these ions on the activity of an enzyme is measured. The ions for example are sodium, potassium, calcium, magnesium, manganese, lithium, lead, zinc, copper, iron or other heavy metals or non-metallic ions comprising chloride, bicarbonate, protons, ammonium and substances that give rise to ammonium. The enzymes which are used may be a transferase, a hydrolase, an oxidoreductase or a lyase. An essential feature is a method to exclude interferences by ions by masking the interfering ions with a binding agent. | ||||||
| 528 | Fiber optic potassium ion sensor | US918486 | 1992-07-22 | US5462989A | 1995-10-31 | Ganapati R. Mauze; Lothar Rupp |
| A sensor (10) is provided for detecting the concentration of potassium ions which comprises a molecule which selectively complexes potassium ions. The molecule, e.g., 2,2-bis[3,4-(15-crown-5)-2-nitrophenylcarbamoxymethyl]tetradecanol-14, has at least one binding site and is provided with a fluorophore group, e.g., Rhodamine-B, at that site. The molecule is one that expands upon complexation of potassium ions, such that the intensity of fluorescence increases. The change in fluorescent intensity is a direct measure of the concentration of potassium ions. A detector employing the sensor is also provided. | ||||||
| 529 | Diluent and method for determination of total calcium | US144928 | 1993-10-27 | US5424214A | 1995-06-13 | Frank R. Shu; Xihai Mu; Suzanne C. Chung; Peter J. Houben; James T. Kessler |
| Diluents and methodologies for determining the concentration of total calcium in a clinical sample (e.g. whole blood, sera plasma urine cerebro spinal fluid) containing protein-bound calcium are disclosed. Methodologies include the steps of: (a) admixing the sample with a diluent, the diluent including effective amounts of a pH buffer and at least two agents capable of complexing free calcium in the sample, where the agent-calcium complex association constants ("log K" in base 10) each have a range from about 1.5 to about 7.0; and (b) contacting an aliquot of the diluted sample with a calcium-specific ion selective electrode. The response of the calcium-specific ion selective electrode is an indication of the concentration of total calcium in the sample. | ||||||
| 530 | Blood gas/electrolyte calibrator and quality controls | US252383 | 1994-06-01 | US5422278A | 1995-06-06 | Kathryn D. Herring |
| Aqueous solutions containing buffers and electrolytes are adjusted to levels required for calibration of both blood gas analyzers and ion selective electrolyte analyzers. A control material, composed of similar matrix, is adjusted to three levels of blood gas and electrolyte conditions. These quality control materials are used to monitor blood gas/electrolyte laboratory instrumentation. | ||||||
| 531 | Long-wavelength fluorescent probe compounds for calcium ions and their use in ratiometrically measuring calcium ion concentrations | US998849 | 1992-12-30 | US5409835A | 1995-04-25 | Joseph R. Lakowicz; Engin U. Akkaya |
| Fluorescent, calcium-binding probe compounds having visible-light excitation and emission wavelengths, and a method of usage for these probe compounds in making wavelength-ratiometric or intensity-ratiometric measurements of calcium ion concentration in samples. The probe compounds generally relate to a heterocyclic part as bonded to a Ca.sup.2+ binding unit, namely, BAPTA, via an ethylenically unsaturated group; preferred examples of the heterocyclic group include benzothiazole, naphthothiazole, thiaflavin, indolenine, chloroindolenine, methoxybenzothiazole, and methoxyindolenine. | ||||||
| 532 | Method, composition and device for measuring the ionic strength or specific gravity of a test sample | US217555 | 1994-03-25 | US5403744A | 1995-04-04 | Chris T. Zimmerle |
| A method, composition and test device for determining the ionic strength or specific gravity of a test sample are disclosed. The method utilizes a test device comprising a test pad, wherein the test pad includes a carrier matrix incorporating a reagent composition capable of producing a detectable and measurable response that correlates to the ionic strength and the buffer capacity, and therefore the specific gravity, of the test sample. The reagent composition, comprising a strong polyelectrolyte, an indicator comprising: (i) a dye that is metachromatic and sensitive to pH changes, or (ii) or a combination of metachromatic dye and a pH indicator dye, in a suitable carrier, and buffered at a pH of 3 or less, is incorporated into a carrier matrix to provide a test pad of a device useful in an ionic strength or specific gravity assay of a test sample. | ||||||
| 533 | Method for quantitative flow injection analysis of metals in body fluids | US81617 | 1993-06-23 | US5387524A | 1995-02-07 | Yutaka Hayashibe; Minoru Takeya; Yasumasa Sayama |
| This invention provides a measuring method for the quantitative flow injection analysis of metal elements contained in body fluids comprising introducing the protein liberated by the reaction of body fluid sample and protein-precipitating reagent into a separating membrane for preventing the passage of protein to separate and remove the liberated protein, and then introducing the reacted solution into quantitative analysis means for determining and measuring the concentration of target metal contained in the body fluid. | ||||||
| 534 | Determination of ions in fluids by a process involving displacement of indicator ions | US907732 | 1992-06-22 | US5384246A | 1995-01-24 | Michael N. Berry; Michael-Harold Town; Georg-Burkhard Kresse; Uwe Herrmann |
| A process and a reagent for the determination of ions in fluids, wherein the influence of these ions on the activity of an enzyme is measured. The ions for example are sodium, potassium, calcium, magnesium, manganese, lithium, lead, zinc, copper, iron or other heavy metals or non-metallic ions comprising chloride, bicarbonate, protons, ammonium and substances that give rise to ammonium. The enzymes which are used may be a transferase, a hydrolase, an oxidoreductase or a lyase. An essential feature is a method to exclude interferences by ions by masking the interfering ions with a binding agent. | ||||||
| 535 | Enzymatic determination of analyte ions in fluids by optimizing measurement levels | US907731 | 1992-06-22 | US5380649A | 1995-01-10 | Michael N. Berry; Michael-Harold Town; Georg-Burkhard Kresse; Uwe Herrmann |
| A process and a reagent for the determination of ions in fluids, wherein the influence of these ions on the activity of an enzyme is measured. The ions for example are sodium, potassium, calcium, magnesium, manganese, lithium, lead, zinc, copper, iron or other heavy metals or non-metallic ions comprising chloride, bicarbonate, protons, ammonium and substances that give rise to ammonium. The enzymes which are used may be a transferase, a hydrolase, an oxidoreductase or a lyase. An essential feature is a method to exclude interferences by ions by masking the interfering ions with a binding agent. | ||||||
| 536 | Separation of strontium from fecal matter | US195248 | 1994-02-14 | US5378631A | 1995-01-03 | Dianne K. Kester |
| A method of separating strontium from a sample of biomass potentially contaminated with various radionuclides. After the sample is reduced, dissociated, and carried on a first precipitate of actinides, the first precipitate is removed to leave a supernate. Next, oxalic acid is added to the supernate to cause a second precipitate of strontium and calcium. Then, after separating the second precipitate, nitric acid is added to the second precipitate to cause a third precipitate of strontium. The calcium remains in solution and is discarded to leave essentially the precipitate of strontium. | ||||||
| 537 | Use of phenol derivative in colorimetric analysis of metal ions | US970643 | 1992-11-02 | US5376552A | 1994-12-27 | Kuniaki Tokuda; Taeko Soma; Naoki Teno |
| A phenol derivative obtained by reacting a carboxylic acid anhydride with a phenol compound, followed by condensation with iminodiacetic acid and formaldehyde, or a salt thereof is effective as an agent for adjusting color forming sensitivity in a colorimetric analysis of metal ions in a fluid such as a living body fluid. | ||||||
| 538 | Compositions for use as diagnostic animal litter and methods for their preparation | US106161 | 1993-08-13 | US5371054A | 1994-12-06 | Richard C. Pluta; Frank J. Washabaugh; William S. Stoy |
| Disclosed are compositions suitable for use as a litter for the accumulation of animal urine comprised of at least one uncalcined clay substrate, said substrate characterized by having a calcium oxide content of less than about 5% by weight and wherein the clay mineral component of said substrate contains at least about 35% by weight attapulgite, combined with at least one chemical pH indicator which provides a visual indication of pH change.Also disclosed are processes for making such compositions and to litters using such compositions. | ||||||
| 539 | Ionized magnesium.sup.2+ concentrations in biological samples | US998518 | 1992-12-30 | US5364642A | 1994-11-15 | Bella T. Altura; Burton M. Altura |
| The present invention provides a method for preparing and storing biological samples prior to measuring ionized Mg.sup.2+ concentrations in order to obtain accurate and reproducible readings. A novel method for accurately reading ionized magnesium ion concentrations in biological samples is provided. A method for monitoring ionized Mg.sup.2+ concentrations and ionized Ca.sup.2+ :Mg.sup.2+ ratios in a patient, useful in diagnosing and prognosing disease states including cardiopulmonary bypass surgery, hypertension, abnormal pregnancy, head trauma, and fetal abnormalities is provided as well as a composition and a method of treating a patient with ionized Mg.sup.2+ or ionized Ca.sup.2+ and Mg.sup.2+. | ||||||
| 540 | Assay method for the determination of lithium with novel substituted crown dyes | US26330 | 1993-03-04 | US5344782A | 1994-09-06 | Cheng-I Lin; Marcel Pirio |
| Assay methods are provided for determining the presence of lithium in high sodium content liquids such as serum, plasma, urine or other sample without deproteinization. The novel compounds are water soluble derivatives of TMC-crownformazans and provide signal enhancement by increased absorbance of the dye-lithium complex over the dye anion. | ||||||
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